Clinical trials: Lung Disease Chronic
Pulmonary Disease, Chronic Obstructive, COPD
Real-Time Support for Exercise Persistence in COPD
The purpose of this exploratory study is to determine the feasibility, acceptability, and efficacy of an exercise persistence intervention for patients with chronic obstructive pulmonary disease (COPD) following pulmonary…
- Conditions
- Pulmonary Disease, Chronic Obstructive, COPD, Emphysema, Chronic Bronchitis
- Trial name
- NCT00373932
- Testing
- Coached exercise persistence intervention, Self-Monitored exercise persistence intervention
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of Washington
COPD, COPD Exacerbation
Study of Physiological Signals During and After COPD Exacerbations
Background : Acute exacerbations of COPD (Chronic Obstructive Pulmonary Disease) are frequent events in the course of the disease and they can deteriorate the respiratory function of the patients, impact their quality of life and…
- Trial name
- DACRE (NCT04034901)
- Testing
- Monitoring of cardiorespiratory parameters with BORA Band
- Where
- France
- Volunteers
- 42 people
- Sponsor
- Biosency
Chronic Graft vs Host Disease
A Study to Investigate the Comparative Effectiveness of Ibrutinib in Steroid Dependent/Refractory cGVHD Participants
The purpose of this study is to evaluate the effectiveness of ibrutinib compared to conventional salvage treatments in participants with steroid dependent/refractory chronic graft versus host disease (cGVHD) by measuring overall…
- Trial name
- NCT04852692
- Where
- 8 sites in South Korea
- Volunteers
- 15 people
- Sponsor
- Janssen Korea, Ltd., Korea
Chronic Respiratory Disease
Telemonitoring Physical Activity in Daily Life on Chronic Respiratory Patients
Physical inactivity is a consequence of chronic diseases and on Chronic Obstructive Pulmonary Disease patients is an independent predictor of the risk of hospitalizations and early mortality.
- Trial name
- SmartReab (NCT03930511)
- Testing
- Pulmonary Rehabilitation
- Where
- 2 sites in Portugal
- Volunteers
- 100 people
- Sponsor
- University of Lisbon
Pulmonary Rehabilitation, Chronic Obstructive Lung Disease
Does Neuromuscular Electrical Stimulation Benefit the Functional Ability of Elderly Patients With Chronic Obstructive Lung Disease
Background: Patients with COPD often experience skeletal muscle dysfunction. For those who are unable or unwilling to undertake physical training, neuromuscular electrical stimulation (NMES) may provide an alternative method of…
- Conditions
- Pulmonary Rehabilitation, Chronic Obstructive Lung Disease, Neuromuscular Electrical Stimulation, Pulmonary Function (FEV1/FVC)
- Trial name
- NEMS for COPD (NCT05838911)
- Testing
- Study Group chest physiotherapy program combined with neuromuscular electrical stimulation (NMES), Control Group Chest physical therapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Bronchiolitis, Pneumonia
A Study of Tobacco Smoke and Children With Respiratory Illnesses
This study aims to assess the feasibility of using an intervention for environmental smoke exposure in children that uses cotinine testing results with written materials and telephone counseling for a potential future study of…
- Conditions
- Bronchiolitis, Pneumonia, Reactive Airway Disease, Asthma
- Trial name
- NCT03062709
- Testing
- Breathe Easy Coalition written materials, Maine Tobacco Helpline, Urine cotinine testing
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- MaineHealth
COPD
Efficacy and Safety of 400 μg Twice Daily of Aclidinium Bromide vs. Placebo When Administered to Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
The purpose of this study was to observe the Efficacy and safety of 400 μg twice daily of aclidinium bromide vs. placebo when administered to patients with moderate to severe chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT01636401
- Testing
- aclidinium bromide 400 μg
- Where
- South Korea
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Bone Marrow Transplant Infection, Bronchiolitis Obliterans
Prospective Study of Belated Pulmonary Complications Occurring in Children Treated With Allogeneic Hematopoietic Stem Cells.
Hematopoietic stem cell transplantation (HSCT) is used to treat an expanding array of malignant and non-malignant disorders. This is a prospective multicenter study, in pediatric allo-BMT recipients to analyze the spectrum of…
- Conditions
- Bone Marrow Transplant Infection, Bronchiolitis Obliterans, Chronic Respiratory Insufficiency, Organizing Pneumonia
- Trial name
- RESPPEDHEM (NCT02032381)
- Testing
- late pulmonary complications occurring in children treated with allogeneic hematopoietic stem cells.
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COPD
Impact of COPD on Muscle Regeneration
Muscle weakness and atrophy are important consequences of chronic obstructive pulmonary disease (COPD) and can affect both respiratory and peripheral muscles.
- Trial name
- NCT02557165
- Testing
- Muscle biopsies
- Volunteers
- 27 people
- Sponsor
- Laval University
Insomnia
Cognitive Behavioral Therapy for Insomnia in People With Chronic Obstructive Pulmonary Disease(COPD)
A two-phase research study is being conducted. In Phase 1 of the study, the cognitive behavioral therapy intervention for insomnia was implemented in a small (n = 5) group of people with moderate to severe COPD and insomnia.
- Trial name
- NCT01072292
- Testing
- CBT-I
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Illinois Chicago
Chronic Obstructive Pulmonary Disease (COPD)
Long Term Safety and Tolerability of QVA149 Versus Tiotropium in Japanese Patients With Chronic Obstructive Pulmonary Disease (COPD)
This is a 52-week treatment, multi-center, randomized, open label, parallel group study to assess the long term safety and tolerability of once-daily QVA149 (indacaterol and NVA237 ([glycopyrronium bromide]) using tiotropium as…
- Trial name
- NCT01285492
- Testing
- QVA149, Tiotropium
- Where
- 35 sites in Japan
- Volunteers
- 160 people
- Sponsor
- Novartis Pharmaceuticals
Chronic Obstructive Pulmonary Disease
Medicated Aerosol Delivery Using A Jet Nebulizer Versus A Vibrating Mesh Nebulizer in COPD Exacerbation
Delivery of inhaled short-acting bronchodilators (SABD) is standard of care in the emergency department (ED) for exacerbation of COPD, the goal of such being rapid reversal of airflow obstruction.
- Trial name
- NCT03051971
- Testing
- Vibrating Mesh Nebulizer, Jet Nebulizer
- Where
- United States
- Sponsor
- Medstar Health Research Institute
Lung Disease Chronic
Powered Assist to Improve Ambulation in Severe Lung Disease
Chronic respiratory disease (CRD) is among the most prevalent and growing diseases worldwide with disabling consequences. Many with a compromised respiratory system cannot support the metabolic energy demands of walking causing…
- Trial name
- REVIVE (NCT03790644)
- Testing
- exoskeleton assist
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- West Park Healthcare Centre
Refractory Chronic Cough
Efficacy of Two Doses of Duloxetine and Amitriptyline in Subjects With Refractory Chronic Cough
This research study is evaluating the effectiveness of escalating doses of Amitriptyline and Duloxetine in reducing cough frequency in patients with refractory chronic cough (RCC)
- Trial name
- MACS-1 (NCT05110144)
- Testing
- Duloxetine 30 MG, Duloxetine 60 MG, Amitriptyline 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Emphysema, Alpha 1-Antitrypsin Deficiency
Efficacy/Safety of HA Inhalation Solution for Hereditary Emphysema in Patients With Alpha-1 Antitrypsin Deficiency
The purpose of the study is to evaluate the safety and efficacy of administering repeated doses of Hyaluronic Acid Inhalation Solution to subjects with Emphysema that have Alpha-1-Antitrypsin deficiency
- Trial name
- NCT03114020
- Testing
- Hyaluronic Acid Inhalation Solution
- Where
- 6 sites in United States, Canada
- Volunteers
- 27 people
- Sponsor
- Gerard Turino
Chronic Obstructive Pulmonary Disease, Acute Exacerbation of COPD
Negative Pressure Ventilation-rehabilitation on Acute Exacerbation of Chronic Obstructive Pulmonary Disease
This investigator-initiated, prospective, single center, randomized, controlled clinical trial enrolled patients with stable Global Initiative for Chronic Obstructive Lung Disease stage II-IV chronic obstruction pulmonary…
- Trial name
- NCT04843696
- Testing
- cuirass ventilator (cuirass diameter 21 cm or 34 cm, Dima Italia Srl.,Bologna, Italy), breathing training, and an educational program (relaxation techniques and a home pacing walking exercise)
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Chang Gung Memorial Hospital
Chronic Obstructive Pulmonary Disease
Multiple Dose Healthy Volunteer Safety Pharmacokinetics Study
Multiple dose safety and pharmacokinetics in healthy male subjects
- Trial name
- NCT00864786
- Testing
- PF03635659
- Where
- Belgium
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pfizer
Pulmonary Disease, Chronic Obstructive
(In)Voluntary Assessed Quadriceps Muscle Endurance in COPD
The primary objective is to assess the relation between involuntary and voluntary assessed quadriceps muscle endurance in patients with COPD. We hypothesized a good correlation (>0.8) between the measurements.
- Trial name
- Bionic (NCT05427773)
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- Radboud University Medical Center
Chronic Pain, Chronic Pain Syndrome
Collaboratory Treatment Pathway for Chronic Pain Patients.
In this multicenter randomized controlled trial, the aim is to evaluate the effectiveness of a standardized treatment pathway (STP) for patients referred to four participating pain clinics, by comparing it to treatment as usual…
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic (Non-malignant) Musculoskeletal Pain, Patients Referred to Multidisciplinary Pain Clinics
- Trial name
- PainPath (NCT07331766)
- Testing
- A collaborative treatment pathway for patients referred to multidisciplinary pain clinics in Norway, Treatment as usual
- Where
- 4 sites in Norway
- Volunteers
- 386 people
- Sponsor
- St. Olavs Hospital
Hepatitis B Virus Infection, Children
Entecavir With or Without Pegylated Interferon α-2b in Children Aged 3-6 Years With Immune-Tolerant Chronic Hepatitis B
This study aims to evaluate the efficacy and safety of entecavir monotherapy versus sequential entecavir plus pegylated interferon α-2b in achieving functional cure in immune-tolerant, HBeAg-positive children aged 3-6 years with…
- Conditions
- Hepatitis B Virus Infection, Children, Chronic Hepatitis B
- Trial name
- NCT07345624
- Testing
- Entecavir, Entecavir + Pegylated interferon α-2b
- Volunteers
- 80 people
- Sponsor
- Qing-Lei Zeng
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