Clinical trials: Lung Disorder
Corona Virus Infection, ARDS
Microbiota in COVID-19 Patients for Future Therapeutic and Preventive Approaches
In light of the rapidly emerging pandemic of SARS-CoV-2 infections, the global population and health care systems are facing unprecedented challenges through the combination of transmission and the potential for severe disease.
- Conditions
- Corona Virus Infection, ARDS, Coinfection
- Trial name
- MICRO-COV (NCT04410263)
- Testing
- Sampling (EDTA blood, pharyngeal and nose swabs, bronchoalveolar lavage ,urine)
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- University of Zurich
SARS-CoV2 Infection
A Trial of Novaferon in Asymptomatic or Mild COVID-19 Patients
This is a phase III randomized, double blinded, placebo-controlled multi-center study to assess the efficacy and safety of aerosolized Novaferon for the treatment of asymptomatic or mildly patients infected with SARS-CoV-2.
- Trial name
- NCT05017714
- Testing
- Recombinant cytokine gene derived protein injection
- Volunteers
- 300 people
- Sponsor
- Beijing 302 Hospital
Chronic Obstructive Pulmonary Disease, Lung Non-Small Cell Carcinoma
A Vaccine (CIMAvax-EGF) for the Prevention of Lung Cancer Development or Recurrence
This early phase I trial studies the side effects of a vaccine called CIMAvax-EGF and to see how well it works in preventing lung cancer from developing in patients at high risk for lung cancer or coming back (recurrence) in…
- Conditions
- Chronic Obstructive Pulmonary Disease, Lung Non-Small Cell Carcinoma, Pneumonia, Stage IB Lung Cancer AJCC v8
- Trial name
- NCT04298606
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Recombinant Human EGF-rP64K/Montanide ISA 51 Vaccine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Respiratory Distress Syndrome
Diaphragm Dysfunction in ARDS Patients With V-V ECMO
Use of veno-venous extracorporeal oxygenation membrane is a therapeutic option for the management of the most severe patients with acute respiratory distress syndrome (ARDS).
- Trial name
- DD-ECMO (NCT04613752)
- Testing
- diaphragmatic function measurements and diaphragmatic ultrasound
- Where
- France
- Volunteers
- 63 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease, Pulmonary Emphysema
Safety Study of Cell Therapy to Treat Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether the cell therapy with bone marrow mononuclear cells is safe in the treatment of chronic obstructive pulmonary disease, specifically the pulmonary emphysema.
- Trial name
- COPD-01 (NCT01110252)
- Testing
- Stem cells stimulation, stem cells collection, stem cells infusion
- Where
- Brazil
- Volunteers
- 4 people
- Sponsor
- UPECLIN HC FM Botucatu Unesp
COPD, Smoking Cessation
Transtheoretical Model Based Nursing Interventions on Smoking Cessation in Patients With COPD
Background: The aim of this study is to evaluate the efficiency of nursing intervention based on smoking cessation transtheoretical model in patients with COPD who smoke Method: Experimental design was used in the study.
- Conditions
- COPD, Smoking Cessation, Home Visit
- Trial name
- NCT04313738
- Testing
- Assigned Interventions
- Volunteers
- 80 people
- Sponsor
- Dokuz Eylul University
Advanced or Metastatic NSCLC
Phase 1/2 Study of HS-10375 in Patients with Advanced or Metastatic Non-Small-Cell Lung Cancer(NSCLC)
HS-10375 is an oral, highly selective, small molecular inhibitor of EGFR C797S. This study will evaluate the safety, tolerability, pharmacokinetics and clinical activity of HS-10375 in Chinese advanced or metastatic NSCLC.
- Trial name
- NCT05435248
- Testing
- HS-10375
- Where
- China
- Volunteers
- 354 people
- Sponsor
- Jiangsu Hansoh Pharmaceutical Co., Ltd.
COPD, Pulmonary Hypertension Secondary
CPET in Evaluation of PH in COPD Patients
To evaluate the entire course of exercise during CPET in COPD patients. To study whether CPET, PFTs and arterial blood gases could discriminate between COPD patients with and without PH.
- Trial name
- NCT04035148
- Testing
- Cardiopulmonary exercise test
- Volunteers
- 50 people
- Sponsor
- Assiut University
COVID-19
Safety in Convalescent Plasma Transfusion to COVID-19
There is currently no specific vaccine or treatment to treat critically ill patients with COVID-19. Different therapies are still under investigation and are use in different health institutions, however, a significant proportion…
- Trial name
- NCT04333355
- Testing
- Convalescent Plasma
- Where
- Mexico
- Volunteers
- 12 people
- Sponsor
- TecSalud Investigación Clínica
Asthma, Bronchial
A Non-interventional, Prospective Study With Benralizumab
This is a prospective, non-interventional, single-arm, multicenter study to investigate asthma control, and health-related quality of life (HRQL), lung function and asthma medication intake in severe eosinophilic asthma patients…
- Trial name
- AIR POWER (NCT06422078)
- Where
- 41 sites in Germany
- Volunteers
- 300 people
- Sponsor
- AstraZeneca
Pulmonary Embolus/Emboli, Thromboembolism, Pulmonary
Venous Phase Dual Energy CT in Patients Suspected for Pulmonary Embolism.
Venous phase spectral or dual energy (DE) chest computed tomography (CT) in patients with suspected pulmonary embolism (PE) compared to standard computed tomography pulmonary angiography (CTPA): sensitivity, evaluation of iodine…
- Trial name
- NCT04859478
- Testing
- Dual energy / spectral portal venous chest computed tomography
- Where
- 2 sites in Denmark
- Volunteers
- 160 people
- Sponsor
- Copenhagen University Hospital at Herlev
Respiration Disorders, Swallowing Disorder
Artificial Intelligence in Diagnosing Dysphagia Patients
In this prospective study we extracted acoustic parameters using PRAAT from patient's attempt to phonate during the clinical evaluation using a digital smart device.
- Conditions
- Respiration Disorders, Swallowing Disorder, Phonation Disorder, Stroke
- Trial name
- NCT05098808
- Testing
- Acoustic features (from signals obtained during phonation)
- Where
- South Korea
- Volunteers
- 449 people
- Sponsor
- The Catholic University of Korea
Prematurity, Low Birth Weight
Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk Newborns
This study aims to evaluate whether a structured nursing guidance program that increases fathers' participation in the care of hospitalized high-risk newborns improves maternal outcomes compared with routine nursing care.
- Conditions
- Prematurity, Low Birth Weight, Respiratory Distress Syndrome, Newborn, Neonatal Hyperbilirubinemia
- Trial name
- NCT07834008
- Testing
- step-by-step parent education, active father participation in breastfeeding support
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
COVID-19 Infection
Immunity Against SARS-CoV2 in Children and Their Parents / COVID-19
The purpose of this study is to provide data on the proportion of seroconverted children and their immune status. It will also provide insight into the number of children currently infected at each time point including healthy…
- Trial name
- PED-COVID (NCT04355533)
- Testing
- serology test, nasopharyngeal swab, rectal swab
- Where
- France
- Volunteers
- 1,056 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lung Cancer
Pifenidone Prophylactic Therapy for Radiation Lung Injury in Patients Who Have Previously Received Immune Checkpoint Inhibitors
Patients with advanced lung cancer who have previously received immunocheckpoint inhibitor therapy, undergone chest radiation therapy again have developed radiation induced lung injury.
- Trial name
- NCT05801133
- Testing
- Pirfenidone
- Where
- China
- Volunteers
- 41 people
- Sponsor
- Hubei Cancer Hospital
Non Small Cell Lung Cancer
Phase II Trial of HM61713 for the Treatment of ≥2nd Line T790M Mutation Positive Adenocarcinoma of the Lung
The purpose of this study is to evaluate the efficacy, safety and pharmacokinetics of HM61713 in patients with T790M-positive non-small cell lung cancer (NSCLC) after treatment with an epidermal growth factor receptor-tyrosine…
- Trial name
- NCT02485652
- Testing
- HM61713
- Where
- 72 sites in United States, Australia and 8 more
- Volunteers
- 162 people
- Sponsor
- Hanmi Pharmaceutical Company Limited
Asthma
Home Telemonitoring of Resting Spontaneous Breathing in Severe Asthma: a Pilot Study
Asthma exacerbations account for a significant morbidity and disproportionate health care costs. However, there is no currently available biomarker or lung function parameter that can accurately predict the risk of future…
- Trial name
- AsthmaDom (NCT02990247)
- Testing
- anharmonic morphological analysis of the respiratory signals (AMARS)
- Where
- 2 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Bordeaux
COVID-19
Omega-3 Oil Use in COVID-19 Patients in Qatar
COVID-19 infection has been widely spread since December 2019 and causing many comorbidities and fatalities. The most common clinical presentation of COVID-19 patients admitted to ICUs is respiratory failure , hypoxia and acute…
- Trial name
- Omega3 (NCT04836052)
- Testing
- Omega 3 fatty acid
- Where
- Qatar
- Volunteers
- 372 people
- Sponsor
- Hamad Medical Corporation
Sickle Cell Anemia, Pulmonary Hypertension
Heart Disease in Sickle Cell Anemia
This study will explore what may cause people with sickle cell anemia to have heart problems and an increased risk of sudden death. People 18 years of age and older with sickle cell anemia may be eligible for this study.
- Trial name
- NCT00113152
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pulmonary Disease, Chronic Obstructive
A Study to Assess the Systemic Exposure, Systemic Pharmacodynamics and Safety and Tolerability of FluticasoneFuroate, Umeclidinium and Vilanterol in Healthy Subjects
This is a double-blind, single dose (four inhalations), four-way cross over study in healthy subjects that will assess the systemic pharmacokinetics (PK) and systemic pharmacodynamics (PD) of Fluticasone Furoate, (FF)…
- Trial name
- NCT01691547
- Testing
- UMEC /VI, UMEC, VI
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline