Clinical trials: Lung Hyperinflation
Chronic Obstructive Pulmonary Disease (COPD)
A Study Comparing the Effects of Trimbow to Fostair in COPD
A randomised, open label 2-way cross-over study to compare the effects of inhaled Beclometasone/Formoterol/Glycopyrronium (TRIMBOW) pMDI to Beclometasone/Formoterol (FOSTAIR) pMDI on hyperinflation and expiratory flow limitation…
- Trial name
- TRIFLOW (NCT03842904)
- Testing
- Trimbow pMDI, Fostair pMDI
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Medicines Evaluation Unit Ltd
Idiopathic Pulmonary Arterial Hypertension.
Albuterol and Dynamic Hyperinflation in Idiopathic Pulmonary Arterial Hypertension
The purpose of this study is to determine if dynamic hyperinflation seen in patients with idiopathic pulmonary artery hypertension (iPAH) improves with albuterol therapy.
- Trial name
- NCT02108743
- Testing
- Albuterol.
- Where
- United States
- Sponsor
- American Medical Association Foundation
Chronic Obstructive Pulmonary Disease (COPD)
A Clinical Study to Investigate if a Single Dose of an Approved Drug Product (Glycopyrrolate Inhalation Solution) Reduces Trapped Air in the Lungs of Participants With Chronic Obstructive Pulmonary Disease.
A clinical study to investigate if a single dose of an approved drug product (glycopyrrolate Inhalation Solution) reduces trapped air in the lungs of participants with chronic obstructive pulmonary disease.
- Trial name
- NCT04155047
- Testing
- Glyocopyrrolate Inhalation Solution administered by Magnair
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Sunovion Respiratory Development Inc.
COPD Exacerbation Acute
Comparing the Effects of Manual Hyperinflation and Diaphragmatic Proprioceptive Neuromuscular Facilitation on Pulmonary Functions in Patients on Mechanical Ventilation
the goal of this clinical trial is to compare between to important physiotherapy modalities applied on mechanically ventilated COPD patients the the main question the study aim to answer is which one of the two modalities has the…
- Trial name
- NCT06221033
- Testing
- manual hyperinflation, Diaphragmatic proprioceptive neuromuscular facilitation technique, traditional physiotherapy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- omar hasham mohamed
Chronic Obstructive Pulmonary Disease (COPD)
Phase IV O2 Consumption Study in COPD Patients.
A Phase IV study evaluating changes in oxygen consumption and cardiac function in Subjects with Chronic obstructive pulmonary disease (COPD) with resting hyperinflation after administration of Symbicort pMDI 160/4.5 μg.
- Trial name
- NCT02533505
- Testing
- Budesonide 160 mcg and formoterol fumarate dihydrate 4.5 mcg Inhalation aerosol
- Where
- 5 sites in United States
- Volunteers
- 51 people
- Sponsor
- AstraZeneca
Pulmonary Disease, Chronic Obstructive
Effect of Spiriva® 18 Microgram on Health-related Quality of Life and Physical Functioning in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Proven Hyperinflation
Primary objective of this observational study was to gain insights into the effects of therapy with Spiriva® (tiotropium bromide) 18 microgram on the health-related quality of life and physical functioning in patients with…
- Trial name
- NCT02172521
- Testing
- Tiotropium bromide
- Volunteers
- 1,536 people
- Sponsor
- Boehringer Ingelheim
Emphysema
EASE Trial: Exhale Airway Stents for Emphysema
This is an international clinical research study evaluating the safety and effectiveness of a new procedure called airway bypass.
- Trial name
- EASE (NCT00391612)
- Testing
- Exhale® Drug-Eluting Stent
- Where
- 37 sites in United States, Australia and 8 more
- Volunteers
- 450 people
- Sponsor
- Broncus Technologies
Central Cord Injury Syndrome, Central Spinal Cord Syndrome
Intermittent Positive-Pressure Breathing Effects in Patients With High Spinal Cord Injury
Background: To determine whether intermittent positive-pressure breathing (IPPB) improved lung compliance, work of breathing, and respiratory function in patients with recent high spinal cord injury (SCI).
- Trial name
- NCT00476866
- Testing
- intermittent positive-pressure breathing (IPPB)
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University of Versailles
COPD
Sustainability of Pulmonary Rehab Gains
People with moderate to severe COPD trap air in their lungs. This lessens their ability to exercise. The investigators developed a computerized breathing retraining program to help patients empty their lungs during exercise.
- Trial name
- NCT02241733
- Testing
- Breathing retraining plus exercise, Exercise only
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- VA Office of Research and Development
Pulmonary Atelectasis
Ventilator Hyperinflation and Manual Rib Cage Compression
This is a randomized crossover trial to evaluate the effects of thoracic compression applied alone or in association with hyperinflation maneuver with the ventilator.
- Trial name
- NCT03630484
- Testing
- Expiratory Rib Cage Compression, Compression + Ventilator Hyperinflation
- Volunteers
- 30 people
- Sponsor
- Brazilian Institute of Higher Education of Censa
COPD
Diagnostic and Therapeutic Approaches to Hyperinflation and Small Airway Disease in COPD
Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. Hyperinflation and affection of the small airways are two components that are not represented in current…
- Trial name
- NCT03287921
- Testing
- mono bronchodilatation, dual bronchodilatation
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Universitätsmedizin Mannheim
Chronic Obstructive Pulmonary Disease
Effects of Cardioselective β-blockers on Dynamic Hyperinflation in COPD
Patients with chronic obstructive pulmonary disease (COPD) are at greater risk of suffering from diseases for which beta-blockers may be indicated and effective.
- Trial name
- NCT01273298
- Testing
- Bisoprolol
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- Laval University
Chronic Obstructive Pulmonary Disease, Sleep Disorders
The Impact of Salmeterol-Fluticasone on Sleep in Patients With COPD
The purpose of this study is to determine if Advair Diskus improves sleep quality by reducing lung hyperinflation in COPD.
- Trial name
- AQuOS-COPD (NCT00741767)
- Testing
- salmeterol-fluticasone
- Where
- United States
- Sponsor
- Northwestern University
Chronic Obstructive Pulmonary Disease
Slow Chest Compression on Dynamic Hyperinflation, Dyspnea and Peripheral Muscle Deoxygenation in Patients With COPD
Background: Commonly, patients with chronic obstructive pulmonary disease (COPD) present dyspnea, dynamic hyperinflation (DH) and important peripheral muscle deoxygenation when performing their activities of daily living (ADLs).
- Trial name
- NCT02746536
- Testing
- Slow chest compression, No slow chest compression
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of the State of Santa Catarina
Copd, Emphysema
4D Medical X-ray Velocimetry for Bronchoscopic Lung Volume Reduction Targeting
This study will investigate the utility of 4D Medical's X-ray Velocimetry (XV) imaging analysis software for the detection of hyperinflation, and compare endobronchial valve placement outcomes with predictive indices obtained…
- Conditions
- Copd, Emphysema, Hyperinflation
- Trial name
- NCT04786171
- Testing
- 4D X-ray Velocimetry
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Vanderbilt University Medical Center
Mechanical Ventilation Complication, Physical Disability
Manual Hyperinflation and Physical Therapy Program on Lung Recruitment Mechanically Ventilated Pediatric Patients
The purpose of this study is to investigate the immediate combined effects of Manual Hyperinflation and standard Physical therapy program on lung recruitment and secretion mass in mechanically ventilated pediatric patients aged…
- Trial name
- MHI (NCT06349785)
- Testing
- rehabilitation of mechanically ventilated patients, supportive care
- Where
- Egypt
- Volunteers
- 32 people
- Sponsor
- New Ismailia National University
Chronic Obstructive Pulmonary Disease
Effects of Inhaled Corticosteroids in the Systemic Inflammation Induced by Exercise in Patients With COPD
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.
- Trial name
- NCT02209974
- Testing
- Fluticasone
- Where
- Spain
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Hospital Son Llatzer
Chronic Obstructive Pulmonary Disease
CHF5993 and CHF1535 pMDI on Lung Hyperinflation and Exercise Endurance Time in Subjects With COPD
Double Blind, Multinational, Multicentre, Randomised, Placebo-Controlled, 3-Way Cross-Over Study To Evaluate The Effect Of A Triple Combination Of Beclometasone Dipropionate And Formoterol Fumarate Plus Glycopyrronium (CHF5993)…
- Trial name
- TRIFORCE (NCT05097014)
- Testing
- CHF5993, CHF1535
- Where
- Germany
- Volunteers
- 106 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
COPD
Effects of Osteopathic Techniques on Residual Volume in Severe Chronic Obstructive Pulmonary Disease
The purpose of this study is to determine whether the selected osteopathic techniques have a positive impact on the residual volume decrease in patients with chronic obstructive pulmonary disease with severe and very severe…
- Trial name
- NCT02755363
- Testing
- osteopathic manual therapy, control group
- Where
- Poland
- Volunteers
- 20 people
- Sponsor
- Medical University of Warsaw
Chronic Obstructive Pulmonary Disease
Indacaterol Versus Tiotropium on Dynamic Hyperinflation in COPD
Exercise intolerance is a major complain of patients with chronic obstructive pulmonary disease (COPD). Dynamic hyperinflation has been recognized as an important limiting factor responsible for the appearance of intolerable…
- Trial name
- NCT01693003
- Testing
- Indacaterol, Tiotropium
- Where
- 2 sites in Brazil
- Volunteers
- 20 people
- Sponsor
- Irmandade Santa Casa de Misericórdia de Porto Alegre