Clinical trials: Lung Hyperinflation
Native Lung Overinflation in Patients That Underwent Single Lung Transplantation Due to Emphysema
The Value of Bronchoscopic Lung Volume Reduction by Endobronchial Valves in Patients With Single Lung Transplantation and Overinflation of the Native Lung
The purpose of the study is to investigate if bronchoscopic lung volume reduction by valves (Zephyr) would reduce native lung overinflation in patients that underwent single lung transplantation due to emphysema, and improve…
- Trial name
- NCT01682018
- Testing
- lung volume reduction using the Zephyr device
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- Rabin Medical Center
Asthma, Hyperinflation
Bronchial Thermoplasty for Severe Asthma With Dynamic Hyperinflation
Bronchial thermoplasty is a treatment for severe asthma that consist in decreasing the thickness of bronchial muscle by heat using a catheter inserted into the bronchi under direct vision with the help of an endoscope This…
- Trial name
- HEAT-SA (NCT02618551)
- Testing
- Bronchial thermoplasty for treatment of severe asthma
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Toulouse
Bronchiectasis
Investigation of Dynamic Hyperinflation and Its Relationship With Functional Exercise Capacity in Children With Bronchiectasis
Prevalence of dynamic hyperinflation and its relationship with functional exercise capacity will be evaluated in children with bronchiectasis.
- Trial name
- NCT04885790
- Testing
- Respiratory assessment using "Spiropalm 6MWT" portable spirometry, Evaluation of functional exercise capacity, Evaluation of peripheral muscle strength
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Izmir Bakircay University
Emphysema or COPD
Study to Assess Safety, Feasibility, and Preliminary Efficacy of the Apreo Implant for Severe Emphysema
The goal of this clinical trial is to test the feasibility of an implant for severe emphysema in up to 30 participants at up to 5 study centers located in Europe and the United Kingdom.
- Trial name
- BREATHE-2 (NCT05949645)
- Testing
- Apreo Implant Group
- Where
- 3 sites in Austria, Netherlands and 1 more
- Volunteers
- 30 people
- Sponsor
- Apreo Health, Inc.
Chronic Obstructive Pulmonary Disease
Acute Effect of Aclidinium on Hyperinflation and Ventilation Inhomogeneity in Severe COPD Patients
Chronic Obstructive Pulmonary Disease (COPD) is characterized by lung hyperinflation and flow limitation. These physiopathological modifications are secondary to loss of elastic recoil and bronchial obstruction due to emphysema.
- Trial name
- NCT02181023
- Testing
- Aclidinium Bromide, Glycopyrronium Bromide
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- University of Milan
Pulmonary Disease, Postoperative Complications
Hyperinflation Respiratory Therapies in Cardiac Surgery Patients
The purpose of this prospective randomized clinical trial is to evaluate three different types of hyperinflation respiratory therapies, Intermittent Positive Pressure Breathing (IPPB), Intermittent positive end expiratory…
- Trial name
- NCT04164173
- Testing
- EzPAP, Metaneb, Intermittent Positive Pressure Breathing (IPPB)
- Where
- United States
- Volunteers
- 324 people
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Obstructive Pulmonary Disease, Hypercapnia
Non-invasive Home Ventilation in Patients With Severe Hypercapnic Chronic Obstructive Pulmonary Disease
In COPD patients with chronic hypercapnic respiratory failure, the prognosis is poor and the treatment with non invasive ventilation is actually well established. However the best mode of ventilation is not well known.
- Trial name
- SOMNOVENT' (NCT03934749)
- Testing
- Non Invasive Ventilation
- Where
- France
- Volunteers
- 1 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Diaphragm
Endobronchial Valves Positioning Effects On Diaphragm Function In Patients With Lung Hyperinflation
This prospective study aims at evaluating diaphragmatic function before and after endobronchial valves positioning in a COPD patients with lung hyperinflation.
- Trial name
- EVELHYN (NCT03827538)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Modena and Reggio Emilia
COPD, Emphysema
Bronchoscopic RElease of Air Trapped in Hyperinflated Emphysematous Lung - Study 3
The objective of this study is to assess the safety and efficacy of Apreo BREATHE system when used to support native airways and release trapped air in the treatment of adult COPD patients with emphysema suffering from dyspnea…
- Trial name
- BREATHE-3 (NCT06891755)
- Testing
- Apreo BREATHE Airway Scaffold, Optimal Medical Management (OMM)
- Where
- 23 sites in United States, Austria and 3 more
- Volunteers
- 250 people
- Sponsor
- Apreo Health, Inc.
Pulmonary Complications
Hemodynamic Responses to Ventilator Hyperinflation Technique
The purpose of this study is to explore acute hemodynamic responses to VHI technique in critical traumatic patients with pulmonary complications in the intensive care unit.
- Trial name
- NCT02739841
- Testing
- Ventilator hyperinflation, Chest physical therapy
- Where
- Thailand
- Volunteers
- 15 people
- Sponsor
- Khon Kaen University
Pulmonary Disease, Chronic Obstructive
The Effect of BEVESPI AEROSPHERE ® Therapy on Exercise Tolerance in COPD
The objective of the study is to determine if a dual inhaled bronchodilator (Glycopyrrolate/Formoterol) is effective in increasing exercise time relative to placebo in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Trial name
- NCT03081156
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- William Stringer, md
Acute Hypoxemic Respiratory Failure, Ventilation, Mechanical
Association Between EIT and CT During PEEP Titration in Patients With Acute Respiratory Failure
This observational study will analyze data already collected by the investigators as part of their routine clinical practice from patients with acute respiratory failure (ARF) treated with mechanical ventilation.
- Trial name
- TAC-EIT-20-5 (NCT07175194)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Istituto Clinico Humanitas
Pneumothorax, Pulmonary Contusion
Electrical Impedance Imaging of Patients on Mechanical Ventilation
The goal of this study is to evaluate the sensitivity and specificity of Electrical Impedance Tomography (EIT) as a bedside diagnostic tool for lung pathologies in patients who are mechanically ventilated.
- Conditions
- Pneumothorax, Pulmonary Contusion, Pleural Effusion, Pulmonary Edema
- Trial name
- NCT02232841
- Testing
- Mechanical Ventilation, CT Scan
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Colorado State University
Chronic Obstructive Pulmonary Disease (COPD)
Changes in Cardiac Function in COPD Patients After Administration of Budesonide/Formoterol (Symbicort®) Versus Placebo
To investigate whether Budesonide/Formoterol (Symbicort ®) therapy can improve heart function at rest by decreasing lung hyperinflation in patients with COPD (Chronic Obstructive Pulmonary Disease).
- Trial name
- AZCO (NCT01760304)
- Testing
- Budesonide / Formoterol
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Disease, Chronic Obstructive
Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients
Chronic obstructive pulmonary disease is a common respiratory condition that is characterized by inflammation of the large and small peripheral airways , the alveoli and adjacent capillary networks.
- Trial name
- NCT03230617
- Testing
- Mechanical ventilator
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pulmonary Disease, Chronic Obstructive
Efficacy of Self-titration of Ventilation in Overlap Syndrome (chronic Obstructive Pulmonar Disease + Sleep Apnea Syndrome ) with Dynamic Hyperinflation. EDIN-IDIN.
The combination of COPD and obstructive sleep apnea (OSA) can lead to undesirable interactions with the treatment approach. The investigators know that continuous positive airway pressure (CPAP) can increase dynamic…
- Trial name
- EDIN-IDIN (NCT06713486)
- Testing
- Fixed pressure obtained in the polysomnography for 28 days, Dynamic pressure in Dreamstation AVAPS-AAM PhilipsRespironic® mode
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Emphysema or COPD, Emphysema
A Multi Center Study Testing a New Implant for Adults With Severe Emphysema
A study taking place at multiple sites in the United States, Europe and Brazil to evaluate how well a new therapy for severe COPD/emphysema works, and how safe it is.
- Conditions
- Emphysema or COPD, Emphysema, COPD
- Trial name
- IAB-2 (NCT07119229)
- Testing
- Implantable Artificial Bronchus
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Pulmair Medical, Inc.
Pulmonary Disease, Chronic Obstructive
Measurements of Diaphragmatic Mobility on COPD Patients
To determine whether the COPD impairs the diaphragmatic mobility (DM), and verify improvements after an inpatient pulmonary rehabilitation (PR).
- Trial name
- NCT02838953
- Testing
- Pulmonary Rehabilitation
- Where
- Italy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Casa Di Cura Villa Serena SpA
Emphysema
Randomized Comparison of the RePneu Lung Volume Reduction Coil (LVRC) to Standard of Care for the Treatment of Emphysema (RESET Study)
The objective of this study is to demonstrate the safety and performance of the PneumRx, Inc. Lung Volume Reduction Coil (LVRC) in a population of patients with emphysema. The PneumRx, Inc.
- Trial name
- NCT01334307
- Testing
- Lung Volume Reduction Coil (LVRC) (PneumRx), Control
- Where
- 3 sites in United Kingdom
- Volunteers
- 47 people
- Sponsor
- Boston Scientific Corporation
COPD, Dyspnea
Device-guided Breathing for Shortness of Breath in COPD
Although drug therapies and pulmonary rehabilitation have greatly improved COPD symptoms, as many as 50% of patients with severe COPD have inadequately controlled dyspnea.
- Conditions
- COPD, Dyspnea, Hyperinflation
- Trial name
- NCT01286181
- Testing
- Twice daily practice of device-guided slow breathing.
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mayo Clinic