Clinical trials: Lung Hyperinflation
COPD, Hyperinflation
Effect of Elastic Chest Compression on Functional Exercise Capacity and Respiratory Performance in Patients With COPD
The goal of this clinical trial is to investigate the effects of elastic chest compression on functional exercise capacity and respiratory performance of patients with COPD.
- Trial name
- NCT06519474
- Testing
- Theraband chest compression
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- National Taiwan University Hospital
Pulmonary Disease, Chronic Obstructive
Comparing the Efficacy of Tiotropium + Olodaterol Fixed Dose Combination (FDC) Over Tiotropium in Improvement of Lung Hyperinflation, Exercise Capacity and Physical Activity in Japanese COPD Patients
This is a multi-centre, randomised, double-blinded, active-controlled, 2-way cross over trial to assess the effects of once daily administration of orally inhaled tiotropium + olodaterol FDC or tiotropium (both delivered by the…
- Trial name
- NCT02629965
- Testing
- tiotropium, olodaterol
- Where
- 43 sites in Japan
- Volunteers
- 184 people
- Sponsor
- Boehringer Ingelheim
Chronic Obstructive Pulmonary Disease
Effects of Pursed-lip Breathing on Exercise Tolerance and Dynamic Hyperinflation in COPD
Pursed-lip breathing (PLB) has been advocated to reduce respiratory rate and improve oxygen saturation in patients with chronic obstructive pulmonary disease (COPD) at rest.
- Trial name
- NCT01173328
- Testing
- Pursed-lip breathing, Normal Breathing
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Universidade Federal do Rio de Janeiro
Pulmonary Disease, Chronic Obstructive
Effects of SIMEOX on Static Hyperinflation in Patients With COPD
This study will investigate the effects on the SIMEOX technology on static hyperinflation in patients with chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT04157972
- Testing
- SIMEOX, PEP
- Where
- Belgium
- Volunteers
- 25 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
COPD
Effect of Brovana and Tiotropium in Chronic Obstructive Pulmonary Disease (COPD)
This will be a double-blind crossover trial in 20 patient with stable COPD. Data from this study will provide proof-of-concept information on whether the (anticipated) additional bronchodilator effect of Brovana added to…
- Trial name
- NCT00773786
- Testing
- Arformoterol (Brovana)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Trinity Health Of New England
Cystic Fibrosis, Lung Clearance Index
Exploratory Study on Link Between Dynamic Hyperinflation and Lung Clearance Index in Cystic Fibrosis
Recent improvements in cystic fibrosis management have enabled an important subset of patients to maintain normal spirometry. Nevertheless, even in these patients with normal spirometry, chest computed tomography (CT) might…
- Trial name
- ICP2DM (NCT03323983)
- Testing
- data collection
- Volunteers
- 12 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Pulmonary Disease, Chronic Obstructive
A Study of Exercise Endurance and Lung Hyperinflation in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD)
This study evaluated the effect of inhaled aclidinium bromide on exercise endurance and in reducing resting and dynamic lung hyperinflation in patients with moderate to severe COPD.
- Trial name
- NCT00500318
- Testing
- Aclidinium Bromide
- Where
- 52 sites in United States, Canada
- Volunteers
- 181 people
- Sponsor
- AstraZeneca
Chronic Obstructive Pulmonary Disease
Effect of Portable NIV on Operational Chest Wall Volumes in COPD
The VitaBreath (Philips, Respironics) is a portable, handheld, battery powered, non-invasive ventilation device, that has been shown to reduce activity-related shortness of breath in patients with COPD.
- Trial name
- NCT03848819
- Testing
- VitaBreath device
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Northumbria University
Hypoventilation, Hypoxemia
Oxygen Supplementation and Ventilator Hyperinflation in the Endotracheal Suction (OSVHES)
This is a double crossover study where all patients are randomly allocated to one of two treatment sequences associated with endotracheal aspiration.The first treatment (A) uses two suctioning methods for each patient: one…
- Trial name
- OSVHES (NCT02440919)
- Testing
- Hyperoxygenation 100% FiO2, Hyperoxygenation 20% FiO2, Hyperinflation (PEEP- ZEEP) Basal FiO2
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Universidade Federal de Sao Carlos
Acute Respiratory Distress Syndrome (ARDS)
Validation of a Semi-automatized Method to Detect Cyclic Hyperinflation on CT-scan in ARDS
This study aims to validate a semi-automatized method to quantify cyclic hyperinflation on CT-scan of ARDS patients. The gold standard will be cyclic hyperinflation assessed on the same CT scan, using manual segmentation of the…
- Trial name
- CT4-ARDS (NCT03870009)
- Testing
- ARDS patients
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Hospices Civils de Lyon
COPD
Static Lung Hyperinflation and Sympathetic Nerve Activity-Associated Large Artery Stiffness in COPD Patients
The goal of this study is to evaluate the acute effects of a long-acting bronchodilator on pulmonary function, vascular function and muscle sympathetic nerve activity in individuals with COPD.
- Trial name
- NCT03611699
- Testing
- Umeclidinium / Vilanterol Dry Powder Inhaler
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Gary L. Pierce
Emphysema or COPD
First in Human Study to Assess an Implant to Treat Severe Emphysema
The goal of this clinical trial is to test the feasibility of an implant for severe emphysema in up to 30 participants. The main questions it aims to answer are: Is it safe? Does it work? Participants who meet eligibility…
- Trial name
- BREATHE-1 (NCT05854550)
- Testing
- Apreo Implant Group
- Where
- 2 sites in Australia
- Volunteers
- 48 people
- Sponsor
- Apreo Health, Inc.
Chronic Obstructive Airway Disease
The Effect of Twice Daily vs. Once Daily Bronchodilation on Hyperinflation in COPD Patients During 24 Hours.
To study the effect of twice daily dual bronchodilation versus once daily single bronchodilation in patients with chronic obstructive pulmonary disease on 24-hour static and dynamic hyperinflation.
- Trial name
- BOTH (NCT03275116)
- Testing
- Tiotropium 'Respimat' 5 mcg, Aclidinium Bromide/Formoterol Fumarate 340/12 mcg
- Where
- Netherlands
- Volunteers
- 49 people
- Sponsor
- Maastricht University Medical Center
COPD
The Changes in End Expiratory Lung Impedence Measured by EIT and End Expiratory Lung Volume Measured by Passive Expiratory in Controlled Mechanical Ventilated Exacerbation COPD Patients
The pathophysiological characteristics of respiratory failure on exacerbation of chronic pulmonary obstructive disease are the rapid deteriorate of respiratory symptoms, combined with aggravated flow limitation, gas trapping…
- Trial name
- NCT05585060
- Testing
- the changes of end expiratory lung impedence, the changes of end expiratory lung volume
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis
Add-on Effects of Tiotropium Over Formoterol in Exercise Tolerance on Chronic Obstructive Pulmonary Disease Patients
The primary objective is to comparatively evaluate the isolated effects of a long-acting beta2-adrenergic (formoterol fumarate 12µg b.i.d.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Chronic Bronchitis, Pulmonary Emphysema
- Trial name
- NCT00680056
- Testing
- Formoterol plus Tiotropium
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Federal University of São Paulo
COPD With Hyperinflation, Diaphragmatic Weakness
Upright MRI in Lung Disease
The diaphragm is the main muscle assisting breathing. This study aims to assess the use of MRI in patients with diaphragmatic weakness and patients with Chronic Obstructive Pulmonary Disease (COPD) who have hyperinflation.
- Trial name
- NCT03531775
- Testing
- Upright MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Pulmonary Disease, Chronic Obstructive
Effects of Dynamic Hyperinflation on the Left-ventricular Diastolic Function in Healthy Male Subjects
The aim of this study is to identify whether actively induced dynamic hyperinflation can cause left-ventricular diastolic dysfunction in healthy male subjects in order to explore the mechanisms of developing cardiac dysfunctions…
- Trial name
- NCT03500822
- Testing
- Metronome-paced tachypnea, Expiratory-stenosis breathing
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Otto Wagner Hospital
Chronic Obstructive Pulmonary Disease, Hyperinflation
A Study to Investigate the Effect of Budesonide/Glycopyrronium/Formoterol Fumarate Metered Dose Inhaler (BGF MDI) Compared With Placebo MDI on Heart and Lung Function in Participants With Chronic Obstructive Pulmonary Disease (COPD) and Hyperinflation
The purpose of the study is to evaluate the effect of BGF MDI compared with placebo MDI on cardiac and lung function when administered in participants diagnosed with COPD and hyperinflation.
- Trial name
- ORATOS (NCT07073950)
- Testing
- Budesonide/Glycopyrronium/Formoterol Fumarate, Metered dose inhaler
- Where
- 7 sites in Germany, United Kingdom
- Volunteers
- 56 people
- Sponsor
- AstraZeneca
COPD, Emphysema
Tiotropium Induced Bronchodilation in Lung CT Scored Emphysema
To evaluate if tiotropium (Spiriva)induced bronchodilation of inspiratory capacity in patients with moderate to severe copd subjected to metronome paced hyperventilation induced dynamic hyperinflation is dependent upon the extent…
- Trial name
- NCT00570544
- Testing
- tiotropium
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Gelb, Arthur F., M.D.
COPD
Single Dose Ultibro Breezhaler by Sd-DPI Versus Ipratropium/Salbutamol by Nebulizer in COPD
Rationale: Inhaled bronchodilators, beta-2-agonist or anticholinergic or combinations, can be delivered by several types of devices: dry powder (DPI), pressurized metered dose inhalers (pMDI), and wet nebulizers.
- Trial name
- ULT01 (NCT02576626)
- Testing
- indacaterol/glycopyrronium 110/50 Breezhaler®, ipratropium/salbutamol 0,5 mg, 2,5 mg by nebulisation
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Wouter H. van Geffen