Clinical trials: Lung Hypoxia
COVID-19, Cardiopulmonary Disease
Comparing Inpatient COVID-19 Outcomes in 2 Different PT Dosing Groups
The objective of this study is to compare the effects of twice-a-day 15-minute sessions of inpatient physical therapy (PT) to the standard daily 30 minute sessions.
- Conditions
- COVID-19, Cardiopulmonary Disease, Weakness, Muscle, Hypoxia
- Trial name
- CCPT (NCT04844307)
- Testing
- Shorter duration higher frequency PT, Standard PT
- Sponsor
- Montefiore Medical Center
Lung Transplantation, Hypoxia
Adaptation of Lung Transplant Recipients at Extreme Altitude
This prospective observational study investigates the effects of intermittent hypoxic conditioning and real high-altitude exposure in lung transplant recipients compared with healthy controls.
- Conditions
- Lung Transplantation, Hypoxia, Altitude, High-altitude Adaptation
- Trial name
- NCT07479511
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Obstructive Pulmonary Disease
Pre-flight Titration of Supplemental Oxygen
The purpose of this study is to evaluate if supplemental oxygen during air travel can be reliably titrated using a Hypoxia-altitude simulation test (HAST).
- Trial name
- NCT01019538
- Testing
- Pre-flight test with supplemental oxygen
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Ullevaal University Hospital
Pulmonary Disease, Chronic Obstructive, Hypercapnia
Sleep and Daytime Use of Humidified Nasal High-flow Oxygen in COPD Outpatients
Humidified Nasal High-flow with Oxygen (HNHF-O2) therapy has been reported to have acute beneficial effects in patients with hypoxemic respiratory failure who have been hospitalized.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxia
- Trial name
- NCT03221387
- Testing
- Humidified nasal high flow with oxygen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Temple University
Hypoxemia
Open Lung Protective Ventilation in Cardiac Surgery
Cardiac surgery with cardiopulmonary bypass (CPB) frequently induces post-operative respiratory dysfunction. The post-operative pulmonary complications (PPCs) significantly increase the peri-operative morbidity and require…
- Trial name
- PROVECS (NCT02866578)
- Testing
- Open lung protective ventilation strategy
- Where
- 6 sites in France
- Volunteers
- 494 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Lung Injury, ARDS
Point-of-care Lung Ultrasound (POCUS)-Integrated Study of Admitted Patients With COVID-19
This study seeks to define the ultrasound profile of patients with COVID-19, and document the progression of these ultrasound findings to develop prognostication and clinical decision instruments that can help guide management of…
- Conditions
- Lung Injury, ARDS, Acute Cardiac Event, Covid19
- Trial name
- PIOS-COVID (NCT05228717)
- Testing
- Point of Care Ultrasound
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- Olive View-UCLA Education & Research Institute
Carcinoma, Non-Small-Cell Lung
Role of FDG PET, Immune and Hypoxic Marker in NSCLC
This is a retrospective study that involves the revision of clinical, instrumental and pathologic data of an estimated cohort of maximum 130 patients with NSCLC treated with surgery with radical intent at our center.
- Trial name
- NCT02519062
- Testing
- No intervention
- Where
- Italy
- Volunteers
- 130 people
- Sponsor
- Istituto Clinico Humanitas
Non-small Cell Lung Cancer
Comparative Study of the Hypoxia Measured in FAZA and F-miso PET/CT Scan in Patients With Non-small Cell Lung Cancer
The purpose of the study is to compare the intratumoral biodistribution of FAZA and F-miso in patients with non-small cell lung cancer and correlate the results of PET scans with immunohistochemistry.
- Trial name
- RTEP6 (NCT02490696)
- Testing
- Miso PET scan, FAZA PET scan
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Centre Henri Becquerel
COVID-19
Study of FT516 for the Treatment of COVID-19 in Hospitalized Patients With Hypoxia
This is a Phase I study with the primary objective of identifying the maximum tolerated dose (MTD) of FT516 using 3 dose-escalation strategies (number of doses and cell dose) for the treatment of coronavirus disease 2019…
- Trial name
- NCT04363346
- Testing
- FT516
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
High Altitude Pulmonary Hypertension
Right Ventricular Function During Exercise in Highlanders/Lowlanders
The purpose of the current study is to evaluate the right ventricular function during graded cycling on an ergometer by transthoracic echocardiography in Kyrgyz highlanders with high altitude pulmonary hypertension (HAPH) by…
- Trial name
- NCT03165032
- Where
- Kyrgyzstan
- Volunteers
- 173 people
- Sponsor
- University of Zurich
Perinatal Death, Respiratory Distress Syndrome, Newborn
Maternal Hyperoxygenation for Intrapartum Fetal Heart Rate Tracing Abnormalities
Hyperoxygenation for resuscitation of abnormal fetal heart rate tracings has been routine obstetric practice. However, there have not been any studies to support this practice.
- Conditions
- Perinatal Death, Respiratory Distress Syndrome, Newborn, Hypoxic-Ischemic Encephalopathy, Neonatal Seizure
- Trial name
- NCT03996317
- Testing
- Room air
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Loma Linda University
Mechanical Ventilation Complication, Hypoxemia
Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure
To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe…
- Conditions
- Mechanical Ventilation Complication, Hypoxemia, Acute Respiratory Distress Syndrome Due to COVID-19, COVID-19 Respiratory Infection
- Trial name
- REDEEM (NCT05562505)
- Testing
- Venovenous ECMO
- Where
- 7 sites in Australia, Germany
- Volunteers
- 140 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
COPD
Closed Loop Oxygen Control in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Nasal High Flow in the Hospital
The trial aims to evaluate whether the Airvo 3 device in OptiO2 mode can maintain patients' SpO2 levels within the target range better than manual oxygen titration in hospitalized COPD patients with hypoxemia/respiratory distress.
- Trial name
- NCT07222410
- Testing
- Closed loop oxygen control, Manual titration
- Where
- 4 sites in United States
- Volunteers
- 70 people
- Sponsor
- Fisher and Paykel Healthcare
Pulmonary Hypertension
Acute Exposure of High Altitude on Cognitive Function
Randomized crossover Trial in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary Hypertension (CTEPH) to assess the acute response to High Altitude (2500m above sea level) on cognitive…
- Trial name
- NCT03637192
- Testing
- Low altitude: 470m above sea level, Säntis; 2500m above sea Level
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Small Cell Lung Cancer (SCLC)
Hypoxia-guided Radiotherapy With Cisplatin-etoposide in Stage I-III : Small Cell Lung Cancer(SCLC)
Since radiation dose escalation to a large volume of tumour inevitably will induce higher toxicity than is currently the case, efforts must be made to limit the volume of tissue irradiated.
- Trial name
- HX4 in SCLC (NCT01210131)
- Testing
- [18F]HX4
- Sponsor
- Maastricht Radiation Oncology
Acute Brain Injury, Traumatic Brain Injury
Implementation of Neuro Lung Protective Ventilation
Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Stroke
- Trial name
- NEUROVENT (NCT03243539)
- Testing
- Lung Protective Ventilation
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Colin Grissom
Hypoxemia
Recruitment Maneuver After Intubation
The purpose of this study is to evaluate the safety and efficacy of a recruitment maneuver immediately after intubation in hypoxemic patients.
- Trial name
- NCT01014299
- Testing
- Recruitment maneuver
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Critical Care, Acute Hypoxic Respiratory Failure
Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial
The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator-Induced Lung Injury
- Trial name
- IT-PSV (NCT06526598)
- Testing
- PMI-targeted pressure support setting and adjustment, VT/RR-targeted pressure support setting and adjustment
- Where
- China
- Volunteers
- 619 people
- Sponsor
- Capital Medical University
Cerebral Palsy, Pediatric ALL
Use of Integrated Pulmonary Index Monitorisation in Children Undergoing Botulinum Toxin Injection
This study aimed to detect hypoxia early with ıntegrated pulmonary index monitoring compared to saturation.
- Trial name
- NCT05724030
- Testing
- integrated pulmonary index, saturation
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people
- Sponsor
- Kocaeli University
Atelectasis, Hypoxemia
Pulmonary Ultrasound for the Assessment of Atelectasis in Anesthetized Children Using a Laryngeal Mask Airway.
This study will use lung ultrasounds (LUS) to evaluate the incidence and severity of intraoperative atelectasis in anesthetized children undergoing minor surgery using a laryngeal mask airway.
- Trial name
- NCT06214312
- Testing
- Lung Ultrasounds
- Where
- Belgium
- Volunteers
- 43 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre