Clinical trials: Lung Hypoxia
Hypoxemia
The Open Lung Approach During One Lung Ventilation in Thoracic Surgery
Question: Ventilatory strategy to counterbalance the effect of one lung ventilation during thoracic surgery. Findings: the open lung approach improved oxygenation and lung compliance, reducing respiratory system driving pressure…
- Trial name
- NCT03435523
- Testing
- Recruitment maneuver
- Volunteers
- 24 people
- Sponsor
- University of Foggia
Lung Function, Postoperative Complications
Lung Function After Abdominal Surgery
The study aims to investigate changes in lung function and diffusion capacity for carbon monoxide after open and minimally invasive abdominal surgery and whether such changes can explain hypoxia after surgery.
- Conditions
- Lung Function, Postoperative Complications, Abdominal Surgery
- Trial name
- NCT04502420
- Testing
- Lung function before and after surgery
- Where
- Sweden
- Volunteers
- 59 people
- Sponsor
- Umeå University
Non-small Cell Lung Cancer
Multimodal Hypoxia Imaging and Intensity Modulated Radiotherapy for Inoperable Non-small-cell Lung Cancer
Radiotherapy, preferably combined with chemotherapy, is the treatment standard for locally advanced, unresectable non-small cell lung cancer (NSCLC).
- Trial name
- HIL (NCT01617980)
- Testing
- Multimodal hypoxia imaging
- Where
- Germany
- Volunteers
- 4 people
- Sponsor
- German Cancer Research Center
Pulmonary Hypertension
Effect of Normobaric Hypoxia and Hyperoxia in Patients With Pulmonary Hypertension
Pulmonary Hypertension (PH) is a severe disease with a bad prognosis. However, thanks to extensive research in this field, there are more and better treatment options that allow patients to participate in recreational activities…
- Trial name
- NCT03195959
- Testing
- Hypoxia and Hyperoxia
- Where
- Switzerland
- Volunteers
- 44 people
- Sponsor
- University of Zurich
COPD, Dyspnea
Is Reduced Hypoxia Through a Robot Intervention, Associated With Sensory and Emotional Descriptions of Dyspnea, Anxiety, Depression, Symptom Burden and Anxiolytics
Chronic Obstructive Pulmonary Disease (COPD) is associated with high morbidity and mortality. The Danish Lung Association estimates that 320,000 Danes live with COPD, of which approximately 50,000 with severe COPD.
- Conditions
- COPD, Dyspnea, Anxiety, Depressive Symptoms
- Trial name
- NCT04375917
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Head and Neck Cancer, Lung Cancer
Identification of Secreted Markers for Tumor Hypoxia in Patients With Head and Neck or Lung Cancers
The purpose of this study is to identify and confirm new blood and tissue markers for prognosis and tumor hypoxia. Tumor hypoxia, or the condition of low oxygen in the tumor, has been shown to increase the risk of tumor spread…
- Conditions
- Head and Neck Cancer, Lung Cancer, Lip Cancer, Lip Neoplasms
- Trial name
- NCT00568490
- Testing
- Tumor biopsy, Phlebotomy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Stanford University
Tumors
One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy
This study will include a one time intravenous (IV) infusion of Clostridium novyi-NT (C. novyi-NT) spores to treat solid tumors which have not responded to standard therapy.
- Trial name
- NCT00358397
- Testing
- Clostridium novyi-NT spores
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Pneumonia, Hypoxemia
Solar Powered Oxygen Delivery
Globally, approximately 2.1 million children die of pneumonia each year. Most deaths occur in resource-poor settings in Africa and Asia. Oxygen (O2) therapy is essential to support life in these patients.
- Trial name
- NCT02100865
- Testing
- Solar powered oxygen, Oxygen from cylinders
- Where
- Uganda
- Volunteers
- 130 people
- Sponsor
- University of Alberta
Lung Cancer, OLV
Spontaneous Breathing Mode: A Risk for Hypoxemia During OLV?
Patients undergoing thoracic surgery with one-lung ventilation (OLV) are prone to hypoxemia, which is primarily attributable to pulmonary ventilation-perfusion (V/Q) mismatch.
- Conditions
- Lung Cancer, OLV, Hypoxemia During Surgery
- Trial name
- OLV (NCT07494006)
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
Pulmonary Hypertension
Acute Exposure of Simulated Hypoxia on Blood and Tissue Oxygenation (aBGA, NIRS)
Randomized crossover trial in patients with pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary Hypertension (CTEPH) to assess the acute response to simulated altitude (FiO2:15.1, equivalent to 2500m above…
- Trial name
- NCT03637114
- Testing
- Simulated Altitude (FiO2: 15.1%)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Hypoxemia, Postoperative Complications
Sigh Ventilation on Postoperative Hypoxemia in Cardiac Surgery
Postoperative pulmonary complications (PPCs) remain a frequent event after pump-on cardiac surgery and are mostly characterized by postoperative hypoxemia.These complications are significant contributors to prolonged intensive…
- Conditions
- Hypoxemia, Postoperative Complications, Cardiac Disease, Acute Lung Injury
- Trial name
- NCT06248320
- Testing
- Sigh ventilation
- Where
- China
- Volunteers
- 192 people
- Sponsor
- Zhongda Hospital
Pulmonary Hypertension, Hypoxic Respiratory Failure
Inhaled Nitric Oxide for the Treatment of Neonatal Hypoxic Respiratory Failure With Pulmonary Hypertension
This is a prospective, open-label, single-arm, multicenter Phase IV clinical study to evaluate the safety of INOmax for the treatment of hypoxic respiratory failure with pulmonary hypertension in newborns (≥ 34 weeks gestational…
- Trial name
- INOFTTONHRFWPH (NCT07099144)
- Testing
- Inhaled nitric oxide (NO)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Lee's Pharmaceutical Limited
Bronchiolitis, Hypoxia
Heated High Flow Oxygen Use in Infants With Bronchiolitis and Hypoxia
Bronchiolitis is a common cold weather seasonal respiratory illness affecting infants and children. Multiple supportive therapies have been tried in infants with bronchiolitis including albuterol, racemic epinephrine, hypertonic…
- Trial name
- HHFNC (NCT01662544)
- Testing
- Oxygen delivery
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Covid19, Hypoxia
Higher vs. Lower Doses of Dexamethasone for COVID-19 and Severe Hypoxia
We aim to assess the benefits and harms of higher (12 mg) vs lower doses (6 mg) of dexamethasone on patient-centered outcomes in patients with COVID-19 and severe hypoxia.
- Trial name
- COVIDSTEROID2 (NCT04509973)
- Testing
- Dexamethasone
- Where
- 53 sites in Denmark, India and 2 more
- Volunteers
- 1,000 people
- Sponsor
- Scandinavian Critical Care Trials Group
Critical Care, Acute Hypoxic Respiratory Failure
A Pilot Trial of Pressure Muscle Index-Targeted PSV Trial
Pressure support ventilation (PSV) is one of the most frequently used ventilator modes in the intensive care unit (ICU). The successful implementation of PSV depends on matching the patient's inspiratory effort with the…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator Lung
- Trial name
- NCT06769360
- Testing
- PMI-targeted PSV setting, VT/RR-targeted PSV setting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
High Altitude, Healthy
Assessment of Total Pulmonary Resistance sPAP/CO Between Sea Level LA vs. High Altitude HA After Re-ascent in Healthy Individuals
To study the effect of a re-ascent after a one-week stay at sea level (after prior descent from 2850m) to high altitude (Quito Ecuador: 2850m) on pulmonary resistance (sPAP/CO) and other hemodynamic outcomes in healthy…
- Conditions
- High Altitude, Healthy, Healthy Adult, High Altitude Effects
- Trial name
- NCT07804589
- Testing
- Re-Ascent from sea level to 2850m
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Silvia Ulrich Somaini
Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Ventilator Pressure and Optimization of Compliance and Hemodynamics
In preterm infants < 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and…
- Conditions
- Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn
- Trial name
- VPOCH (NCT06512935)
- Testing
- Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Idiopathic Pulmonary Fibrosis, Hypoxemia
Effects of Oxymizer Pendant Cannula Versus Conventional Nasal Cannula During Endurance Shuttle Walk Tests in Hypoxemic Patients With Idiopathic Pulmonary Fibrosis
Aim of this study is to investigate the effects of an Oxymizer pendant nasal cannula in hypoxemic patients with idiopathic pulmonary fibrosis during walking.
- Trial name
- IPF/Oxymizer2 (NCT03411876)
- Testing
- Oxymizer® pendant nasal cannula, conventional nasal cannula
- Where
- Germany
- Volunteers
- 22 people
- Sponsor
- Klaus Kenn
Hypoventilation, Hypoxemia
Oxygen Supplementation and Ventilator Hyperinflation in the Endotracheal Suction (OSVHES)
This is a double crossover study where all patients are randomly allocated to one of two treatment sequences associated with endotracheal aspiration.The first treatment (A) uses two suctioning methods for each patient: one…
- Trial name
- OSVHES (NCT02440919)
- Testing
- Hyperoxygenation 100% FiO2, Hyperoxygenation 20% FiO2, Hyperinflation (PEEP- ZEEP) Basal FiO2
- Where
- Brazil
- Volunteers
- 78 people
- Sponsor
- Universidade Federal de Sao Carlos
Pulmonary Disease, Chronic Obstructive, Hypertension, Pulmonary
Aerobic Interval Training in Patients With Chronic Obstructive Pulmonary Disease (COPD) and Hypoxemia
Patients with severe Chronic Obstructive Pulmonary Disease (COPD) and low oxygen levels in the blood are at risk of developing pulmonary hypertension and strain on the right side of the heart, both of which are known to increase…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypertension, Pulmonary, Hypoxia
- Trial name
- NCT03092622
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- Norwegian University of Science and Technology