Clinical trials: Lung Hypoxia
Covid19, Hypoxic Respiratory Failure
SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival
Patients suffering lung failure, possibly from COVID-19 or hypoxic lung failure, will need life-saving support from a breathing machine.
- Trial name
- SAVE-ICU (NCT04415060)
- Testing
- Isoflurane Inhalant Product, Sevoflurane inhalant product
- Where
- 13 sites in Canada
- Volunteers
- 800 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pulmonary Emphysema
Clinical Study of the Efficacy and Safety of the Application of Allogeneic Mesenchymal (Stromal) Cells of Bone Marrow, Cultured Under the Hypoxia in the Treatment of Patients With Severe Pulmonary Emphysema
Actively developing stem cells (SCs) transplantation techniques cause natural interest to the problem of regeneration in the lungs.
- Trial name
- NCT01849159
- Testing
- Mesenchymal stem cells, Reference therapy: 400 mL of 0.9% NaCl solution
- Where
- Russia
- Sponsor
- Federal Research Clinical Center of Federal Medical & Biological Agency, Russia
One Lung Ventilation OLV, Esophageal Atresia
The Effect of Dexmedetomidine on Oxygen During One Lung Ventilation in Pediatric Surgery.
The children who will undergo OLV (one lung ventilation) through general anesthesia will be divided into two groups: The first will be intravenous infusion of dexmedetomidine at 0.4 mcg / kg / hour, and the second will be…
- Conditions
- One Lung Ventilation OLV, Esophageal Atresia, Hydrocystoma, Pneumonectomy
- Trial name
- RCT (NCT04932746)
- Testing
- Dexmedetomidine
- Where
- Syria
- Volunteers
- 110 people
- Sponsor
- Damascus University
COVID-19, Hypoxemia
iNOPulse for COVID-19
This randomized, controlled trial will assess the efficacy and safety of pulsed iNO in subjects with COVID-19 who are hospitalized and require supplemental oxygen.
- Conditions
- COVID-19, Hypoxemia, Hypoxemic Respiratory Failure
- Trial name
- NO-COVER (NCT04398290)
- Testing
- Inhaled nitric oxide (iNO), Nitrogen gas, Oxygen gas
- Where
- United States
- Sponsor
- Roger Alvarez
Hypoxemia
Pilot Study to Evaluate the Revoxa™ System in Hypoxic Patients
Patients with COVID-19 may suffer from profound hypoxia, requiring the use of supplemental oxygen at high concentrations and flow rates.
- Trial name
- NCT04699942
- Testing
- Conventional (low flow) oxygen delivery via nasal cannula, Revoxa Oxygen Rebrearther
- Where
- Canada
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Dr. David Maslove
Pulmonary Disease, Chronic Obstructive
Changes in Blood Gases, Disturbance of Breath During Sleep and Cardiovascular Co-morbidity in COPD Patients
Respiration failure type 2 is loss of the lungs ability to take up oxygen (O2) and get rid of carbon dioxide (CO2). The diagnosis is based on blood gas measurement of pressures of O2 and CO2.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Hypercapnia, Hypoxemia
- Trial name
- NCT00888342
- Testing
- supplementary oxygen, zopiclone, alcohol
- Where
- 2 sites in Norway
- Volunteers
- 150 people
- Sponsor
- LHL Helse
Atelectasis, Pneumonia
Comparison of Three Scores for Ultrasound Assessment and Monitoring of Pulmonary Aeration
This study is designed to compare three ultrasound-based aeration scores that were previously validated in specific populations, and to assess their correlation with computed tomographic measurement of pulmonary aeration in a…
- Conditions
- Atelectasis, Pneumonia, Acute Respiratory Distress Syndrome, Pulmonary Embolism
- Trial name
- NCT02450825
- Testing
- Lung ultrasound examination on Day 1 and Day 2 to 4, Lung ultrasound examination on Day 1, GE Vivid Ultrasound system
- Where
- Canada
- Volunteers
- 77 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Anesthesia, Atelectasis
Comparison of Two FiO2 (1 or 0.5) for Tracheal Extubation in Post-anesthesia Care Unit
The purpose of the study is to assess the optimal fraction of inspired oxygen (0.5 or 1) for extubation or removal of a supraglottic airway device after general anesthesia.
- Conditions
- Anesthesia, Atelectasis, Postoperative Complications, Hypoxemia
- Trial name
- EXTUBO2 (NCT04879290)
- Testing
- FiO2 0.5, FiO2 1
- Where
- France
- Volunteers
- 119 people
- Sponsor
- University Hospital, Caen
COVID-19, Acute Respiratory Failure
Low-field Thoracic Magnetic Stimulation Increases Peripheral Oxygen Saturation Levels in COVID-19 Patients
This study aimed to present a proof-of-concept that a 30 minutes single-session of low-field thoracic magnetic stimulation (LF-ThMS) on the dorsal thorax can be employed to increase oxygen saturation (SpO2) levels in coronavirus…
- Conditions
- COVID-19, Acute Respiratory Failure, Oxygen Deficiency
- Trial name
- NCT04895267
- Testing
- Low-field thoracic magnetic stimulation (LF-ThMS)
- Where
- Mexico
- Volunteers
- 17 people
- Sponsor
- Elias Manjarrez
Altitude, Pulmonary Hypertension
Effect of Bosentan on Exercise Capacity at High Altitude
This study is to determine whether bosentan will alter exercise capacity after rapid ascent to high altitude. We hypothesize that bosentan administration will improve arterial oxygenation and exercise capacity.
- Trial name
- NCT00432978
- Testing
- Bosentan administration
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System
Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease
Titrated Ambulatory Oxygen in Fibrotic ILD and COPD With Isolated Exertional Hypoxemia
Fibrotic forms of interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD) are chronic lung disease which often affect how well oxygen can get from the lungs into the blood.
- Conditions
- Interstitial Lung Disease, Chronic Obstructive Pulmonary Disease, Hypoxemia
- Trial name
- NCT07512687
- Testing
- Portable Oxygen Concentrator, Portable compressed oxygen D-tanks, No ambulatory oxygen therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- State University of New York at Buffalo
Iron-deficiency, Ventricular Function
Iron Status and Cardiopulmonary Physiology
This study involved human volunteers undertaking a high-altitude expedition. It assessed changes in physiological parameters of relevance to high-altitude cardiopulmonary physiology.
- Conditions
- Iron-deficiency, Ventricular Function, Pulmonary Vascular Resistance Abnormality, Altitude Hypoxia
- Trial name
- NCT03707249
- Testing
- Ferric Carboxymaltose Injectable Product, Normal Saline 0.9% Infusion Solution Bag
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Royal Centre for Defence Medicine
Covid19, Urine
Risk Stratification of COVID-19 Using Urine Biomarkers
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in infected patients, it produces symptoms which range from completely asymptomatic to those expressing severe…
- Conditions
- Covid19, Urine, Biomarker, Acute Respiratory Failure With Hypoxia
- Trial name
- NCT04681040
- Where
- 7 sites in United States, Brazil and 3 more
- Volunteers
- 964 people
- Sponsor
- National Center for Global Health and Medicine, Japan
Coronavirus Disease 2019 (COVID-19), Pneumonia
Frespaciguat (MK-5475) in Participants With Hypoxemia Due to COVID-19 Pneumonia (MK-5475-009)
The purpose of this study is to evaluate safety, tolerability, and pharmacodynamics of frespaciguat after administration of multiple doses to participants with COVID-19 pneumonia.
- Conditions
- Coronavirus Disease 2019 (COVID-19), Pneumonia, Hypoxemia
- Trial name
- NCT04425733
- Testing
- Frespaciguat
- Sponsor
- Merck Sharp & Dohme LLC
ARDS, Human, Extracorporeal Membrane Oxygenation Complication
Effects of Induced Moderate Hypothermia on ARDS Patients Under Venovenous ExtraCorporeal Membrane Oxygenation
Acute respiratory distress syndrome (ARDS) is a lesional pulmonary edema that occurs as a result of direct or indirect lung injury.
- Conditions
- ARDS, Human, Extracorporeal Membrane Oxygenation Complication, Hypothermia
- Trial name
- HypoLungECMO (NCT05306392)
- Testing
- Moderate Hypothermia, Normothermia
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Hypoxemia, Neonatal Disease
Evaluation of a Multi-country Medical Oxygen Program
REAL-MOXY is a set of 5 mixed methods studies designed to understand how oxygen and pulse oximetry are used (or not used) at a facility level, to identify opportunities and barriers for strengthening oxygen systems for…
- Conditions
- Hypoxemia, Neonatal Disease, Pneumonia, Sepsis
- Trial name
- REAL-MOXY (NCT06087315)
- Testing
- Multi-faceted oxygen systems strengthening interventions (different for each country)
- Where
- 3 sites in Cambodia, Nigeria and 1 more
- Volunteers
- 1,200 people
- Sponsor
- Murdoch Childrens Research Institute
Amyotrophic Lateral Sclerosis (ALS)
Developing New Ways to Detect Respiratory Impairment Early in ALS
The goal of this observational study is to develop new ways to detect early changes associated with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
- Trial name
- NCT07844590
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
PPHN, Hypoxic Respiratory Failure
Predictors of Inhaled Nitric Oxide Responsiveness in Patients With PPHN
To identify biochemical, clinical, or genetic biomarkers that may predict responsiveness to iNO in neonates with PPHN/HRF. The primary outcome will be identification of any biomarker(s) associated with response to iNO therapy.
- Trial name
- PINOR (NCT06043635)
- Sponsor
- Nationwide Children's Hospital
COPD, Hypoxia
Hypobaric Flight Simulation in COPD Patients
Aim of this study was to evaluate the hypoxic response during hypobaric flight simulation in normal individuals as well as in normocapnic and hypercapnic COPD patients as well as to evaluate the impact of a flight simulation on…
- Conditions
- COPD, Hypoxia, Aviation
- Trial name
- NCT02848391
- Testing
- Environmental
- Where
- Germany
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Krankenhaus Kloster Grafschaft
Pulmonary Infection, Pulmonary Nodule
COMBO Endoscopy Oropharyngeal Airway in Sedated Fiberoptic Bronchoscopy for Patients: A Simon Two-Stage Trial
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing fiberoptic bronchoscopy with propofol.
- Conditions
- Pulmonary Infection, Pulmonary Nodule, Endotracheal Tumour, Bronchiectasis
- Trial name
- NCT07063290
- Testing
- the COMBO Endoscopy Oropharyngeal Airway
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Zhejiang University