Clinical trials: Lung Hypoxia
Hypoxia-Induced Pulmonary Artery Hypertension
Effects of Bosentan (Tracleer) in the Course of Pulmonary Artery Hypertension Induced by Hypoxia
Excessive rise in pulmonary artery pressure induced by low oxygen tension (hypoxia) is one of the factors implicated in high-altitude pulmonary oedema.
- Trial name
- NCT00260819
- Testing
- Bosentan, Bosentam TRACLEER
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Pulmonary Complications (PPCs), Hypoxemia
Lung Ultrasound Score and Postoperative Pulmonary Complications in Major Non-Thoracic Surgery
This prospective observational cohort study aims to evaluate the predictive value of perioperative lung ultrasound (LUS) score in determining early postoperative oxygen requirement and pulmonary complications in patients…
- Trial name
- LUS-POSTOP (NCT07515001)
- Volunteers
- 97 people
- Sponsor
- Dicle University
High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation
Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
Trial of Non-Invasive Positive Pressure Ventilation Management of High Altitude Pulmonary Edema
- Conditions
- High Altitude Pulmonary Edema, Non-Invasive Positive Pressure Ventilation, Hypoxia
- Trial name
- NCT04288219
- Testing
- Non-Invasive Positive Pressure Ventilation, Nifedipine, supplemental oxygen
- Where
- Nepal
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Head and Neck Cancer, Lung Cancer
Clinical Evaluation of the New Hypoxia Imaging Agent HX4
Positron Emission Tomography (PET) with fluorine-18 fluoromisonidazole (FMISO) has been used for several years as a non invasive imaging technique to study tumor hypoxia.
- Conditions
- Head and Neck Cancer, Lung Cancer, Liver Cancer
- Trial name
- NCT01213030
- Testing
- [F-18] FMISO, [F-18] HX4
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Siemens Molecular Imaging
COVID-19
DAS181 for Severe COVID-19: Compassionate Use
The objective of the study is to investigate the safety and potential efficacy of DAS181 for the treatment of severe COVID-19.
- Trial name
- NCT04324489
- Testing
- DAS181
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Renmin Hospital of Wuhan University
COVID-19, Acute Respiratory Distress Syndrome
Tolerability and Efficacy of RJX in Patients With COVID-19
This study is designed as a 2-part, 2-cohort, double-blind, randomized, placebo controlled, multicenter Phase 1/2 study to evaluate the safety, tolerability and efficacy of RJX in patients with COVID-19.
- Conditions
- COVID-19, Acute Respiratory Distress Syndrome, SARS-CoV-2, Hypoxemia
- Trial name
- RJX (NCT04708340)
- Testing
- Rejuveinix (RJX) Active Comparator
- Where
- 3 sites in United States
- Volunteers
- 237 people
- Sponsor
- Reven Pharmaceuticals, Inc.
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Sleep-Assessment in Patients Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito Ecuador: 2850m) to sea level on sleeping parameters by polygraphy in patients with pulmonary arterial hypertension PAH, who live permanently >2600m.
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, Polygraphy, Sleep
- Trial name
- NCT07801963
- Testing
- Descent to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Refractory Pulmonary Tuberculosis
Pimonidazole Hydrochloride to Detect Low Oxygen in Tuberculosis-Infected Lungs
This study will determine whether a drug called pimonidazole hydrochloride shows areas of low oxygen in tuberculosis (TB)-infected lungs.
- Trial name
- NCT00374517
- Testing
- Pimonidazole hydrochloride
- Where
- 2 sites in South Korea
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hypoxemia, ARDS
Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass
More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass.
- Conditions
- Hypoxemia, ARDS, Lung Injury, Acute, Cardiopulmonary Bypass
- Trial name
- NCT05647382
- Testing
- blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhuan Zhang
Acute Respiratory Distress Syndrome, Acute Respiratory Failure With Hypoxia
Severe ARDS: Generating Evidence
An assessment of early management of moderate-severe ARDS in the United States, including ventilator management and use of rescue therapy.
- Conditions
- Acute Respiratory Distress Syndrome, Acute Respiratory Failure With Hypoxia, Acute Respiratory Failure
- Trial name
- SAGE (NCT03021824)
- Where
- 28 sites in United States
- Volunteers
- 2,400 people
- Sponsor
- Montefiore Medical Center
Intensive Care Unit ICU, Intubation
The Effects of Endotracheal Suctioning on Pain and Serum Markers
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients.
- Conditions
- Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation
- Trial name
- NCT06692400
- Testing
- endotracheal tube suctioning
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Persistent Fetal Circulation Syndrome, Hypertension, Pulmonary, of Newborn, Persistent
Early iNO for Oxidative Stress, Vascular Tone and Inflammation in Babies With Hypoxic Respiratory Failure
The investigators in this study are concerned about the harmful effects of oxygen exposure in newborn infants, particularly at high concentrations.
- Conditions
- Persistent Fetal Circulation Syndrome, Hypertension, Pulmonary, of Newborn, Persistent, Persistent Pulmonary Hypertension of Newborn
- Trial name
- NCT01891500
- Testing
- Inhaled nitric oxide, Nitrogen Gas, Crossover iNO
- Where
- United States
- Sponsor
- University of Florida
Hypoxic Respiratory Failure With Pulmonary Hypertension
Inhaled Nitric Oxide (INO) In Hypoxic Respiratory Failure
This Phase 3, Double-blind, Randomized, Placebo controlled, multicenter study is to confirm the efficacy of inhaled nitric oxide for the management of hypoxic respiratory failure associated with pulmonary hypertension in preterm…
- Trial name
- NCT00922532
- Testing
- Inhaled Nitric Oxide
- Sponsor
- Mallinckrodt
Hypoxic Pulmonary Vasoconstriction, Hypoxemia
Effects in Oxygenation and Hypoxic Pulmonary Vasoconstriction in ARDS Secondary to SARS-CoV2
Summary Currently, the COVID-19 pandemic has overtaken health systems worldwide, exceeding the capacity of intensive care units.
- Conditions
- Hypoxic Pulmonary Vasoconstriction, Hypoxemia, Acute Respiratory Distress Syndrome, SARS-CoV-2 Acute Respiratory Disease
- Trial name
- COVID-19 (NCT04998253)
- Testing
- Effects in oxygenation and hypoxic pulmonary vasoconstriction
- Where
- Mexico
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unidad Temporal COVID-19 en Centro Citibanamex
Lung Squamous Cell Carcinoma, Carcinoma, Non-Small-Cell Lung (NSCLC)
Intermittent Hypoxic Training as Neoadjuvant Therapy for Lung Squamous Cell Carcinoma
The goal of this clinical trial is to learn if adding intermittent hypoxic training (IHT) to standard neoadjuvant chemo-immunotherapy can increase the pathologic complete response (pCR) rate in patients aged 18 to 75 of both…
- Trial name
- NCT07618793
- Testing
- Intermittent Hypoxic Training (IHT), Standard Neoadjuvant Chemo-immunotherapy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- zhang yi
Covid19, Hypoxemia
A Study of Micro Dose Ambrisentan in Hospitalized Patients With Respiratory Insufficiency Due to COVID-19
Patients with COVID-19 frequently develop lower respiratory complications. Difficulty breathing and a low concentration of oxygen in the blood are of concern in patients with COVID-19, as they indicate that the lungs may be…
- Trial name
- NCT04771000
- Testing
- Ambrisentan
- Where
- 13 sites in Croatia, Spain
- Volunteers
- 88 people
- Sponsor
- Noorik Biopharmaceuticals AG
Lung Cancer
EF5 in Assessing Tumor Response to Anticancer Therapy in Patients With Stage I, Stage II, or Stage III Non-Small Cell Lung Cancer
RATIONALE: Knowing the level of oxygen in tumor tissue may help predict the effectiveness of anticancer therapy. EF5 is a drug used in the measurement of oxygen in tumor tissue.
- Trial name
- NCT00041028
- Testing
- EF5, flow cytometry, immunohistochemistry staining method
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Duke University
Lung Surgery, Hypoxia
The Effect of Nasal Cannula During the First 2 Hours Postoperative in Patient Undergoing Thoracotomy
During early postoperative after lung resection surgery, patients without oxygen supplementation may experience hypoxemia. Oxygen supplementation can be given via oxygen mask or cannular.
- Conditions
- Lung Surgery, Hypoxia, Postoperative
- Trial name
- NCT01725464
- Testing
- oxygen cannular
- Where
- Thailand
- Volunteers
- 34 people
- Sponsor
- Mahidol University
Bronchiolitis
Nebulized 3% Hypertonic Saline vs. Standard of Care in Patients With Bronchiolitis
The purpose of this study is to determine whether nebulized 3% hypertonic saline is more effective than the current standard of care in the treatment of viral bronchiolitis in children.
- Trial name
- NCT02834819
- Testing
- 3% Nebulized Hypertonic Saline
- Volunteers
- 18 people
- Sponsor
- University of Colorado, Denver
Pulmonary Disease, Postoperative Respiratory Complications
Screening of Postoperative Pulmonary Complications by Electrical Impedance Tomography
The purpose of this study is to determine whether Electrical Impedance Tomography can be used as sensitive and specific predictor in the detection of postoperative pulmonary complications (e.g.
- Conditions
- Pulmonary Disease, Postoperative Respiratory Complications, Malignant Neoplasm of Stomach, Liver Diseases
- Trial name
- NCT02337673
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Johannes Gutenberg University Mainz