Clinical trials: Lung Hypoxia
Hypoxia Altitude Simulation Test, High Altitude
Hypoxia-altitude Testing to Predict Altitude Related Adverse Health Effects in Chronic Obstructive Pulmonary Disease (COPD) Patients
The predictive value of the hypoxia altitude simulation test (HAST) or other baseline values to predict altitude-related adverse health effects (ARAHE) is not established.
- Trial name
- NCT04915378
- Testing
- hypoxia altitude simulation test (HAST) at 760m, High Altitude (3100m)
- Where
- Kyrgyzstan
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Pain, Hypoxemia
Effects of Walking Apnea At High Lung Volume on Hypoalgesia
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxemia, Hypercapnia, Apnea
- Trial name
- NCT06638528
- Testing
- Walking apnea at High Lung Volume, Walking normal breathing
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidad Rey Juan Carlos
Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease
Assessment of Six-minute Walking Distance 6MWD Between High Altitude HA vs. Sea Level LA in Patients With Pulmonary Arterial Hypertension PAH
To study the effect of relocation from high altitude (Quito: 2850m) to sea level on six-minute walking distance and scores in patients with pulmonary arterial hypertension PAH, who live permanently >2600m.
- Conditions
- Pulmonary Arterial Hypertension (PAH), Pulmonary Vascular Disease, Six-minute Walk Test, High Altitude Effects
- Trial name
- NCT07804472
- Testing
- Descent from 2850m to sea level
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Silvia Ulrich Somaini
Pulmonary Hypertension
Acute Exposure to High Altitude on Symptoms
Randomized crossover Trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response to High Altitude (2500m above sea level) in altitude related symptoms
- Trial name
- NCT03593005
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Hypoxemia, Pneumonia, Viral
Nitric Oxide Therapy for COVID-19 Patients With Oxygen Requirement
Preliminary data support the effect of Nitric Oxide (NO) on improving the oxygenation in mechanically ventilated patients and spontaneously breathing patients with COVID-19.
- Conditions
- Hypoxemia, Pneumonia, Viral, Coronavirus Infection
- Trial name
- NICOR (NCT04476992)
- Testing
- Nitric Oxide-Sessions, Nitric Oxide-Continuous and Sessions
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
COPD (Chronic Obstructive Pulmonary Disease)
Effects of Blood Flow Restriction Aerobic Exercise on Inflammation, Hypoxia, Exercise Capacity, and Lung Function in COPD
Purpose: This study aims to compare the effects of the classical pulmonary rehabilitation (PR) program and blood flow restriction (BFR) applied during low-intensity aerobic exercise within PR on systemic inflammation, hypoxemia…
- Trial name
- BFR-COPD (NCT07261293)
- Testing
- Blood Flow Restriction Aerobic Exercise Training, Conventional Aerobic Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Istinye University
Asthma, OSA
The Role of Endothelium A and EGFR Receptor in Fibrocytes From Asthma With Obstructive Sleep Apnea
The investigators will compare the circulating fibrocyte proportion in asthmatic patients with obstructive sleep apnea (OSA) and not with OSA In addition, the investigators will compare the expression of epidermal growth factor…
- Trial name
- NCT02749565
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung Memorial Hospital
Hypoxic Pulmonary Vasoconstriction
Effects of Iloprost on Hypoxic Pulmonary Vasoconstriction and Exercise Capacity at High Altitude
The objective of this study is to determine if single dose administration of inhaled iloprost will reduce pulmonary artery pressure, reduce hypoxic pulmonary vasoconstriction and improve arterial oxygenation at rest and during…
- Trial name
- NCT00708565
- Testing
- iloprost
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Loma Linda Health Care System
Smoking, Oxygen Deficiencies
The Effects of Secondary Smoking During One Lung Ventilation
Smoking and perhaps secondary smoking is associated with many perioperative and postoperative complications, especially respiratory events. Hypoxemia and airway damage can be associated with secondary smoking.
- Trial name
- NCT03006224
- Testing
- One Lung Ventilation
- Volunteers
- 60 people
- Sponsor
- Inonu University
Hypoxemia, Anoxia
Reproducibility of 6 Minute Walk Tests for Oxygen Desaturation
This trial will test the hypothesis that the 6 minute walk test (6MWT) is not reproducible as a measure for oxygen desaturation.
- Conditions
- Hypoxemia, Anoxia, Chronic Obstructive Pulmonary Disease
- Trial name
- 6MWT (NCT00740220)
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Wake Forest University Health Sciences
Pulmonary Hypertension, Familial Persistent, of the Newborn
A Study To Evaluate Safety And Efficacy Of IV Sildenafil In The Treatment Of Neonates With Persistent Pulmonary Hypertension Of The Newborn
This study will evaluate whether IV sildenafil can reduce the time on inhaled nitric oxide treatment and reduce the failure rate of available treatments for persistent pulmonary hypertension of the newborn.
- Trial name
- NCT01720524
- Testing
- iv sildenafil
- Where
- 42 sites in United States, Belgium and 10 more
- Volunteers
- 59 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Hypoxemia, Pulmonary Sepsis
Lung Protective One-lung Ventilation With Fix and Variable Tidal Volume
During One-lung ventilation, the use of lower tidal volumes (VT) is helpful to avoid over-distension, provide sufficient oxygenation, but can result in increased atelectasis.
- Conditions
- Hypoxemia, Pulmonary Sepsis, ARDS, Human, Pneumonia
- Trial name
- NCT03364465
- Testing
- change of ventilatory settings
- Where
- Hungary
- Volunteers
- 140 people
- Sponsor
- University of Debrecen
SARS-CoV-2 Infection, Respiratory Failure With Hypoxia
Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure
Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.
- Trial name
- QUANTICO-RETRO (NCT04534400)
- Testing
- thoracic CT-scan
- Where
- 2 sites in France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Strasbourg, France
Acute Respiratory Distress Syndrome
Extrapulmonary Interventional Ventilatory Support in Severe Acute Respiratory Distress Syndrome (ARDS)
A prospective, randomized study will be performed investigating the effects of a pumpless extracorporeal interventional lung assist [iLA] on the implementation of a lung-protective ventilatory strategy in patients with acute…
- Trial name
- Xtravent (NCT00538928)
- Testing
- lung protective ventilation
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- University of Regensburg
COPD, Hypoxia
Automated Oxygen Administration -Rethinking Interventions Alleviating Dyspnea in Patients With COPD
Chronic Obstructive Pulmonary Disease (COPD) is associated with high morbidity and mortality. The Danish Lung Association estimates that 320,000 Danes live with COPD, of which approximately 50,000 with severe COPD.
- Conditions
- COPD, Hypoxia, Closed-Loop Communication, Dyspnea
- Trial name
- NCT04370990
- Testing
- O2matic
- Where
- 5 sites in Denmark
- Volunteers
- 157 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Hepatopulmonary Syndrome
Supine Exercise in Hepatopulmonary Syndrome Patients With Orthodeoxia
Hepatopulmonary syndrome (HPS) is a rare condition that presents in about a quarter of patients with liver cirrhosis. In addition, a small subset of these HPS patients also have orthodeoxia, defined as a drop in oxygen levels…
- Trial name
- NCT04004104
- Testing
- Upright Exercise, Supine Exercise
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Bleeding, Hypoxia
Video-guided Percutaneous Tracheostomy (PCT) Versus Conventional PCT: Comparing Safety and Efficacy
The purpose of this study is to compare the feasibility, safety, efficacy and ease of performance of a video-assisted PCT (via an endotracheal tube embedded with a mini video-camera) with the standard ("blind") PCT technique.
- Conditions
- Bleeding, Hypoxia, Atelectasis, Pneumothorax
- Trial name
- NCT01012518
- Testing
- Standard PCT, Video-guided PCT
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix
EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer
This clinical trial is studying the amount of EF5 and motexafin lutetium present in tumor cells and/or normal tissues of patients with abdominal (such as ovarian, colon, or stomach cancer) or non-small cell lung cancer.
- Conditions
- Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix, Fallopian Tube Cancer, Gastrointestinal Stromal Tumor
- Trial name
- NCT00087191
- Testing
- EF5, motexafin lutetium, pharmacological study
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Idiopathic Pulmonary Fibrosis, Hypoxemia
Study to Evaluate the Effect of GBT440 Administered to Subjects With IPF on Supplemental Oxygen at Rest
This is an open label study in which eligible IPF subjects who are using supplemental oxygen at rest will receive GBT440 orally daily.
- Trial name
- Zephyr (NCT02989168)
- Testing
- GBT440
- Where
- 9 sites in United States, United Kingdom
- Volunteers
- 14 people
- Sponsor
- Global Blood Therapeutics
Altitude Edema
Advair HFA in Healthy and HAPE Predisposed Subjects
The current protocol is composed of two studies. The first study is designed to carefully evaluate the safety of high-dose salmeterol/fluticasone (Advair HFA) versus placebo (hydrofluoroalkane, HFA) administration over 7 days, as…
- Trial name
- SWIFTARC (NCT06040268)
- Testing
- Advair HFA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver