Clinical trials: Lung Hypoxia
Pain, Hypoxia
Effects of Walking Apnea at High Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at high lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158282
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
High Altitude Pulmonary Hypertension
High Altitude Residents With High Altitude Pulmonary Hypertension (HAPH), SDB Assessed at HA (3200 m) vs LA (760 m)
To study the effect of relocation from 3200m (Aksay) to 760m (Bishkek) in highlanders with High Altitude Pulmonary Hypertension (HAPH) who permanently live >2500m on sleep disordered breathing
- Trial name
- NCT06489717
- Testing
- SDB assessment
- Where
- Kyrgyzstan
- Volunteers
- 24 people
- Sponsor
- University of Zurich
Pulmonary Hypertension
Acute Exposure of High Altitude on Cardiac Output
Randomized crossover trial in patients with Pulmonary Hypertension (PAH, CTEPH) to assess the acute response High Altitude (Säntis; 2500m above sea level) on non-invasive cardiac output assessments by Finapres® NOVA Technology at…
- Trial name
- NCT03637218
- Testing
- Assessment at Low Altitude (470m above sea level), Exposure to High Altitude (2500m above sea level)
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
Carcinoma, Non-Small-Cell Lung
64CuATSM and Hypoxia in Stage IV Non-small Cell Lung Cancer With Carboplatin, Paclitaxel, and Bevacizumab
The purpose of this study is to determine: Whether bevacizumab increases the amount of oxygen in cancer as measured by a special positron emission tomography (PET) scan using 64Cu-ATSM.
- Trial name
- NCT01006226
- Testing
- 64Cu-ATSM PET
- Sponsor
- Washington University School of Medicine
Covid19, Hypoxemic Respiratory Failure
Automatic Oxygen Titration With O2matic® to Patients Admitted With COVID-19 and Hypoxemic Respiratory Failure
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen.
- Conditions
- Covid19, Hypoxemic Respiratory Failure, Hypoxemia
- Trial name
- O2matic-COVI (NCT04565106)
- Testing
- Closed-loop control of oxygen supplementation by O2matic
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Hvidovre University Hospital
Acute Respiratory Tract Infection, Acute Respiratory Insufficiency
An Open Randomized Study of Dalargin Efectiveness in Combination With Leitragin Drug in Patients With Severe and Critical Manifestations of SARS-COVID-19
The purpose of the study is to evaluate an effectiveness of the drug Dalargin in combination with Leitragin for the prevention and treatment of severe pulmonary complications symptoms associated with severe and critical…
- Conditions
- Acute Respiratory Tract Infection, Acute Respiratory Insufficiency, Pneumonia, Septic Shock
- Trial name
- NCT04346693
- Testing
- Standard therapy recommended by the Ministry of Health of the Russian Federation., Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin intramuscular injection, Standard therapy recommended by the Ministry of Health of the Russian Federation and Leitragin inhalation
- Where
- Russia
- Volunteers
- 320 people
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Oxygen Deficiency, Pulmonary Arterial Hypertension
The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia
Treatment of O2 naïve patients with PAH will be included in this investigator-initiated trial (IIT) to assess efficacy and safety of oxygen substitution.
- Conditions
- Oxygen Deficiency, Pulmonary Arterial Hypertension, CTEPH
- Trial name
- SOPHA (NCT04207593)
- Testing
- Oxygen
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Heidelberg University
Persistent Pulmonary Hypertension of Newborn
Nebulized Magnesium Sulfate and Sildenafil for Persistent Pulmonary Hypertension of Newborn
The aim of this study is to evaluate the effectiveness of nebulized magnesium sulfate combined with sildenafil citrate, compared with sildenafil citrate alone, in treating neonates with severe persistent pulmonary hypertension on…
- Trial name
- NCT04898114
- Testing
- Magnesium sulfate, Sildenafil Citrate, Isotonic saline
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
High Altitude Pulmonary Hypertension
Exercise Endurance Time on the 2nd Day at 2500 m High Altitude
The impact of a sojourn at 2500 m of high altitude for 26-30 h on constant work-rate exercise test time in patients with precapillary pulmonary hypertension
- Trial name
- NCT05131737
- Testing
- High altitude exposure, Low altitude exposure
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University of Zurich
SARS-CoV 2, COVID-19
Convalescent Plasma Trial in COVID -19 Patients
Plasma therapy using convalescent plasma has been shown to be effective in severe acute respiratory syndrome, Ebola virus infection and in H1N1 influenza.
- Trial name
- NCT04356534
- Testing
- plasma therapy using convalescent plasma with antibody against SARS-CoV-2, Routine care for COVID-19 patients
- Where
- Bahrain
- Volunteers
- 40 people
- Sponsor
- Royal College of Surgeons in Ireland - Medical University of Bahrain
Hypoventilation, Hypoxemia
Postoperative Respiratory and Activity Monitoring
This study plans to learn more about specific breathing and activity recommendations for patients after surgery. Participants will be monitored after abdominal surgery to identify what activities help them breathe better and…
- Conditions
- Hypoventilation, Hypoxemia, Postoperative Pulmonary Complications
- Trial name
- NCT06239831
- Testing
- ExSpiron and ActivPAL Monitors
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Colorado, Denver
Hypoxemia, Gastric Cancer (Diagnosis)
High-Flow Nasal Cannula Oxygenation During Sedated Gastrointestinal Endoscopy in Patients With Chronic Obstructive Pulmonary Disease
Hypoxemia is the most common adverse event during propofol sedation for gastrointestinal endoscopy in patients with chronic obstructive pulmonary disease (COPD) due to diminished pulmonary reserve.
- Conditions
- Hypoxemia, Gastric Cancer (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD), Esophageal Cancer
- Trial name
- NCT07791979
- Testing
- High-flow nasal cannula
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhejiang University
Covid19
Hyperbaric Oxygen as an Adjuvant Treatment for Patients With Covid-19 Severe Hypoxemia
The severity of COVID-19 is related to the level of hypoxemia, respiratory failure, how long it lasts and how refractory it is at increasing concentrations of inspired oxygen.
- Trial name
- NCT04477954
- Testing
- Hyperbaric Oxygen
- Where
- 3 sites in Argentina
- Volunteers
- 40 people
- Sponsor
- Asociación Argentina de Medicina Hiperbárica e Investigación
Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia
Efficacy Evaluation of UCB-MNCs in the Treatment of Refractory Neonatal Diseases
Hypoxic-ischemic encephalopathy (HIE), bronchopulmonary dysplasia (BPD), short bowel syndrome (SBS) are refractory in clinical treatment.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Bronchopulmonary Dysplasia, Short Bowel Syndrome
- Trial name
- NCT06427642
- Testing
- Mononuclear cells, Mild hypothermia therapy, Breathing support technique
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shandong Qilu Stem Cells Engineering Co., Ltd.
Esophageal Cancer, Lung Cancer
Dexmedetomidine and Hypoxic Pulmonary Vasoconstriction in Thoracic Surgical Procedures and One-Lung Ventilation
The purpose of this study is to evaluate the effects of Dexmedetomidine when used during thoracic surgery. The primary outcome will be changes in oxygenation as measured the PaO2 during one lung ventilation.
- Conditions
- Esophageal Cancer, Lung Cancer, Chest Wall Disorders
- Trial name
- Dex-One-Lung (NCT00839605)
- Testing
- Dexmedetomidine
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Missouri-Columbia
Respiratory Control in Premature Infants
Prematurity-Related Ventilatory Control
The purpose of this research study is to improve our understanding of unstable breathing and heart blood flow patterns seen in premature infants.
- Trial name
- PreVent (NCT03464396)
- Testing
- Bedside Physiology study, Carotid Body Function Test, Room Air Challenge
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- Washington University School of Medicine
PPHN, Persistent Pulmonary Hypertension of the Newborn
Study To Investigate Safety And Efficacy Of Sildenafil In The Newborns With Persistent Pulmonary Hypertension (PPHN)
Sildenafil is efficacious in newborns with persistent pulmonary hypertension and its use will reduce the need for inhaled nitric oxide.
- Conditions
- PPHN, Persistent Pulmonary Hypertension of the Newborn, Hypoxic Respiratory Failure
- Trial name
- NCT01069861
- Testing
- sildanefil
- Where
- United Kingdom
- Volunteers
- 4 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Pain, Hypoxia
Effects of Walking Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function
The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent walking apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze…
- Conditions
- Pain, Hypoxia, Hypercapnia, Apnea
- Trial name
- NCT06158295
- Testing
- Voluntary apnoea
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centro Universitario La Salle
Hypoxemia, Pneumonia
Effect of High-Flow Nasal Cannula Oxygen Therapy on Hypoxemia in Pediatric Sedated Bronchoscopy
Due to children's lower oxygen reserves and higher oxygen consumption, sedation can easily lead to respiratory adverse events such as hypoxemia.
- Conditions
- Hypoxemia, Pneumonia, Pulmonary Neoplasm
- Trial name
- NCT07563075
- Testing
- High-flow nasal cannula, Regular Nasal Cannula
- Where
- 4 sites in China
- Volunteers
- 430 people
- Sponsor
- Zhejiang University
Pulmonary Atelectasis, Postoperative Complications
poStoperative Anesthesia Care: Facial Mask vs Hfnc and Thoracic Ultrasound for Reduction of Atelectasis Incidence
The primary aim of this study is to assess the efficacy of post-operatory HFNC in reducing the incidence of hypoxemia after gynecological oncology surgery, compared to the standard application of O2 through a Venturi mask; The…
- Conditions
- Pulmonary Atelectasis, Postoperative Complications, Gynecologic Cancer, Anesthesia
- Trial name
- SAMURAI (NCT04566419)
- Testing
- HFNC - Airvo 2, Oxygen
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS