Clinical trials: Lung Lesions
Peripheral Pulmonary Lesions
EBUS-Guided TBNA Increases the Diagnostic Yield of Peripheral Pulmonary Lesions
The diagnosis of peripheral pulmonary lesions(PPLs) remained a clinical challenge for physicians. Bronchoscope with sampling procedures was recognized as a useful method to obtain the correct diagnosis of PPLs.
- Trial name
- NCT00626587
- Testing
- Olympus NA-2C-1 Transbronchial needle aspiration (TBNA)
- Where
- Taiwan
- Volunteers
- 182 people
- Sponsor
- Chang Gung Memorial Hospital
Lung; Node
Robotic Bronchoscopy for Peripheral Pulmonary Lesions
In this study, the feasibility of performing robotic navigation of peripheral airways in human subjects for the purpose of biopsying peripheral lung lesions will be evaluated.
- Trial name
- NCT03727425
- Testing
- Robotic assisted bronchoscopy
- Where
- 5 sites in United States
- Volunteers
- 55 people
- Sponsor
- Auris Health, Inc.
Lung Cancer
The Role of Narrow Band Imaging Videobronchoscopy in Lung Cancer
Narrow band imaging (NBI) videobronchoscopy is an optical technique in which filtered light enhances superficial neoplasm based on their neoangiogenic pattern.
- Trial name
- NBI (NCT01178190)
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Asan Medical Center
Lung Cancer
The Lung PCA: A Multi-Dimensional Atlas of Pulmonary Premalignancy
This protocol pertains specifically to the prospective lung squamous cell carcinoma pre-malignant lesion (PML) cohort that will form a primary study group for the Lung Pre-Cancer Atlas.
- Trial name
- NCT03881098
- Testing
- Bronchoscopies, Sputum Sample, Venipuncture
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Colorado, Denver
Non Small Cell Lung Cancer Metastatic, Radiotherapy
Phase III, Multicenter, Randomized Controlled Clinical Study of Three-Dimensional Radiotherapy for Primary Tumors in Non-Oligometastatic Stage IV Non-Small Cell Lung Cancer
For patients with non-small cell lung cancer and more than five metastatic lesions (non-oligometastatic disease), does radical treatment of the primary lung lesion, in addition to pharmacotherapy, also provide benefits in terms…
- Trial name
- NCT07462728
- Testing
- Three-Dimensional Radiotherapy for Primary lungTumors
- Volunteers
- 200 people
- Sponsor
- Guizhou Medical University
Metastatic Cancer
In-Situ Therapeutic Cancer Vaccine for Metastatic Cancer Combining AlloStim With Tumor Cryoablation
This is a Phase I/II study to investigate the feasibility of creating a personalized therapeutic cancer vaccine within the body. A vaccine contains a source of tumor antigen and an adjuvant.
- Trial name
- NCT00861107
- Testing
- AlloStim-7, percutaneous tumor cryoablation, AlloStim8 or AlloStim-9
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mirror Biologics, Inc.
Lung Surgery
Evaluation of the Effectiveness and Security of TenaTac® in the Prevention of Air Leaks in Thoracic Surgery
Lung surgery remains a high-risk procedure, with serious adverse events that can occur later, including postoperative bleeding or hemothorax, pneumopathy or surgical site infection but also ... per- and post-operative air leaks.
- Trial name
- TENATAC (NCT06597604)
- Testing
- Intraoperative use of TenaTac in lung surgery, Intraoperative use of usual sealant in lung surgery
- Where
- 2 sites in France
- Volunteers
- 154 people
- Sponsor
- Hopitaux Prives de Metz, Groupe UNEOS
Lung Neoplasms, Pulmonary Neoplasm
ENB Vs. Conventional Bronchoscopy With Fluoroscopy for Safe and Effective Biopsy of Pulmonary Lesions
Evaluate results for participants with lung lesions randomized to either 4D Electromagnetic Navigation Bronchoscopy (4D-ENB) versus Conventional Bronchoscopy with Fluoroscopy for diagnostic biopsy and detection of lung cancer.
- Trial name
- NCT04447482
- Testing
- ENB with image-guided lung biopsy, Conventional Bronchoscopy guided by Fluoroscopy
- Where
- 4 sites in China
- Volunteers
- 212 people
- Sponsor
- Shanghai Youhe Medical Technology Co., Ltd.
Lung Cancer, Stereotactic Body Radiotherapy
Stereotactic Body Radiotherapy for Lung Lesions With Markerless Tracking (MLT) on the VERO® SBRT System
Stereotactic Body Radiotherapy (SBRT) delivers an ablative dose of radiation to tumours, with high precision. This technique offers an alternative to surgery for lung lesions.
- Conditions
- Lung Cancer, Stereotactic Body Radiotherapy, Lung Diseases, Lung Cancer Metastatic
- Trial name
- SBRT_LOV (NCT06722885)
- Testing
- Standard radiotherapy treatment
- Where
- Belgium
- Sponsor
- Universitair Ziekenhuis Brussel
High-risk Lung Nodules
Immunoprevention for High-risk Lung Lesions
The main purpose of this study is to assess nadunolimab as an immunoprevention strategy for high-risk lung nodules in participants who are current or former tobacco smokers. The study may last up to 5 years for each participant.
- Trial name
- NCT07284485
- Testing
- Nadunolimab
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Robert Samstein
Small Cell Lung Carcinoma
An Exploratory Study of Lurbinectedin With Radiotherapy in SCLC With Single-lesion Progression After First Course Treatment
This exploratory trial aims to determine if it is safe to use radiotherapy and lurbinectedin to treat SCLC with Single-lesion progression after first course treatment.
- Trial name
- NCT06501976
- Testing
- Lurbinectedin, Radiation Therapy
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Solitary Pulmonary Nodule, Biopsy, Fine-Needle
iNod System Human Feasibility Assessment
The purpose of this study is to demonstrate feasibility to access, visualize, and obtain specimens adequate for cytology of lung lesions in subjects with suspected lung cancer when using the iNod System.
- Trial name
- iNod (NCT02832284)
- Testing
- iNod System
- Where
- 3 sites in United States
- Volunteers
- 23 people
- Sponsor
- Boston Scientific Corporation
Peripheral Lung Lesions
Localization of Peripheral Pulmonary Lesions: A Pilot Study
Despite technological advancements directed towards the diagnosis of peripheral pulmonary lesions, an optimal approach has yet to be designed.
- Trial name
- NCT03536026
- Testing
- Conventional bronchoscopy, VIDA Pulmonary Workstation 2, Biopsy
- Sponsor
- Washington University School of Medicine
Non Small Cell Lung Cancer, Lung Metastases
SBRT Dose Escalation for Reirradiation of Inoperable Lung Lesions
Prospective phase I study to evaluate the maximum tolerated dose (MTD) of SBRT for thoracic re-irradiation. Dose limiting toxicity will be pneumonitis ≥ G3.
- Trial name
- STRILL (NCT04455438)
- Testing
- SBRT dose escalation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Istituto Clinico Humanitas
Cutaneous Manifestations, Skin Manifestations
Cutaneous Manifestations of Coronavirus Disease 2019(COVID-19).
An outbreak of Corona virus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-coV-2) occurred in Wuhan city, Hubei province, China in December 2019.
- Conditions
- Cutaneous Manifestations, Skin Manifestations, COVID-19, COVID-19 Pneumonia
- Trial name
- NCT05094687
- Where
- Pakistan
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Jinnah Postgraduate Medical Centre
Lung Diseases
Safety and Effectiveness Study for a Needle Guidance System in Lung Biopsies
This study is designed to provide clinical data regarding safety and clinical effectiveness of the ActiSight Needle Guidance System in assisting radiologically guided percutaneous needle biopsy or aspiration of pulmonary lesions…
- Trial name
- NCT01183182
- Testing
- ActiSight Needle Guidance System
- Where
- 3 sites in Canada
- Volunteers
- 48 people
- Sponsor
- ActiViews Ltd.
Cancer
Fluorescence Bronchoscopy and Molecular Characterization of Abnormal Bronchial Lesions: Novel Approaches for Early Detection of Lung Cancer in High Risk Patients
Despite intensive research efforts, there are still no simple and effective screening tools to detect early lung cancer. The majority of newly diagnosed patients have higher stage, often disseminated, non-resectable disease.
- Trial name
- NCT00512642
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Non-Small Cell Lung Cancer
Docetaxel + Plinabulin Compared to Docetaxel + Placebo in Patients With Advanced NSCLC
To compare the overall survival of NSCLC patients receiving 2nd- or 3rd-line systemic therapy with docetaxel + plinabulin (DP Arm) to patients treated with docetaxel + placebo (D5W) (D Arm) for advanced or metastatic disease.
- Trial name
- DUBLIN-3 (NCT02504489)
- Testing
- Docetaxel + Plinabulin (DP), Docetaxel (D)
- Where
- 57 sites in United States, Australia and 1 more
- Volunteers
- 559 people
- Sponsor
- BeyondSpring Pharmaceuticals Inc.
Lung Ground-Glass Opacity
GGO-dominant PPLs Diagnosis Using CLE and ssRAB-guided Cryobiopsy
The purpose of the study is to evaluate the diagnostic performance and safety of cryobiopsy for ground-glass opacity (GGO)-dominant peripheral pulmonary lesions (PPLs) under the guidance of shape-sensing robotic-assisted…
- Trial name
- NCT06910046
- Testing
- CLE and ssRAB-guided cryobiopsy
- Where
- China
- Volunteers
- 119 people
- Sponsor
- Shanghai Chest Hospital
CoV2 SARS Pneumonia
Predicting the Progression to Chronic Fibrosis of Lung Lesions Related to Covid-19 Infection From Chest CT Images
The main differences observed between SARSCoV-2 pneumonia and other epidemic viral pneumopathies (e.g., seasonal influenza) are the greater infectivity of SARSCoV-2, the clinical severity of the disease, particularly in young…
- Trial name
- PREDISCAN (NCT04483752)
- Testing
- CHEST CT SCAN
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Chirurgical Marie Lannelongue