Clinical trials: Lung Mechanics
COPD, Chronic Hypercapnic Respiratory Failure
Short Term Physiological Effects of Nasal High Flow Oxygen on Respiratory Mechanics
Nasal High Oxygen Flow (HOF) has been demonstrated to reduce the re-intubation rate in hypoxic patients and ameliorate breathing pattern in hypercapnic patients.
- Trial name
- NCT02363920
- Testing
- HOF, noninvasive mechanical ventilation (NIV)
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Severe Asthma
Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiation
Eosinophilic inflammation in the small airways of patients with severe asthma is considered to be an important marker of disease severity.
- Trial name
- IMPOSE (NCT05147155)
- Testing
- Mepolizumab
- Where
- Greece
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Obesity, Mechanical Ventilation Pressure High
Evaluation of Regional Lung Mechanics in Obese Patients Undergoing Laparoscopic Surgery
This study will evaluate what is the impact of laparoscopy and Trendelenburg position on lung regional ventilation distribution in obese patients, focusing on the differences between the different phases of surgery.
- Conditions
- Obesity, Mechanical Ventilation Pressure High, Intraoperative Respiratory Injury
- Trial name
- OBESE-EIT (NCT05554536)
- Testing
- PEEP titration trial
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Respiratory Distress, Lung Injury
Infant Pulmonary Mechanics: High Flow Nasal Cannula Versus Nasal CPAP
This study is designed to evaluate the effect of heated humidified high flow nasal cannula (HHHFNC) as compared to noninvasive nasal continuous positive airway pressure (NCPAP) on lung function as a measure of lung injury in…
- Trial name
- NCT01939067
- Testing
- Heated Humidified High Flow Nasal Cannula, Nasal Continuous Positive Airway Pressure
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Chronic Obstructive Pulmonary Disease (COPD)
Effects of Different Modes of Respiratory MuscleTraining on Respiratory Mechanics and NRD in Patient With Stable COPD.
Chronic Obstructive Pulmonary Disease (COPD) is a chronic respiratory disease characterized by persistent airflow limitation. The patients are suffering dyspnea year by year, resulting in the decreased exercise tolerance and…
- Trial name
- NCT03500042
- Testing
- inspiratory pressure threshold device
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhujiang Hospital
Drug Use, Dexmedetomidine
Effect of Dexmedetomidine on Oxygenation and Lung Mechanics
Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when…
- Trial name
- NCT06355960
- Testing
- GROUP Dexmedetomidine, GROUP B, GROUP C
- Where
- Egypt
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pseudomonas Aeruginosa Meningitis
Ceftazidime Pharmacokinetic in Cerebrospinal Fluid Between Continuous and Intermittent Administration
Meningitis is an infection where morbidity and mortality depend on the delay of the initial treatment for a good prognostic. The antibiotherapy rapidity allows to decrease the mortality.
- Trial name
- NCT00752882
- Testing
- ceftazidime
- Volunteers
- 24 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lung Infection, Mechanical Ventilation
Ventilator Hyperinflation With Increase of Inspiratory Time
The investigators hypothesis is that the adjustment of the inspiratory time may optimize the distribution of ventilation and increase tidal volume, producing potential therapeutic effects on the displacement of secretions and…
- Trial name
- NCT03630510
- Testing
- Ventilator hyperinflation
- Where
- Brazil
- Volunteers
- 38 people
- Sponsor
- Brazilian Institute of Higher Education of Censa
One-lung Ventilation (OLV), Thoracic Surgery
Comparison of FCV and VCV in One-Lung Ventilation
One-lung ventilation (OLV) is commonly used during thoracic surgery but may negatively affect lung mechanics and gas exchange. Different ventilation strategies are used during OLV, and their effects on respiratory parameters…
- Conditions
- One-lung Ventilation (OLV), Thoracic Surgery, Respiratory Mechanics
- Trial name
- FCVOLVent (NCT07392086)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Respiration, Artificial, Pleural Effusion
Impact of Draining Significant Effusion on Gas Exchange and Lung Mechanics in Patient Under Mechanical Ventilation
Patients with acute respiratory failure (ARF) who were receiving mechanical ventilator support, had significant pleural effusion (both transudates and exudates) and drainage plan were evaluated.
- Conditions
- Respiration, Artificial, Pleural Effusion, Ultrasonography
- Trial name
- NCT03394872
- Testing
- Drainage of the pleural effusion
- Volunteers
- 27 people
- Sponsor
- Dokuz Eylul University
Atelectasis, Mechanical Ventilation
Effects of Periodic Recruitment Maneuvers on Atelectasis and Respiratory Mechanics During Elective Spine Surgery Assessed by Lung Ultrasonography
During general anesthesia, particularly in patients undergoing spine surgery in the prone (face-down) position, increased intrathoracic and abdominal pressure may reduce lung compliance and promote the development of atelectasis…
- Conditions
- Atelectasis, Mechanical Ventilation, General Anesthesia, Prone Position
- Trial name
- NCT07325812
- Testing
- Alveolar Recruitment Maneuver
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Pectus Excavatum
Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum
The aim of the current study was to compare the effects of sevoflurane and desflurane on respiratory mechanics in patients undergoing repair of pectus excavatum.
- Trial name
- NCT01486953
- Testing
- Desflurane, Sevoflurane
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- The Catholic University of Korea
Obesity; Drug
Evaluation of the Effect of Different Doses Dexmedetomidine Infusion on Lung Mechanics and Oxygenation in Obese Patients
The objective of this study is to evaluate the effect of different doses of dexmedetomidine infusion intraoperative on lung mechanics and oxygenation regarding PaO2/Fraction of inspired oxygen), Intraoperative oxygenation, lung…
- Trial name
- NCT04730375
- Testing
- Dexmedetomidine Injection [Precedex]
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- National Cancer Institute, Egypt
SARS Pneumonia
Respiratory Mechanics and Gas Exchange in Patients With COVID-19 and Hypoxemic Acute Respiratory Failure
Data on respiratory mechanics and gas exchange in acute respiratory failure in COVID-19 patients is limited. Knowledge of respiratory mechanics and gas exchange in COVID-19 can lead to different selection of mechanical…
- Trial name
- COVID-VENT (NCT04445961)
- Testing
- Respiratory mechanics measurement, Gas exchange measurement
- Where
- 3 sites in Russia
- Volunteers
- 117 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Coronary Artery Disease, Heart Failure
Study to Determine if Using Ventilation During Open Heart Surgery Improves Lung Outcomes
To demonstrate that using continuous mechanical lung ventilatory support in combination with Positive End Expiratory Pressure (PEEP)during open heart surgery will improve lung function and decrease lung complications after…
- Trial name
- PEEP (NCT01522222)
- Testing
- continuous, mechanical ventilatory support
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aurora BayCare Medical Center
One-lung Ventilation (OLV)
Correlation of Oxygenation and Saturation Indices in One-Lung Ventilation
One-lung ventilation is commonly used during thoracic surgery but is frequently associated with impaired oxygenation and altered respiratory mechanics.
- Trial name
- OLV-INDICES (NCT07381517)
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Diabetes Mellitus, Cardiac Surgical Procedures
Pulmonary Effects of Diabetes Mellitus
Type 2 diabetes mellitus (T2DM) poses a significant burden on the patients and the health care system. The increasing number of surgery performed in elderly population results in an increased number of perioperative T2DM-related…
- Conditions
- Diabetes Mellitus, Cardiac Surgical Procedures, Respiratory Mechanics, Capnography
- Trial name
- NCT03768973
- Testing
- Elective cardiac surgery
- Where
- Hungary
- Volunteers
- 310 people
- Sponsor
- Szeged University
COVID-19
The Prognostic Factors of COVID-19 ARDS Patients and Their Long-term Follow-up of Pulmonary Function Test
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging infectious disease with high transmissibility. Around 20-25% of infected individuals develop severe COVID-19 disease requiring hospitalization and…
- Trial name
- NCT05490914
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Laparoscopic Surgery, Positive End-Expiratory Pressure
Recruitment Maneuvers and PEEP-guided Electrical Impedance Tomography for Abdominal Laparoscopic Surgery Patients
Abdominal laparoscopy is widely utilized due to its benefits, including minimal invasiveness, improved cosmetic outcomes, and shorter hospital stays.
- Conditions
- Laparoscopic Surgery, Positive End-Expiratory Pressure, Electrical Impedance Tomography
- Trial name
- PEEP-EIT (NCT06850844)
- Testing
- electrical impedance tomography, Conventional Ventilation
- Where
- Vietnam
- Volunteers
- 70 people
- Sponsor
- Nguyen Dang Thu
Chronic Obstructive Pulmonary Disease, Pulmonary Hypertension
Iloprost in Gas Exchange/Pulm Mechanics in Chronic Obstructive Pulmonary Disease (COPD)
The investigators believe that iloprost will improve gas exchange in COPD patients with pulmonary hypertension.
- Trial name
- Iloprost (NCT00561223)
- Testing
- iloprost Inhalation, iloprost
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Oklahoma