Clinical trials: Lung Mechanics
Pulmonary Hypertension
Effects of Bosentan on Respiratory Mechanics
Bosentan has been largely used in the treatment of pulmonary hypertension (PH). It can improve exercise capacity, lower Borg dyspnoea score nad these effects are usually associated with the concomitant improvement in…
- Trial name
- NCT00679068
- Testing
- Bosentan
- Where
- Italy
- Volunteers
- 4 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Copd, Muscle Weakness
Mechanical Muscle Proprieties in Patient with COPD
This study aims to determine if patients with Chronic Obstructive Pulmonary Disease (COPD) exhibit altered muscle properties (specifically changes in tone and stiffness) in both their respiratory muscles and skeletal muscles when…
- Conditions
- Copd, Muscle Weakness, Muscle Weakness Condition
- Trial name
- NCT06410950
- Testing
- MyotonPRO Assessment of Muscle Biomechanical Properties
- Where
- Romania
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Spitalul Clinic de Boli Infecțioase și Pneumoftiziologie Dr. Victor Babeș Timișoara
Copd
Measuring Lung Mechanics in Patients with COPD Using the REOM Handheld Portable Device
The purpose the study is to determine the agreement between the information obtained about lung mechanics (lung function) from the Rapid Expiratory Occlusion Monitor (REOM) handheld portable device with that obtained by…
- Trial name
- NCT05913323
- Testing
- Rapid Expiratory Occlusion Monitor (REOM), Standard oscillometry, Standard pulmonary function test
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Congenital Heart Disease, Pulmonary Hypertension
Integrated Computational modelIng of Right Heart Mechanics and Blood Flow Dynamics in Congenital Heart Disease
Advances in paediatric cardiology and cardiac surgery have enabled the survival of most patients born with congenital heart disease (CHD) into adulthood.
- Trial name
- NCT03217240
- Testing
- Cardiac Magnetic Resonance - MRI, Cardiopulmonary Exercise Test, Blood Sampling for all participants
- Where
- 3 sites in Singapore
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Heart Centre Singapore
Respiratory Distress Syndrome, Adult
Effects of Different Assisted Mechanical Ventilation in Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) Patients
The aim of this study is to evaluate the effects in terms of gas exchange, respiratory mechanics and comfort of breathing, of different assisted mechanical ventilation in ALI/ARDS patients.
- Trial name
- NCT00267241
- Testing
- Mechanical Ventilation
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Pulmonary Disease, Respiratory Failure
Ventilator Mode and Respiratory Physiology
Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes…
- Conditions
- Pulmonary Disease, Respiratory Failure, Respiratory Effort, Breathing Mechanics
- Trial name
- NCT06624254
- Testing
- lung mechanics, respiratory drive and effort
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Lung Cancer
Effects of Humidified Ventilation on Arterial Oxygenation and Respiratory Mechanics During One Lung Ventilation
A continuous loss of moisture and heat occurs during mechanical ventilation and prediposes patients to airway damage. Vaporizing humidifier has known to be advantages of improvement of oxygenation and protection of airway damage.
- Trial name
- NCT01636973
- Testing
- Vaporizing humidifier
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Airway Pressure Stress Index, Transpulmonary Pressure Stress Index
Effects of Chest Wall Elastance on Pulmonary Mechanics of Acute Respiratory Failure (ARF)
Patients with chest wall elastance increasing could worsen lung function. Increasing of chest wall elastance plays a great role in lung mechanics, and could influence mechanical ventilation settings.
- Conditions
- Airway Pressure Stress Index, Transpulmonary Pressure Stress Index, Acute Respiratory Failure, Chest Wall Elastance
- Trial name
- NCT02196870
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Southeast University, China
Dyspnea, Quality of Life
STRETCH OF RESPIRATORY MUSCLES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
THE AIM OF THIS STUDY IS TO TEST IF THE STRETCHING OF THE RESPIRATORY ACCESSORY MUSCLE PROVIDE SOME BENEFIT ON THORACOABDOMINAL MECHANICS, FUNCTIONAL CAPACITY, PSYCHOLOGICAL AND SOCIAL ASPECTS IN PATIENTS WITH CHRONIC OBSTRUCTIVE…
- Conditions
- Dyspnea, Quality of Life, Respiratory Symptoms
- Trial name
- NCT02036762
- Testing
- Stretching Exercises
- Where
- 3 sites in Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
ARDS, Human
Effect of Chest Compression on Respiratory Mechanics in ARDS Patients
In some ARDS patients, a mild chest compression (5 kg) improves lung compliance. We aim to determine wether such an improvement is due to a better recruitment or to a reduction of overdistension
- Trial name
- NCT05598476
- Testing
- 5kg bag
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Prematurity, Respiratory Distress Neonatal
Effect of Automated Oxygen Control on Early-childhood Lung Mechanics
Preterm infants are at higher risk of long-term respiratory problems and abnormal lung function in childhood. Respiratory support including mechanical ventilation, that is the use of a machine to move air into and out of the…
- Conditions
- Prematurity, Respiratory Distress Neonatal, Oxygen Delivery
- Trial name
- NCT07866820
- Testing
- Forced oscillometry technique
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College Hospital NHS Trust
Restrictive Lung Disease
Effects of Dexmedetomidine on Oxygenation and Lung Mechanics in Morbidly Obese Patients Undergoing Bariatric Operations
The study aims to investigate the effect of dexmedetomidine on oxygenation and lung mechanics in morbidly obese patients
- Trial name
- NCT02843698
- Testing
- Dexmedetomidine, Normal saline
- Where
- Egypt
- Volunteers
- 42 people
- Sponsor
- Cairo University
Acute Respiratory Distress Syndrome (ARDS)
Validation of Digital Chest-X-ray (CXR) to Assess Lung Recruitment in ARDS
Lung recruitability is essential for optimal Positive end-expiratory pressure (PEEP) selection in ARDS patients. It is defined as the potential for the non aerated or poorly aerated lung mass to become aerated due to the increase…
- Trial name
- RECRUTEX (NCT02081105)
- Testing
- PEEP of 5 or 15 cm H2O
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Collapsed Lung, Hemodynamic Stability
Role of Inhaled Nitric Oxide in Vascular Mechanics and Right Ventricular Function
The aim of this study is to evaluate the role of nitric oxide on pulmonary vasculature and right ventricular function in postoperative cardiac surgery patients.
- Trial name
- NCT06097026
- Testing
- Alveolar recruitment maneuver, Nitric Oxide
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Fernando Suarez Sipmann
ASA Class I/II Patients, General Anesthetic
PCV vs VCV in Low-Flow Anesthesia
The aim of this observational study is to investigate the effects of ventilation modes on intraoperative and postoperative lung functions in patients under general anesthesia.
- Conditions
- ASA Class I/II Patients, General Anesthetic, Low Flow Anesthesia
- Trial name
- NCT07305129
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- HULYA TOPCU, MD
Intraoperative Oxygenation and Pulmonary Mechanics
Effects of Magnesium Sulfate on Oxygenation and Lung Mechanics During One-Lung Ventilation
This prospective observational study aims to evaluate the effects of intravenous magnesium sulfate on intraoperative oxygenation and lung mechanics in patients undergoing thoracic surgery with one-lung ventilation.
- Trial name
- NCT07325773
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Marmara University
Mechanical Ventilation
Acute Effects of Open and Closed Suction Systems in Mechanically Ventilated Patients
Seventy-one patients in intensive care were randomized for initial treatment with open suction systems or closed suction systems in a cross-over design.
- Trial name
- NCT03256214
- Testing
- Closed suction system, Open suction system
- Volunteers
- 71 people
- Sponsor
- University of Sao Paulo
Copd
Impact of Long-acting Bronchodilator- -Corticoid Inhaled Therapy on Ventilation, Lung Function and Breathlessness
Multicentre, prospective, non-randomised, single-arm, open label, mechanistic study to investigate the mechanism of action of BGF 160 on ventilation pattern complexity and variability
- Trial name
- VARI-OSCIL (NCT06110403)
- Testing
- TRIXEO AEROSPHERE
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Lille
Laparoscopic Surgery, Pneumoperitoneum
Role of Individualized PEEP Vs Fixed PEEP in Mechanical Ventilation During Laparoscopic Surgeries
To compare the effects of Individualized positive end-expiratory pressure with recruitment maneuver on respiratory parameters and oxygenation in mechanical ventilation during laparoscopic surgeries with the fixed positive…
- Conditions
- Laparoscopic Surgery, Pneumoperitoneum, Positive End Expiratory Pressure (PEEP)
- Trial name
- NCT06929078
- Testing
- Protective lung ventilation methods with different positive end-expiratory pressure during Laparoscopic Surgeries
- Where
- Pakistan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Noor-Ul-Ain
Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Ventilator Pressure and Optimization of Compliance and Hemodynamics
In preterm infants < 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and…
- Conditions
- Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn
- Trial name
- VPOCH (NCT06512935)
- Testing
- Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham