Clinical trials: Lung Mechanics
COPD
Effect of a New Combination Bronchodilator on Exercise in GOLD Stage II Moderate COPD
Preliminary information from our laboratory indicated that even patients with milder chronic obstructive pulmonary disease (COPD) can have significant physiological derangements which become more pronounced during exercise…
- Trial name
- NCT01491802
- Testing
- LAMA/LABA, LAMA
- Where
- Canada
- Volunteers
- 17 people
- Sponsor
- Queen's University
Hypoxia
The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients
The area of aesthesia-induced atelectasis is much larger in the obese compared with the non-obese, but there may also be more airway closure and impaired matching of ventilation and lung blood flow.
- Trial name
- NCT02961920
- Testing
- IE ratio 1:1, IE ratio 1:2
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Gachon University Gil Medical Center
Pneumoperitoneum
Moderate vs Deep Neuromuscular Block on Biotrauma During Laparoscopy
The purposes of this study is to investigate the effects of moderate vs. deep neuromuscular block on respiratory mechanics and biotrauma in patients with intraoperative protective lung ventilation for laparoscopy.
- Trial name
- NCT03576118
- Testing
- Deep neuromuscular block, Moderate neuromuscular block
- Where
- South Korea
- Volunteers
- 74 people
- Sponsor
- Ajou University School of Medicine
Severe Asthma
Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiation
Eosinophilic inflammation in the small airways of patients with severe asthma is considered to be an important marker of disease severity.
- Trial name
- IMPOSE (NCT05147155)
- Testing
- Mepolizumab
- Where
- Greece
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Respiratory Failure
Electrical Stimulation in Patients With Prolonged Mechanical Ventilation
Muscle atrophy and diaphragm dysfunction are common complication in patients with prolong mechanical ventilator (PMV) and is associated with increased rate of weaning failure and days of hospitalization.
- Trial name
- NCT02227810
- Testing
- electrical stimulation (high frequency), electrical stimulation (low frequency)
- Where
- Taiwan
- Volunteers
- 53 people
- Sponsor
- Chang Gung Memorial Hospital
Endotracheal Extubation, Airway Obstruction
Efficacy Study of a Novel Device to Clean the Endotracheal Tube
The purpose of this study is to evaluate the in-vivo efficacy of a novel device (endOclear) for cleaning the endotracheal tube (ETT) lumen from secretions.
- Conditions
- Endotracheal Extubation, Airway Obstruction, Airway Control, Pneumonia, Ventilator-Associated
- Trial name
- NCT01765530
- Testing
- ETT cleaning maneuver
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- Massachusetts General Hospital