Clinical trials: Lung Nodule
Lung Cancer, Lung; Nodule
Prospective Evaluation of the Tool-in-lesion Technology of the Galaxy System in Routine Clinical Practice
A prospective observational study evaluating the accuracy of the tool-in-lesion technology of the Galaxy SystemTM in normal clinical practice.
- Trial name
- Match 2 (NCT06685133)
- Testing
- Robotic assisted bronchoscopy
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Noah Medical
Lung Diseases, Lung Cancer, Protection Against
Phase II Trial to Modulate Intermediate Endpoint Biomarkers in Former and Current Smokers
The purpose of this study is to find out if an investigational combination drug called Lovaza (made with fish oils)+Curcumin C3 Complex (made from a root called curcumin) can help reduce the size of lung nodules.
- Trial name
- NCT03598309
- Testing
- Curcumin C3 complex®, Lovaza®
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Lung Cancer (NSCLC)
Postoperative EGFR-TKI Therapy forContralateral Pulmonary Nodules in Patients With EGFR-Mutant NSCLC（ARMOR2501）
Background Synchronous multifocal primary lung cancer (sMPLC) presents a therapeutic challenge, particularly for bilateral lesions.
- Trial name
- ARMOR2501 (NCT06924398)
- Testing
- Postoperative EGFR-TKI Therapy
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Sun Yat-sen University
Lung Cancer, Solitary Pulmonary Nodule
4-[18F]Fluoroglutamine PET/CT in Imaging Patients With Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules
This clinical trial studies positron emission tomography (PET) imaging utilizing 18F-(2S,4R)4-fluoroglutamine, a glutamic acid derivative, to image patients with Newly Diagnosed Lung Cancer or Indeterminate Pulmonary Nodules.
- Conditions
- Lung Cancer, Solitary Pulmonary Nodule, Cigarette Smoking Behavior
- Trial name
- GLN (NCT03568799)
- Testing
- 18F-(2S,4R)4-fluoroglutamine
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Pulmonary Disease
DECAMP 1 PLUS: Prediction of Lung Cancer Using Noninvasive Biomarkers
DECAMP 1 PLUS aims to improve the efficiency of the diagnostic evaluation of patients with indeterminate pulmonary nodules (8-25 mm).
- Trial name
- NCT04165564
- Testing
- Institutional standard of care, Biosamples of airway and blood
- Where
- 19 sites in United States
- Volunteers
- 85 people
- Sponsor
- Boston University
Pulmonary Nodule, Lung Cancer
Transbronchial Biopsy Assisted by Robot Guidance in the Evaluation of Tumors of the Lung
This study is designed to evaluate clinical safety and diagnostic accuracy of the robotic-assisted bronchoscopy with biopsy performed with the Monarch™ Endoscopy Platform in a broad range of patients with pulmonary lesions.
- Trial name
- TARGET (NCT04182815)
- Testing
- Robotic assisted bronchoscopy
- Where
- 19 sites in United States, Canada and 1 more
- Volunteers
- 691 people
- Sponsor
- Auris Health, Inc.
Incident Lung Nodule
Lung Nodule Intervention Cohort Study
Incident lung nodule is quite common in China. The major treatment method is long-term floolow up without a specific intervention. We aim to investigate the efficacy an safty of a novel transdermal therapy with Chinese herb.
- Trial name
- LNICS (NCT05441202)
- Testing
- transdermal therapy
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Chinese Chronic Respiratory Disease Research Network
Lung Nodule
Tri-modality Sampling Using Radial Probe Endobronchial Ultrasound for the Diagnosis of Peripheral Pulmonary Lesions
As the former radial probe endobronchial ultrasound (RP-EBUS) guided transbronchial forceps biopsy of peripheral pulmonary nodules has some limitations, the purpose of this study is to investigate a novel biopsy technique that…
- Trial name
- NCT06123312
- Testing
- Tri-modality biopsy
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- Pusan National University Hospital
Ground-Glass Opacity
Cryoablation vs Thoracoscopic Surgery for GGN
The aim of this study is to investigate the efficacy and safety of Cryoablation and Thoracoscopic Surgery in the treatment of pulmonary ground-glass nodules.
- Trial name
- NCT06848881
- Testing
- Cryoablation, Thoracoscopic Surgery
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Shanghai Chest Hospital
Lung Neoplasms, Lung Cancer
Lung Nodule Prospective Database
Lung cancer is one of the most common cancers in the Singapore population, being the 2nd most commonly diagnosed cancer amongst males and 3rd most commonly diagnosed cancer amongst females.
- Conditions
- Lung Neoplasms, Lung Cancer, Lung Adenocarcinoma
- Trial name
- NCT03922828
- Testing
- CT scans
- Where
- Singapore
- Volunteers
- 20 people
- Sponsor
- Singapore General Hospital
Lung Cancer Diagnosis
Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening
The PROACT LUNG study is a prospective multi-center observational study to validate a blood-based test for the early detection of lung cancer by collecting blood samples from high-risk participants who will undergo a routine…
- Trial name
- PROACT-LUNG (NCT06122077)
- Testing
- blood draw
- Where
- 36 sites in United States
- Volunteers
- 20,000 people
- Sponsor
- Freenome Holdings Inc.
Peripheral Pulmonary Nodules
RAB Versus Ultrathin Bronchoscopy With VBN in the Diagnosis of PPNs
The purpose of this study is to evaluate whether the diagnostic yield of robotic-assisted bronchoscopy is not inferior to that of the virtual bronchoscopic navigation combined with ultrathin bronchoscopy.
- Trial name
- NCT06962436
- Testing
- Robotic bronchoscopy system, Ultrathin bronchoscope combined with virtual bronchoscopic navigation
- Where
- 5 sites in China
- Volunteers
- 186 people
- Sponsor
- Shanghai Chest Hospital
Pulmonary Nodule, Solitary
The Benefit of UHR-CT: Precision of Repeated Volume Measurements of Pulmonary Nodules
To assess the variability of semi-automated volume measurements of pulmonary nodules on same-day repeated scans of equal radiation dose from two different CT scanners: One high-end CT scanner with standard spatial resolution…
- Trial name
- Coffee Break (NCT04209972)
- Testing
- Precision Ultra-High-Resolution CT scanner, Genesis high-end CT scanner
- Where
- Netherlands
- Volunteers
- 92 people
- Sponsor
- Radboud University Medical Center
Lung Cancer
Study Using Combined Virtual 4-D Electromagnetic (EM) Tip-Tracked Devices & EBUS in Diagnosis of Lung Nodules
The purpose of this study is to determine the safety and biopsy yield of EM Tip Tracked devices compared to standard bronchoscopy.
- Trial name
- NCT01947530
- Testing
- Navigational Bronchoscopy, Standard Bronchoscopy
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University Health Network, Toronto
Pulmonary Nodule, Solitary, Pulmonary Nodule, Multiple
Intravenous Indocyanine Green for Localization of Intra-thoracic Lesions
This is a clinical trial to evaluate the intravenous administration of indocyanine green (ICG) as a method of intra-thoracic lesion localization.
- Trial name
- NCT03097627
- Testing
- ICG Intervention, Near Infrared Camera
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Nodule, Solitary
A Clinical Study of Optimized CT-guided Pulmonary Nodule Microcoil Localization Technique
In the early stage of the study, the CT-guided micro-coil locating method for pulmonary small nodules was optimized. This study will use a single set of target values non-randomized controlled trials to evaluate the safety and…
- Trial name
- NCT03649906
- Testing
- Optimized Localization Technique
- Where
- China
- Volunteers
- 125 people
- Sponsor
- Beijing Aerospace General Hospital
Tuberculosis
Prevalence of Latent Tuberculosis (TB) Infection Diagnosed by Interferon-gamma Release Assay and Tuberculin Skin Tests in Patients With Old Healed TB
We easily regard nodules and fibrosis in upper lobes of lung as TB sequelae. The aim of this study is to confirm the prevalence of latent TB infection diagnosed by interferon-gamma release assay and tuberculin skin tests in…
- Trial name
- NCT01099098
- Where
- South Korea
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Pulmonary Function Assessment, Disease Free Survival
Pulmonary Watershed Topographic Map Navigation for Lung Nodule Resection
A method of ICG counterstaining localization under target artery occlusion without cutting，It's a new method of localization of small pulmonary nodules.
- Conditions
- Pulmonary Function Assessment, Disease Free Survival, NSCLC, Stage I
- Trial name
- NCT06404164
- Testing
- Wedge resection under watershed analysis method
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Guangdong Provincial People's Hospital
Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary
Differentiation of Benign and Malignant Pulmonary Nodules by Volatile Organic Compounds in Human Exhaled Breath
The goal of this observational study is to develop an advanced expiratory algorithm model utilizing exhaled breath volatile organic compound (VOC) markers.
- Conditions
- Pulmonary Nodules, Multiple, Pulmonary Nodules, Solitary, Lung Cancer
- Trial name
- NCT06518655
- Testing
- Gas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
- Where
- 15 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- ChromX Health
Pulmonary Nodules
A Prospective Cohort Study of Chinese Patients With Pulmonary Nodules: Prediction of Lung Cancer Using Noninvasive Biomarkers
The broad goals of this study is to identify changes in genomic landscape during transition from stage 0 to stage 1 lung cancer.
- Trial name
- NCT04462185
- Testing
- A genomic and transcriptomic landscape analysis
- Where
- 6 sites in China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- AnchorDx Medical Co., Ltd.