Clinical trials: Lung Pathogenesis
Childhood Pneumonia, Mycoplasma Pneumonia
Evaluation of Pathogenesis and Diagnosis of Mycoplasma Pneumoniae Community-acquired Pneumonia (CAP)
To investigate the Mycoplasma pneumoniae-specific circulating antibody-secreting cell (ASC) response and Mycoplasma pneumoniae-specific interferon (INF)-γ-secreting T cell response, along with polymerase chain reaction (PCR) and…
- Conditions
- Childhood Pneumonia, Mycoplasma Pneumonia, Antibody-secreting Cells, Enzyme-linked Immunospot (ELISpot)
- Trial name
- myCAP (NCT03613636)
- Testing
- Enzyme-linked immunospot (ELISpot) assay [Blood]
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- University Children's Hospital, Zurich
Allergic Bronchopulmonary Aspergillosis (ABPA)
Pathogenesis and Inflammatory Phenotype of Allergic Bronchopulmonary Aspergillosis
This study aims to reveal the immune and inflammatory regulatory molecular mechanisms related to the progression of allergic bronchopulmonary aspergillosis (ABPA), and to build a precision typing based on inflammation and…
- Trial name
- NCT07040332
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Qianfoshan Hospital
COVID-19
Predictive Immune Biomarkers of COVID-19 Pathogenesis to Influence Therapeutic Management
Persons infected with Severe Acute Respiratory Syndrome (SARS) SARS-CoV-2 vary in severity from being asymptomatic to having fever, cough, sore throat, general weakness and fatigue and muscular pain and in the most severe cases…
- Trial name
- IMMUNOMARKCOV (NCT04668170)
- Testing
- Blood collection on admission and longitudinally, Blood collection on their first consultation and 10 to 14 days later
- Where
- 2 sites in France
- Volunteers
- 304 people
- Sponsor
- University Hospital, Toulouse
COVID-19
Pathogenesis of BTK-mediated Hyper-Inflammatory Responses in COVID-19 (RESPOND)
Background: Coronavirus disease 2019 (COVID-19) is an acute respiratory syndrome. It is caused by the SARS-CoV-2 virus. People with severe COVID-19 infection have a hyper-inflammatory response.
- Trial name
- NCT04394884
- Where
- 3 sites in United States
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Interstitial Lung Diseases
Study of the Etiology and Immunological Pathogenesis in Acute Exacerbation of Idiopathic Pulmonary Fibrosis (AE-IPF)
Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and lethal pathological process with limited therapeutic options, which is the most common and severe of the idiopathic interstitial pneumonias (IIPs).
- Trial name
- NCT02509364
- Testing
- No intervention
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Asthma, Inflammation
Pathogenesis and Genetics of Environmental Asthma Ozone Study
The goals of the research are designed to accomplish genetic association studies of candidate genes in healthy normal individuals exposed to 0.2 ppm for 2.25 hours with intermittent exercise in order to search for associations…
- Trial name
- NCT00574158
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
To Compare the Serum Apoptosis-associated Markers Between Patients With Active TB and Patients With LTBI, To Evaluate the Efficiency of Apoptosis-associated Markers to Differentiate Potential of Active TB From LTBI
The Role of Apoptosis Associated Markers in Pathogenesis of Pulmonary Tuberculosis
To compare the serum apoptosis-associated markers between patients with active TB and patients with LTBI To evaluate the efficiency of apoptosis-associated markers to differentiate potential of active TB from LTBI
- Trial name
- NCT01676155
- Where
- Taiwan
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Pulmonary Hypertension, Pulmonary Arterial Hypertension
MIF- Thyroxine Interactions in the Pathogenesis of Pulmonary Arterial Hypertension
The investigators will investigate the interrelationship of macrophage migration inhibitory factor (MIF) and free T4 in patients with PAH.
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Interstitial Lung Disease
- Trial name
- NCT02858791
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Asthma
Lysophosphatidylglycerol in Asthma Pathogenesis
The study aims to investigate the relationship between the small molecule metabolite lysophosphatidylglycerol and asthma clinical features and explore its involvement in asthma pathogenesis.
- Trial name
- NCT06327516
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Pseudomonas Infection, Cystic Fibrosis
Role of Toxins in Lung Infections Caused by Pseudomonas Aeruginosa
Some bacteria that cause disease can produce toxic substances that may worsen the disease. Pseudomonas aeruginosa is a bacteria that can produce a variety of toxins and is of special interest for patients with cystic fibrosis and…
- Trial name
- NCT00027183
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Rheumatoid Arthritis, Interstitial Lung Disease
Deciphering Rheumatoid Arthritis-associated Interstitial Lung Disease Pathogenesis 2
The overall goal of this study is to identify risk and prognosis factors of Interstitial Lung Disease (ILD) in patients with rheumatoid arthritis (RA).
- Trial name
- TRANSLATE2 (NCT04227535)
- Where
- France
- Volunteers
- 509 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Primary Lung Cancer, Microbial Colonization
Exploratory Study of the Microbiome of Upper Gastrointestinal in the Pathogenesis of Multiple Primary Lung Cancer
This is an exploratory, single-center, being conducted at Beijing Haidian Hospital in order to detect the relationship between microbiome of upper gastrointestinal and pathogenesis of multiple primary lung cancer.
- Trial name
- NCT06973499
- Testing
- Microbiome Profiling and Symptom Assessment
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beijing Haidian Hospital
Covid19
Medical-biological Research of the Pathogenesis of COVID-19 Disease Caused by SARS-CoV-2
Сonducting in-depth medical and biological studies of the pathogenesis of the disease caused by the SARS-CoV-2 in Moscow, the Moscow region and some other regions of the Russian Federation.
- Trial name
- COV2020 (NCT04611841)
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Federal Research and Clinical Center of Physical-Chemical Medicine
Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Neutrophils
Mechanism of Delayed Neutrophil Apoptosis in Acute Lung Injury
Literature basis Acute respiratory distress syndrome (ARDS) is a clinical syndrome characterized by respiratory distress and progressive hypoxemia, which is caused by diffuse alveolar and pulmonary interstitial edema caused by…
- Conditions
- Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS), Neutrophils, Apoptosis, Immunosuppression
- Trial name
- NCT04607434
- Testing
- Ocotillol Type Ginsenoside Derivatives
- Where
- China
- Volunteers
- 40 people
- Sponsor
- The First Hospital of Jilin University
Smokers, Human Bronchial Epithelial Cells
Smoker Extracellular Vesicles Influence on Human Bronchial Epithelial Cells
Cigarette smoking is a habit that has spread all over the world and is a significant risk factor for many diseases including cardiovascular disease, chronic obstructive pulmonary disease(COPD),asthma and lung cancer.
- Conditions
- Smokers, Human Bronchial Epithelial Cells, Lung Pathogenesis, Biomarkers
- Trial name
- Aerotox-1 (NCT03608293)
- Testing
- Broncho Alveolar Lavages (BAL)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Lung Diseases, Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis--Pathogenesis and Staging - SCOR in Occupational and Immunological Lung Diseases
To conduct cross-sectional and longitudinal studies of patients with idiopathic pulmonary fibrosis (IPF) and patients with progressive systemic sclerosis (PSS), with and without associated lung disease.
- Conditions
- Lung Diseases, Pulmonary Fibrosis, Lung Diseases, Interstitial, Scleroderma, Systemic
- Trial name
- NCT00005317
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Coronavirus Disease 2019
COVID-19 Associated Lymphopenia Pathogenesis Study in Blood
Background: COVID-19 is an acute respiratory syndrome. One symptom of COVID-19 is a reduction in the number of cells called lymphocytes in the blood. Lymphocytes are a type of white blood cell that fights infections.
- Trial name
- NCT04401436
- Where
- 3 sites in United States
- Volunteers
- 240 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma
Sphingolipids in Asthma Pathogenesis
The study aims to investigate the relationship between the small molecule metabolite sphingolipids and asthma clinical features and explore its involvement in asthma pathogenesis.
- Trial name
- NCT06539221
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
COVID-19
Predictive Immune Biomarkers for COVID-19 Pathogenesis
The spectrum of the COVID-19 disease ranges from benign to asymptomatic to viral pneumopathy that can progress to acute respiratory distress syndrome (ARDS).
- Trial name
- COVIDBioToul (NCT04385108)
- Testing
- Blood collection on admission and longitudinally, Blood collection on their first consultation and 10 to 14 days later
- Where
- France
- Volunteers
- 565 people
- Sponsor
- University Hospital, Toulouse
HIV Infections, Pneumocystis Pneumonia
Pneumocystis in Pathogenesis of HIV-associated Emphysema
A. Statement of Hypotheses: HIV-infected patients have an increased incidence of emphysema compared to non-HIV-infected smokers, and it has been hypothesized that this accelerated disease progression is the result of one or more…
- Conditions
- HIV Infections, Pneumocystis Pneumonia, Emphysema, Chronic Obstructive Pulmonary Disease
- Trial name
- PACT (NCT00869544)
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Pittsburgh