Clinical trials: Lung Pathogenesis
COVID-19 Disease
VEGF and sFlt-1 Levels in the Pathogenesis and Severity of COVID-19 Disease
To assess blood levels of vasoactive mediators that may regulate pulmonary endothelial permeability and contribute to multi-organ injury in patients with COVID-19 disease and to correlate the levels of these mediators with…
- Trial name
- NCT04587323
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Alabama at Birmingham
Asthma, Vitamin D Resistant Rickets
Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent Patients
Research Title: Evaluation of airway reactivity, allergy and inflammatory mediators in exhaled breath condensate in vitamin D resistant rickets.
- Trial name
- NCT01578824
- Testing
- Methacholine Challenge Test
- Where
- Israel
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Chronic Obstructive Pulmonary Disease, HIV
Longitudinal Evaluation of HIV-associated Lung Disease Phenotypes
The overall hypotheses of this proposal are that discrete phenotypes of HIV Chronic Obstructive Pulmonary disease (COPD) differ in their trajectories, biomarkers, and risk factors and that persistent viral infection including…
- Conditions
- Chronic Obstructive Pulmonary Disease, HIV, Emphysema
- Trial name
- LEAP (NCT02238327)
- Testing
- blood draw, questionnaires, Lung function testing
- Where
- United States
- Volunteers
- 232 people
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease
Study on the Etiology, Risk Factors and Pathogenesis of COPD Based on Clinical Bioinformatics
The risk factors and causes of chronic obstructive pulmonary disease（COPD）are not clear, so the prevalence of COPD is high and the prevention effect is not good.
- Trial name
- NCT05069194
- Where
- China
- Volunteers
- 13,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Lung Cancer, Microbiome
Study of the Correlation of Tumor Tissue Microbiome to the Pathogenesis of Lung Cancer
Lung cancer is the malignant tumor with the highest incidence, accounting for the first cause of tumor death. At present, smoking, occupational and environmental exposure, air pollution and genetic factors are considered to be…
- Trial name
- STARS (NCT04260295)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Huashan Hospital
Acute Lung Injury, Metabolic Disturbances
Acute Lung Injury After Cardiac Surgery: Pathogenesis
The purpose of the present study is to visualize the inflammatory response and coagulation disorders during cardiac surgery in order to identify possible predictors for acute lung injury postoperatively.
- Conditions
- Acute Lung Injury, Metabolic Disturbances, Inflammation, Coagulation; Intravascular
- Trial name
- ALI (NCT02475694)
- Testing
- No intervention
- Volunteers
- 50 people
- Sponsor
- Aalborg University Hospital
COVID-19
Cardiac Injury in COVID-19: a Pathology Study
The primary goal of the study is to conduct the first systematic cardiac autopsy study in 60 patients dying from COVID-19 to understand the pathology and pathogenesis of cardiac injury in patients with COVID-19, with/without…
- Trial name
- NCT04367792
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- A.O. Ospedale Papa Giovanni XXIII
Bronchopulmonary Dysplasia
Gastrointestinal Microbiome Influence on the Development of Bronchopulmonary Dysplasia
The purpose of this study is to advance our knowledge of the factors that contribute to the development of bronchopulmonary dysplasia (BPD), a chronic lung affecting premature infants.
- Trial name
- MiBPD (NCT03229967)
- Testing
- 16S rRNA stool microbiome sequencing.
- Where
- 2 sites in United States
- Volunteers
- 197 people
- Sponsor
- University of Tennessee
Cystic Fibrosis, Pulmonary Fibrosis
Role of Genetic Factors in the Development of Lung Disease
This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease.
- Conditions
- Cystic Fibrosis, Pulmonary Fibrosis, Tuberous Sclerosis, Asthma
- Trial name
- NCT00001532
- Where
- 2 sites in United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Emphysema, Pulmonary Disease, Chronic Obstructive
Biomarkers and Genetic Factors Related to Emphysema
Emphysema, a common type of chronic obstructive pulmonary disease (COPD), is a long-term lung disease that is usually caused by cigarette smoking.
- Trial name
- NCT00757120
- Where
- United States
- Volunteers
- 145 people
- Sponsor
- Washington University School of Medicine
IDIOPATHIC PULMONARY FIBROSIS
The Role of Gastric Content Microaspirations in the Pathogenesis of Idiopathic Pulmonary Fibrosis
The pathogenesis of idiopathic pulmonary fibrosis (IPF) is debatable. Looking for an insult to lung parenchyma that generates the pathogenesis of the disease is challenging.
- Trial name
- NCT01714934
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center