Clinical trials: Lung Protective Ventilation
Adherence, Treatment
Standard Operating Procedure As a Valuable Tool to Increase Adherence to Lung Protective Ventilation Among Anesthesiologists.
Lung Protective Ventilation (LPV) is considered the gold standard of care nowadays. Even though, all over the world reported adherence to this concept, among anesthesiologists, is only 15%.
- Trial name
- NCT05831683
- Testing
- Introduction of Standard Operating Procedure regarding lung protective ventilation during general anaesthesia.
- Where
- Czechia
- Volunteers
- 164 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Hypoxemia, Ventilator Lung
Driving Pressure-guided Lung Protective Ventilation
The study, named as "The Efficacy of Driving Pressure-guided Lung Protective Ventilation in Surgical Repair of Acute Type A Aortic Dissection: an open-label, randomized control clinical trial", aims to investigate whether driving…
- Trial name
- DPV (NCT06361420)
- Testing
- Driving pressure-guided positive end expiratory pressure, Optimal oxygenation-guided positive end expiratory pressure, Ventilation strategy
- Where
- China
- Volunteers
- 43 people
- Sponsor
- Yong Lin, PhD
Postoperative Complications, Abdominal Surgery
Intraoperative Lung Protective Ventilation Needs Periodic Lung Recruitment Maneuvers
Postoperative Pulmonary Complications (PPC) are common. It severely affects postoperative recovery, particularly in abdominal surgery.
- Conditions
- Postoperative Complications, Abdominal Surgery, Intraoperative Mechanical Ventilation
- Trial name
- REMAIN-1 (NCT05556174)
- Testing
- periodic lung recruitment maneuvers
- Where
- China
- Volunteers
- 1,060 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Chronic Thromboembolic Pulmonary Hypertension, Acute Lung Injury
Lung Protective Ventilation in Pulmonary Thromboendarterectomy (PTE) Patients
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by unresolved thromboemboli in the pulmonary arteries, which lead to pulmonary hypertension and, left untreated, right heart failure.
- Trial name
- NCT00747045
- Testing
- Ventilation Strategy
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- University of California, San Diego
Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury
Ultra Protective Ventilation During Venoarterial Extracorporeal Membrane Oxygenation (UPV-ECMO)
Mechanical ventilation, in spite of being a life-saving technique, can also induce lung injury (VILI) mediated by an inflammatory response, thus having a profound impact in the course of critically ill patients.
- Conditions
- Cardiogenic Pulmonary Edema, Ventilator-Induced Lung Injury, Extracorporeal Circulation; Complications
- Trial name
- UPV-ECMO (NCT03041428)
- Testing
- Ultraprotective ventilation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundación para la Investigación Biosanitaria del Principado de Asturias
Atelectasis, Perioperative Oxygenation
Individualized vs Standard PEEP and Oxygen Reserve Index in Laparoscopic Hernia Surgery
During laparoscopic surgery under general anesthesia, lung function can be affected by increased abdominal pressure and patient positioning.
- Conditions
- Atelectasis, Perioperative Oxygenation, Laparoscopic Inguinal Hernia Repair, Mechanical Ventilation
- Trial name
- NCT07775573
- Testing
- Standard PEEP Ventilation, Individualized PEEP Ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Acute Respiratory Failure
Neurally Adjusted Ventilatory Assist (NAVA) Study in Adults With Acute Respiratory Failure
The purpose of this study is to compare a specific mode of artificial ventilation (help from a breathing machine) with other modes.
- Trial name
- NCT01730794
- Testing
- NAVA ventilation, Conventional Lung Protective Ventilation
- Where
- 14 sites in China, Spain
- Volunteers
- 306 people
- Sponsor
- Massachusetts General Hospital
Covid19, SARS-CoV Infection
Host Response Mediators in Coronavirus (COVID-19) Infection - Is There a Protective Effect of Losartan and Other ARBs on Outcomes of Coronavirus Infection?
SARS-CoV-2 is a member of a class of viruses: angiotensin converting enzyme 2 (ACE2)-binding viruses that study calls "ABVs". The World Health Organization (WHO) and others are performing randomized controlled trials (RCTs) of…
- Trial name
- ARBs CORONA II (NCT04606563)
- Testing
- Losartan, Valsartan, Azilsartan
- Where
- 13 sites in Canada, France
- Volunteers
- 341 people
- Sponsor
- University of British Columbia
Lung-protective Ventilation, Respiratory Function Monitor
Optimization of Ventilation Strategies in Preterm and Term Infants in a Single-center Intervention Study
This study was a non-blinded, non-randomized intervention study in a single-center clinical setting, analyzing ventilation quality with and without RFM visibility.
- Trial name
- NCT05512689
- Testing
- Ventilations while using a respiratory function monitor
- Where
- Austria
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
ARDS (Acute Respiratory Distress Syndrome)
Lung EIT Image Guide Ventilation in ARDS
The goal of this multi-center randomized controlled clinical trial is to learn if an individualized, bedside electrical impedance tomography (EIT)-guided ventilation strategy (including EIT-guided prone positioning and PEEP…
- Trial name
- NCT07309783
- Testing
- Recruitment maneuver and PEEP setting guided by EIT, PEEP setting according to routine practice, Prone positioning guided by EIT
- Where
- China
- Volunteers
- 574 people
- Sponsor
- Peking Union Medical College Hospital
Pulmonary Complication
Lung Protective Ventilation During Pulmonary Lobectomy in Children
The investigator will evaluate the influence of lung protective ventilation on postoperative clinical outcome in pediatric patients.
- Trial name
- NCT02680925
- Testing
- lung protective ventilation, Conventional ventilation
- Where
- South Korea
- Volunteers
- 114 people
- Sponsor
- Seoul National University Hospital
Mechanical Ventilation
Protective Ventilatory Strategy in Potential Organ Donors
The aim of the study is to verify if a "PROTECTIVE" ventilatory strategy (low tidal volume and high PEEP, application of CPAP during the apnea test and recruitment maneuvers), improves lung function and increases the number of…
- Trial name
- NCT00260676
- Testing
- change ventilation
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Turin, Italy
Moderated-high Risk of Postoperative Pulmonary Complication, Abdominal Surgery Expected More Than Two Hours
Individualized Perioperative Open Lung Ventilatory Strategy
The purpose of this study is to determine whether individualized ventilatory management combining the use of low tidal volumes, alveolar recruitment maneuvers, individually titrated positive end-expiratory pressure and…
- Trial name
- iPROVE (NCT02158923)
- Testing
- Alveolar recruitment maneuver, Calculation of optimal PEEP, Postoperative CPAP
- Where
- 7 sites in United States, Argentina and 2 more
- Volunteers
- 920 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
ARDS
Effectiveness of Recruitment Maneuvers and Lung Protective Ventilation Strategy in ARDS
The study was designed to comparison the effectiveness of recruitment maneuvers(RM) and lung protective ventilation strategy(LPVS) for patients with moderate to severe ARDS.
- Trial name
- ARDS (NCT05023226)
- Testing
- RM, LPVS
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Asia University
Acute Respiratory Distress Syndrome
Ultra Protective Ventilation Without Extracorporeal Circulation in Severe ARDS Patients (VT4ARDS)
Despite the use of protective ventilation, neuromuscular blocking agent and prone position, ARDS mortality remains high (30%-50%) in observational studies, and pneumothorax rate in randomized controlled trial remains stable…
- Trial name
- VT4ARDS (NCT02816372)
- Testing
- Tidal volume reduction to 4 ml/kg Predicted Body Weight (PBW)
- Where
- France
- Volunteers
- 37 people
- Sponsor
- Hospices Civils de Lyon
ARDS, Acute Respiratory Distress Syndrome
A Comparison of Optimal PEEP Determination Guided by EIT and Conventional Protective Ventilation Tool in ARDS Patients
The study of positive end-expiratory pressure(PEEP) in the setting mode has not yet been conclusive. there are several ways to choose the best positive end-expiratory pressure(PEEP) mode for ARDS patients.
- Trial name
- NCT03498807
- Testing
- Ventiltor P/V Loop, Electrical Impedance Tomography
- Where
- Taiwan
- Volunteers
- 87 people
- Sponsor
- Hui-Ju Hsu
ARDS, Critical Illness
Implementation of Nudges to Promote Utilization of Low Tidal Volume Ventilation (INPUT) Study
This study is a large pragmatic stepped-wedge trial of electronic health record (EHR)-based implementation strategies informed by behavioral economic principles to increase lung-protective ventilation (LPV) utilization among all…
- Conditions
- ARDS, Critical Illness, Acute Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- INPUT (NCT04663802)
- Testing
- Default order set, Physician-targeted accountable justification, Respiratory therapist (RT)-targeted accountable justification
- Where
- 5 sites in United States
- Volunteers
- 7,342 people
- Sponsor
- University of Pennsylvania
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Acute Brain Injury, Traumatic Brain Injury
Implementation of Neuro Lung Protective Ventilation
Patients who experience lung injury are often placed on a ventilator to help them heal; however, if the ventilator volume settings are too high, it can cause additional lung injury.
- Conditions
- Acute Brain Injury, Traumatic Brain Injury, Intracerebral Hemorrhage, Stroke
- Trial name
- NEUROVENT (NCT03243539)
- Testing
- Lung Protective Ventilation
- Where
- United States
- Volunteers
- 728 people
- Sponsor
- Colin Grissom
Postoperative Pulmonary Complications (PPCs), One-lung Ventilation (OLV)
Individualized Open Lung Ventilation and Postoperative Pulmonary Complications in Thoracic Surgery
This prospective, single-center, randomized controlled trial aims to evaluate the efficacy of an intraoperative "Individualized Open Lung Ventilation" strategy compared to a standard lung-protective ventilation strategy in…
- Conditions
- Postoperative Pulmonary Complications (PPCs), One-lung Ventilation (OLV), Thoracic Surgery, Video Assisted
- Trial name
- NCT07387822
- Testing
- Standard Lung-Protective Ventilation, Individualized Open Lung Ventilation
- Where
- China
- Volunteers
- 352 people
- Sponsor
- Aerospace Center Hospital