Clinical trials: Lung Surgery
Lung Cancer (NSCLC), Neoadjuvant Immunotherapy
Safety, Efficacy, and Survival Outcomes of Neoadjuvant/Induction Immunotherapy in Surgical and Radiotherapeutic Management of Non-Small Cell Lung Cancer
This multicenter retrospective real-world study aims to evaluate the safety, efficacy and survival outcomes of neoadjuvant/induction immunotherapy in patients with non-small cell lung cancer (NSCLC).
- Conditions
- Lung Cancer (NSCLC), Neoadjuvant Immunotherapy, Radiotherapy, Lung Surgery
- Trial name
- NCT06926179
- Testing
- neoadjuvant immunotherapy
- Where
- 4 sites in China
- Volunteers
- 500 people
- Sponsor
- Peking University Cancer Hospital & Institute
Lung Cancer
Carboplatin and Paclitaxel Albumin-Stabilized Nanoparticle Formulation Followed by Radiation Therapy and Erlotinib in Treating Patients With Stage III Non-Small Cell Lung Cancer That Cannot Be Removed By Surgery
RATIONALE: Drugs used in chemotherapy, such as carboplatin and paclitaxel albumin-stabilized nanoparticle formulation, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from…
- Trial name
- NCT00553462
- Testing
- carboplatin, erlotinib hydrochloride, paclitaxel albumin-stabilized nanoparticle formulation
- Where
- 99 sites in United States
- Volunteers
- 78 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Thoracic, Surgery
The Effectiveness of Transcutaneous Electrical Nerve Stimulation After Thoracic Surgery
The purpose of this randomised and controlled study is to investigate the effects of transcutaneous electrical nerve stimulation combined with physiotherapy and rehabilitation program on pulmonary function and functional exercise…
- Conditions
- Thoracic, Surgery, Pain, Pulmonary Function
- Trial name
- NCT04879108
- Testing
- Physiotherapy rehabilitation and Transcutaneous Electrical Nerve Stimulation, Physiotherapy Rehabilitation
- Volunteers
- 60 people
- Sponsor
- Marmara University
Lung Cancer, Tracheal Neoplasm
Airway and/or Pulmonary Vessels Transplantation
First study (BRONC-ART) The purpose of this prospective study is to evaluate the 90-day morbidity and mortality rates of bronchial transplantation using cryopreserved aortic allograft in proximal lung cancer surgery.
- Conditions
- Lung Cancer, Tracheal Neoplasm, Tracheal Stenosis
- Trial name
- TRACHBRONCAR (NCT01331863)
- Testing
- Airway and/or pulmonary Vessels Transplantation
- Where
- France
- Volunteers
- 16 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Congenital Heart Disease, Pulmonary Arterial Hypertension
Drug Therapy and Surgery in Congenital Heart Disease With Pulmonary Hypertension
The purpose of this study is to test the hypothesis that treating PAH-CHD patients preoperatively with PAH drugs and keeping them on treatment for six months after surgery reduces the risk of immediate postoperative death and the…
- Trial name
- NCT01548950
- Testing
- Sildenafil singly or in association with Bosentan
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- University of Sao Paulo General Hospital
Anesthesia Induced Atelectasis
Which Ventilatory Strategy is Better for Lung in Upper Abdominal Surgeries?
Ventilated Patients especially those undergoing upper abdominal surgeries are prone to lung atelectasis. They are at risk of adverse effects secondary to inadequate lung ventilation.
- Trial name
- NCT04872361
- Testing
- Low PEEP, High PEEP, High PEEP/RM
- Where
- Egypt
- Volunteers
- 117 people
- Sponsor
- Mansoura University
Acute Lung Injury(ALI)
Dexmedetomidine Dose-Dependent on Lung Function and AQP1 in One-Lung Ventilation Surgery
This randomized controlled trial evaluated the dose-dependent effects of dexmedetomidine (DEX) on pulmonary function and aquaporin-1 (AQP1) expression during one-lung ventilation (OLV) in thoracoscopic surgery.
- Trial name
- NCT07145814
- Testing
- dexmedetomidine 0.3 µg/kg/h, dexmedetomidine 0.5 µg/kg/h, 0.9 % saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- People's Hospital of Guangxi Zhuang Autonomous Region
Lung Cancer (NSCLC)
Real-Time Non-Invasive Localization for Multiple Lung Nodules
This study compares real-time non-invasive localization and manual CT-guided needle localization for multiple lung nodules under 20 mm. It primarily aims to evaluate the successful resection rate of pulmonary nodules.
- Trial name
- NCT07257549
- Testing
- Manual needle localization, Real-time non-invasive localization
- Where
- China
- Volunteers
- 120 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Stage I Non-Small Cell Lung Cancer AJCC v7, Stage IA Non-Small Cell Lung Carcinoma AJCC v7
Stereotactic Body Radiation Therapy Followed by Surgery in Treating Patients With Stage I-IIIA Non-small Cell Lung Cancer
This pilot clinical trial studies the effects of stereotactic body radiation therapy followed by surgery in treating patients with stage I-IIIA non-small cell lung cancer.
- Conditions
- Stage I Non-Small Cell Lung Cancer AJCC v7, Stage IA Non-Small Cell Lung Carcinoma AJCC v7, Stage IB Non-Small Cell Lung Carcinoma AJCC v7, Stage II Non-Small Cell Lung Cancer AJCC v7
- Trial name
- NCT03348748
- Testing
- Laboratory Biomarker Analysis, Quality-of-Life Assessment, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Roswell Park Cancer Institute
Pulmonary Artery Stenosis
Evaluation of Visceral Pleural Lumbar Lymphatic Drainage
Anatomic variations of the pulmonary arterial tree can cause technical difficulties during pulmonary lobectomy in general and video-assisted thoracic surgery (VATS).
- Trial name
- SEGPUL (NCT03628326)
- Testing
- Pulmonary arterial tree
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bariatric Surgery, Obesity, Morbid
Use of Electroanalgesia in Pain and Pulmonary Function.
It is a consensus in the literature that changes in lifestyle and carbohydrate-rich diet are part of a context that has led to an obesity pandemic.
- Trial name
- NCT04800640
- Testing
- Experimental: Electroanalgesia
- Where
- Brazil
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Centro Universitário Augusto Motta
Lung Cancer
Thoracoscopy in Patients With Stage IIIA Non-Small Cell Lung Cancer
RATIONALE: Diagnostic procedures such as thoracoscopy may help to measure a patient's response to previous treatment. PURPOSE: Diagnostic trial to determine the accuracy of thoracoscopy in patients who have stage IIIA non-small…
- Trial name
- NCT00003566
- Testing
- videothoracoscopy
- Where
- 72 sites in United States, Puerto Rico
- Volunteers
- 75 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Malignant Mesothelioma
Pemetrexed, Cisplatin, and Vitamin B12 in Treating Patients With Mesothelioma of the Chest That Cannot Be Removed by Surgery
RATIONALE: Pemetrexed may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as cisplatin, work in different ways to stop the growth of tumor cells, either by…
- Trial name
- ALIMESO (NCT00541073)
- Testing
- vitamin B12, cisplatin, pemetrexed disodium
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Oscar Lambret
Carcinoma, Non- Small Cell Lung
Phase III Study to Determine Efficacy of Durvalumab in Stage II-III Non-small Cell Lung Cancer (NSCLC) After Curative Intent Therapy.
This is a Phase III double-blind, placebo-controlled study of Durvalumab versus Placebo in patients with stage II-III NSCLC who are MRD-positive following curative intent therapy.
- Trial name
- MERMAID-2 (NCT04642469)
- Testing
- Durvalumab
- Where
- 115 sites in United States, Argentina and 23 more
- Volunteers
- 30 people
- Sponsor
- AstraZeneca
Congenital Heart Surgery, Cardiopulmonary Bypass
Use of Phenoxybenzamine [PBZ] IV to Assist High Flow Low Pressure Perfusion [HFLPP] on Cardio-pulmonary Bypass
Cardiopulmonary bypass [CPB] in small size bodies can result in decreased peripheral perfusion. This results in anaerobic metabolism as evidenced by lactic acidosis.
- Trial name
- NCT00620945
- Testing
- Phenoxybenzamine
- Volunteers
- 87 people
- Sponsor
- The Cleveland Clinic
Obesity, Bariatric Surgery Candidate
Effects of Recruitment Manouever on Oxygenation, Oxygen Reserve Index and Postoperative Pulmonary Complications
General anesthesia and mechanical ventilation decrease pulmonar volume; attenuate small airway closure, atelectasis, and increase the rate of hypoxia and postoperative pulmonary complications.
- Trial name
- NCT05705245
- Testing
- recruitment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Balikesir University
Esophagectomy, Pulmonary Wedge Resection
A Retrospective Analysis of Statin Use and Outcome After Thoracic Cancer Surgery
There is data to support an association between impaired preoperative endothelial function and adverse postoperative outcome. This study will investigate the potential association between perioperative statin use and improved…
- Conditions
- Esophagectomy, Pulmonary Wedge Resection, Pulmonary Lobectomy, Pulmonary Pneumonectomy
- Trial name
- NCT01169051
- Volunteers
- 569 people
- Sponsor
- Vanderbilt University Medical Center
Respiratory Insufficiency
Respiratory Weaning Following Cardiac Surgery.
Respiratory weaning failure worsens prognostic of patients following on-pump cardiac surgery. There are increasing evidences that pulmonary, diaphragmatic or cardiologic echographies are useful in order to improve this critical…
- Trial name
- ETCCCV (NCT02821429)
- Testing
- Combined Thoracic Echography Record
- Where
- France
- Sponsor
- University Hospital, Toulouse
Lung Non-Small Cell Carcinoma, Positive Surgical Margin
Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lung Cancer
This trial studies the side effects of single fraction stereotactic body radiation therapy after surgery in treating patients with non-small cell lung cancer.
- Conditions
- Lung Non-Small Cell Carcinoma, Positive Surgical Margin, Resected Mass, Stage III Lung Cancer AJCC v8
- Trial name
- NCT04073745
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Stereotactic Body Radiation Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Roswell Park Cancer Institute
Lung Cancer
Nefopam as a Multimodal Analgesia for Thoracic Surgery
Acute postoperative pain after video-assisted thoracoscopic surgery is very severe. Because pain after thoracic surgery prevents early recovery, and increases postoperative complications, its is important to prevent pain after…
- Trial name
- NCT05173337
- Testing
- Nefopam
- Where
- South Korea
- Volunteers
- 46 people
- Sponsor
- Kangbuk Samsung Hospital