Clinical trials: Lung Transplant; Complications
Depression, ESRD
Morbidity and Mortality Among Dialysis Patients After Treatment for Depression
Morbidity and Mortality among Dialysis Patients after Treating Depression Objectives Our investigation has two objectives: 1. To assess whether treatment and recovery from depression decreases adverse clinical events in chronic…
- Trial name
- NCT00442429
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Portland VA Medical Center
Post Opeative Pulmonary Complication
The Effect of Acapella and Incentive Spirometry on Blood Gases and Peak Expiratory Flow Rate After Coronary Artery Bypass Graft.
The goal of this clinical trial is to learn if whether the Acapella and Incentive Spirometry have effect on Blood Gas and Peak Expiratory Flow Rate among patients undergoing Coronary Artery Bypass Graft Surgery.
- Trial name
- NCT07337746
- Testing
- Incentive Spirometry therapy, Acapella therapy
- Where
- 2 sites in Iraq
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Diabetic Foot Ulcer
Nitric Oxide Generating Gel Dressing in Patients With Diabetic Foot Ulcers
This is a 2 part study to assess the safety and efficacy of a nitric oxide (NOx) generating dressing on chronic diabetic foot ulcers (DFU). Nitric oxide has a range of effects on the body including vasodilation and angiogenesis.
- Trial name
- ProNOx1 (NCT01982565)
- Testing
- NOx dressing, Standard of Care
- Where
- 10 sites in United Kingdom
- Volunteers
- 130 people
- Sponsor
- Edixomed Ltd
Solid Organ Transplantation, Pregnancy
Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant, Transplantlines Next Generation
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth.
- Conditions
- Solid Organ Transplantation, Pregnancy, Long-term Follow-up, Kidney Transplant
- Trial name
- NCT07291258
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
End Stage Renal Disease, Kidney Transplant; Complications
COVID Vaccine Immunity in Kidney Transplant Recipients
50 end-stage renal disease (ESRD) patients whom have had at least 2 doses of messenger ribonucleic acid (mRNA) vaccine, and undergoing transplantation at the University of Alabama at Birmingham (UAB) will be enrolled.
- Trial name
- NCT05387343
- Testing
- Coronavirus (COVID-19) SARS-CoV-2 inSIGHT™ T Cell Immunity Test
- Sponsor
- University of Alabama at Birmingham
Endocrine System Diseases, Thyroid Diseases
Endocrine Changes and Their Correction in Heart and Lung Transplant Recipients and Donors
The aim of this study is to assess the impact of endocrine changes and their correction on survival and organ function in heart and lung transplant recipients.
- Conditions
- Endocrine System Diseases, Thyroid Diseases, Cortisol Deficiency, Diabetes Insipidus
- Trial name
- NCT04351945
- Testing
- Blood test
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Graft-versus-host-disease, Graft Versus Host Disease, Chronic
Physical Therapy in Patients Undergoing Allo-HSCT With cGVHD
Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT) represents the only curative option for many patients diagnosed with various hematologic neoplasms.
- Conditions
- Graft-versus-host-disease, Graft Versus Host Disease, Chronic, Stem Cell Transplant Complications, Hematological Malignancy
- Trial name
- NCT06279585
- Testing
- Physical therapy
- Where
- Spain
- Volunteers
- 108 people
- Sponsor
- University of Seville
Primary Graft Dysfunction, Lung Transplantation
This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft Dysfunction
Lung transplant recipient survival lags other solid organ recipients, with the main early cause of death being primary graft dysfunction (PGD).
- Conditions
- Primary Graft Dysfunction, Lung Transplantation, Acute Lung Injury(ALI), Natural Killer Cell Mediated Immunity
- Trial name
- MARAVIROC (NCT06853223)
- Testing
- Maraviroc
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Diabetic Neuropathic Pain, Chronic Low Back Pain
Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy
The purpose of the study is to determine whether the combination of the the three drugs gabapentin, duloxetine, and donepezil are effective in treating pain in people with diabetic neuropathy or patients with failed low back…
- Trial name
- NCT00619983
- Testing
- donepezil, duloxetine, donepezil 2.5 mg and duloxetine 30mg
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University
Lung Transplant; Complications
Performance Diagnosis of a Patent Foramen Ovale During Lung Transplantation Using Transesophageal Echocardiography
The investigators hypothesis is that an injection into the inferior vena cava associated with a provocation maneuver should allow to increase the incidence of FOP found by transesophageal echocardiography in a population of…
- Trial name
- FOP-TP (NCT04165161)
- Testing
- search for a patent foramen ovale
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hopital Foch
Sickle Cell Disease, Chronic Kidney Diseases
Peer i-Coaching for Activated Self-Management Optimization in Adolescents and Young Adults With Chronic Conditions
The purpose of this study is to test the efficacy of a peer support coaching intervention to improve activated chronic illness self-management versus an attention control group in 225 adolescents and young adults with childhood…
- Conditions
- Sickle Cell Disease, Chronic Kidney Diseases, Systemic Lupus Erythematosus, Childhood Cancer
- Trial name
- PiCASO (NCT03938324)
- Testing
- PiCASO Intervention Group
- Where
- United States
- Volunteers
- 222 people
- Sponsor
- Duke University
Lung Transplant Rejection
Study of Transbronchial Cryobiopsy in Monitoring Complications of Lung Transplantation
The goal of this randomized controlled trial is to compare the diagnostic efficacy and safety of transbronchial cryobiopsy (TBCB) and traditional transbronchial lung biopsy for diagnosing the lung transplantation rejection , so…
- Trial name
- NCT05792384
- Testing
- transbronchial lung cryobiopsy with a 1.1 mm flexible cryoprobe, transbronchial lung biopsy with biopsy forceps
- Volunteers
- 120 people
- Sponsor
- China-Japan Friendship Hospital
Lung Transplant Infection, Lung Transplant; Complications
AlloSure Lung Assessment and Metagenomics Outcomes Study
ALAMO is a prospective, multi-center, perspective, registry of patients receiving LungCare™ (AlloSure®-Lung, AlloMap Lung, and HistoMap) for surveillance post-transplant.
- Conditions
- Lung Transplant Infection, Lung Transplant; Complications, Lung Transplant Failure and Rejection
- Trial name
- ALAMO (NCT05050955)
- Where
- 22 sites in United States, Canada
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- CareDx
Lung Transplant Infection, Lower Respiratory Tract Infection
Preliminary Study of Dornase Alfa to Treat Chest Infections Post Lung Transplant.
Patients who have undergone lung transplantation are at an increased risk of developing chest infections due to long-term medication suppressing the immune response.
- Trial name
- NCT01952470
- Testing
- Dornase Alfa, Isotonic Saline.
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- The Alfred
Pulmonary Complications
Pulmonary Complications of Allografts
This is a prognostic study of the late lung complications arising at the patient's having received an allograft of hematopoetic stem cells.
- Trial name
- ALLOPULM (NCT01219972)
- Where
- France
- Volunteers
- 245 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Renal Failure
Two Schedules of Hepatitis B Vaccination in Predialysis Chronic Renal Failure Patients
Patients with chronic renal disease have to be vaccinated as soon as dialysis is forestalled and this could improve seroconversion rate of hepatitis B vaccination.
- Trial name
- NCT01468051
- Testing
- four doses of Euvax B vaccine, 20 μg (1 ml) three doses of Euvax B vaccine
- Volunteers
- 51 people
- Sponsor
- Tehran University of Medical Sciences
Cognitive Dysfunctions
Neurological Complications - Pulmonary Transplant
A monocentric prospective open study to evaluate the frequency and nature of cognitive complications in the 3rd month post pulmonary transplant.
- Trial name
- NCT01818193
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hopital Foch
Lung Transplant; Complications
Trial Comparing Immediate Versus Extended Release Tacrolimus; Reducing Calcineurin Inhibitor Related Toxicity in Lung Transplantation Patients
Lung transplantation is a life-saving option in patients with end-stage lung disease. The introduction of calcineurin inhibitors has significantly improved long-term outcome in lung transplantation.
- Trial name
- REVOLUTION (NCT05001074)
- Testing
- Extended release tacrolimus, Immediate release tacrolimus
- Where
- Netherlands
- Volunteers
- 145 people
- Sponsor
- Heleen Grootjans
Pulmonary Complication, Post Operative Complication
Lung Ultrasound Score as Post Operative Predictive Value of Pulmonary Complications in Living Liver Transplant Recipient
The aim of this study is to determine if lung ultrasound score has a strong predictive value for post operative pulmonary complications in living liver transplant recipient
- Trial name
- NCT06498895
- Testing
- lung ultrasound
- Volunteers
- 25 people
- Sponsor
- Ain Shams University
Hematopoietic Stem Cell Transplantation, Hematologic Malignancy
The Association of Microbiota Composition With cGVHD After Allo-HSCT
Previous studies had found that the microbe in intestinal after allogeneic hematopoietic cell transplantation(allo-HSCT) were closely associated with overall survival and post-transplantation complications, especially graft…
- Conditions
- Hematopoietic Stem Cell Transplantation, Hematologic Malignancy, Chronic Graft-versus-host-disease, Complication
- Trial name
- NCT05355675
- Testing
- blood sample, stool sample
- Where
- 10 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University