Clinical trials: Lung Transplant Recipients
Bronchiolitis Obliterans, Sleep Disordered Breathing Central
Sleep Disorders in Bronchiolitis Obliterans Syndrome 2&3
This study is to determine whether sleep disorders contribute to impaired quality of life and mobility in patients with Bronchiolitis Obliterans syndrome and whether non invasive positive airways pressure ventilation can improve…
- Trial name
- NCT02109237
- Testing
- Assessment of sleep disorders and treatment if required
- Where
- Australia
- Sponsor
- The Prince Charles Hospital
Chronic Lung Disease, Hematopoietic Cell Transplantation
Parametric Response Mapping (PRM) for the Detection of Chronic Lung Injury in Hematopoietic Cell Transplant Recipients
The study will have two separate patient cohorts: Cohort 1 will include patients with newly diagnosed chronic graft versus host disease (GVHD), whereas cohort 2 will include patients with newly diagnosed chronic lung disease…
- Conditions
- Chronic Lung Disease, Hematopoietic Cell Transplantation, Graft Versus Host Disease
- Trial name
- NCT05866302
- Where
- 6 sites in United States
- Volunteers
- 375 people
- Sponsor
- University of Michigan Rogel Cancer Center
Lung Transplant Recipient
BRIDGE - Blocking Receptor of IL-1β for Donor Graft Edema Reduction
This study will determine if primary graft dysfunction (which causes low blood oxygen levels and fluid or inflammation in the lungs) after lung transplant can be prevented through the use of the study drug (IL-1 receptor…
- Trial name
- NCT07410312
- Testing
- Anakinra
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Infection
Voriconazole as Prophylactic Therapy in Lung Transplant Recipients
The purpose of this study is to compare the safety and efficacy of Voriconazole with Itraconazole following lung transplantation.
- Trial name
- VORI (NCT00455364)
- Testing
- Voriconazole
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Lung Transplant Recipients, Muscle Weakness
Efficacy of Early Inspiratory Muscle Training in Lung Transplanted Patients
Lung transplantation is an effective therapeutic option in the end-stage of chronic respiratory diseases. Lung transplantation improves lung function in terms of capacity and volume.
- Conditions
- Lung Transplant Recipients, Muscle Weakness, Respiratory Insufficiency, Pulmonary Rehabilitation
- Trial name
- NCT05271019
- Testing
- Threshold load device
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Puerta de Hierro University Hospital
Invasive Fungal Infections, Lung Transplantation
Isavuconazole Therapeutic Drug Monitoring in Transplant Recipients
Isavuconazole is an antifungal medicine used to prevent or treat serious fungal infections in people who have received a solid organ transplant (mainly lung, and also kidney or liver) or a hematopoietic stem cell (bone marrow)…
- Conditions
- Invasive Fungal Infections, Lung Transplantation, Hematopoietic Stem Cell Transplantation (HSCT), Kidney Transplantation
- Trial name
- TRIM-1 (NCT07716878)
- Testing
- Isavuconazole
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhibin Xu
End-stage Lung Disease
Perioperative Recovery Outcomes With a Spontaneous Breathing Strategy in Older Lung Transplant Recipients
The goal of this prospective, multicenter, single-arm cohort study is to learn whether a lung transplantation approach that preserves patients' spontaneous breathing during surgery can improve early recovery in adults aged 70…
- Trial name
- NCT07384507
- Testing
- Lung transplantation that preserves spontaneous breathing function
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Cytomegalovirus Infection
Quantiferon - Cytomegalovirus (CMV) and the Prediction of CMV Infection In High Risk Solid Organ Transplant Recipients
Cytomegalovirus (CMV) is a common cause of illness in patients who have undergone a transplant. Serious infections due to CMV can affect many parts of the body including the lungs, the gut, and the liver.
- Trial name
- NCT00817908
- Where
- Canada
- Volunteers
- 131 people
- Sponsor
- University of Alberta
COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm
Pharmacokinetics of Sotrovimab as Pre-exposure Prophylaxis for COVID-19 in Hematopoietic Stem Cell Transplant Recipients, COVIDMAB Study
This phase I trial studies the process by which sotrovimab is absorbed, distributed, metabolized, and eliminated by the body (pharmacokinetics) in hematopoietic stem cell transplant recipients.
- Conditions
- COVID-19 Infection, Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
- Trial name
- NCT05135650
- Testing
- Questionnaire Administration, Sotrovimab, Biospecimen Collection
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fred Hutchinson Cancer Center
Allogeneic Hematopoietic Cell Transplant Recipients
Prospective Phase II Study for Assessment of Regulatory Immune Cell Populations After Allogeneic HSCT
Allogeneic hematopoietic cell transplantation offers high cure rates for patients with hematological and oncological diseases. Graft-versus-host disease (attack of donor's white blood cells on patient's tissues) is a serious…
- Trial name
- NCT00587574
- Where
- 2 sites in Austria, Czechia
- Volunteers
- 150 people
- Sponsor
- Medical University of Vienna
Lung Transplant Recipients
Physical Activity Tele-coaching in Lung Transplant Recipients
Lung transplantation is an established treatment for patients with end-stage lung disease. Despite the overall success of the treatment to prolong survival and restore lung function, limitations in exercise capacity in the range…
- Trial name
- NCT03873597
- Testing
- Tele-coaching + Usual Care
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Northumbria University
Lung Transplant Rejection
HP 129Xe MRI for Evaluation of CLAD in Lung Transplant Recipients
To evaluate the feasibility of hyperpolarized 129Xe MRI in lung transplant recipients and assess structural and functional pulmonary changes using hyperpolarized 129Xe MRI
- Trial name
- NCT05550662
- Testing
- 129Xenon
- Where
- 2 sites in Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Stem Cell Transplantation
Physical Impairments in Allogeneic-HSCT
Pulmonary functions, exercise capacity and muscle strength deteriorate in survived hematopoietic stem cell transplantation (HSCT) recipients due to toxic effects of chemotherapy, radiotherapy, conditioning regimens and/or…
- Trial name
- NCT03448627
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Gazi University
Metabolic Syndrome
Feasibility of a Home Exercise Program to Manage Post-transplant Metabolic Syndrome
Post-transplant metabolic syndrome (PTMS) affects about 50% liver transplant (OLT) and 25% lung transplant (LTx) recipients at 12-18 months post-transplant.
- Trial name
- NCT04965142
- Testing
- Exercise Training
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- University Health Network, Toronto
Liver Transplant
Immune Response to COVID-19 Vaccine in Recipients of Living Donor Liver Transplantation
A prospective cohort study to evaluate the response to COVID-19 vaccine in liver transplantation patients.
- Trial name
- NCT05051605
- Testing
- COVID-19 Vaccine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Lung Transplant
Cyclosporine Inhalation Solution (CIS) in Lung Transplant Recipients
Currently there are no approved therapies for lung transplant recipients in the United States (US). Treatment with CIS following lung transplantation has previously been demonstrated to result in a clinically meaningful…
- Trial name
- NCT00633373
- Testing
- Cyclosporine Inhalation Solution
- Where
- 8 sites in United States
- Sponsor
- APT Pharmaceuticals, Inc.
Lung Transplantation, Fungal Infections
Pharmacokinetic Profile of Inhaled Liposomal Amphotericin B in Lung Transplant Recipients - Ambisome Study
The purpose of this study is to determine the steady state concentrations of inhaled liposomal amphotericin B (Ambisome®) in lung transplant recipients via aerosolized nebulization.
- Trial name
- NCT00177710
- Testing
- Amphotericin B
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Transplant; Complication, Rejection
Volatile Organic Compounds as Markers of Acute Rejection in Lung Transplant
The aim of research is to identify markers of acute rejection by VOC analysis in exhaled breath of bilateral-lung transplanted patients.
- Trial name
- VOC-TP (NCT03172091)
- Testing
- eNose (electronic nose), Spectrometry
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hopital Foch
Chronic Rejection, Lung Transplantation
Predictive Factors for Chronic Rejection in Lung Transplant Recipients: COLT Study
Obliterative Bronchiolitis (OB) is the major cause of long-term lung allograft loss for patients with end stage pulmonary diseases like cystic fibrosis.
- Trial name
- COLT (NCT00980967)
- Testing
- Study of predictive factors
- Where
- 11 sites in France
- Volunteers
- 700 people
- Sponsor
- Nantes University Hospital
Organizing Pneumonia, Lung Transplant Rejection
Organizing Pneumonia in Lung Transplant Recipients, a Restrospective Exploratory Study (OPIL-Study)
The aim of this study is to generate evidence regarding organizing pneumonia in lung transplant recipients.
- Trial name
- OPIL (NCT06203964)
- Testing
- No intervention
- Where
- Switzerland
- Volunteers
- 280 people
- Sponsor
- University of Zurich