Clinical trials: Lung Transplantation, active
COVID-19, COVID-19 (SARS-CoV-2 Infection)
Evaluation of Safety, Tolerance, and Efficacy of Allogeneic LB-DTK-COV19 in Severe Coronavirus Disease 2019 Patients
The goal of this clinical trial is to evaluate the safety, tolerability, and efficacy of allogeneic SARS-CoV-2-Specific T cells (LB-DTK-COV19) in patients with persistent clinical symptoms following a positive SARS-CoV-2 PCR test…
- Trial name
- NCT07709637
- Testing
- LB-DTK-COV19
- Where
- South Korea
- Volunteers
- 1 people
- Sponsor
- LucasBio
Idiopathic Pulmonary Fibrosis and Progressive Fibrotic Interstitial Lung Disease
Human Autologous Lung Stem Cell Transplant for Idiopathic Pulmonary Fibrosis
Purpose: To demonstrate the safety and efficacy of autologous Lung Spheroid Stem Cells (LSCs) administered by intravenous infusion in patients with idiopathic pulmonary fibrosis Progressive Fibrotic Interstitial Lung Disease.
- Trial name
- HALT-IPF (NCT04262167)
- Testing
- Lung Spheroid Stem Cells 100 million, Lung Spheroid Stem Cells 200 million
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Graft Rejection, Kidney Transplantation
TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Response to Extracorporeal Photo-aphereSiS
With this project, the research team aims to identify the molecular pathways associated with the response to extracorporeal photonchemioapheresis (ECP) in kidney or lung transplant patients suffering from chronic rejection, by…
- Conditions
- Graft Rejection, Kidney Transplantation, Lung Transplantation, Antibody-Mediated Rejection
- Trial name
- TRACKLESS (NCT07316829)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Bone Marrow Failure Syndrome, Severe Aplastic Anemia
CD34+ (Non-Malignant) Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation
This study's goal is to determine the frequency and severity of acute graft versus host disease, to evaluate incidence of primary and secondary graft rejection, to assess event free survival and overall survival, to determine the…
- Conditions
- Bone Marrow Failure Syndrome, Severe Aplastic Anemia, Severe Congenital Neutropenia, Amegakaryocytic Thrombocytopenia
- Trial name
- NCT01966367
- Testing
- CD34 Stem Cell Selection Therapy
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Diane George
Post Intensive Care Syndrome (PICS), PTSD - Post Traumatic Stress Disorder
ICU-VR Prior to ICU Admission
Rationale: A substantial proportion of the Intensive Care Unit (ICU) survivors develop psychological impairments due to their ICU admission.
- Trial name
- NCT06642636
- Testing
- Intensive Care Unit-specific Virtual Reality
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Denzel Drop
Diaphragm Injury, Respiratory Failure
Diaphragm Structure and Pathobiology in Patients Being Bridged to Lung Transplant
This study is designed to characterize the changes in diaphragm structure, function and biology during bridging to lung transplant by mechanical ventilation or extracorporeal life support.
- Conditions
- Diaphragm Injury, Respiratory Failure, Mechanical Ventilation Complication
- Trial name
- DIASPORA (NCT03667027)
- Testing
- Respiratory support
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Hematologic Neoplasms
Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies
Background: People with blood cancers often receive blood or bone marrow transplants. But even with these treatments, the risk of relapse is high.
- Trial name
- NCT05327023
- Testing
- donor lymphocyte infusion, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Chronic Graft Versus Host Disease
Improving Outcomes Assessment in Chronic GVHD
The purpose of this study is to see if recent guidelines proposed by the National Institutes of Health for the diagnosis, staging, and response assessment of people with chronic GVHD can improve our understanding of this…
- Trial name
- NCT00637689
- Where
- 9 sites in United States
- Volunteers
- 601 people
- Sponsor
- Fred Hutchinson Cancer Center
SARS-CoV-2 Infection, Kidney Transplant Infection
SARS-COV-2 Infection in Kidney Transplant Recipients: a Brazilian Multicenter Study
COVID-19 is the pandemic disease caused by the SARS-CoV-2 coronavirus. It is a highly contagious viral disease, the condition of which main clinical symptoms are characterized by fever and respiratory symptoms.
- Trial name
- NCT04494776
- Where
- Brazil
- Volunteers
- 500 people
- Sponsor
- Helio Tedesco Silva Junior
Sleep Wake Disorders, Lung Transplantation
Low-Frequency rTMS for In-Hospital Sleep Disturbance After Lung Transplantation
This randomized, double-blind, sham-controlled trial will evaluate whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can improve in-hospital sleep quality in adult lung transplant recipients during early…
- Trial name
- TMS-SLEEP-LTx (NCT07796425)
- Testing
- Active Low-Frequency Repetitive Transcranial Magnetic Stimulation
- Volunteers
- 152 people
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Lung Transplant
Pre-transplant Health Coaching to Improve Patient-Reported Outcomes in Lung Transplant Candidates
To examine the effectiveness of an individual health coaching intervention for lung transplant candidates. This intervention will include up to 12 health coaching sessions via phone call over a 12-16 week period.
- Trial name
- NCT05426200
- Testing
- Health Coaching
- Where
- 3 sites in United States
- Volunteers
- 230 people
- Sponsor
- Mayo Clinic
Cystic Fibrosis
Lung Transplant READY CF 2: A Multi-site RCT
Lung transplant is an option for treating end-stage lung disease in cystic fibrosis (CF). In the United States, more people with CF and low lung function die each year than undergo lung transplant.
- Trial name
- NCT06030206
- Testing
- Investigator-designed lung transplant education resource (Research Intervention), Publicly available transplant education resource (Attention-control)
- Where
- 11 sites in United States
- Volunteers
- 132 people
- Sponsor
- University of Washington
Respiratory Failure, Interstitial Lung Disease (ILD)
Routine vs On-demand ECMO for Lung Transplantation
Lung transplantation is a complex procedure performed in patients with terminal lung disease. The transplant procedure stresses the patient's heart and lungs, which are already taxed by the underlying disease process.
- Conditions
- Respiratory Failure, Interstitial Lung Disease (ILD), Pulmonary Fibrosis, COPD (Chronic Obstructive Pulmonary Disease)
- Trial name
- REVOLUTION (NCT06615492)
- Testing
- Routine ECMO, On-demand ECMO
- Where
- 4 sites in Canada
- Volunteers
- 218 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Pulmonary Hypertension, Kidney Transplantation
Characteristics of Pulmonary Vascular Changes in Patients With Kidney Transplantation
The aim of the study is to investigate pulmonary hemodynamics at rest and during exercise in patients before and after kidney transplantation.
- Conditions
- Pulmonary Hypertension, Kidney Transplantation, Haemodialysis
- Trial name
- NCT04842591
- Testing
- exercise echocardiography
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Graz
Interstitial Lung Disease (ILD)
REGEND001 Autologous Basal Layer Stem Cell Transplantation for Interstitial Lung Disease (ILD): A Translational Application Study
This clinical trial evaluates the safety and efficacy of REGEND001, an autologous bronchial basal layer stem cell therapy, in patients with interstitial lung disease (ILD).
- Trial name
- NCT06998706
- Testing
- REGEND001 Autologous Basal Layer Stem Cell Suspension
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- Ruijin Hospital
Lung Transplant; Complications
Early Use of Long-acting Tacrolimus in Lung Transplant Recipients
Lung transplantation is a life-saving therapy for patients with advanced lung disease, however, necessitates the use of life-long immunosuppressive therapy for the prevention of acute and chronic rejection.
- Trial name
- NCT04469842
- Testing
- Tacrolimus Extended Release Oral Tablet [Envarsus], Tacrolimus, Mycophenolate Mofetil Hydrochloride
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Vanderbilt University Medical Center
Lung Transplant; Pain
Evaluating the Impact of Cryo-analgesia on Recovery After Double Lung Transplantation
The goal of this pilot trial is to learn whether the use of cryo nerve block and its effect on sensation in the chest alters recovery after bilateral lung transplantation, and to which extent these parameters are influenced.
- Trial name
- CRyoLTRiX (NCT06959056)
- Testing
- cryo nerve block at T3-T8 intercostal nerves bilaterally
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- University Hospital, Gasthuisberg
Metastatic Lung Cancer
Fecal Microbiota Transplantation With Immune Checkpoint Inhibitors in Lung Cancer
Immunotherapy has recently become a main-stream treatment option in cancer care, with improved clinical outcomes in many malignancies, especially that of lung cancer. The long-term benefits of this treatment however are limited.
- Trial name
- NCT05502913
- Testing
- Antibiotics, FMT (Fecal Microbiota Transplantation)
- Where
- 2 sites in Israel
- Volunteers
- 80 people
- Sponsor
- Soroka University Medical Center
Post-Lung Transplantation Bronchiectasis
Lung Ultrasound Artefact Analysis for Exclusion of Acute Rejection in Lung Transplant Recipients
This study is being done to study a safe and non-invasive way to diagnose lung rejection and infection.
- Trial name
- NCT04582279
- Testing
- Lung ultrasound
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic