Clinical trials: Lung Tumors
Solid Tumor, Adult, Lung Adenocarcinoma
TP53 R248Q TCR-T Cell Therapy for Advanced Solid Tumor
To evaluate the safety and efficacy of T cell therapy with mutated TP53 R248Q specific TCR transduction in patients with advanced solid tumor expressing the TP53 R248Q mutation and the HLA-A*11:01 allele.
- Conditions
- Solid Tumor, Adult, Lung Adenocarcinoma, Pancreas Cancer, Colorectal Cancer
- Trial name
- NCT06619886
- Testing
- Autologous, engineered T Cells targeting TP53 R248Q
- Where
- China
- Volunteers
- 9 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Non Small Cell Lung Cancer
Assessment of Video Assisted Thoracoscopic Surgery (VATS) Versus Open Surgery for Patients Undergoing Lobectomy
Assessment of VATS versus standard open surgery for treatment of non small cell lung cancer.
- Trial name
- NCT00912366
- Testing
- Lobectomy
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Medtronic - MITG
Colorectal Cancer, Metastatic Cancer
Cetuximab and Combination Chemotherapy as First-Line Therapy in Treating Patients With Colorectal Cancer That Has Spread to the Liver and/or Lung
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread.
- Trial name
- ERBIFORT (NCT00557102)
- Testing
- cetuximab, filgrastim, fluorouracil
- Where
- France
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute, France
Neoplasms, Non-small-cell Lung Cancer
A Study to Learn About How Different Amounts of the Study Medicine PF-07826390 Act in the Body of People With Cancer When Taken Alone or With Other Anti-cancer Medicines.
The purpose of this study is to learn about the: safety (the effect of the study medicine on the participant's body), effects of the study medicine alone or in combination with sasanlimab - the best amount of the study medicine.
- Conditions
- Neoplasms, Non-small-cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Renal Cell Carcinoma
- Trial name
- NCT06546553
- Testing
- PF-07826390, sasanlimab, SOC (anti-PD-1 + platinum -based chemo)
- Where
- 8 sites in United States
- Volunteers
- 10 people
- Sponsor
- Pfizer
Malignant Melanoma, Carcinoma, Non-Small-Cell Lung
A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement
First-in-human study to assess safety, tolerability, PK, and preliminary activity of PF-07284890 as a single agent and in combination with binimetinib in participants with BRAF V600-mutated advanced solid tumor malignancies with…
- Conditions
- Malignant Melanoma, Carcinoma, Non-Small-Cell Lung, Brain Neoplasms, Primary, Brain Neoplasms
- Trial name
- NCT04543188
- Testing
- PF-07284890, Binimetinib, Midazolam
- Where
- 45 sites in United States, Canada and 1 more
- Volunteers
- 65 people
- Sponsor
- Pfizer
NSCLC, Anxiety Postoperative
Influence of a PSychological Intensive Support Program for Lung Cancer Patients ON Post-operative Outcomes.
Anxiety is common among patients diagnosed with lung cancer, affecting 50-60% of cases, and over 30% report moderate to severe psychological distress.
- Conditions
- NSCLC, Anxiety Postoperative, Depression
- Trial name
- IPSILON (NCT07260227)
- Testing
- HADS (Hospital Anxiety and Depression Scale)
- Volunteers
- 138 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Non-Small Cell Lung Cancer
Early Palliative Care in Patients With Advanced Lung Cancer Using an e-Health Ecosystem
Palliative care has long been associated primarily with end-of-life support. However, its scope is much broader. As highlighted in the Hastings Center Report, the purposes of medicine include not only curing disease but also…
- Trial name
- AIRPAL (NCT07039994)
- Testing
- Standard intervention, E-health intervention
- Where
- 2 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Jesús González
Breast Cancer, Prostate Cancer
Holistic Acupuncture for Patients With Chemotherapy Induced Nausea
The study explores whether acupuncture as a supplement to conventional antiemetic medicine is superior in reducing the level of chemotherapy induced nausea compared to conventional anitemetic medicine alone.
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Gynaecologic Cancer
- Trial name
- NCT07201194
- Testing
- Holistic acupuncture and acupressure, Standard medical treatment
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Vejle Hospital
Non Small Cell Lung Cancer
Texture Features and PDL1 in CT-PET 18 FDG
Search correlation between texture features in CT-PET 18 FDG and overexpression of PDL1 in non-small cell lung carcinomas during the inital staging.
- Trial name
- NCT04309422
- Where
- France
- Volunteers
- 84 people
- Sponsor
- University Hospital, Montpellier
Carcinoma, Non-Small-Cell Lung
Efficacy Study of Induction Chemotherapy Before Surgery in Operable Non-small Cell Lung Cancer
This study is randomized phase III trial designed to assess whether (preoperative) neoadjuvant chemotherapy followed by surgery plus adjuvant chemotherapy with gemcitabine and cisplatin (experimental treatment) improves 3-year…
- Trial name
- NCT00329472
- Testing
- gemcitabine, cisplatin
- Sponsor
- Samsung Medical Center
Pleural Effusion, Malignant, Lung Neoplasms
Management of Malignant Pleural Effusion - Indwelling Pleural Catheter or Talc Pleurodesis
Prospective study of the effect of Talc Pleurodesis vs. Indwelling Pleural catheter in treatment of patients with malignant pleural effusion
- Trial name
- NCT02825095
- Testing
- Talc Pleurodesis, Indwelling Pleural Catheter, chest ultrasound
- Volunteers
- 120 people
- Sponsor
- Rambam Health Care Campus
Lung Cancer
The Role of Sedation Technique in EBUS-TBNA
There is a paucity of data concerning the impact of the sedation technique used for endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) on diagnostic accuracy.
- Trial name
- NCT02245295
- Testing
- Moderate Sedation for EBUS/TBNA, General anesthesia for EBUS/TBNA
- Where
- Switzerland
- Volunteers
- 232 people
- Sponsor
- University of Zurich
Epigenetics, DNA Methylation
Methylated Biomarkers of Smoking as a Selection Tool in Participants for Lung Cancer Screening
The MET-SELS study aims to revolutionize how we identify individuals for lung cancer screening by moving beyond the limitations of self-reported smoking history.
- Conditions
- Epigenetics, DNA Methylation, Lung Cancer Screening, Risk Stratification With Biomarker
- Trial name
- MET-SELS (NCT07631624)
- Testing
- DNA-methylation in saliva
- Where
- Belgium
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Nonsmall Cell Lung Cancer Stage III
Multidisciplinary Treatment of Stage III ALK+ NSCLC With Neoadjuvant Alectinib and Chemotherapy
This is a multicenter, phase 2 non-randomized study to investigate the clinical feasibility and therapeutic efficacy of employing a MDT-based strategy in unresectable stage III ALK positive NSCLC following neoadjuvant alectinib…
- Trial name
- NCT07573696
- Testing
- After neoadjuvant alpelisib combined with chemotherapy, a multidisciplinary decision was made
- Volunteers
- 50 people
- Sponsor
- Wen-zhao ZHONG
Covid19, Cancer
A Study on the Immune-response to COVID-19 Vaccination in Cancer Patients - the IOSI-COVID-19-001 Study
This is a single centre prospective observational study to assess the immune response to SARS-CoV-2 vaccines in cancer patients receiving active treatment or in follow-up at the IOSI and in non-cancer patients (age and gender…
- Trial name
- NCT04800146
- Testing
- Blood sample
- Where
- Switzerland
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Ilaria Colombo
Lung Cancer Screening
Audit of Lung Cancer Screening Practice in Chest Physicians: An Update
The investigators will conduct nationally representative survey in chest physicians in Egypt in 2016-2017. Self-administered questionnaire will be used to assess the physicians' knowledge of lung cancer screening guidelines…
- Trial name
- NCT02944903
- Testing
- Audit
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Assiut University
Advanced Cancer, Metastatic Melanoma
A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancer
The purpose of this study is to determine the safety of an extracellular signal regulated kinase (ERK1/2) inhibitor LY3214996 administered alone or in combination with other agents in participants with advanced cancer.
- Conditions
- Advanced Cancer, Metastatic Melanoma, Metastatic Non-small Cell Lung Cancer, Colorectal Cancer
- Trial name
- NCT02857270
- Testing
- LY3214996, Midazolam, Abemaciclib
- Where
- 13 sites in United States, Australia and 2 more
- Volunteers
- 210 people
- Sponsor
- Eli Lilly and Company
Lung Cancer
Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia
Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?
- Trial name
- NCT02324283
- Testing
- desflurane, propofol
- Where
- Japan
- Volunteers
- 80 people
- Sponsor
- Juntendo University
Large Cell Lung Carcinoma, Lung Adenocarcinoma
Paclitaxel, Carboplatin, and Bevacizumab With or Without Cixutumumab in Treating Patients With Stage IV or Recurrent Non-small Cell Lung Cancer
This randomized phase II trial studies how well carboplatin, paclitaxel, and bevacizumab (CPB) work when given with or without cixutumumab in treating patients with non-small cell lung cancer that is stage IV or has come back…
- Conditions
- Large Cell Lung Carcinoma, Lung Adenocarcinoma, Recurrent Non-Small Cell Lung Carcinoma, Stage IV Non-Small Cell Lung Cancer
- Trial name
- NCT00955305
- Testing
- Bevacizumab, Carboplatin, Cixutumumab
- Where
- 165 sites in United States
- Volunteers
- 175 people
- Sponsor
- National Cancer Institute (NCI)
Lung Cancer
Establishment of a PDT Patient Registry
This is a non-intervention patient registry to gather data on the use of photodynamic therapy under real-life conditions. It will involve up to 20 sites in USA.
- Trial name
- NCT03589456
- Testing
- No intervention
- Where
- 10 sites in United States
- Volunteers
- 22 people
- Sponsor
- Concordia Laboratories Inc.
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