Clinical trials: Lung Tumors
Small Cell Lung Cancer
Phase II Trial of RAD001 (Everolimus) in Previously Treated Small Cell Lung Cancer
This is a phase II, two-stage, open-label, single-agent study of the experimental drug RAD001 (everolimus) in patients with previously treated small cell lung cancer. RAD001 will be administered orally at a dose of 10 mg daily.
- Trial name
- NCT00374140
- Testing
- RAD001 (everolimus)
- Where
- 19 sites in United States
- Volunteers
- 40 people
- Sponsor
- Ahmad Tarhini
Metastatic Lung Non-Small Cell Carcinoma, Advanced Lung Non-Small Cell Carcinoma
EMB-01 in Combination With Osimertinib in Patients With EGFR Mutant Lung Cancer
This phase Ib/II trial studies the side effects and best dose of EMB-01 when given together with osimertinib in patients with EGFR-mutant non-small cell lung cancer that has spread to other places in the body (advanced or…
- Conditions
- Metastatic Lung Non-Small Cell Carcinoma, Advanced Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8, Stage IVA Lung Cancer AJCC v8
- Trial name
- NCT05498389
- Testing
- EMB-01, Osimertinib
- Where
- 3 sites in United States, China
- Volunteers
- 115 people
- Sponsor
- Shanghai EpimAb Biotherapeutics Co., Ltd.
NSCLC, SCLC
Study of Oral MRT-2359 in Selected Cancer Patients
This Phase 1/2, open-label, multicenter study is conducted in patients with previously treated selected solid tumors, including non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC), high-grade neuroendocrine cancer…
- Conditions
- NSCLC, SCLC, High Grade Neuroendocrine Cancer, DLBCL
- Trial name
- NCT05546268
- Testing
- Oral MRT-2359
- Where
- 17 sites in United States
- Volunteers
- 174 people
- Sponsor
- Monte Rosa Therapeutics, Inc
Non-small Cell Lung Cancer
Phase II Clinical Study of Pyrotinib in First-line Treatment of Primary HER2-amplified/Mutated Advanced Non-small Cell Lung Cancer
This is a multicenter, single-arm phase II clinical study to evaluate the safety and efficacy of pyrotinib maleate as a first-line treatment for HER2-mutated or amplified non-small cell lung cancer.
- Trial name
- NCT05751018
- Testing
- Pyrotinib
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Peking Union Medical College Hospital
Lung Cancer, Non-small Cell
Effects of VNS on RT-induced Inflammation and Prognosis of Patients With NSCLC
Lung cancer (LC) remains a leading cause of death among cancers worldwide. Though radiotherapy is one of the most frequently used treatments, it increases side-effects (pain, fatigue) and inflammation, possibly leading to further…
- Trial name
- NCT03553485
- Testing
- Transcutaneous vagus nerve stimulation, Radiotherapy
- Where
- Belgium
- Volunteers
- 12 people
- Sponsor
- Vrije Universiteit Brussel
Limited Stage Small Cell Lung Cancer
Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy
This is a prospective, open,multicenter, randomized controlled phase III clinical trial. In patients with LS-SCLC who achieve remission after first-line chemoradiotherapy, the efficacy and safety of PCI or MRI surveillance is…
- Trial name
- NCT04829708
- Testing
- MRI Surveillance, Prophylactic Cranial Irradiation
- Where
- 2 sites in China
- Volunteers
- 534 people
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancer, Colorectal Cancer
Feasibility of Quality of Life Assessment in Routine Clinical Oncology Practice at the University Hospital of Besancon
Symptoms related to the disease and/or treatment are common in cancer patients and can affect patient health-related quality of life (HRQol). Unfortunately these symptoms can be underestimated and underreported by the physician.
- Conditions
- Breast Cancer, Colorectal Cancer, Lung Cancer
- Trial name
- QOLIBRY (NCT02844608)
- Testing
- Quality of Life Questionnaires
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Non-Small Cell Lung Cancer
MONET1-MOtesanib NSCLC Efficacy and Tolerability Study
To determine if treatment with AMG 706 (motesanib diphosphate) in combination with paclitaxel and carboplatin improves overall survival compared to treatment with placebo in combination with paclitaxel and carboplatin in subjects…
- Trial name
- NCT00460317
- Testing
- AMG 706, paclitaxel, carboplatin
- Volunteers
- 1,450 people
- Sponsor
- Amgen
Lung Cancer, Surgery
Cetuxibab to Reduce Circulating Tumor Cells in Early Stage NSCLC
Cetuximab to reduce the amound of circulating tumor cells in early stage NSCLC
- Conditions
- Lung Cancer, Surgery, Circulating Tumor Cell
- Trial name
- NCT04648189
- Testing
- Cetuximab
- Where
- 2 sites in Netherlands
- Sponsor
- The Netherlands Cancer Institute
Non Small Cell Lung Cancer
Trial on Refinement of Early Stage Lung Cancer Adjuvant Therapy
The purpose of this randomized phase II trial is to determine the clinical feasibility - in terms of patients without dose limiting toxicities or premature treatment withdrawal or death - of the combination of Cisplatin and…
- Trial name
- NCT00349089
- Testing
- Pemetrexed, Cisplatin, Vinorelbine
- Where
- 14 sites in Belgium, Germany and 1 more
- Volunteers
- 132 people
- Sponsor
- Thoraxklinik-Heidelberg gGmbH
Lung Cancer, Markerless Image Guidance
Markerless Image Guidance Using Intrafraction Kolovoltage X-ray Imaging for Lung Cancer Radiotherapy
In radiotherapy, tumour tracking allows us to ensure the radiation beam is accurately targeting the tumour while it moves in a complex and unpredictable way.
- Conditions
- Lung Cancer, Markerless Image Guidance, Intrafraction Kolovoltage X-ray Imaging
- Trial name
- VALKIM (NCT04310891)
- Testing
- Markerless Tumour Tracking
- Where
- Australia
- Volunteers
- 5 people
- Sponsor
- Royal North Shore Hospital
DFS
A Multicenter Randomized Controlled Study of Interventional Treatment for Operable Stage Ⅱ-Ⅲ Non-small Cell Lung Cancer With Potential Recurrence as Minimal Residual Disease(MRD) Positive
A prospective, multicenter clinical study designed to explore the efficacy of adaptive therapy based on MRD status in patients with stage II-III non-small cell lung cancer(NSCLC) after treatment.
- Trial name
- NCT06524518
- Testing
- Chemotherapy combined with immunization
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Xuanwu Hospital, Beijing
Brain Metastases, Non-small Cell Lung Cancer
Phase II Trial of Double Dose of Icotinib in Treating Brain Metastases From Non-small Cell Lung Cancer
Brain metastases, a common complication,occur in 25-40% of patients with non-small cell lung cancer (NSCLC). Whole-brain radiation therapy(WBRT) and Stereotactic Radiosurgery (SRS) are important approaches to the treatment of…
- Trial name
- NCT01688713
- Testing
- Icotinib
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Zhejiang Cancer Hospital
Small Cell Lung Cancer (SCLC)
A Phase 2, Open-label, Randomized, Multicenter Study of Tarlatamab Dosing Regimens in Subjects With SCLC
The primary objective of this study is to describe the antitumor activity of tarlatamab in participants with small cell lung cancer (SCLC).
- Trial name
- DeLLphi-309 (NCT06745323)
- Testing
- Tarlatamab
- Where
- 78 sites in United States, Argentina and 14 more
- Volunteers
- 252 people
- Sponsor
- Amgen
Attention Deficit Disorder With Hyperactivity, Asthma
Study of an Intervention to Improve Problem List Accuracy and Use
The aim of this study is to identify patients with problem list gaps and intervene to correct these gaps by creating clinical decision support interventions that alert providers to likely problem list gaps and offer clinicians…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Asthma, COPD, Breast Cancer
- Trial name
- MAPLE (NCT01105923)
- Testing
- MAPLE
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brigham and Women's Hospital
Non-small Cell Lung Cancer Metastatic
Combination of Cryosurgery and NK Immunotherapy for Advanced Non-Small Cell Lung Cancer
The aim of this study is the safety and efficacy of cryosurgery plus NK immunotherapy to advanced NSCLC.
- Trial name
- NCT02843815
- Testing
- Cryosurgery, NK Immunotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Fuda Cancer Hospital, Guangzhou
Carcinoma, Non-Small Cell Lung
A Study Evaluating the Efficacy and Safety of Adjuvant Platinum-Doublet Chemotherapy, With or Without Atezolizumab, in Patients Who Are ctDNA Positive After Complete Surgical Resection of Stage IB to Select IIIB Non-Small Cell Lung Cancer
This is a Phase II, multicenter, double-blind, randomized study designed to evaluate the efficacy and safety of adjuvant treatment with atezolizumab in combination with platinum-doublet chemotherapy followed by atezolizumab…
- Trial name
- CATHAYA (NCT04611776)
- Testing
- Atezolizumab, Carboplatin, Cisplatin
- Sponsor
- Hoffmann-La Roche
Non-Small Cell Lung Cancer, Urothelial Cancer
A Study of Avelumab in Combination With Axitinib In Non-Small Cell Lung Cancer (NSCLC) or Urothelial Cancer (Javelin Medley VEGF)
This is a Phase 2 study to evaluate the safety and efficacy of avelumab in combination with axitinib in patients with advanced or metastatic non-small cell lung cancer (NSCLC) who have received at least one prior platinum…
- Trial name
- NCT03472560
- Testing
- Avelumab (MSB0010718C), Axitinib (AG-013736)
- Where
- 39 sites in United States, Hungary and 6 more
- Volunteers
- 61 people
- Sponsor
- Pfizer
Resectable Non-Small Cell Lung Cancer
Neoadjuvant KRAS G12C Directed Therapy With Adagrasib (MRTX849) With or Without Nivolumab
This is an open label phase 2 clinical trial evaluating the clinical safety, feasibility and efficacy of neoadjuvant Adagrasib alone or in combination with nivolumab in patients with NSCLC with KRAS G12C mutation.
- Trial name
- Neo-Kan (NCT05472623)
- Testing
- Adagrasib, Adagrasib/Nivolumab
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Squamous Cell Carcinoma of Lung
Nab-paclitaxel as Second-line Therapy in Locally Advanced or Metastatic Squamous Lung Cancer
The purpose of this study is to determine the efficacy of nab-paclitaxel monotherapy in previously treated advanced or metastatic squamous lung cancer.
- Trial name
- NCT01969955
- Testing
- nanoparticle albumin-bound paclitaxel
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Chinese Academy of Medical Sciences
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.