Clinical trials: Lupus Erythematosus
Systemic Lupus Erythematosus
Cardiology Prevention in Systemic Lupus Erythematosus (SLE)
We propose a feasibility study of aggressive CV risk factor management directed by preventive cardiology compared to usual care.
- Trial name
- NCT00610805
- Testing
- Preventive Cardiology, Usual Care
- Where
- 2 sites in United States
- Sponsor
- University of Pittsburgh
Systemic Lupus Erythematosus (SLE)
Study to Evaluate the Safety, Tolerability and Short Term Efficacy of Extracorporeal Specific Immunoadsorption LupusorbTM Columns for the Treatment of Systemic Lupus Erythematosus (SLE) Patients
Systemic Lupus Erythematosus (SLE) is a chronic, autoimmune, inflammatory disease primarily affecting women of childbearing age, and associated with severe morbidity and mortality of its victims.
- Trial name
- NCT00608127
- Testing
- LupusorbTM
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Verto LTD
Lupus Nephritis
ACTHar in the Treatment of Lupus Nephritis
Systemic Lupus Erythematosus (SLE) is a disease in which the immune system attacks the healthy cells and tissues, causing inflammation that can damage organs in the body.
- Trial name
- ACTHar (NCT02226341)
- Testing
- CellCept, ACTHar gel
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Columbia University
Systemic Lupus Erythematosus
Validation of the Lupus Low Disease Activity State (LLDAS) in the Asia Pacific Region
Lupus Low Disease Activity State (LLDAS) study is an international, multi-centre prospective study, developed by the Asia Pacific Lupus Collaboration (APLC) to investigate whether the attainment of LLDAS is associated with…
- Trial name
- APLCLLDAS (NCT03138941)
- Where
- 20 sites in Australia, China and 9 more
- Volunteers
- 5,000 people
- Sponsor
- Monash University
Systemic Lupus Erythematosus
Sequential Belimumab and T-cell Based Therapy in SLE
Systemic lupus erythematosus (SLE) is a disease in which the immune system (the bodily system that fights infection) attacks the body's own cells and tissues, causing inflammation and organ damage if not promptly and…
- Trial name
- NCT04447053
- Testing
- Belimumab Injection [Benlysta]
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University Hospital, Singapore
Autoimmune Diseases, Autoinflammatory Diseases
Observational Study of Pediatric Rheumatic and Immunologic Diseases in China: The CAPRID Registry
An observational, multi-center, longitudinal registry study for Chinese pediatric patients with rheumatic and immunologic diseases.
- Trial name
- NCT06417502
- Where
- 9 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Peking Union Medical College Hospital
SLE - Systemic Lupus Erythematosus
CD19/BCMA CAR-T for SLE
The purpose of this clinical trial is to learn if CD19/BCMA CAR-T works to treat refractory SLE in adults. It will also learn about the safety and efficacy of the CD19/BCMA CAR-T cell product.
- Trial name
- NCT07266337
- Testing
- CD19/BCMA CAR T-cells
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Chengdu Ucello Biotechnology Co., Ltd.
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Congenital Heart Block, Neonatal Lupus
Preventive IVIG Therapy for Congenital Heart Block
Neonatal lupus (NL) is the name given to a group of conditions that can affect the babies of mothers who have certain autoantibodies against components of the body's cells that are called SSA/Ro and SSB/La.
- Conditions
- Congenital Heart Block, Neonatal Lupus, Autoantibody-associated Heart Block
- Trial name
- PITCH (NCT00460928)
- Testing
- intravenous immune globulin (IVIG)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- NYU Langone Health
Thrombocytopenia
Cyclophosphamide and Hydroxychloroquine for Thrombocytopenia in SLE
Treating severe thrombocytopenia is a challenge in the management of systemic lupus erythematosus. Although rheumatologists have followed some rules in real practice,there is very few evidence to support the current treatment…
- Trial name
- CHORUS (NCT02444728)
- Testing
- Hydroxychloroquine, Cyclophosphamide, Azathioprine
- Where
- 15 sites in China
- Volunteers
- 50 people
- Sponsor
- Chinese SLE Treatment And Research Group
Systemic Lupus Erythematosus
Cyclophosphamide and Rabbit Antithymocyte Globulin (rATG)/Rituximab in Patients With Systemic Lupus Erythematosus
This study is designed to examine whether treating patients with lupus with high dose cyclophosphamide together with rATG/rituximab (drugs which reduce the function of the immune system), followed by return of their previously…
- Trial name
- NCT00278538
- Testing
- Hematopoietic stem cell transplantation
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Northwestern University
Systemic Lupus Erythematosus (SLE)
Clinical Study of Cizutamig in Systemic Lupus Erythematosus
The purpose of this study is to assess the safety, tolerability, PK, PD, immunogenicity, and preliminary clinical activity of Cizutamig in patients with Systemic Lupus Erythematosus
- Trial name
- NCT07215663
- Testing
- Cizutamig
- Where
- 17 sites in China
- Volunteers
- 47 people
- Sponsor
- Candid Therapeutics
Systemic Lupus Erythematosus
AntiDFS70 Lupus Nephritis
Systemic lupus erythematous (SLE) is a heterogeneous autoimmune disease that involve many different organs and display a variable clinical course.
- Trial name
- NCT06119763
- Testing
- anti dfs70 antibodies
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Systemic Lupus Erythematosus (SLE)
Hematological Manifestations in Systemic Lupus Erythematosus Patients
The goal of this observational study is to evaluate hematological abnormalities among patients with systemic lupus erythematosus (SLE) admitted to a tertiary care center in Nepal.
- Trial name
- NCT06936007
- Where
- Nepal
- Volunteers
- 99 people
- Sponsor
- Patan Academy of Health Sciences
Systemic Lupus Erythematosus
A Study to Evaluate the Efficacy and Safety of Belimumab Administered in Combination With Rituximab to Adult Subjects With Systemic Lupus Erythematosus (SLE) - BLISS-BELIEVE
The purpose of this study is to assess whether co-administration of belimumab and a single cycle of rituximab will optimize treatment with belimumab, which will result in improvements of clinical status with a favorable safety…
- Trial name
- NCT03312907
- Testing
- Belimumab, Rituximab, Standard therapy (Including Immunosuppressants)
- Where
- 79 sites in United States, Argentina and 9 more
- Volunteers
- 292 people
- Sponsor
- GlaxoSmithKline
Systemic Lupus Erythematosus, Lupus Nephritis
An Open-label, Study to Assess Safety, Efficacy and Cellular Kinetics of YTB323 in Severe, Refractory Systemic Lupus Erythematosus
The study is intended to assess safety, efficacy and cellular kinetics of YTB323 treatment in participants with severe refractory systemic lupus erythematosus.
- Trial name
- NCT05798117
- Testing
- YTB323
- Where
- 10 sites in Australia, France and 3 more
- Volunteers
- 21 people
- Sponsor
- Novartis Pharmaceuticals
Systemic Lupus Erythematosus, Physical Activity
Activity and Nutrition Trial in Lupus to Energize and Renew
Participants from the Fatigue and Lifestyle Physical Activity and SLE Study will be approached to enroll in a 6 week pilot intervention.
- Conditions
- Systemic Lupus Erythematosus, Physical Activity, Sleep
- Trial name
- ANTLER (NCT02281513)
- Testing
- Smartphone Application, Fitbit Activity Monitor, Coaching Sessions
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Northwestern University
Lupus Nephritis
Open Label Pilot Trial of Rituximab in Lupus Membranous Nephritis
The objective of this study is to assess the as efficacy of rituximab as induction therapy in membranous lupus nephritis. Safety and tolerability will additionally be assessed.
- Trial name
- NCT00908986
- Testing
- Rituximab
- Sponsor
- Northwell Health
Systemic Lupus Erythematosus
A Study Describing the Efficacy and Safety of Belimumab Administered in Adult Participants With Early Systemic Lupus Erythematosus (SLE)
This is a prospective, open-label, single arm 3-year clinical study to describe the short-term and long-term efficacy and safety of belimumab in participants with autoantibody positive early SLE with ongoing disease activity…
- Trial name
- NCT06411249
- Testing
- Belimumab (GSK1550188)
- Where
- 104 sites in United States, Argentina and 9 more
- Volunteers
- 302 people
- Sponsor
- GlaxoSmithKline
Lupus Nephritis
Safety and Efficacy of Combination Belimumab and Voclosporin in the Treatment of Proliferative Forms of Lupus Glomerulopathy: Synergy Trial
This is a Phase IV, open-label, randomized trial to determine whether the combination of Belimumab (BEL) and Voclosporin (VCS), plus background therapy with Mycophenolate Mofetil (MMF), improves the proportion of patients with…
- Trial name
- SYNERGY (NCT07225387)
- Testing
- Voclosporin
- Where
- 7 sites in United States
- Volunteers
- 30 people
- Sponsor
- NephroNet, Inc.