Clinical trials: Lymph Node Metastases
Breast Cancer
Dose-Dense Chemotherapy Plus Bevacizumab in High Risk Lymph Node Positive Breast Cancer: A Pilot Study
This research focuses on women with breast cancer whose disease has not significantly progressed, but who have 5 or more lymph nodes involved.
- Trial name
- NCT00378638
- Testing
- bevacizumab combined with dose dense chemotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Chap, Linnea I., M.D.
Melanoma
RP1 in Primary Melanoma to Reduce the Risk of Sentinel Lymph Node Metastasis
This early-phase study will examine Vusolimogene Oderparepvec, a genetically modified oncolytic viral strain of the herpes simplex type 1 (HSV-1) virus, with potential oncolytic, immunostimulating and antineoplastic activities.
- Trial name
- NCT06216938
- Testing
- Vusolimogene oderparepvec (RP1)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yana Najjar
Cervical Cancer
Usefulness of FDG-PET for Advanced Cervical Cancer
The objective of this study is to determinate whether the adding of FDG-PET is helpful in the treatment of advanced cervical cancer with concurrent chemoradiation.
- Trial name
- NCT00146458
- Testing
- 18F-fluorodeoxyglucose positron emission tomography
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Esophageal Neoplasm, Esophageal Cancer TNM Staging Primary Tumor (T) T2
Efficacy of Intensity Modulated Radiation Therapy After Surgery in Early Stage of Esophageal Carcinoma;
The purpose of this study is to determine the efficacy of preventive intensity modulated radiation therapy after surgery in stage T2-3N0M0 disease of thoracic esophageal squamous cell carcinoma(UICC 7th edition) and to identify…
- Conditions
- Esophageal Neoplasm, Esophageal Cancer TNM Staging Primary Tumor (T) T2, Esophageal Cancer TNM Staging Primary Tumor (T) T3, Esophageal Cancer TNM Staging Regional Lymph Nodes (N) N0
- Trial name
- IMRT (NCT01745107)
- Testing
- Prophylactic postoperative radiation therapy
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese Academy of Medical Sciences
Head and Neck Melanoma
Targeted Silica Nanoparticles for Real-Time Image-Guided Intraoperative Mapping of Nodal Metastases
Current imaging devices usually detect cancer prior to surgery. However, these devices cannot be used during the surgical procedure to visualize lymph nodes with cancer (called "sentinel lymph nodes").
- Trial name
- NCT02106598
- Testing
- fluorescent cRGDY-PEG-Cy5.5-C dots
- Where
- 2 sites in United States
- Volunteers
- 67 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Cervix Neoplasms, Ovarian Neoplasms
Diagnostic Imaging of Lymph Nodes in Gynaecologic Oncology
The purpose of the study is to determine the diagnostic accuracy of a new magnetic resonance imaging (MRI) technique, the diffusion weighted imaging with body background signal suppression (DWIBS) in the detection of lymph node…
- Conditions
- Cervix Neoplasms, Ovarian Neoplasms, Endometrial Neoplasms, Vulvar Neoplasms
- Trial name
- NCT00288821
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- UMC Utrecht
Image-guide Surgery, Lymph Node Metastasis
Navigated Abdominal Lymph Node Dissections
Image-guided navigation surgery allows for full utilization of pre-operative imaging during surgery, and has the potential of reducing both irradical resections and morbidity.
- Trial name
- N16LND (NCT05867095)
- Testing
- Surgical navigation, Conventional
- Where
- Netherlands
- Volunteers
- 69 people
- Sponsor
- The Netherlands Cancer Institute
Oropharyngeal Cancer, Oral Cancer
Effectiveness of Adjuvant Radiotherapy in Small Oropharyngeal Squamous Cell Cancer and Single Lymph Node Metastasis.
Radiotherapy with or without adjuvant chemotherapy represents an important column of modern therapy in advanced squamous cell originated tumours of the head and neck.
- Conditions
- Oropharyngeal Cancer, Oral Cancer, Lymph Node Metastasis
- Trial name
- NCT00964977
- Testing
- Radiation therapy
- Where
- 49 sites in Germany, Netherlands and 1 more
- Volunteers
- 209 people
- Sponsor
- Johannes Gutenberg University Mainz
Vulvar Cancer, Lymph Node Metastasis
MRI and Magnetometer-guided Sentinel Lymph Node Detection in Vulvar Cancer
The aim of the feasibility study is to evaluate whether SPIO-MRI and a magnetometer could be a potential substitute to the routine dual technique in pre-and intraoperative SLN localization.
- Trial name
- POSVUC (NCT06273501)
- Testing
- Magtrace
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Lymph Nodes, Peritoneal Tumour
Histotripsy for Peritoneal Tumour and Lymph Node: a Pilot Study
Peritoneal cancer is tricky to be managed. It is not easy to be detected or diagnosed at early stage without symptom, or with common symptoms of many diseases or discomfort and often leads to advance stage at time of diagnosis…
- Trial name
- NCT07873619
- Testing
- Histotripsy
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The University of Hong Kong
Head and Neck Cancer, Lymph Node Metastases
Sentinel Node in Larynx and Pharynx Cancers
This study explores the feasibility of sentinel lymph node identification in pharynx and larynx cancers using flexible endoscopy-guided tracer injection.
- Trial name
- FLEX-NODE (NCT04068636)
- Testing
- Radioactive tracer injection via flexible endoscopy and SPECT scan for visualization of lymph nodes.
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center
Hepatocellular Carcinoma
Combination of SBRT, PD-L1 Inhibitor, and Lenvatinib in Hepatocellular Carcinoma (HSBRT2401)
Abdominal lymph node metastasis (LNM) is one of the major modes of extrahepatic metastasis in hepatocellular carcinoma (HCC). Immunotherapy targeting the PD-1/PD-L1 checkpoints combined with targeted therapy is the standard…
- Trial name
- HSBRT2401 (NCT06261125)
- Testing
- Stereotactic body radiotherapy, Adebrelimab, Lenvatinib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Mian XI
Breast Cancer, Breast Neoplasms
Augmented-Reality ICG Fluorescence Second-Look for Residual Nodal Disease After Axillary Dissection in Breast Cancer
This study tests whether special imaging goggles can help surgeons find lymph nodes that may be left behind during breast cancer surgery.
- Conditions
- Breast Cancer, Breast Neoplasms, Sentinel Lymph Node, Lymphatic Metastasis
- Trial name
- AR4SLN (NCT07696754)
- Testing
- Augmented-reality ICG fluorescence second-look imaging
- Where
- North Macedonia
- Volunteers
- 30 people
- Sponsor
- Ss. Cyril and Methodius University of Skopje
Metastasis Cervical Lymph Nodes of Unknown Primary Carcinoma
The Final Diagnosis and Treatment Result of Metastatic Cervical Carcinoma of Unknown Primary
Investigate the final diagnosis and treatment result of metastatic cervical carcinoma of unknown primary
- Trial name
- NCT00302588
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Head and Neck Cancer
Detection of Cervical Lymph Node Metastases With a High-Resolution Positron Emission Tomography (PET) Imaging System
The goal of this clinical research study is to learn if using the PEMFlex Solo II, a high-resolution camera for PET scan imaging, on an area of the body that has, or is suspected to have cancer will give researchers the same or…
- Trial name
- NCT01030497
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- M.D. Anderson Cancer Center
Melanoma, Skin Cancer
Interferon Alfa With or Without Combination Chemotherapy Plus Interleukin-2 in Treating Patients With Melanoma
RATIONALE: Interferon alfa may interfere with the growth of cancer cells. Interleukin-2 may stimulate a person's white blood cells to kill melanoma cells.
- Trial name
- NCT00002882
- Testing
- Aldesleukin (IL-2), Recombinant Interferon Alfa (IFN-A), Cisplatin
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- M.D. Anderson Cancer Center
Small Bowel Cancer, Small Bowel Carcinoid Tumor
Surgery With Extended (D3) Mesenterectomy for Small Bowel Tumors
The study is designed to investigate the safety and efficacy of central D3 lymphadenectomy in cases of small bowel tumors. Such dissection is under debate; consensus guidelines are vague when it comes to surgical techniques and…
- Conditions
- Small Bowel Cancer, Small Bowel Carcinoid Tumor, Quality of Life, Lymph Node Metastases
- Trial name
- NCT05670574
- Testing
- Surgery with extended (D3) mesenterectomy for small bowel tumors
- Where
- Norway
- Volunteers
- 150 people
- Sponsor
- Sykehuset i Vestfold HF
Thyroid Cancer
Selective Neck Dissection Versus Modified Neck Dissection in PTC
This study is a phase III, randomized controlled, open label non inferiority study. Patients who meet the inclusion criteria are randomly assigned 1:1 to either the experimental group (selective neck dissection) or the control…
- Trial name
- NCT06554652
- Testing
- Lymph node tracer navigated selective neck dissection, Modified neck dissection
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Fudan University
Lung Cancer
Fludeoxyglucose F 18 in Detecting Lymph Node Metastasis in Patients With Stage I or Stage II Non-Small Cell Lung Cancer That Can Be Removed by Surgery
RATIONALE: Diagnostic procedures using fludeoxyglucose F 18 and a surgical probe may help find lymph node metastases in patients with early-stage non-small cell lung cancer.
- Trial name
- NCT00732563
- Testing
- chemotherapy, lymphadenectomy, neoadjuvant therapy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Roswell Park Cancer Institute
Prostate Cancer, Lymph Node Cancer Metastatic
Study of Predicting Lymph Node Metastasis of High-risk Prostate Cancer by Artificial Intelligence Multi-omics Analysis
The pathological-omics and imaging-omics in this study are combined to construct an artificial intelligence (AI) model that can predict whether high-risk prostate cancer patients may have lymph node metastasis.
- Conditions
- Prostate Cancer, Lymph Node Cancer Metastatic, Artificial Intelligence (AI)
- Trial name
- NCT07112599
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Anhui Medical University