Clinical trials: Lymph Node Neoplasm
Prostate Cancer
High-Dose Lymph Node Intensity Modulated Radiation Therapy and Hypofractionated Prostate (SIB)
The purpose of this study is to find out the effects (good and bad) of using newer technologies that allow very precise delivery of radiation.
- Trial name
- SIB (NCT02177292)
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Medical College of Wisconsin
Breast Cancer, Muscle Strength
Effectiveness of PNF Training for Improving for Muscle Strength, Function, and Pain After Axillary Lymph Node Dissection
Breast cancer is the most common type of cancer affecting women of all ages worldwide. Advanced and comprehensive treatment options have increased survival rate and life expectancy, necessitating a focus on the complications of…
- Trial name
- NCT05288036
- Testing
- Proprioceptive Neuromuscular Rehabilitation group, Progressive Resistance Exercise Group, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Siewert Type II/III Gastroesophageal Junction Adenocarcinoma
Safety and Short-term Outcomes of Modular Robotic System for Siewert II/III Gastroesophageal Junction Cancer
Siewert type II/III gastroesophageal junction (GEJ) adenocarcinoma is a challenging malignancy located at the anatomical transition between the esophagus and stomach.
- Trial name
- ROBOT-GEJ (NCT07790809)
- Testing
- Robotic-assisted radical resection for Siewert type II/III gastroesophageal junction cancer
- Where
- China
- Volunteers
- 25 people
- Sponsor
- The First Hospital of Jilin University
Vaginal Cancer
Lymphoscintigraphy in Patients With Vaginal Cancer
Primary Objectives: 1. Determine the feasibility of using pretreatment lymphoscintigraphy to identify the sentinel lymph node(s) in patients with vaginal cancer dispositioned to receive radiation therapy. 2.
- Trial name
- NCT00528034
- Testing
- Lymphoscintigraphy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Central Nervous System Neoplasms, Central Nervous System Tumor
Mapping Draining Lymph Nodes in CNS Malignancies
The purpose of this research study is to determine whether the lymph nodes that drain a brain tumor can be detected by imaging after injection of a substance called Tc-99m tilmanocept directly into the brain tissue around the…
- Trial name
- NCT04096716
- Testing
- Tc-99m tilmanocept
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Washington University School of Medicine
Cancer, Shoulder Pain
Effectiveness of Oncological Physiotherapy on Painful Shoulder Cervical Ganglion in Head and Neck Cancer
Objective: To estimate whether oncological physiotherapy treatment with neurodynamic and kinesitherapy (passive and active) in patients with "painful shoulder due to accessory spinal nerve dissection" operated on for head and…
- Conditions
- Cancer, Shoulder Pain, Rehabilitation
- Trial name
- NCT05604235
- Testing
- Therapeutic upper limb strength exercise treatment, Treatment with passive and active mobilization of the upper limb.
- Where
- 3 sites in Spain
- Volunteers
- 20 people
- Sponsor
- University of Alcala
Breast Adenocarcinoma
Doxorubicin Hydrochloride, Cyclophosphamide, and Paclitaxel With or Without Bevacizumab in Treating Patients With Lymph Node-Positive or High-Risk, Lymph Node-Negative Breast Cancer
This randomized phase III trial studies doxorubicin hydrochloride, cyclophosphamide, and paclitaxel to see how well they work with or without bevacizumab in treating patients with cancer that has spread to the lymph nodes (lymph…
- Trial name
- NCT00433511
- Testing
- Bevacizumab, Cyclophosphamide, Doxorubicin Hydrochloride
- Where
- 842 sites in United States, Peru and 1 more
- Volunteers
- 4,994 people
- Sponsor
- National Cancer Institute (NCI)
Melanoma
Gene Expression Profiles and ctDNA for Risk Stratification in Patients With Melanoma
This study aims at assessing the role of MerlinTM and ctDNA in predicting the nodal status in patients with >pT3b melanoma, therefore candidate for adjuvant therapy regardless of sentinel lymph node status.
- Trial name
- CORRESPOND (NCT06566404)
- Volunteers
- 200 people
- Sponsor
- European Institute of Oncology
Breast Cancer
Evaluation of Magseed as Localization Device for Biopsy Proven Metastatic Axillary Lymph Nodes
Currently, breast cancer patients who are treated with neoadjuvant chemotherapy (NAC) before surgery may have a biopsy clip placed in the lymph node at the time of or shortly after percutaneous biopsy.
- Trial name
- NCT03718455
- Testing
- Axillary Magseed
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Cancer of the Breast
Axillary Reverse Mapping
We hypothesize that variations in anatomic location of the arm lymphatic drainage system put the arm lymphatics at risk for disruption during a SLNB and / or ALND.
- Trial name
- ARM (NCT00572481)
- Testing
- Axillary Reverse Mapping
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University of Arkansas
Colorectal Neoplasms
Follow-up After Oncological Resection by Endoscopic Colorectal ESD (Endoscopic Submucosal Dissection)
Colorectal cancer is a common and leading cause of death. Pre-cancerous lesions, as well as some so-called superficial cancers, can be resected via endoscopy.
- Trial name
- FORCE (NCT07871227)
- Testing
- Surgery, Radiochimiotherapy
- Where
- 14 sites in France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Bordeaux
Esophageal Squamous Cell Carcinoma
Adjuvant Chemotherapy in Combination With Tislelizumab in Lymph Node-Positive Esophageal Squamous Cell Carcinoma
Esophageal cancer is one of the most common malignancies in China, and esophageal squamous cell carcinoma (ESCC) is the predominant histological type.
- Trial name
- NCT05984342
- Testing
- Tislelizumab
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Affiliated Cancer Hospital of Shantou University Medical College
Lymph Node Metastasis, Colorectal Cancer
Clinical Trial Comparing Carnoy's and GEWF Solutions
Regional lymph node metastasis is a major determinant of local recurrence and overall survival rates in patients with colorectal cancer.
- Trial name
- NCT02704988
- Testing
- Carnoy Solution, GEWF Solution
- Where
- Brazil
- Volunteers
- 181 people
- Sponsor
- Hospital Moinhos de Vento
Lung Neoplasms, Lymph Node Excision
Mediastinal Lymph Node Dissection Versus Spared Mediastinal Lymph Node Dissection in Stage I GGN NSCLC
Lung cancer is the leading cause of cancer related death worldwide. Lobectomy or sub-lobectomy with mediastinal lymph node dissection is the standard surgery. About 50% lung nodules are pure ground-glass or part-solid nodules.
- Trial name
- NCT04631770
- Testing
- Systemic mediastinal lymph node dissection, Spared mediastinal lymph node dissection
- Where
- China
- Volunteers
- 1,362 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
NSCLC, Stage IV
Early Response Evaluation in NSCLC Patients Treated With Immunotherapy
A pilot study with biomarker exploration.50 patients with stage IV non-small cell lung cancer (NSCLC) that are eligible for treatment with nivolumab.
- Trial name
- NCT04082988
- Testing
- 18F-FDG PET-CT
- Where
- 2 sites in Netherlands
- Volunteers
- 9 people
- Sponsor
- The Netherlands Cancer Institute
Colonic Neoplasms
Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer
The study is a feasibility and validation study of the sentinel lymph node (SLN) procedure in all stages of colon cancer. If the SLN can be reliably identified, it could be submitted to a more accurate histopathological…
- Trial name
- NCT00826579
- Testing
- Sentinel lymph node procedure, Bone marrow aspiration
- Where
- 3 sites in Switzerland
- Volunteers
- 192 people
- Sponsor
- University Hospital, Basel, Switzerland
Oral Squamous Cell Carcinoma (OSCC)
Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell Carcinoma
This observational study will evaluate whether salivary interleukin-6 levels and selected interleukin gene polymorphisms are associated with regional lymph node involvement in patients with oral squamous cell carcinoma.
- Trial name
- IL6-OSCC (NCT07692360)
- Testing
- Saliva Collection and Biomarker Analysis
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- University of Pavia
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 2
Lymphedema is a chronic, debilitating disorder characterized by abnormal tissue swelling, adipose deposition and tissue fibrosis, resulting from disruption, blockage, or genetic abnormalities of the lymphatic system.
- Trial name
- EvaLymph-Leg2 (NCT05421377)
- Testing
- clinical assessment
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- KU Leuven
Lymphadenectomy, Endometrial Cancer
SENTInel Node Mapping Versus Comprehensive Lymphadenectomy in p53-Mutated Endometrial Cancer: A Non-Inferiority Randomized Trial
This study evaluates surgical strategies for treating patients with FIGO 2023 stage I and II high-risk endometrial cancer (EC) exhibiting p53 mutations.
- Conditions
- Lymphadenectomy, Endometrial Cancer, Gene, p53, Sentinel Lymph Node Biopsy (SLNB)
- Trial name
- SENTIMETREP53 (NCT06900582)
- Testing
- Sentinel Lymph Node Mapping, Comprehensive pelvic and para-aortic lymphadenectomy
- Volunteers
- 374 people
- Sponsor
- University Hospital, Strasbourg, France
Cancer of the Head and Neck
Positronic Emission Tomography (PET) Imaging in Post Radiation Evaluation of Head and Neck Tumours (PET PREVENT Trial)
The purpose of this trial is to determine the ability of positron emission tomography (PET) to detect residual cancer in neck lymph nodes of patients following curative treatment with radiation therapy for squamous cell cancer…
- Trial name
- NCT00147472
- Testing
- PET scan in addition to conventional CT imaging
- Where
- 4 sites in Canada
- Volunteers
- 400 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
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