Clinical trials: Lymph Node Neoplasm
Breast Cancer
Intraoperative Imaging of Lymph Nodes
One-third of the global population battles cancer, with surgery being the primary treatment for localized forms. Successful treatment often hinges on the thorough removal of primary tumors and pinpointing cancerous sentinel lymph…
- Trial name
- NCT06276439
- Testing
- Surgical removal of breast cancer and lymph nodes
- Where
- North Macedonia
- Volunteers
- 48 people
- Sponsor
- University of Illinois at Urbana-Champaign
Malignant Melanoma, Carcinoma, Squamous Cell
Post-Operative Drainage Following Lymph Node Dissection
The purpose of this study is to determine whether the use of fibrin sealant reduces post-operative drainage following groin and axillary lymph node dissection.
- Trial name
- NCT00324272
- Testing
- Fibrin Sealant (Tisseel) used in the Experimental Arm.
- Volunteers
- 74 people
- Sponsor
- Oxford University Hospitals NHS Trust
Pancreas Cancer, Pancreas Adenocarcinoma
Para-aortic Lymph Node Metastasis in Resectable Pancreatic Cancer
Lymph node metastases are a strong prognostic predictor for pancreatic cancer. Para-aortic lymph nodes (PALN) are the final nodes for periampullary cancers before the cancer cells enter the systemic lymphatic circulation.
- Conditions
- Pancreas Cancer, Pancreas Adenocarcinoma, Lymph Node Metastasis
- Trial name
- PALN (NCT06065891)
- Testing
- PALN resection
- Where
- 6 sites in Denmark, Sweden
- Volunteers
- 300 people
- Sponsor
- Jon Unosson
Breast Cancer, Sentinel Lymph Node
Impact of a Predictive Model on Sentinel Lymph Node Biopsy in Initially Lymph Node-positive, HER2-positive Breast Cancer
The aim of the study was to develop and validate a nomogram to assess axillary pathological complete response (pCR) in patients with initially lymph node-positive, human epidermal growth factor receptor 2 (HER2)-positive breast…
- Trial name
- NCT06149377
- Testing
- Test cohort
- Where
- China
- Volunteers
- 716 people
- Sponsor
- Fujian Medical University Union Hospital
Breast Neoplasms
Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast Cancer
RATIONALE: Patients with HER2-negative advanced breast cancer have limited choice on targeted therapies, and often show only modest responses to available immunotherapies.
- Trial name
- NCT05981001
- Testing
- Surgery for harvesting tumor-draining lymph nodes, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Breast Cancer
Current Value of Axillary Ultrasound in the Staging of Breast Cancer. Is BSGC Still Necessary?
AUS/FNAC allows the identification of tumors without axillary tumor involvement, or with low axillary tumor burden, many of which do not benefit from SLNB, in the staging of early breast cancer.
- Trial name
- NCT03193008
- Where
- Spain
- Volunteers
- 1,400 people
- Sponsor
- Corporacion Parc Tauli
Breast Cancer
Molecular Marker Profiling of Axillary Lymph Nodes in Predicting Response in Patients With Locally Advanced or Metastatic Breast Cancer Who Are Undergoing Chemotherapy Followed By Surgery
RATIONALE: Comparing results of diagnostic procedures, such as molecular marker profiling, done before and after chemotherapy, may help doctors predict a patient's response to treatment and help plan the best treatment.
- Trial name
- NCT00233974
- Testing
- PET (positron emission tomography)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Breast Neoplasms
Robotic-Assisted Versus Endoscopic-Assisted Axillary Lymph Node Dissection in Breast Cancer
This is a multicenter, retrospective observational study comparing the safety and efficacy of robotic-assisted versus endoscopic-assisted axillary lymph node dissection (ALND) in patients with node-positive breast cancer.
- Trial name
- NCT07693361
- Where
- 2 sites in China
- Volunteers
- 127 people
- Sponsor
- Guangzhou Women and Children's Medical Center
Lung Cancer
EBUS/Spectrum Analysis
To evaluate the clinical benefit of spectrum analysis of endobronchial ultrasound images of lymph nodes during EBUS TBNA for lymph node staging in patients with lung cancer.
- Trial name
- NCT01972386
- Testing
- Spectrum Image Analysis using a Linear Array Ultrasound Bronchoscope
- Where
- Canada
- Volunteers
- 122 people
- Sponsor
- University Health Network, Toronto
Melanoma, Lymph Node Cancer
CMP-001 in Combo With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease
The purpose this research study is to determine if the combination of nivolumab and CMP-001 improves the likelihood of eradicating (destroying) disease in the lymph node (pathologic response rate).
- Trial name
- NCT03618641
- Testing
- CMP-001, Nivolumab
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Diwakar Davar
Breast Cancer
Response-Based Local Therapy for Regionally Advanced Breast Cancer
The goal of this interventional clinical trial is to evaluate if an individualized treatment strategy (involving radiation boost, surgery, and systemic consolidation) can improve progression-free survival in patients with breast…
- Trial name
- NCT07376538
- Testing
- Response-adapted comprehensive treatment strategy
- Where
- China
- Volunteers
- 157 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Lung Cancer
Characteristics of Mediastinal Lymph Node With False Positive FDG PET/CT Results in Lung Cancer Staging : Relation With TB and Latent TB Infection
The purpose of this study is to analyze pathologic and radiologic characteristics of mediastinal lymph nodes with false positive FDG PET/CT results in lung cancer staging and assess relationship between false positive mediastinal…
- Trial name
- NCT01376856
- Where
- South Korea
- Volunteers
- 33 people
- Sponsor
- Yonsei University
Melanoma
Exploring an Alternative Pre-operative SLN Mapping Method Using a Magnetic Tracer and MRI for Melanoma Patients
Sentinel lymph node biopsy (SLNB) is crucial in the management of malignant melanoma treatment and is currently performed by pre-operatively inject a colloid nanomaterial labeled with Technetium (99mTc) as radioactive tracer.
- Trial name
- SCARLETT (NCT05145829)
- Testing
- Diagnostic Test: Sentinel node mapping using MRI
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Zuyderland Medisch Centrum
Endometrial Cancer, Lymph Node Metastases
Sentinel Node Mapping in High Risk Endometrial Cancer
This study will evaluate the role of systematic lymphadenectomy after sentinel node (SLN) mapping in high risk endometrial cancer (high grade histologies or deep myometrial invasion).
- Trial name
- ALICE (NCT03366051)
- Testing
- Sentinel Node Mapping, Lymphadenectomy
- Where
- 5 sites in Brazil
- Volunteers
- 178 people
- Sponsor
- AC Camargo Cancer Center
Refusal of Breast Surgery in Patients With Breast Cancer With a cCR After NST and a Confirmed Pathological Complete Response (pCR) Using VAB and SLNB
Refusal of Breast Surgery in Patients With Breast Cancer With a Clinical Complete Response (cCR) After Neoadjuvant Systemic Therapy and a Confirmed Pathological Complete Response (pCR) Using Vacuum-assisted Biopsy (VAB) and Sentinel Lymph Node Biopsy (SLNB)
The main goal of the study is to abandon breast surgery in patients with breast cancer with a clinical complete response (cCR) after neoadjuvant systemic therapy and confirmed pCR using Vacuum-assisted biopsy (VAB) and sentinel…
- Trial name
- VAB (NCT04293796)
- Testing
- Vacuum-assisted biopsy
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- N.N. Petrov National Medical Research Center of Oncology
Head Cancer, Neck Cancer
Study Comparing Lymphoseek® vs. Albumin Nanocolloid in Head and Neck, Melanoma and Breast Cancer
Comparison of the concordance of albumin nanocolloid and Lymphoseek® in the detection of lymph nodes of primary and secondary stage drainage by performing two lymphogammagrams
- Conditions
- Head Cancer, Neck Cancer, Melanoma, Breast Cancer
- Trial name
- SENTINELSEEK (NCT04261179)
- Testing
- Lymphoseek, Nanocoll
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Anna Cruceta
Ovarian Cancer, Sentinel Lymph Node
Sentinel Lymph Node Assessment in Ovarian Cancer (TRSGO-SLN-OO5)
The aim of the study to evaluate the feasibility and accuracy of sentinel lymph node technique in ovarian cancer.
- Trial name
- NCT04714931
- Testing
- Sentinel lymph node detection
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Mouth Neoplasms, Oral Cancers
Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative
The goal of this clinical trial is to compare the survival outcomes, morbidity and cost-effectiveness of sentinel node biopsy versus limited elective neck dissection in node-negative early oral cancers.
- Conditions
- Mouth Neoplasms, Oral Cancers, Oral Squamous Cell Carcinoma (OSCC), Oral Squamous Cell Carcinomas
- Trial name
- SECOND N0 (NCT05774483)
- Testing
- Sentinel Node Biopsy, Limited Elective Neck Dissection
- Where
- 3 sites in India
- Volunteers
- 508 people
- Sponsor
- Tata Memorial Hospital
Lymphedema, Lymphedema Arm
Reduction of Arm Volume and Improvement in Lymphedema Via Surgery
This clinical trial aims to evaluate the effectiveness of lymphatic microsurgical treatments in reducing limb volume in female patients with breast cancer-related lymphedema (BCRL).
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Arm, Lymphedema of Upper Limb
- Trial name
- REFRESH (NCT06606145)
- Testing
- Lymphovenous Anastomosis, Vascularized Lymph Node Transfer, Combined Lymphovenous Anastomosis and Vascularized Lymph Node Transfer
- Where
- Belgium
- Volunteers
- 179 people
- Sponsor
- Universitair Ziekenhuis Brussel
Breast Cancer
Dose-Dense Chemotherapy Plus Bevacizumab in High Risk Lymph Node Positive Breast Cancer: A Pilot Study
This research focuses on women with breast cancer whose disease has not significantly progressed, but who have 5 or more lymph nodes involved.
- Trial name
- NCT00378638
- Testing
- bevacizumab combined with dose dense chemotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Chap, Linnea I., M.D.
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