Clinical trials: Lymph Node Neoplasm
Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of Axillary
Optical Detection of Peripheral Nerve Bundles During Surgery
Investigation of application possibilities of optical spectroscopy within the field of surgical resection procedures to spare nerve tissue.
- Conditions
- Malignant Lymphoma of Lymph Nodes of Inguinal Region, Malignant Lymphoma of Lymph Nodes of Axillary, Malignant Lymphoma of Lymph Nodes of the Cervix, Carcinoma of Parotid Gland
- Trial name
- NerveSpect (NCT01731379)
- Testing
- Surgical resection
- Where
- Netherlands
- Volunteers
- 35 people
- Sponsor
- Philips Healthcare
Advanced Solid Tumor, Tumor Associated Lymph Node T Cell
Phase I Clinical Study of Tumor-associated Lymph Node T Cell Therapy for Advanced Solid Tumors
A total of 17 to 23 participants are anticipated to be enrolled in the Phase I clinical trial, which is further divided into two distinct parts: one part involves single-agent cell therapy, while the other entails a combination…
- Conditions
- Advanced Solid Tumor, Tumor Associated Lymph Node T Cell, Immunotherapy
- Trial name
- TAL-T (NCT06302062)
- Testing
- Tumor Associated Lymph node T cell, cyclophosphamide, IL-2
- Where
- China
- Volunteers
- 23 people
- Sponsor
- Guangzhou FineImmune Biotechnology Co., LTD.
Metastasis Cervical Lymph Nodes of Unknown Primary Carcinoma
The Final Diagnosis and Treatment Result of Metastatic Cervical Carcinoma of Unknown Primary
Investigate the final diagnosis and treatment result of metastatic cervical carcinoma of unknown primary
- Trial name
- NCT00302588
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Intrahepatic Cholangiocarcinoma (Icc), Adjuvant Chemoradiotherapy
A Prospective Phase II Study of Postoperative Concurrent Chemoradiotherapy in Patients With Intrahepatic Cholangiocarcinoma
This is a single-arm prospective phase II clinical trial to investigate the efficacy and safety of adjuvant concurrent chemoradiotherapy with simultaneous integrated boost following hepatectomy for intrahepatic cholangiocarcinoma…
- Conditions
- Intrahepatic Cholangiocarcinoma (Icc), Adjuvant Chemoradiotherapy, Narrow Margin, Lymph Node Involvement
- Trial name
- NCT07063888
- Testing
- Adjuvant Concurrent Chemoradiotherapy with Simultaneous Integrated Boost
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Breast Cancer
Oral Vinorelbine or Capecitabine Combined With Trastuzumab as Adjuvant Treatment for Patients With Lymph Node Negative, HER-2 Positive and Small Tumor Size Breast Cancer (ORCHID)
This is a prospective, open-lable Phase II clinical trial (ORCHID study) evaluating the effectiveness and safety of oral vinorelbine or capecitabine combined with trastuzumab as adjuvant treatment for patients with lymph node…
- Trial name
- ORCHID (NCT04296162)
- Testing
- Vinorelbine, Capecitabine, Trastuzumab
- Where
- China
- Volunteers
- 182 people
- Sponsor
- Fudan University
Stem Cell Transplantation, Leukemia
Thiotepa-Clofarabine-Busulfan With Allogeneic Stem Cell Transplant for High Risk Malignancies
Any time the words "you," "your," "I," or "me" appear, it is meant to apply to the potential participant. The goal of this clinical research study is to learn if thiotepa, busulfan, and clofarabine, when given before an…
- Conditions
- Stem Cell Transplantation, Leukemia, Lymphoma
- Trial name
- NCT00857389
- Testing
- Thiotepa, Clofarabine, Busulfan
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- M.D. Anderson Cancer Center
Thyroid Cancer, Papillary
The Efficacy and Safety of Prophylactic Central Lymph Node Dissection in Papillary Thyroid Carcinoma
The aim of this study is to investigate the efficacy and safety of prophylactic central lymph node dissection in papillary thyroid carcinoma.
- Trial name
- NCT02418390
- Testing
- prophylactic central lymph node dissection
- Where
- South Korea
- Volunteers
- 101 people
- Sponsor
- Seoul National University Hospital
Prostate Cancer
Dendreon Lymph Node Biopsy in Metastatic Castrate-Resistant Prostate Cancer
This study aims to evaluate patients with metastatic castrate-resistant prostate cancer (mCRPC) undergoing treatment with sipuleucel-T for evidence of treatment-associated immune activation in lymph nodes and peripheral blood.
- Trial name
- NCT02036918
- Testing
- Sipuleucel-T, Lymph Node Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Duke University
Breast Cancer
Clinical Application of Dual Sentinel Lymph Node Staining Method in Breast Cancer
This study aimed to evaluate the feasibility of dual sentinel node staining method using mixture of indocyanine green(ICG) and radioisotope (RI) in breast cancer patients who receive neoadjuvant chemotherapy.
- Trial name
- NCT02168452
- Testing
- sentinel lymph node biopsy(SLNB)
- Where
- South Korea
- Volunteers
- 5 people
- Sponsor
- National Cancer Center, Korea
Lymphadenopathy, Stage I Testicular Seminoma
Retroperitoneal Lymph Node Dissection in Treating Patients With Testicular Seminoma
This phase II trial studies how well retroperitoneal lymph node dissection (RPLND) works in treating patients with stage I-IIa testicular seminoma.
- Conditions
- Lymphadenopathy, Stage I Testicular Seminoma, Stage II Testicular Seminoma
- Trial name
- NCT02537548
- Testing
- Laboratory Biomarker Analysis, Retroperitoneal Lymph Node Dissection
- Where
- 14 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Southern California
Breast Cancer
Feasibility of One-Step Sentinel Lymph Node (SLN) Biopsy With Radiolabeled Methylene Blue (IND 70,627)
The purpose of this study is to develope a one-step procedure to perform a biopsy of axillary lymph nodes on the same side as the breast tumor in women diagnosed with breast cancer.
- Trial name
- NCT00784849
- Testing
- Methylene blue
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Lymph Node Metastases, Gastric Cancer
The Criteria for Lymph Node Sorting for Pathological Examination in Gastric Cancer
The aim of this study is intending to provide the optimal procedures of lymph node sorting for pathological examination after curative surgery for gastric cancer, which can discriminate the differences of the status of lymph node…
- Conditions
- Lymph Node Metastases, Gastric Cancer, Exanimation
- Trial name
- NCT03478449
- Testing
- lymph node sorting for pathological examination
- Where
- China
- Volunteers
- 276 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Breast Cancer
Evaluating the Ability of 99mTc-Tilmanocept to Identify Clipped Nodes in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy and Sentinel Lymph Node Dissection
The purpose of the present study is to evaluate the ability of 99mTc-TM to identify the clipped node after neoadjuvant chemotherapy (NAC) and to compare this percentage with historical national data.
- Trial name
- NCT05236387
- Testing
- 99m Tc-TM
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Carcinoma
Extent of Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma
Occult lymph node metastasis is common in micro papillary thyroid cancer. However, the role of lymph node dissection in the treatment of microPTC remains controversial.
- Trial name
- NCT01149161
- Testing
- Routine central neck dissection
- Where
- South Korea
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Head and Neck Cancer
Mapping of Sentinel Lymph Node Drainage Using SPECT (SUSPECT) (SUSPECT)
This study aims to explore the feasibility, safety and outcome of a non-invasive sentinel node mapping (SNM) to individually tailor the elective nodal irradiation (ENI) to the ipsilateral neck only and to exclude the…
- Trial name
- SUSPECT (NCT02572661)
- Testing
- radiation in Squamous Head and Neck Cancer
- Where
- Netherlands
- Volunteers
- 61 people
- Sponsor
- The Netherlands Cancer Institute
Sentinel Lymph Node, Early Gastric Cancer
Feasibility Study of Sentinel Navigation Surgery After Non-curative Endoscopic Resection
Purpose: To prove the feasibility of sentinel node navigation surgery (SNNS) in early gastric cancer patients with the risk of lymph node metastasis after endoscopic resection and preparation of multicenter phase 3 trial of…
- Trial name
- SENORITA2 (NCT03123042)
- Testing
- Sentinel basin dissection
- Where
- 9 sites in South Korea
- Volunteers
- 243 people
- Sponsor
- National Cancer Center, Korea
Vulvar Cancer
Ultrasound Morphometric and Cyto/Histological Combined Pre-operative Assessment of Inguinal Lymph Node Status in Women With Invasive Vulvar Carcinoma
Vulvar cancer is a rare and very aggressive cancer, mainly spreading through lymphatics, in which the preoperative evaluation is critical to address surgery between sentinel node biopsy or radical groin lymphadenectomy.
- Trial name
- Morpho-Node (NCT02988765)
- Testing
- Groin ultrasound +/- fine needle aspiration
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Catholic University of the Sacred Heart
Rectal Cancer, Radiotherapy
Short-Course Radiotherapy With Tumor-Draining Lymph Node Preservation Followed by PD-1 Inhibitors in pMMR/MSS Stage II-III Rectal Cancer
This study aims to evaluate the efficacy (pathological complete response rate) of short-course radiotherapy with preservation of tumor-draining lymph nodes followed by sequential PD-1 inhibitor neoadjuvant therapy in patients…
- Conditions
- Rectal Cancer, Radiotherapy, PD-1 Inhibitor
- Trial name
- PKUCH- R11 (NCT07394192)
- Testing
- short-course radiotherapy that preserves tumor-draining lymph nodes
- Volunteers
- 44 people
- Sponsor
- Peking University Cancer Hospital & Institute
Endometrial Cancer, Cervical Cancer
Determining the Sensitivity of Sentinel Lymph Nodes Identified With Robotic Fluorescence Imaging
Description: This is a multi-institutional study investigating the sensitivity and negative predictive value of sentinel lymph nodes mapped with robotic assisted near infrared imaging after cervical injection of indocyanine green…
- Trial name
- FIRES (NCT01673022)
- Testing
- IC Green
- Where
- 7 sites in United States
- Volunteers
- 430 people
- Sponsor
- Indiana University
Breast Cancer Metastatic, Breast Carcinoma
Immun Checkpoint Washout in Patients With Invasive Ductal Breast Cancer
Invasive ductal carcinoma is the most common type of invasive breast cancer. In cases where axillary lymph node metastases are diagnosed through screening, they can be found in up to 25% of cases, and in symptomatic cases, up to…
- Trial name
- NCT07003009
- Testing
- Malign Lymph Node Washout, Benign Lymph Node Washout
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul Training and Research Hospital