Clinical trials: Lymph Node Neoplasm
Castleman Disease, Multicentric Castleman Disease
Tocilizumab for KSHV-Associated Multicentric Castleman Disease
Background: Kaposi's sarcoma-associated herpes virus (KSHV)-associated multicentric Castleman disease (KSHV-MCD) is caused by a herpes virus known as KSHV.
- Conditions
- Castleman Disease, Multicentric Castleman Disease, Giant Lymph Node Hyperplasia
- Trial name
- NCT01441063
- Testing
- Zidovudine, Tocilizumab, Valganciclovir (VGC)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Cancer Institute (NCI)
Thyroid Cancer, Thyroidectomy With Central Lymph Node Dissection
Does Parathyroid Autofluorescence Reduces Unintensional Parathyroidectomy During Total Thyroidectomy With Central Lymph Node Compartment Dissection
The aim of the study is to evaluate the effectiveness of autofluorescence in the intraoperative preservation of parathyroids during total thyroidectomy with central lymph node compartment dissection.
- Trial name
- FLUOBCC (NCT04339478)
- Where
- 2 sites in Greece, Jordan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Lung Cancer
Molecular Assessment of Lymph Nodes in Patients With Resected (Stage I to IIIA) Non-small Cell Lung Cancer
This is a prospective study of surgically resected samples and lymph nodes of lung cancer patients. For histopathologically positive lymph nodes from a complete resection, the investigators would like to analyse tumor tissue by…
- Trial name
- NCT00213733
- Where
- 5 sites in France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Strasbourg, France
Mediastinal Lymphadenopathy, Non-small Cell Lung Carcinoma
Optical Biopsy for Thoracic Lymph Nodes.
EUS-FNA is the recommended diagnostic examination of choice when patients present with suspected lower mediastinal lymph nodes on imaging.
- Conditions
- Mediastinal Lymphadenopathy, Non-small Cell Lung Carcinoma, Sarcoidosis
- Trial name
- NCT02689050
- Testing
- Needle based confocal laser endomicroscopy (nCLE)
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Colon Cancer, Colon Surgery
Indocyanine Green (ICG) in the ex Vivo Detection of Sentinel Lymph Node (SLN)in Colon Cancer
Evaluation of the possibility to detect sentinel lymph node(s) after ex vivo Indocyanine Green injections around the tumour in pieces of colectomy from patients with colon cancer.
- Trial name
- 2068 (NCT01995591)
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- Jules Bordet Institute
Thyroid Cancer, Lymph Node Metastases
Predictive Factors of Lymph Node Metastasis in Patients With Papillary Microcarcinoma of the Thyroid
Papillary thyroid microcarcinoma (PTMC), defined as a tumor with larger diameter ≤ 1 cm, is considered a tumor with an indolent course and an excellent prognosis.
- Trial name
- NCT04274829
- Testing
- Thyroidecomt and lymphectomy
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Cagliari
Lymph Node Metastases, Non-small Cell Lung Cancer Stage I
Mediastinal Staging Accuracy of a Selective Lymphadenectomy Strategy in Early Stage NSCLC (ECTOP-1003)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-1003. Systemic mediastinal lymphadenectomy is deemed indispensable in lung cancer surgery for accurate staging and complete…
- Trial name
- NCT03216551
- Testing
- Intra-operative frozen section
- Where
- China
- Volunteers
- 1,076 people
- Sponsor
- Fudan University
Metastatic Cancer, Soft Tissue Sarcoma
A Clinical Trial Assessing BT-001 Alone and in Combination With Pembrolizumab in Metastatic or Advanced Solid Tumors
This is a Phase I/IIa, multicenter, open-label, consecutive cohorts, dose-escalation study of BT-001 with repeated IT administrations alone and in combination with IV infusions of pembrolizumab.
- Conditions
- Metastatic Cancer, Soft Tissue Sarcoma, Merkel Cell Carcinoma, Melanoma
- Trial name
- NCT04725331
- Testing
- BT-001, Pembrolizumab [KEYTRUDA®]
- Where
- 5 sites in Belgium, France
- Volunteers
- 31 people
- Sponsor
- Transgene
Breast Cancer
Multi-Beam Intensity-Modulated Radiation Therapy for Node-Positive Breast Cancer
This study is being performed to understand the safety of a new radiation treatment called "Multi-Beam Intensity Modulated Radiation Therapy" ( IMRT).
- Trial name
- NCT01127373
- Testing
- Multi-Beam Intensity-Modulated Radiation Therapy, BreastQ questionnaire-
- Where
- 7 sites in United States
- Volunteers
- 116 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sentinel Lymph Node
Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in Initially Node Positive Breast Cancer Patients, Could it Omit Axillary Dissection ?
The aim of this study is to determine the accuracy and safety of SLNB after neoadjuvant chemotherapy.
- Trial name
- NCT06130241
- Testing
- sentinle lymphnode biopsy
- Volunteers
- 30 people
- Sponsor
- Assiut University
Breast Cancer, Female
99mTc-ADAPT6 SPECT-based Non-invasive Quantification of HER2-expression in Breast Cancer With Metastatic Lymph Nodes
An open-label, single center study with 99mTc-ADAPT6 SPECT and biopsies of primary tumour and metastatic lymph nodes in breast cancer patients, where the primary endpoint of the study is to find out the correlation between the…
- Trial name
- 99mTc-ADAPT6 (NCT05412446)
- Testing
- ADAPT6-SPECT
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Uterine Cervical Neoplasms
LESs Surgical Radicality for EaRly Stage Cervical Cancer
This study is an open-label, multicenter, randomized, phase II non-inferiority trial (proof of concept study). Its purpose is to evaluate the safety and efficacy of extrafascial hysterectomy plus pelvic-lymph node dissection…
- Trial name
- LESSER (NCT02613286)
- Testing
- Extrafascial Hysterectomy, Modified radical hysterectomy
- Volunteers
- 40 people
- Sponsor
- Hospital de Câncer de Pernambuco
Breast Cancer
Proton Therapy for Lymph Nodes in Breast Cancer
The purpose of this study is to determine if proton radiation therapy will reduce the amount of heart that is exposed to radiation, thereby decreasing the frequency and/or severity of any cardiac side effects.
- Trial name
- BR01 (NCT01365845)
- Testing
- Photon, 3D-Proton/Conventional plan or 3D-proton only
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Florida
Porocarcinoma, Sentinel Lymph Node
Sentinel Lymph Node Biopsy in Porocarcinoma
Eccrine porocarcinoma (EPC) is a slow-growing carcinoma arising from the eccrine sweat glands. Based on its clinical presentation it can be confused with malignant and benign skin lesions, both.
- Trial name
- NCT03647631
- Testing
- sentinel lymph node biopsy
- Where
- Italy
- Volunteers
- 2 people
- Sponsor
- Ospedale Policlinico San Martino
Breast Cancer
Prospective Pilot Study ANDPrecise
This study aims at providing first evidence that axillary clearance by using an operation technique including the precise LigaSure instrument and closure of dead space of the axilla will result in an operation were a drain is not…
- Trial name
- ANDPrecise (NCT02292407)
- Testing
- LigaSure Precise instrument
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- The Netherlands Cancer Institute
Breast Cancer, Sentinel Lymph Node
Sentinel Node Localization and Staging with Low Dose Superparamagnetic Iron Oxide
Sentinel lymph node (SLN) status is pivotal for treatment decisions in breast cancer patients. The dual technique with Technetium99m (Tc99) and blue dye (BD) is yet the current routine for SLN detection.
- Trial name
- MAGSNOW (NCT05359783)
- Testing
- Superparamagnetic Iron Oxide
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Vastra Gotaland Region
Sentinel Lymph Node, Ovarian Cancer Stage I
SEntine Lymph Node in earLY Ovarian Cancer (SELLY)
The present study aims at investigating the feasibility, the detection rate and the negative predictive value of sentinel node in predicting the presence or absence of lymph node metastasis in ovarian cancer patients
- Trial name
- SELLY (NCT03563781)
- Testing
- Sentinel node detection
- Where
- Italy
- Volunteers
- 176 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Melanoma (Skin)
Studying Tumor Tissue Samples From Patients With Melanoma Who Have Undergone Sentinel Lymph Node Biopsy
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT00897481
- Testing
- gene expression analysis, mutation analysis, diagnostic laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Leeds Cancer Centre at St. James's University Hospital
Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms
Station-Specific Lymph Node Metastasis After Neoadjuvant Chemoimmunotherapy for Middle Thoracic Esophageal Squamous Cell Carcinoma
Neoadjuvant chemoimmunotherapy (NCIT) is increasingly used for locally advanced esophageal squamous cell carcinoma (ESCC). However, the station-specific distribution of residual lymph node metastasis after NCIT remains…
- Conditions
- Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms, Metastasis
- Trial name
- NCT07902544
- Volunteers
- 717 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Breast Cancer
Axillary Radiotherapy for Early Stage Breast Cancer With Limited Positive Sentinel Lymph Nodes
This study is designed to evaluate the feasibility and safety of axillary radiotherapy for early stage breast cancer with limited positive sentinel lymph nodes.
- Trial name
- NCT02612012
- Testing
- axillary radiotherapy
- Where
- China
- Volunteers
- 475 people
- Sponsor
- Fudan University