Clinical trials: Lymph Node Neoplasm
Mouth Neoplasms, Oral Cancers
Sentinel Node Biopsy Versus Limited Elective Neck Dissection in Early Cancers of Oral Cavity NoDe Negative
The goal of this clinical trial is to compare the survival outcomes, morbidity and cost-effectiveness of sentinel node biopsy versus limited elective neck dissection in node-negative early oral cancers.
- Conditions
- Mouth Neoplasms, Oral Cancers, Oral Squamous Cell Carcinoma (OSCC), Oral Squamous Cell Carcinomas
- Trial name
- SECOND N0 (NCT05774483)
- Testing
- Sentinel Node Biopsy, Limited Elective Neck Dissection
- Where
- 3 sites in India
- Volunteers
- 508 people
- Sponsor
- Tata Memorial Hospital
Diagnosis, Axilla; Breast
Benign-Malign Differentiation of Axillary Lymph Nodes: The Role Of Superb Microvascular Imaging
102 patients who have suspicious ALNs were included in our prospective study, which was approved by a tertiary health care facility ethics committee.
- Trial name
- NCT05927727
- Testing
- Ultrasound and biyopsy
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ankara Education and Research Hospital
Invasive Breast Cancer, Ductal Carcinoma in Situ of the Breast
Axillary Reverse Mapping (ARM) Technique
The purpose of this pilot study is to compare a new surgical technique (axillary reverse mapping) to standard axillary surgery in patients diagnosed with invasive or in situ breast cancer.
- Trial name
- ARM (NCT03109522)
- Testing
- axillary reverse mapping (ARM), Standard axillary surgery (SLNB or ALND)
- Where
- 2 sites in Canada
- Volunteers
- 130 people
- Sponsor
- McMaster University
Colon Cancer, Lymph Node Metastasis
Italian Study on the Right Hemicolectomy: How the Lymphadenectomy is Performed
The objective of the study is the analysis of lymphadenectomy in the course of right hemicolectomy, in relation to the radicality of the surgical resection that is performed.
- Conditions
- Colon Cancer, Lymph Node Metastasis, Surgical Procedure, Unspecified
- Trial name
- CoDIG-2 (NCT05943951)
- Testing
- Right hemicolectomy
- Where
- 62 sites in Italy
- Volunteers
- 788 people
- Sponsor
- Gabriele Anania
Immune Microenvironment, Luminal A
Tumor Immune Mechanism of Axillary Lymph Node Metastasis in Early Luminal Type A Breast Cancer
Luminal type A breast cancer is a type with good clinical prognosis, and the proportion of lymph node metastasis is low, but a small number of patients have more lymph node metastasis when the primary tumor is very small, and the…
- Conditions
- Immune Microenvironment, Luminal A, Lymph Node Metastases
- Trial name
- NCT04322331
- Testing
- no intervention
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Peking University People's Hospital
Head and Neck Cancer
Dynamic Contrast Enhanced Computed Tomography (CT) for Head and Neck Cancer
For patients undergoing treatment for head and neck cancer, this study will use dynamic contrast-enhanced CT scans to try to determine which lymph nodes in the neck contain cancer and require surgical removal.
- Trial name
- NCT01549379
- Testing
- Dynamic Contrast Enhanced CT scan
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Prostate Cancer
Multispectral Fluorescence as a Tool to Separate Healthy and Disease Related Lymphatic Anatomies in Prostate Cancer.
Multispectral imaging of the lymphatic draining pattern of the tumor and the abdominall wall/lower limb to evaluate technical feasibility to differentiate these patterns and in the future reduce the amount of complications that…
- Trial name
- SPLIT (NCT05120973)
- Testing
- multispectral imaging, fluorescence for lymphatic mapping
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- The Netherlands Cancer Institute
Chemotherapy Effect, Chemotherapeutic Toxicity
Apatinib Plus XELOX as Neoadjuvant Therapy in Locally Advanced Gastric Cancer
Apatinib plus XELOX regime as Neoadjuvant Therapy in Locally Advanced Gastric Cancer PatientsWith lymph node metastasis
- Conditions
- Chemotherapy Effect, Chemotherapeutic Toxicity, Gastric Cancer
- Trial name
- NCT03229096
- Testing
- Apatinib plus XELOX
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Shanghai Zhongshan Hospital
Melanoma
Study of Neo-adjuvant Use of Vemurafenib Plus Cobimetinib for BRAF Mutant Melanoma With Palpable Lymph Node Metastases
This study will evaluate the clinical and pathological response to vemurafenib and cobimetinib in the neoadjuvant treatment of patients with histologically confirmed, BRAF V600 mutation-positive Stage IIIB and C melanoma.
- Trial name
- NCT02036086
- Testing
- Vemurafenib, Cobimetinib
- Where
- 3 sites in Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Lymphedema, Breast Cancer
Arm Circumference Measurement With or Without Bioimpedance Spectroscopy in Finding Lymphedema Early in Patients With Stage I-III Breast Cancer
This randomized pilot clinical trial studies arm circumference measurement with or without bioimpedance spectroscopy in finding extra lymph node fluid build up in the arm (lymphedema) early in patients with stage I-III breast…
- Trial name
- NCT03648983
- Testing
- arm circumference measurement, Bioimpedance spectroscopy
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Albert Einstein College of Medicine
Cervical Cancers
A Clinical Study Comparing Chemotherapy Combined With PD-1 Inhibitor Versus Concurrent Chemoradiotherapy in Cervical Cancer Patients With Positive Lymph Nodes After Surgery: A Multicenter Randomized Controlled Clinical Trial
This study aims to conduct a prospective, multicenter, randomized controlled trial targeting patients with cervical cancer who have been pathologically confirmed to have lymph node metastasis after surgery.
- Trial name
- NCT06866951
- Testing
- Chemo-immunotherapy, CCRT
- Where
- China
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Patients Who Underwent Gastrectomy With Lymph Node Dissection for Gastric Cancer
Postoperative Morbidity and Mortality After Gastrectomy for Gastric Cancer: Prospective Cohort Study
Gastric cancer is still one of the main health care issue and gastrectomy with lymph node dissection is the only chance to be cure.
- Trial name
- NCT01919242
- Testing
- gastrectomy
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Esophageal Cancer
Celecoxib, Paclitaxel, and Carboplatin in Treating Patients With Cancer of the Esophagus
RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00066716
- Testing
- carboplatin, celecoxib, paclitaxel
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Weill Medical College of Cornell University
Rectal Cancer
Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Rectal Cancer
This is a single-arm, prospective, multicenter study evaluating a novel neoadjuvant treatment strategy for patients with early, mid-low rectal adenocarcinoma that is microsatellite stable (MSS).
- Trial name
- mRCAT-E (NCT07068763)
- Testing
- Lymph-node-sparing short-course radiotherapy, Capecitabine, PD-1/CTLA-4 inhibitor (Aiparolitoworixureli injection)
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Sir Run Run Shaw Hospital
Malignant Melanoma, Merkel Cell Carcinoma
Lymph Node Identification in Skin Malignancy Using ICG Transcutaneously Study
A diagnostic sensitivity study comparing intradermal indocyanine green (ICG) and near infrared fluorescence imaging (NIRFI) with intradermal technetium 99m and traditional lymphoscintigraphy (LS) for transcutaneous identification…
- Trial name
- LIMIT (NCT03545334)
- Testing
- Visionsense™ VS3 - Stereoscopic High Definition Visualisation System (VS3-3DHD)
- Where
- Switzerland
- Volunteers
- 93 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Gastric Cancer Stage II, Gastric Cancer Stage III
Investigation of Impact of Indocyanine Green on Volume of Lymphadenectomy in Resectable Gastric Cancer
The study aims to evaluate the safety and benefits of using indocyanine green in lymph node dissection for gastric cancer surgery. The primary endpoint is the average number of lymph nodes removed.
- Conditions
- Gastric Cancer Stage II, Gastric Cancer Stage III, Gastric Cancer, Gastrectomy for Gastric Cancer
- Trial name
- ICGastr (NCT06755554)
- Testing
- Endoscopic injection of Indocyanine green
- Where
- 2 sites in Ukraine
- Volunteers
- 105 people
- Sponsor
- Ukrainian Society of Clinical Oncology
Endometrial Cancer
Pre-operative Studies for Prediction of Lymph Nodes Involvement in Endometrial Cancer Patients
The study evaluates pre-operative prediction of the risk for lymph nodes involvement in endometrial cancer patients. Patients will undergo ultrasound exam (bi and three dimensional) and biomarker test - Ca 125, in addition to…
- Trial name
- NCT02560571
- Testing
- ultrasound, blood test
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Lung Cancer (NSCLC)
Ultrasound-guided Cryobiopsy of Mediastinal/Hilar Lymph Nodes
EBUS-guided cryobiopsy of mediastinal and hilar lymph nodes has shown to be a useful diagnostic tool to obtain tissue for histological analysis and further targeted therapies in lung malignancies.
- Trial name
- NCT06921681
- Testing
- Cryobiopsy of lymph nodes group 6 sec, Cryobiopsy lymphnode group 3 sec
- Where
- Switzerland
- Volunteers
- 136 people
- Sponsor
- University of Zurich
Colon Cancer
Comparison of D2 vs D3 Lymph Node Dissection for Right Colon Cancer (RICON)
Comparing different method of surgical technique D2 lymph node dissection vs D3 for right colon cancer.
- Trial name
- NCT03200834
- Testing
- Right Hemicolectomy with D2 lymph node dissection, Right Hemicolectomy with D3 lymph node dissection
- Where
- Ukraine
- Volunteers
- 239 people
- Sponsor
- G.V. Bondar Republican Cancer Center
Breast Neoplasms
Gadofosveset for Axillary Staging in Breast Cancer Patients
The aim of this pilot-study is to examine the accuracy of gadofosveset enhanced MRI compared to current nodal staging methods. The accuracy of MRL will be determined on the basis of a node-to-node matching of imaged nodes to the…
- Trial name
- NCT01437865
- Testing
- Gadofosveset contrast agent enhanced MRI Axilla
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.