Clinical trials: Lymph Node Neoplasm
Chronic Lymphocytic Leukemia
Lymph Node Microenvironment Modifications in Patients With CLL Treated With Venetoclax-based Regimens
CLL subjects who should receive treatment with a venetoclax-based regimen as per standard of care will be enrolled into this trial, after providing informed consent.
- Trial name
- LymBIO (NCT04790045)
- Testing
- Venetoclax
- Volunteers
- 30 people
- Sponsor
- Paolo Ghia
Stomach Neoplasms
Robotic Total Gastrectomy for Locally Advanced Proximal Gastric Cancer
The purpose of this study is to explore the clinical Efficacy of robotic assisted spleen-preserving No. 10 lymph node dissection for patients with locally advanced upper third gastric adenocarcinoma（cT2-4a, N-/+, M0）.
- Trial name
- NCT03524287
- Testing
- Robotic Assisted No.10 Lymph Node Dissections
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Fujian Medical University
Ocular Sebaceous Carcinoma, Ocular Basal Cell Carcinoma
Sentinel Lymph Node Biopsy in Ocular Surface and Adnexal Cancers
The study involves enrollment of patients with sebaceous carcinoma, Merkel's carcinoma, Porocarcinoma, Melanoma, and squamous cell Ca of the ocular surface and adnexa both primary and relapsed after surgical and/or…
- Conditions
- Ocular Sebaceous Carcinoma, Ocular Basal Cell Carcinoma, Ocular Surface Squamous Neoplasia, Merkel Cell Carcinoma, Unspecified
- Trial name
- BLS (NCT05797415)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ovarian Cancer, Lymph Node Metastasis
Magtrial: Magtrace® as Tracer for Sentinel Lymph Node Detection in Early Stage Epithelial Ovarian Cancer
Epithelial ovarian cancer (EOC) remains the tumour with the most unfavourable prognosis within the field of gynaecological oncology.
- Trial name
- NCT05375526
- Testing
- Magtrace
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Maastricht University Medical Center
Follicular Lymphoma
CD180 Overexpression in Follicular Lymphoma
Background:Altered Toll-like receptor (TLR) expression levels and/or mutations in its signaling pathway (such as MyD88 mutation) contribute to the pathogenesis of lymphoproliferative disorders (LPD).
- Trial name
- NCT02978898
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Breast Cancer
Feasibility of One-Step Sentinel Lymph Node (SLN) Biopsy With Radiolabeled Methylene Blue (IND 70,627)
The purpose of this study is to develope a one-step procedure to perform a biopsy of axillary lymph nodes on the same side as the breast tumor in women diagnosed with breast cancer.
- Trial name
- NCT00784849
- Testing
- Methylene blue
- Where
- 2 sites in United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Breast Cancer
Evaluation of NeoNavia® Biopsy System in Axillary Lymph Nodes
The aim of the study is to document performance characteristics of a biopsy device indicated for use in axillary lymph nodes, to provide basic insights into the complexity of axillary biopsy procedures and generate hypothesis for…
- Trial name
- PULSE (NCT03975855)
- Testing
- NeoNavia® Biopsy System
- Where
- 7 sites in Germany
- Volunteers
- 140 people
- Sponsor
- NeoDynamics AB
Differentiated Thyroid Cancer, Lymph Node Metastases
Thyroglobulin Point of Care Assay for Rapid Detection of Metastatic Differentiated Thyroid Carcinoma
Background: Despite a favorable prognosis, metastatic cervical lymph nodes (LN), are not uncommon among patients with differentiated thyroid cancer (DTC).
- Trial name
- NCT05078853
- Testing
- Point of care assay for thyroglobulin (POC-Tg) evaluation of a suspected cervical lymph node
- Where
- 5 sites in Israel
- Volunteers
- 250 people
- Sponsor
- Soroka University Medical Center
Lung Cancer, Lymph Node Metastasis
Maximizing Lymph Node Dissection on Fresh and Fixed Lung Cancer Resection Specimens
Lung cancer patients undergoing upfront surgery, highly benefit from a systematic lymph node dissection in the mediastinum and in the surgical specimens. The latter is performed by the pathologist.
- Conditions
- Lung Cancer, Lymph Node Metastasis, Pathologic Processes
- Trial name
- NCT06252129
- Testing
- Subjects undergoing a lung specimen lymph node dissection, Control group
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Anatomic Stage III Breast Cancer AJCC v8, Breast Inflammatory Carcinoma
Lymphovenous Bypass Procedure Before Underarm Lymph Node Surgery in Preventing Lymphedema in Patients With Inflammatory or Locally Advanced Non-inflammatory Breast Cancer or Melanoma
This pilot trial studies whether a procedure called lymphovenous bypass would prevent lymphedema (arm swelling) in patients with inflammatory breast cancer or non-inflammatory breast cancer that has spread to nearby tissues or…
- Conditions
- Anatomic Stage III Breast Cancer AJCC v8, Breast Inflammatory Carcinoma, Locally Advanced Breast Carcinoma, Melanoma
- Trial name
- NCT03941756
- Testing
- Indocyanine Green, Lymphangiography, Lymphovenous Bypass
- Where
- United States
- Volunteers
- 252 people
- Sponsor
- M.D. Anderson Cancer Center
Non-small Cell Lung Cancer
The Accuracy of Targeted Lymph Node Dissection of Non-small Cell Lung Cancer Patients According to Predictive Models
Investigators combined the clinical and radiomics characteristics of resectable non-small cell lung cancer patients to construct an accurate model for preoperative prediction of mediastinal lymph node status.
- Trial name
- NCT06768853
- Testing
- Lymph node dissection based on the guidelines, Lymph node dissection based on the model
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhongnan Hospital
Ovarian Cancer, Sentinel Lymph Node
Sentinel Lymph Node Assessment in Ovarian Cancer (TRSGO-SLN-OO5)
The aim of the study to evaluate the feasibility and accuracy of sentinel lymph node technique in ovarian cancer.
- Trial name
- NCT04714931
- Testing
- Sentinel lymph node detection
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Acibadem University
Breast Cancer
The OPBC-07/microNAC Study
The aim of this multicenter retrospective cohort study is to determine the safety of omission of axillary lymph node dissection in patients with residual micrometastases after neoadjuvant chemotherapy.
- Trial name
- NCT06529302
- Where
- 84 sites in United States, Argentina and 28 more
- Volunteers
- 2,000 people
- Sponsor
- University Hospital, Basel, Switzerland
Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling
Sentinel Lymph Node Sampling for Patients With Middle-high Risk Endometrial Cancer Confined to the Uterus
Aim To investigate the effect of sentinel lymph node (SLN) sampling on the prognosis of patients with middle-high risk endometrial cancer obviously confined to the uterus before surgery.
- Conditions
- Middle-high Risk Endometrial Cancer, Sentinel Lymph Node Sampling, Prognosis
- Trial name
- NCT04276532
- Testing
- sentinel lymph node sampling (SLN), pelvic lymphonodectomy (PLN)
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Xiaojun Chen
Breast Cancer
Internal Mammary Sentinel Lymph Node Biopsy in Early Breast Cancer Patients With Clinically Axillary Node -Positive
In addition to the axillary lymph nodes, the internal mammary lymph nodes (IMLNs) drainage is another important lymphatic channel of the breast.
- Trial name
- IMSLNB-CANP (NCT01668914)
- Testing
- IM-SLNB, 99mTc-SC, Histologic Examination
- Where
- China
- Volunteers
- 126 people
- Sponsor
- Shandong Cancer Hospital and Institute
Breast Cancer
Sentinel Lymph Node Biopsy Using Peritumoral Injection With Blue Dye Confirmation
We continue to collect information in support of the hypothesis that the histology of the first draining lymph node (sentinel node) accurately predicts the histology of the rest of the axillary lymph nodes.
- Trial name
- NCT00575744
- Testing
- Sentinel Node Biopsy
- Where
- United States
- Volunteers
- 699 people
- Sponsor
- University of Arkansas
Esophageal Squamous Cell Carcinoma (ESCC)
TDLN-Guided Lymphadenectomy After Neoadjuvant Immunochemotherapy for ESCC
This is a prospective, multicenter, observational cohort study of patients with esophageal squamous cell carcinoma who have received neoadjuvant immunochemotherapy and are scheduled to undergo curative esophagectomy with standard…
- Trial name
- NCT07697898
- Testing
- Curative Esophagectomy With Systematic Lymphadenectomy
- Volunteers
- 400 people
- Sponsor
- Tongji Hospital
Lung Cancer, Cancer of Lymph Node
Strategy of Surgical Resection With Adjuvant Therapy for IIIA NSCLC and N2 Disease Only in Subaortic or Paraaortic Level
The purpose of this study is to identify the treatment outcomes of surgical resection with sequential adjuvant chemotherapy and radiotherapy in patients with stage IIIA non-small cell lung cancer and N2 disease at only the sub…
- Conditions
- Lung Cancer, Cancer of Lymph Node, Effects of Chemotherapy, Surgery
- Trial name
- NCT02555592
- Testing
- Primary surgical resection with sequential adjuvant therapy
- Where
- South Korea
- Volunteers
- 25 people
- Sponsor
- Pusan National University Hospital
Breast Cancer Lymphedema
Effect of the Axillary Lymphatic /Vein Reflux Ratio on Postoperative Upper Limb Edema and Dysfunction in Breast Cancer
The purpose of this study is to compare the difference in the incidence of upper limb edema and dysfunction between the Preponderant lymphatic reflux group (high ratio of axillary lymphatic reflux to axillary vein reflux) and the…
- Trial name
- PLEDGE-R (NCT05246592)
- Testing
- Branches Sparing, None Branches Sparing
- Where
- 3 sites in China
- Volunteers
- 258 people
- Sponsor
- Xiangyun Zong
Head and Neck Cancer, Lymph Node Metastases
Sentinel Node in Larynx and Pharynx Cancers
This study explores the feasibility of sentinel lymph node identification in pharynx and larynx cancers using flexible endoscopy-guided tracer injection.
- Trial name
- FLEX-NODE (NCT04068636)
- Testing
- Radioactive tracer injection via flexible endoscopy and SPECT scan for visualization of lymph nodes.
- Where
- Netherlands
- Volunteers
- 16 people
- Sponsor
- Radboud University Medical Center