Clinical trials: Lymph Node Neoplasm
Breast Cancer, Early-Stage Invasive Breast Carcinoma
Radiotherapy and Long-term Outcomes in Early Breast Cancer With SLNB Omission
This prospective, multicenter observational cohort study evaluates long-term outcomes in patients with early-stage invasive breast cancer who undergo breast-conserving surgery without sentinel lymph node biopsy or other axillary…
- Trial name
- APROOB Cohort (NCT07803081)
- Testing
- Adjuvant Breast Radiotherapy
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Samsung Medical Center
Breast Neoplasms, Breast Diseases
Clinical Evaluation of OSNA Breast Cancer System to Extensive Frozen Section Histopathology
The study will determine the sensitivity, specificity, negative predictive value and positive predictive value of the OSNA Breast Cancer System by comparing its performance to an extensive intraoperative frozen section protocol…
- Trial name
- NCT01368744
- Testing
- OSNA Breast Cancer System
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Sysmex America, Inc.
Gastric Carcinoma
The Clinical Significance of Examining Metastatic Lymph Nodes in Individual Gastric Mesenteries in the Patients With Gastric Cancer Undergoing Gastrectomy
This study aims to examine the predictive value of metastatic gastric mesenteries, which contains metastatic lymph node, in 6 gastric mesenteries; and importantly, to further evaluate the relationship between the number of…
- Trial name
- NCT07139418
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Jichao Qin
Breast Cancer
Fluorescent Dyes for Lymph Node Mapping
The goal of this clinical research study is to find lymph nodes before surgery using a dye called indocyanine green (IC-Green). Objectives: 1.
- Trial name
- NCT01095913
- Testing
- Indocyanine green (ICG)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer Metastatic, Prostate Cancer
Dutch National Randomized Study: PSMA-PET/CT As a Triage Tool for Pelvic Lymph Node Dissection in Prostatectomy Patients
To determine if the use of Prostate-Specific Membrane Antigen Positron Emission Computer Tomography (PSMA PET/CT) as a selection tool for performing extended lymph node dissection (ePLND) for prostate cancer (PCa) in the primary…
- Conditions
- Prostate Cancer Metastatic, Prostate Cancer, Lymph Node Metastases
- Trial name
- PSMA-SELECT (NCT05000827)
- Testing
- PSMA-PET/CT, Nomogram
- Where
- Netherlands
- Volunteers
- 706 people
- Sponsor
- Canisius-Wilhelmina Hospital
Acute Myeloid Leukemia, Acute Lymphoid Leukemia
Irradiation-based Myeloablative Conditioning Followed by Treg/Tcon Immunotherapy in HSCT
To evaluate if hyper-fractionated TBI or TMLI followed by Treg/Tcon adoptive immunotherapy improve cGvHD/disease free survival after allogeneic HSCT in patients affected by high-risk acute leukemias or other hematologic…
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Myeloproliferative Disorders, Lymphoma
- Trial name
- NCT03977103
- Testing
- High dose irradiation conditioning + Treg/Tcon
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- University Of Perugia
Prostate Cancer
Bilateral Versus Unilateral Lymph Node Dissection in High-Risk Prostate Cancer (BALANCE)
BALANCE is a multicenter, prospective, randomized controlled trial enrolling men with unilateral high-risk localized prostate cancer identified by prostate biopsy, multiparametric MRI, and PSMA PET imaging.
- Trial name
- BALANCE (NCT07580196)
- Testing
- Unilateral Extended Pelvic Lymph Node Dissection, Bilateral Extended Pelvic Lymph Node Dissection
- Where
- 14 sites in Italy
- Volunteers
- 820 people
- Sponsor
- University of Turin, Italy
Breast Cancer, Sentinel Lymph Node
Sentinel Lymph Node Biopsy in Early Breast Cancer: a Real-world Multicenter Cross-sectional Study (CABS001 Study)
Objective: To investigate the current clinical practice of sentinel lymph node biopsy (SLNB) in patients with early stage breast cancer in China.
- Trial name
- NCT04156841
- Testing
- mapping agent, neoadjuvant chemotherapy
- Where
- China
- Volunteers
- 21,000 people
- Sponsor
- Xijing Hospital
Colonic Neoplasms, Sentinel Lymph Node
Fluorescent Sentinel Lymph Node Identification in Colon Carcinoma Using Submucosal Bevacizumab-800CW.
This prospective study aims to assess the safety and feasibility of lymph node identification using bevacizumab-800CW in patients with cT1-3N0-2 tumours, using peritumoral submucosal injections
- Conditions
- Colonic Neoplasms, Sentinel Lymph Node, Fluorescence, Colorectal Neoplasms
- Trial name
- IBIZA-1 (NCT05498051)
- Testing
- Sentinel lymph node identification
- Where
- Netherlands
- Volunteers
- 5 people
- Sponsor
- Meander Medical Center
Gastric Cancer Stage
Expanded Indications of Endoscopic Submucosal Dissection for Early Gastric Cancer in China
Background: The main treatment methods for early gastric cancer (EGC) include endoscopic submucosal dissection (ESD) and radical gastrectomy.
- Trial name
- NCT06869356
- Testing
- D2 gastrectomy
- Where
- China
- Volunteers
- 1,291 people
- Sponsor
- Beijing Friendship Hospital
Lung Neoplasms, Pulmonary Neoplasms
Feasibility of Fluorescence Imaging With Bevacizumab-800CW During Bronchoscopy
In this feasibility study, bronchoscopy will be combined with fluorescence molecular imaging using the near-infrared fluorescence (NIRF) tracer bevacizumab-800CW for assessment of pulmonary lesions and/or lymph nodes considered…
- Conditions
- Lung Neoplasms, Pulmonary Neoplasms, Lymph Node Involvement, Pulmonary Nodule
- Trial name
- DEFLECT I (NCT06809946)
- Testing
- injection with 15 mg bevacizumab-800CW before bronchoscopy, injection with 25 mg bevacizumab-800CW before bronchoscopy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- University Medical Center Groningen
Breast Cancer, Surgery
Medico-economic Study of Three Strategies of Sentinel Lymph Node Analysis in Operable Breast Cancer
Breast carcinoma requires frequently an adjuvant therapy after surgical excision: in this way, one of the major criteria indicating the need of adjuvant chemotherapy is the diagnosis of a metastatic lymph-node invasion, mainly in…
- Trial name
- SAGE (NCT02056886)
- Testing
- SLN detection +/- complementary axillary lymphadenectomy
- Where
- 17 sites in France
- Volunteers
- 858 people
- Sponsor
- Institut Cancerologie de l'Ouest
Breast Cancer
Ultrasound-assisted CNSs Mapping Versus Dual-tracer-guided Sentinel Lymph Node Biopsy
The investigators suggested ultrasound-assisted Carbon nanoparticle suspensions (CNSs) mapping had great clinical value in clinical application and might serve as a useful alternative to the dual-tracer-guided SLNB.
- Trial name
- UltraCars (NCT04951245)
- Testing
- UC group: ultrasound-assisted CNSs guided, GC group: CNSs plus ICG dual-tracer-guided
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Guangdong Provincial People's Hospital
Lung Cancer, Lymph Node Metastasis
99mTc-3PRGD2 SPECT/CT for Integrin Imaging of Lung Cancer
This is a prospective, multicenter, self-controlled phase 3 clinical trial designed to evaluate the safety and efficacy of an integrin αVβ3-targeted imaging, 99mTc-3PRGD2 SPECT/CT, for diagnosis of lung cancer and mapping the…
- Trial name
- TRIIL (NCT04233476)
- Testing
- 99mTc-3PRGD2 injection
- Where
- 11 sites in China
- Volunteers
- 409 people
- Sponsor
- RDO Pharm.
Colorectal Cancer
FAPI PET/CT for Lymph Node Staging in Colorectal Carcinoma
To describe the accuracy of FAPI PET/CT in the detection of regional lymph node metastases in patients with colorectal cancer in comparison with standard diagnostic imaging and (in operated patients) histopathology, aiming to…
- Trial name
- FAPI-CRC1 (NCT05209750)
- Testing
- FAPI PET/CT
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- The Netherlands Cancer Institute
Non Small Cell Lung Cancer
The Canada Lymph Node Score: A Feasibility Randomized Controlled Trial
For patients diagnosed with early stage Non-Small Cell Lung Cancer (NSCLC) on preoperative computerized tomography (CT) and positron emission tomography (PET) scans, surgical resection is usually the preferred method of…
- Trial name
- CLNS (NCT03859349)
- Testing
- Selective Targeted Sampling, Systematic Sampling
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Thyroid Cancer Patients, Lymph Node Metastasis
Irreversible Electroporation for Recurrent or Metastatic Cervical Lymph Node Metastases From Thyroid Cancer: A Prospective Multicenter Single-Arm Study
This is a single-arm, open-label, multicenter, exploratory clinical trial designed to systematically evaluate the efficacy, safety, and patient benefit of ultrasound-guided irreversible electroporation (IRE) ablation for…
- Trial name
- IRE-TCLN (NCT07328243)
- Testing
- Irreversible Electroporation (IRE) Ablation
- Where
- 3 sites in China
- Volunteers
- 85 people
- Sponsor
- Tian'an Jiang
Esophageal Adenocarcinoma
RAMIE Versus MIE for Resectable Esophageal Cancer, a Randomized Controlled Trial (ROBOT-2 Trial).
BACKGROUND: For patients with esophageal cancer, radical esophagectomy with 2-field lymphadenectomy is the cornerstone of the multimodality treatment with curative intent.
- Trial name
- ROBOT-2 (NCT04306458)
- Testing
- Minimally invasive esophagectomy, daVinci Xi system
- Where
- Germany
- Volunteers
- 218 people
- Sponsor
- University Medical Center Mainz
Triple Negative Breast Cancer, Hormone Receptor Positive (HR+), HER2-negative Breast Cancer
Pre-op Pembro + Radiation Therapy in Breast Cancer (P-RAD)
This research trial is studying a combination of neoadjuvant radiotherapy (RT), immunotherapy (pembrolizumab) and chemotherapy for lymph node-positive, triple negative (TN) or hormone receptor positive/HER2-negative breast…
- Conditions
- Triple Negative Breast Cancer, Hormone Receptor Positive (HR+), HER2-negative Breast Cancer, Biopsy-proven, Positive Lymph Node(s)
- Trial name
- NCT04443348
- Testing
- Radiation Therapy Boost, Pembrolizumab, Paclitaxel
- Where
- 10 sites in United States
- Volunteers
- 120 people
- Sponsor
- Laura M. Spring, MD
Early-stage Breast Cancer
Sentinel Lymph Node Identification in Patients With Breast Cancer Using SPECT/CT
Role of SPECT/CT in detection of sentinel lymph node in patients with breast cancer that is in early stage with small mass with no nodal or distant metastasis using radioactive material nannocolloid that can change surgical…
- Trial name
- NCT03468374
- Testing
- lymphoscintigraphy, Single Photon Emission Tomography
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Assiut University
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