Clinical trials: Lymphadenectomy
Upper Tract Urothelial Carcinoma
Feasibility and Safety of Extraperitoneal Laparoscopic Extended Retroperitoneal Lymph Node Dissection at Time of Nephroureterectomy for Upper Tract Urothelial Carcinoma
Extended pelvic lymph node dissection in bladder carcinoma provides staging and, in selected patients, a survival benefit. Recent studies showed the therapeutic benefit of retroperitoneal lymph node dissection (RPLND) in advanced…
- Trial name
- NCT03544437
- Testing
- extraperitoneal laparoscopic extended retroperitoneal lymph node dissection
- Where
- China
- Volunteers
- 40 people
- Sponsor
- RenJi Hospital
Colorectal Neoplasms Malignant, Lymph Node Excision
Chemoradiotherapy Sequenced Radical Surgery for Colorectal Cancer With PALNM
In left-sided colon and rectal cancer, the occurrence of synchronous para-aortic lymph node metastasis is rare, with the incidence of being approximate 1-2%.
- Conditions
- Colorectal Neoplasms Malignant, Lymph Node Excision, Chemoradiotherapy
- Trial name
- NCT05129774
- Testing
- Radical surgery with PALND, Radical surgery without PALND
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Qilu Hospital of Shandong University
Rectal Neuroendocrine Neoplasm
Lateral Pelvic Lymph Node Dissection for Rectal Neuroendocrine Neoplasms Undergoing Laparoscopic Total Mesenteric Excision
The purpose of this study is to investigate the metastatic status of lateral pelvic lymph nodes in rectal neuroendocrine neoplasms (rNENs) undergoing laparoscopic total mesenteric excision (TME).
- Trial name
- NCT06279299
- Testing
- lateral pelvic lymph node dissection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- National Cancer Center, China
Colon Cancer
Safe D3 Right Hemicolectomy for Cancer Through Multidetector Computed Tomography (MDCT) Angio
When performing a resection of the right colon due to cancer one aims not only to remove the tumor bearing bowel segment, but also lymph nodes draining the affected area.
- Trial name
- NCT01351714
- Testing
- D3 resection
- Where
- 2 sites in Norway
- Volunteers
- 700 people
- Sponsor
- Sykehuset i Vestfold HF
Breast Cancer Lymphedema
Axillary Reverse Mapping (ARM) in Breast Cancer Surgery to Prevent Lymphedema. (ARMtrial)
Breast cancer related lymphedema (BCRL) is a debilitating and distressing condition affecting approximately one out of five breast cancer survivors.
- Trial name
- NCT03333226
- Testing
- Axillary Reverse Mapping (ARM)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University Hospital of Ferrara
Esophageal Cancer, Sentinel Lymph Node
The Value of Indocyanine Green-guided Near-infrared Fluorescence Technology in Tracing Sentinel Lymph Nodes During Esophagectomy
Sentinel lymph nodes, as the primary site of tumor metastasis, play a pivotal role in assessing patient prognosis and planning subsequent treatment strategies.
- Conditions
- Esophageal Cancer, Sentinel Lymph Node, Lymphadenectomy, Indocyanine Green
- Trial name
- NCT07303231
- Testing
- Minimally invasive surgery for esophageal cancer using near-infrared indocyanine green fluorescence to visualize the sentinel lymph node
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Fujian Medical University Union Hospital
Urologic Cancer, Lymph Node Metastasis
Urologic Lymphadenectomy in AMIGO
This research study involves the use of two navigation systems, the 3D Slicer-based navigation system, and the Siemens Monaco systems, to simplify the complexity of image-guided lymphadenectomy procedures (surgery to remove one…
- Trial name
- NCT05132283
- Testing
- 3D Slicer, Monaco
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Breast Cancer, Invasive Breast Cancer
Sentinel Node Biopsy Following NeoAdjuvant Chemotherapy in Biopsy Proven Node Positive Breast Cancer
Title of Study: Sentinel node biopsy following neoadjuvant chemotherapy in biopsy proven node positive breast cancer. Objectives of the study: Primary objective 1.
- Trial name
- SN-FNAC (NCT00909441)
- Testing
- Sentinel Lymph Node Biopsy
- Where
- Canada
- Volunteers
- 153 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Esophageal Neoplasms
Esophagectomy:Three-field Versus Two-field Lymphadenectomy (ECTOP-2002)
This is a clinical trial from Eastern Cooperative Thoracic Oncology Project (ECTOP), numbered as ECTOP-2002. Esophageal carcinoma is an aggressive disease with a poor prognosis.
- Trial name
- NCT01807936
- Testing
- Lymphadenectomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Fudan University
Gastric Cancer
Upfront Surgery Versus NeoAdjuvant Chemotherapy Followed by Surgery for Resectable Advanced Gastric Cancer: SNAC Study
Based on the concerns about the actual low strength of evidence of the efficacy of NAC on survival of proper gastric cancer treated with adequate D2 gastrectomy as compared to the results of optimal upfront surgery (S), and…
- Trial name
- SNAC (NCT06472063)
- Testing
- pre- or perioperative treatment and D2 gastrectomy
- Where
- Italy
- Volunteers
- 684 people
- Sponsor
- San Luigi Gonzaga Hospital
Hepatocellular Carcinoma
Hepatectomy Versus Hepatectomy With Lymphadenectomy in Hepatocellular Carcinoma
The preventive lymphadenectomy is not performed routinely for hepatocellular carcinoma (HCC) patients in clinical practice. While many patients suffered the recurrence without the evidence of portal or hepatic vascular invasion…
- Trial name
- NCT02031952
- Testing
- hepatectomy combined with lymphadenectomy, hepatectomy alone
- Where
- China
- Volunteers
- 87 people
- Sponsor
- Sun Yat-sen University
Breast Neoplasms
Selective Lymph Node Dissection Using Fluorescent Dye in Node-positive Breast Cancer
In this study, navigation of lymphatic passage after sentinel lymph node with indocyanine green was performed during axillary lymph node dissection in breast surgery .
- Trial name
- NCT02781259
- Testing
- Axillary lymph node dissection, Indocyanine green, Imaging devices
- Where
- South Korea
- Volunteers
- 150 people
- Sponsor
- Samsung Medical Center
Lymphedema, Lymphedema Arm
Reduction of Arm Volume and Improvement in Lymphedema Via Surgery
This clinical trial aims to evaluate the effectiveness of lymphatic microsurgical treatments in reducing limb volume in female patients with breast cancer-related lymphedema (BCRL).
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Arm, Lymphedema of Upper Limb
- Trial name
- REFRESH (NCT06606145)
- Testing
- Lymphovenous Anastomosis, Vascularized Lymph Node Transfer, Combined Lymphovenous Anastomosis and Vascularized Lymph Node Transfer
- Where
- Belgium
- Volunteers
- 179 people
- Sponsor
- Universitair Ziekenhuis Brussel
Lymphedema, Lymphedema Arm
A Study of a Comprehensive Prevention Program to Reduce Lymphedema After Axillary Lymph Node Dissection in People With Breast Cancer
The purpose of this study to test whether a comprehensive program may help the lymph fluid to drain out of the arm and prevent lymphedema in participants with breast cancer.
- Conditions
- Lymphedema, Lymphedema Arm, Lymphedema of Upper Arm, Breast Cancer
- Trial name
- NCT06144164
- Testing
- Immediate Lymphatic Reconstruction, Volumetric arm measurements, Lymphatic massage
- Where
- 7 sites in United States
- Volunteers
- 285 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Gastric Cancer
Efficacy of Laparoscopic Subtotal Gastrectomy With D2 Lymph Node Dissection for Locally Advanced Gastric Cancer
It was confirmed that the laparoscopic surgery decreases the postoperative pain and reduces the recovery periods in the various surgical fields such as cholecystectomy and colectomy etc.
- Trial name
- KLASS-02-RCT (NCT01456598)
- Testing
- Laparoscopic gastrectomy, Open gastrectomy
- Where
- 13 sites in South Korea
- Volunteers
- 1,050 people
- Sponsor
- Ajou University School of Medicine
Breast Cancer
Evaluating the Ability of 99mTc-Tilmanocept to Identify Clipped Nodes in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy and Sentinel Lymph Node Dissection
The purpose of the present study is to evaluate the ability of 99mTc-TM to identify the clipped node after neoadjuvant chemotherapy (NAC) and to compare this percentage with historical national data.
- Trial name
- NCT05236387
- Testing
- 99m Tc-TM
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Cervical Cancer, Surgery
Sentinel Lymph Node Biopsy Versus Pelvic Lymphadenectomy in Early-stage Cervical Cancer (PHENIX/CSEM 010)
The diagnostic value of sentinel lymph node biopsy in early-stage cervical cancer has been well studied. However, there were no randomized controlled study on comparing the long-term outcomes of sentinel lymph node biopsy and…
- Conditions
- Cervical Cancer, Surgery, Quality of Life
- Trial name
- NCT02642471
- Testing
- no systematic pelvic lymphadenectomy
- Where
- China
- Volunteers
- 1,080 people
- Sponsor
- Sun Yat-sen University
Overall Survival Comparison Between the 2 Arms
Pretherapeutic Paraaortic Lymphadenectomy in Women With Locally Advanced Cervical Cancer Versus Definitive Chemoradiotherapy
This is an international, prospective, multicenter and randomized phase III study designed to determine if patients with locally advanced cervical cancer have longer overall survivals with pretherapeutic paraaortic surgical…
- Trial name
- LiLACs (NCT02848716)
- Testing
- Surgery followed with chemoradiation, Standard chemoradiation, chemoradiation
- Sponsor
- Muriel POUBLANC
Vulvar Cancers
Comparative Trial Between Open and Single-port Robotic-assisted Groin Lymphadenectomy in Vulvar Cancer
Vulvar squamous cell carcinoma is a rare cancer that is usually treated with surgery. Some patients need removal of lymph nodes from one or both groins, called inguinofemoral lymphadenectomy.
- Trial name
- SP-RAIL (NCT07853287)
- Testing
- Inguinofemoral lymphadenectomy
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Endometrial Cancer
Sentinel Lymph Node Dissection (SLND) in Patients With Apparent Early Stage Endometrial Cancer
The investigators hypothesize that SLND (unlike lymphadenectomy) decreases complications such as hemorrhage, lower extremity lymphedema and lymphocyst formation while enhancing quality of life in EC patients with low risk for…
- Trial name
- NCT02834988
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- University of Miami