Clinical trials: Lymphatic Function
Leiomyomatosis
Official Record of Patients Diagnosed With Lymphangioleiomyomatosis (LAM)
Pulmonary lymphoangioleiomyomatosis (LAM) is a rare destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor.
- Trial name
- NCT00001869
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Advanced Cancer, Ovarian Cancer
COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies
Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM902 as monotherapy and in combination with COM701 in subjects with advanced…
- Conditions
- Advanced Cancer, Ovarian Cancer, Lung Cancer, Colon Cancer
- Trial name
- NCT04354246
- Testing
- Dose escalation: COM902 monotherapy., Evaluation of safety/tolerability: COM902 in combination with COM701 (both at the RDFE), Cohort expansion: COM902 (RDFE) monotherapy.
- Where
- 9 sites in United States
- Volunteers
- 94 people
- Sponsor
- Compugen Ltd
Cerebral Cavernous Malformation
Functional Magnetic Resonance Imaging (fMRI) Vascular Reactivity in Cerebral Cavernous Malformations (CCM)
The goal is to characterize vascular reactivity and cardiac pulsatility of normal appearing white matter in patients with CCM during hypercarbia/hypocarbia using quantitative real-time high-speed multi-echo fMRI to develop…
- Trial name
- NCT05298709
- Testing
- Hyperventilation and CO2 challenge
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of New Mexico
Alzheimer's Disease (AD)
Amyloid-β Clearance Mechanisms in Alzheimer's Disease
The focus of this study is to examine the protein-plaque clearance (Aß) in relation to the blood-brain-barrier, the glymphatic system, brain lymphatic system and enzymatic degradation.
- Trial name
- AmyClearAD (NCT05059158)
- Testing
- positron emission tomography (PET)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Ludwig-Maximilians - University of Munich
22Q11 Deletion Syndrome, tACS
Using Transcranial Alternating Current Stimulation to Improve Executive Function in 22q11.2 Deletion Syndrome
The purpose of this project is to explore the effects of transcranial alternating current stimulation (tACS) in children, adolescents and young adults with a 22q11.2 microdeletion.
- Trial name
- NCT05664412
- Testing
- at-home tACS using Starstim-Home tES
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Stephan Eliez
Aplastic Anemia, Myelodysplastic Syndromes
Brain Cognitive Network Abnormalities in Anemia Patients Using fNIRS
Anemia is a global public health concern and is closely linked to dysfunction of brain cognitive neural networks, a key mechanism underlying cognitive impairment.
- Conditions
- Aplastic Anemia, Myelodysplastic Syndromes, Autoimmune Hemolytic Anemia, Functional Near-Infrared Spectroscopy
- Trial name
- AN-CNA (NCT07578675)
- Where
- China
- Volunteers
- 323 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Von Willebrand Diseases
Frequency of Hemorrhages Associated With the Functional Anomalies of Willebrand Factor in Emergency Patients
ECMO has improved the outcome of heart or respiratory failure and carcinogenic shock and are increasingly used. However bleeding complications occurring in up to 50% of patients are poorly understood and worsen the overall…
- Trial name
- WITECMO-H (NCT03070912)
- Where
- 7 sites in France
- Volunteers
- 257 people
- Sponsor
- University Hospital, Lille
Leukemia, Acute, Brain Neoplasms
Physical Activity and Quality of Life in Childhood Cancersurvivors- a Long-term Follow-up
The project intends to study physical functional capacity and degree of physical activity health related quality of life and fatigue.
- Conditions
- Leukemia, Acute, Brain Neoplasms, Physical Fitness, Quality of Life
- Trial name
- NCT07046481
- Testing
- Physical activity
- Sponsor
- Region Skane
Dementia, Mild
Investigational Dementia Treatment Study
This research investigates the effect of active versus sham tACS paired with cognitive exercises in a regimen protocol of weeks, everyday.
- Trial name
- tACS (NCT05203523)
- Testing
- transcranial alternative current stimulation (tACS), cognitive exercises
- Where
- 2 sites in Canada
- Volunteers
- 73 people
- Sponsor
- University of Manitoba
Bleeding Disorders, Iron
Impact of IV Iron on Bleeding Symptoms in Iron Deficient Patients With Inherited Bleeding Disorders
This is a prospective, single-arm, single-center observational study evaluating the impact of intravenous (IV) iron replacement in patients with inherited bleeding disorders and iron deficiency (ferritin <50ng/dL).
- Conditions
- Bleeding Disorders, Iron, Platelet, Bleeding
- Trial name
- IRON-BD (NCT07083583)
- Testing
- IV Iron (standard of care)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Nicoletta C Machin
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia
High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma
This randomized clinical trial studies how well a high-intensity intervention parenting program works in improving learning and school functioning in Latino children with acute leukemia or lymphoblastic lymphoma.
- Conditions
- Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Lymphoblastic Lymphoma, Acute Leukemia
- Trial name
- NCT03178617
- Testing
- Educational Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 3 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
SCD
Effect of Virtual Reality on Pain and Function in Children With Sickle Cell Disease: A Randomized Controlled Trial
Significance or rationale of the study: Virtual reality (VR) is a promising non-pharmacological pain management tool. It enhances motor function by promoting cortical reorganization and neuroplasticity.
- Trial name
- RCT (NCT05952817)
- Testing
- virtual reality
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Afnan Bkri
Multiple Myeloma
Study of Elotuzumab in Combination With Lenalidomide and Dexamethasone in Subjects With Multiple Myeloma and Various Levels of Renal Function
The purpose of the study is to assess the concentration of Elotuzumab in Myeloma patients with very low kidney function including patients on dialysis.
- Trial name
- NCT01393964
- Testing
- Lenalidomide, Dexamethasone, Elotuzumab (BMS-901608; HuLuc63)
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Bristol-Myers Squibb
Monoclonal Gammopathy of Unknown Significance
Unravel MGUS (Monoclonal Gammopathy of Unknown Significance)
This is a study to investigate the functional consequences of paraprotein production in MGUS (Monoclonal Gammopathy of Unknown Significance).
- Trial name
- NCT02933021
- Testing
- Blood sample taken, Answering a lifestyle questionnaire, Follow-up phone call from researcher (two years after first visit)
- Where
- 9 sites in United Kingdom
- Volunteers
- 664 people
- Sponsor
- RxCelerate Ltd
Sickle Cell Anemia
Endothelial Function in Patients With Sickle Cell Anemia Before and After Sildenafil
The investigators would like to study the endothelial function in sickle cell patients without pulmonary hypertension in an in vivo method during a steady state condition before and after sildenafil treatment for 1 month, and to…
- Trial name
- NCT00937144
- Testing
- Viagra (Sildenafil)
- Where
- Israel
- Volunteers
- 15 people
- Sponsor
- The Baruch Padeh Medical Center, Poriya
Anticoagulants and Bleeding Disorders, Surgery
Residual Anti-Xa Activity After Last Treatment Dose of Enoxaparin
The main objective of this study is to determine the time interval following the last treatment dose of enoxaparin at which the amount of anti-Xa level activity is reliably less than 0.2 international unit per milliliter (IU/mL)…
- Conditions
- Anticoagulants and Bleeding Disorders, Surgery, Regional Anesthesia Morbidity
- Trial name
- NCT03296033
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Wake Forest University Health Sciences
Hematological Neoplasm, Endothelial Dysfunction
The Endothelial Cell Dysfunction and Outcome Project for Hematological Neoplasms
The endothelium is a semipermeable monolayer of endothelial cells (EC) organized as a complex biological interface that separates all tissues from circulating blood.
- Trial name
- EndoCDO-H (NCT05502887)
- Testing
- Sublingual in vivo microscopy with the Glycocheck microscope
- Where
- Germany
- Volunteers
- 1,000 people
- Sponsor
- Prof. Dr. Thomas Luft
Anemia, Aged
A Phase II Study to Assess Changes in Physical Function in Elderly Patients With Chronic Anemia
The purpose of this study is to assess changes in physical function in elderly patients (>= 65 years of age) with chronic anemia (Hb <= 11.0 g/dL) due to anemia of unknown cause and receiving weekly subcutaneous doses of Epoetin…
- Conditions
- Anemia, Aged, Hemoglobins
- Trial name
- NCT00210795
- Testing
- epoetin alfa
- Volunteers
- 12 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Myeloid Leukemia
Chemotherapy-related Cognitive Impairment and Acute Leukemia
This is an ancillary study of an intervention study (NCT04570709). The parent study is a single institution, feasibility trial of 20 (10 control and 10 intervention) patients with the primary objective of assessing feasibility…
- Trial name
- NCT04644419
- Testing
- none (observational study)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- UNC Lineberger Comprehensive Cancer Center
Sickle Cell Disease
Gerofit Exercise Intervention for Older Adults With Sickle Cell Disease (SICKLE-FIT Study)
The purpose of this study to assess the feasibility, acceptability, and safety of a personalized exercise training program adapted from Gerofit to improve physical health and quality of life for adults with SCD
- Trial name
- SICKLE-FIT (NCT05714098)
- Testing
- Gerofit Exercise Program
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Duke University