Clinical trials: Lymphatic Function
Advanced Cancer, Ovarian Cancer
COM902 (A TIGIT Inhibitor) in Subjects With Advanced Malignancies
Phase 1 open label sequential dose escalation and cohort expansion study evaluating the safety, tolerability and preliminary antitumor activity of COM902 as monotherapy and in combination with COM701 in subjects with advanced…
- Conditions
- Advanced Cancer, Ovarian Cancer, Lung Cancer, Colon Cancer
- Trial name
- NCT04354246
- Testing
- Dose escalation: COM902 monotherapy., Evaluation of safety/tolerability: COM902 in combination with COM701 (both at the RDFE), Cohort expansion: COM902 (RDFE) monotherapy.
- Where
- 9 sites in United States
- Volunteers
- 94 people
- Sponsor
- Compugen Ltd
Amyloidosis, Paraproteinemias
Prospective Identification of Cardiac Amyloidosis by Cardiac Magnetic Resonance Imaging
Cardiac amyloidosis describes a process by which abnormally folded proteins infiltrate the heart tissue. Given the insidious nature of this disease process, diagnosis is often too late for a meaningful intervention.
- Conditions
- Amyloidosis, Paraproteinemias, Cardiomyopathies
- Trial name
- PICA-CMR (NCT02462213)
- Testing
- Amyloidosis, Cardiac Amyloidosis
- Where
- United States
- Sponsor
- University of Cincinnati
Stem Cell Transplantation, Immunotherapy
Rehabilitation Needs for Hematologic Cancer Candidate for Hematopoietic Stem Cell Transplantation or CAR T-Cell Therapy
Hematopoietic Stem Cell Transplantation (HSCT) and CAR T-cell therapy are effective treatments for blood cancers, extending patients lives. However, these treatments can cause side effects like muscle weakness and fatigue.
- Conditions
- Stem Cell Transplantation, Immunotherapy, CAR T-Cell Therapy
- Trial name
- HEMATOneeds (NCT06506396)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Modena and Reggio Emilia
Sickle Cell Disease, Aging
SickleFit Exercise and Nutrition Study
To goal of this study is to pilot the SickleFit exercise and nutrition intervention in adults with sickle cell disease in a randomized control trial
- Trial name
- NCT07442851
- Testing
- SickleFit Exercise plus Nutrition
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Duke University
Extracorporeal Membrane Oxygenation Complication, Hemorrhage
Platelets and Extracorporeal Membrane Oxygenation Veno-venous
In severe lung or heart disease, ExtraCorporeal Membrane Oxygenation (ECMO) may be used temporarily and can be responsible for major haemorrhagic complications. Thrombocytopenia and possibly thrombopathy promote bleeding.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Blood Platelet Disorder, Thrombosis
- Trial name
- PLAT-VV-ECMO (NCT07580469)
- Testing
- blood draws
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Splenectomy
Physiology and Pathologies Linked to Human Splenic Function : Direct and Ex-vivo Perfusion Explorations
Human splenic physiology remains poorly understood due to lack of functional exploration. However, through its ability to recognize alterations or modifications in circulating cells and to trigger an innate and adaptive response…
- Trial name
- SPLEENVIVO (NCT06418256)
- Testing
- Spleen, blood and plasma collection
- Where
- 5 sites in France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sickle Cell Disease
Neurovascular Determinants of Cognitive Function in Adults With Sickle Cell Disease
Cognitive impairment is a poorly understood, serious, and emerging complication for adult patients with sickle cell disease. Because there is extensive microvascular damage from oxidative damage in sickle cell disease, the…
- Trial name
- NCT02946905
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Anemia
A Functional Food for the Prevention of Iron-deficiency Anemia
It has been estimated that 1 in 2 women expecting a baby will be diagnosed with iron deficiency. In turn iron deficiency can affect the health and wellbeing or both mother and child.
- Trial name
- NCT01055431
- Testing
- Control bread, Teff Bread
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Manchester Metropolitan University
Hemophilia A
Phenotypic Heterogeneity in Hemophilia A: An Investigation of the Role of Platelet Function
The is study will examine whether variation in clinical bleeding frequency and severity among boys with severe Hemophilia A (Factor VIII deficiency) is associated with variations in laboratory measurements of platelet activity.
- Trial name
- NCT02225483
- Where
- 2 sites in Canada
- Volunteers
- 42 people
- Sponsor
- CancerCare Manitoba
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Community-Based Exercise and Nutrition Training and Education Program for Cancer Survivors
This clinical trial evaluates whether a supervised community-based exercise and nutrition program is usable and effective for improving cancer survivors' confidence for maintaining their physical activity and nutrition.
- Trial name
- NCT06565260
- Testing
- Exercise Intervention, Medical Device Usage and Evaluation, Nutritional Intervention
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Roswell Park Cancer Institute
Haematological Malignancy
Impact of Oral Nutritional Supplements on Patients Undergoing Haematopoietic Stem Cell Transplantation
Malnutrition is common after haematopoietic stem cell transplantation (HSCT), and is a well-known prognostic factor for survival.
- Trial name
- NCT05460013
- Testing
- Traditional Control, Oral Nutritional Supplement
- Where
- China
- Volunteers
- 100 people
- Sponsor
- RenJi Hospital
B-cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, in Relapse
CIK Cell Therapy for Relapsed or Refractory Acute B-Lymphoblastic Leukemia: Prognostic Impact on Patients With Early CAR-T Cell Dysfunction
This is a single-center, double-blind, randomized trial. Patients with relapsed or refractory acute B-lymphoblastic leukemia(r/r B-ALL) experiencing early functional exhaustion of CAR-T cells will be randomly allocated into three…
- Conditions
- B-cell Acute Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia, in Relapse, Refractory Acute Lymphoid Leukemia
- Trial name
- NCT06389305
- Testing
- peripheral blood lymphocytes, CIK cell
- Where
- China
- Volunteers
- 213 people
- Sponsor
- Beijing GoBroad Hospital
Executive Functioning, Pediatric ALL
Effectiveness of EEG Neurofeedback in Pediatric Occupational Therapy to Improve Executive Functioning
EEG Neurofeedback is a noninvasive way that allows the central nervous system to self regulate and the frontal cortex to be accessed through quieting of the limbic system at the subcortical level.
- Trial name
- NCT04221620
- Testing
- Zengar Electroencephalogram (EEG) Neurofeedback device
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northern Arizona University
Sickle Cell Disease, Sickle Cell Trait
Bone Loss, Physical Function and Frailty in Older Women With Sickle Cell Trait Sickle Cell Trait
This is a cross-sectional, clinical research study comparing postmenopausal women of African Descent (AD) with different hemoglobin genotypes: normal and sickle cell trait (SCT). This research study has two purposes.
- Trial name
- NCT07083531
- Testing
- Healthy volunteers without SCT, Healthy volunteers with SCT
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- UConn Health
Lymphedema, Oropharyngeal Cancer
Complete Decongestive Therapy (CDT) for Treatment of Head and Neck Lymphedema
Objectives: Specific Aim 1: Estimate the prevalence of head and neck lymphedema in patients who have been treated with surgery and/or radiation therapy (± chemotherapy) for oral cavity and oropharyngeal cancer.
- Conditions
- Lymphedema, Oropharyngeal Cancer, Head and Neck Cancer, Oral Cancer
- Trial name
- NCT00951470
- Testing
- Follow -Up Visits, Full CDT, Modified CDT Program
- Sponsor
- M.D. Anderson Cancer Center
Leukemia, Myeloid, Chronic-Phase
Imatinib Response in Patients With Chronic Myeloid Leukemia (CML) in Function of Abl Polymorphisms
The main objective of this study is to evaluate the existence of a relationship between the presence of certain abl polymorphisms (or haplotypes) upon CML diagnosis and the occurrence of primary resistance to the treatment of CML…
- Trial name
- abl LMC (NCT01650467)
- Where
- 3 sites in France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Heart Failure
Liver Function Abnormalities in Patients With Acute Heart Failure
The aim of this study is to evaluate liver function test abnormalities and to identify associated cardiac and non cardiac factors mediating hepatic impairment in acute heart failure patients
- Trial name
- NCT06491628
- Testing
- Avoiding the risk factors
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Kidney Failure, Acute, Kidney Failure, Chronic
Does An Abnormal PFA 100 Predict Bleeding After Renal Biopsy?
The kidneys are highly vascular organs and any trauma or surgery poses risk of severe bleeding. Platelet function is an integral part of the blood clotting during the initial, so-called vascular phase.
- Conditions
- Kidney Failure, Acute, Kidney Failure, Chronic, Blood Platelet Disorders, Hemorrhage
- Trial name
- NCT00334204
- Testing
- measuring Platelet Function Analyser-100 (PFA-100) platelet function before kidney biopsy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Mississippi Medical Center
Head and Neck Neoplasms, Head and Neck Lymphedema
Response to Intermittent Pneumatic Compression Therapy in Head and Neck Cancer-Related Lymphedema
Assessment of lymphatic structure and function pre- and post- treatment and during recovery in head and neck cancer related lymphedema patients using NIR fluorescence lymphatic imaging: Response to ICD therapy in HNC Patients.
- Conditions
- Head and Neck Neoplasms, Head and Neck Lymphedema, Head and Neck Cancer
- Trial name
- NCT02946021
- Testing
- Head and neck garments for pneumatic compression device, NIRFLI with ICG
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Tactile Medical
Arthroplasty, Hip Replacement, Anemia
Postoperative Anemia and Functional Outcomes After Fast-track Primary Hip Arthroplasty
The purpose of this study is to evaluate the possible association between postoperative anaemia and functional outcomes the first 2 weeks after primary hip arthroplasty.
- Trial name
- NCT01514006
- Where
- 2 sites in Denmark
- Volunteers
- 125 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet