Clinical trials: Lymphedema, Lower Limb
Quality of Life, Gynaecological Cancer
Side Effects Screening and Early Intervention to Impact in Quality of Life of Gynaecological Cancer Patients
The goal of this randomized study is to assess the impact on self-perceived quality of life (QoL) of systematic screening and early treatment of aftereffects in patients with gynaecological cancers.
- Conditions
- Quality of Life, Gynaecological Cancer, Lymphedema, Lower Limb, Sexual Dysfunction
- Trial name
- HALIS (NCT05918770)
- Testing
- systematic screening and early treatment
- Volunteers
- 168 people
- Sponsor
- Hospital Universitario 12 de Octubre
Lymphedema of Leg, Lymphedema
Inspiratory and Calf Muscles Training in Patients With Leg Lymphedema
Lymphedema results in the accumulation of protein-rich fluid in the subcutaneous tissue as a result of the failure of the lymphatic system, which returns water and protein in the interstitial spaces to the bloodstream.
- Conditions
- Lymphedema of Leg, Lymphedema, Exercise
- Trial name
- NCT05609526
- Testing
- Compression Therapy, Inspiratory muscle training, Calf muscle exercise training
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Lymphedema
Comparative Trial to Monitor Interface Pressure in Relation to Volume Change in Leg Lymphoedema
Although there is no doubt about the need for compression therapy in lymphoedema, it is not investigated in much detail how much pressure is needed to get optimum volume reduction.
- Trial name
- NCT01828606
- Testing
- coban 2 system, coban lite system
- Where
- 3 sites in Denmark, Germany and 1 more
- Volunteers
- 60 people
- Sponsor
- Nij Smellinghe Hosptial
Gynaecological Malignant Tumours With Indication of Pelvic Lymphadenectomy
Lower-Limb Drainage Mapping in Pelvic Lymphadenectomy for Gynaecological Cancer
The purpose of this study is to evaluate the feasibility of an isotopic technique to identify, and to map the lower-limb drainage nodes during pelvic lymphadenectomy for gynaecological cancers.
- Trial name
- SENTIJAMBE (NCT01946672)
- Testing
- Lower-limb drainage isotopic intraoperative detection
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Lymphedema
Quality of Life Changes on Lower Extremity Lymphedema Patients Using an Advanced Pneumatic Compression Device (PCD)
Assessment of quality of life and symptoms changes in primary or secondary, unilateral or bilateral lower extremity lymphedema patients using an advanced pneumatic compression system.
- Trial name
- NCT02661646
- Testing
- Advanced Pneumatic Compression Device
- Where
- 6 sites in United States
- Volunteers
- 249 people
- Sponsor
- Tactile Medical
Lymphedema of Leg, Lymphedema Congenital
Physiological Study to Assess Mechanism of Action of MOBIDERM® in Lower-limb Lymphedema Patients
MOBIDERM® demonstrated his interest through clinical studies on the treatment of lower or upper limb lymphedema (Mestre et al 2017; Quéré et al. 2014).
- Conditions
- Lymphedema of Leg, Lymphedema Congenital, Lymphedema Primary, Lymphedema, Secondary
- Trial name
- ACTIODERM (NCT04252690)
- Testing
- MOBIDERM® autofit : auto-adjustable compression stocking
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Thuasne
Lymphedema
Comfort Subcutaneous Drainage: a Descriptive Study Among Palliative Phase Cancer Patients
Physical embarrassment, pain and psychological impact linked to the body image distortion are often associated to these lymphedemas.
- Trial name
- NCT02494115
- Testing
- subcutaneous drainage
- Where
- 3 sites in France
- Volunteers
- 24 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Lymphedema, Gait Dysfunction
Impact of Virtual Reality (VR) Based Exercises on Lower Limb Lymphedema Outcomes (LELO)
This randomized controlled study aims to investigate the effects of virtual reality (VR)-assisted gait training, in addition to Complex Decongestive Therapy (CDT), on gait parameters, physical function, quality of life, and edema…
- Conditions
- Lymphedema, Gait Dysfunction, Physical Rehabilitation, Chronic Edema
- Trial name
- VR-LELO (NCT07472543)
- Testing
- Complex Decongestive Therapy (CDT) plus virtual reality (VR)-assisted gait training group, Complex Decongestive Therapy alone group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Lymphedema, Lymphoedema
Effect of Lymphovenous Anastomosis on Lower Limb Lymphedema: Pragmatic Randomized Controlled Trial
This multicentre pragmatic randomised controlled trial evaluates lymphovenous anastomosis (LVA) for lower-limb lymphedema (LLL) in Denmark.
- Conditions
- Lymphedema, Lymphoedema, Lymphoedema of Leg, Lymphedema of Leg
- Trial name
- NCT07073586
- Testing
- Lymphovenous Anastomosis, Complete Decongestive Therapy
- Where
- 2 sites in Denmark
- Volunteers
- 66 people
- Sponsor
- Herlev and Gentofte Hospital
Lymphedema, Lymphedema of Leg
A Clinical Study to Evaluate the Effectiveness of a Novel Portable Non-Pneumatic Active Compression Device vs. an Advanced Pneumatic Compression Device for Treating Lower Extremity Lymphedema
To evaluate the Koya wearable device - a Novel Portable Non-Pneumatic Active Compression Device (NPCD) in contrast to an advanced pneumatic compression device (APCD)
- Conditions
- Lymphedema, Lymphedema of Leg, Chronic Venous Insufficiency, Venous Insufficiency
- Trial name
- TEAYS (NCT05507346)
- Testing
- Cross over Device (PCD or Dayspring - alternate to first group)
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Koya Medical, Inc.
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 2
Lymphedema is a chronic, debilitating disorder characterized by abnormal tissue swelling, adipose deposition and tissue fibrosis, resulting from disruption, blockage, or genetic abnormalities of the lymphatic system.
- Trial name
- EvaLymph-Leg2 (NCT05421377)
- Testing
- clinical assessment
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- KU Leuven
Primary Lower Limb Lymphedema, Secondary Lower Limb Lymphedema
Pilot Efficacy Study of the Stendo Pulsating Suit in Patient With Leg Lymphoedema
This study aims at evaluating the efficacy of the Stendo pulsating suit in patients with a leg lymphedema hospitalized for intensive Complex Decongestive Physiotherapy (CDP).
- Trial name
- NCT02234674
- Testing
- Current intensive CDP, intensive CDP where Stendo pulsating suit replaces pressotherapy
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Stendo
Lymphoedema of Leg
Intermittent Pneumatic Compression for Treating Lower Limb Lymphoedema
The treatment of lymphoedema and its associated complications represent a considerable drain on increasingly limited NHS resources.
- Trial name
- IMPRESS II (NCT03856281)
- Testing
- Intermittent Pneumatic Compression
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cwm Taf University Health Board (NHS)
Lower Extremity Lymphedema
Non-inferiority of Compression Bandage Alone in Lower Extremity Lymphedema Management
Lymphedema is much more than a disease with edema. Impaired lymphatic drainage triggers adipose tissue deposition and fibrosis. Fibrosis causes lymphatic vessel dysfunction. Therefore, treatment of fibrosis is important.
- Trial name
- NCT06750679
- Testing
- Compression bandage, Manual lymphatic drainage added to compression
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Abant Izzet Baysal University
Lymphedema, Stage IA Cervical Cancer
Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer
This clinical trial studies lymphedema after surgery in patients with endometrial cancer, cervical cancer, or vulvar cancer. Collecting information over time about how often lymphedema occurs in patients undergoing surgery and…
- Conditions
- Lymphedema, Stage IA Cervical Cancer, Stage IA Uterine Corpus Cancer, Stage IA Vulvar Cancer
- Trial name
- LEG (NCT00956670)
- Testing
- Quality-of-Life Assessment, Questionnaire Administration, Study of High Risk Factors
- Where
- 213 sites in United States
- Volunteers
- 1,055 people
- Sponsor
- Gynecologic Oncology Group
Lymphoedema of Leg, Lymphedema Arm
Added Value of Reconstructive Lymphatic Surgery to Usual Care in Lymphoedema
The primary objective of this research proposal is to investigate in patients with lymphoedema of the upper limb or lower limb (P) the added value of reconstructive lymphatic surgery (I) to the decongestive lymphatic therapy…
- Conditions
- Lymphoedema of Leg, Lymphedema Arm, Lymphedema
- Trial name
- SurLym (NCT05064176)
- Testing
- Usual care, Reconstructive lymphatic surgery
- Where
- 3 sites in Belgium
- Volunteers
- 180 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lower Extremity Lymphedema
Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment
The goal of this pilot study is to learn if a revised method of compression improves lymphatic function compared to the current method of compression.
- Trial name
- NCT07613931
- Testing
- Advanced pneumatic compression device (APCD), Advanced pneumatic compression device (APCD) with revised compression programming, Indocyanine Green (IC-Green)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Tactile Medical
Lymphedema, Lymphedema Lower Extremity
Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of Koya Dayspring Active Wearable Compression Technology for Treating Lower Extremity Lymphedema
- Conditions
- Lymphedema, Lymphedema Lower Extremity, Chronic Venous Insufficiency, Secondary Lymphedema
- Trial name
- TIBER (NCT04897035)
- Testing
- Dayspring Active Wearable Compression System
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Koya Medical, Inc.
Lymphedema of Limb, Sentinel Lymph Node
Early Detection of Lower Extremity Lymphedema After Lymphadenectomy in Gynecological Cancer
This study aims to detect and treat early lower limb lymphedema secondary to lymphadenectomy with the aim of increasing the quality of life of patients with this chronic condition.
- Trial name
- NCT03917771
- Testing
- Early lymphedema detection, Usual follow-up
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- Hospital Donostia
Gynecologic Cancer
Randomized Trial of Exercise on Lower Extremity Edema After Lymphadenectomy in Gynecologic Cancer
The primary outcome is the change in lower extremity edema-related symptoms. Secondary outcomes include the compliance rate of management guidelines for lower extremity edema, the performance rate for pelvic and lower extremity…
- Trial name
- NCT01849224
- Testing
- Pelvic and lower extremity exercise
- Where
- South Korea
- Volunteers
- 148 people
- Sponsor
- National Cancer Center, Korea