Clinical trials: Lymphedema
Skin and Connective Tissue Diseases, Neglected Tropical Diseases
Early Detection and AI-Based Management of Skin-Related Neglected Tropical Diseases in Sub-Saharan Africa by Frontline Health Workers
Skin-related Neglected Tropical Diseases (Skin NTDs) affect about 1.8 billion people worldwide, particularly in poor and rural communities where healthcare access is limited.
- Conditions
- Skin and Connective Tissue Diseases, Neglected Tropical Diseases, Leprosy, Buruli Ulcer
- Trial name
- SkincAIr (NCT07506967)
- Testing
- A mobile app with AI functionality for diagnosing skin-related NTDs
- Where
- 5 sites in Democratic Republic of the Congo, Ethiopia and 3 more
- Volunteers
- 2,420 people
- Sponsor
- Kenya Medical Research Institute
Breast Cancer Related Lymphedema
Effects of Core-Focused Exercise Training and Kinesiology Taping in Women With Breast Cancer-Related Lymphedema
The aim of the present study is to investigate the effects of trunk- focused exercise training and kinesiology taping, in addition to standard lymphedema treatment (complex decongestive therapy-CDT) on posture, pain…
- Trial name
- NCT07673939
- Testing
- Complex Decongestive Therapy, Trunk Focused exercises, Kinesiology taping
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hacettepe University
Lymphatic Filariasis, Soil Transmitted Helminth Infections
Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis
Approximately 3,500 people will participate per year. The study population will include females and males over 5 years of age who live in filariasis endemic areas. The study will be performed in Indonesia in B. timori and W.
- Trial name
- DOLF-Indo (NCT01905423)
- Testing
- Albendazole (annual), Diethylcarbamazine (annual), Albendazole (semiannual)
- Where
- Indonesia
- Volunteers
- 17,108 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Breast Cancer
Efficacy Verification in Early Diagnosis and Management of Lymphedema Through Home Body Water Analyzer
Breast cancer is the second most common cancer in women. One in five women who have been treated for breast cancer develop lymphedema. Lymphedema is a very common result of breast cancer and its treatment.
- Trial name
- NCT06580743
- Testing
- No intervention
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Minnesota
Post Thrombotic Syndrome
Treatment Trial for Post-Thrombotic Syndrome
The purpose of this study is to determine if complex lymphedema therapy is effective in decreasing disease severity and improving quality of life in patients with post thrombotic syndrome.
- Trial name
- NCT00633971
- Testing
- complex lymphedema therapy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Vermont
Unilateral Breast Neoplasms
Arm Swelling Occurence in Breast Cancer Patients With Nodal Radiotherapy: Impact of Informing Them of AI-predicted Risk
Radiotherapy after breast cancer surgery can lead to side effects like arm lymphedema (arm swelling). Lymphedema can cause long-term discomfort and affect quality of life.
- Trial name
- PRE-ACT-01 (NCT07187726)
- Testing
- XAINET AI tool
- Where
- 27 sites in France, Netherlands
- Volunteers
- 724 people
- Sponsor
- UNICANCER
Diabetic Foot, Pressure Ulcer
A Real-World Registry of Chronic Wounds and Ulcers
WOUNDJOURNEY is a longitudinal, real-world, observational registry designed to capture the full clinical course and patient journey associated with chronic wounds and ulcers.
- Conditions
- Diabetic Foot, Pressure Ulcer, Surgical Wound Dehiscence, Vasculitis
- Trial name
- WOUNDJOURNEY (NCT02280733)
- Testing
- Usual care
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- U.S. Wound Registry
Lymphatic Filariases, Scabies
Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji
Lymphatic Filariasis (LF), scabies and soil transmitted helminths (STH) are common neglected tropical diseases affecting the people of Fiji.
- Conditions
- Lymphatic Filariases, Scabies, Impetigo, Soil Transmitted Helminths
- Trial name
- FIT (NCT03177993)
- Testing
- 3 drug dose - IDA, 3 drug dose - IDA with second dose of ivermectin, 2 drug dose - DA
- Where
- Fiji
- Volunteers
- 4,773 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Lymphedema
Effect of Metabolic Syndrome on Complex Decongestive Physiotherapy Outcomes in Lymphedema Patients
As a result of our research, investigators could not find any study investigating the effectiveness of complex decongestive physiotherapy (KBF) in lymphedema patients with metabolic syndrome.
- Trial name
- NCT05426993
- Testing
- Complex decongestive physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gulhane School of Medicine
Open Surgery, Lymphedema
A Post-market, Real-world Experience: Expanding Access to Care by Incorporating the Symani® Surgical System and Enabling Surgeons
The objective of this study is to evaluate the Symani System's safety and effectiveness for microsurgical anastomosis during free tissue transfer surgery and lymphovenous anastomosis surgery.
- Conditions
- Open Surgery, Lymphedema, Free Tissue Transfer, Microsurgery
- Trial name
- PRECISE (NCT06725030)
- Testing
- Symani Surgical System
- Where
- 6 sites in United States
- Volunteers
- 455 people
- Sponsor
- MMI (Medical Microinstruments, Inc.)
Arm Lymphedema, Breast Cancer
Lymphedema Evaluation After Adjuvant Hypofractionated Radiotherapy for 1-2 Macrometastatic Sentinel Lymph Nodes
In this observational prospective studi patients with invasive breast cancer no more than 5 cm and clinically node negative, scheduled for conservative surgery and Sentinel Node Biopsy (SNB), are enrolled in the protocol if they…
- Conditions
- Arm Lymphedema, Breast Cancer, Radiotherapy Side Effect
- Trial name
- AXILL-ART (NCT06321653)
- Testing
- Hypofractionated radiotherapy scheme
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- European Institute of Oncology
Breast Cancer, Breast Cancer Female
Lymphedema Severity on Shoulder Joint Function and Muscle Activation Patterns in Breast Cancer Survivors
Breast cancer-related lymphedema (BCRL) is a common complication affecting the upper extremity following breast cancer treatment.
- Trial name
- NCT05934695
- Testing
- Lymphedema severity stratification
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Ahram Canadian University
Lymphedema, Recurrent Breast Cancer
Sentinel and/or Axillary Lymph Node Biopsy With or Without Axillary Reverse Mapping in Reducing Incidence and Severity of Arm Lymphedema in Stage 0-2 Patients.
Lymph node biopsy followed by axillary reverse mapping may reduce the incidence and severity of arm lymphedema. This randomized phase II trial is studying how well sentinel and/or axillary lymph node biopsy with or without…
- Conditions
- Lymphedema, Recurrent Breast Cancer, Stage IA Breast Cancer, Stage IB Breast Cancer
- Trial name
- NCT01276054
- Testing
- technetium Tc 99m sulfur colloid, methylene blue, indocyanine green solution
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Southern California
Breast Cancer, Lymphedema Arm
Impact of the ARM Technique on the Prevention of Lymphedema After Axillary Lymphadenectomy: A Multicenter Randomized Clinical Trial
To evaluate the reduction of secondary lymphedema following axillary lymphadenectomy by incorporating the ARM technique during the procedure, without negatively impacting patient prognosis.
- Trial name
- ARM-LIFE (NCT07515300)
- Testing
- Axillary Reverse Mapping
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitari de Bellvitge
Lymphedema of Leg, Lymphedema, Secondary
Imaging Sodium and Lymphatics in Lymphedema
Recent evidence supports lymphatic regulation of tissue sodium handling, however fundamental gaps persist in knowledge regarding the role of lymphatics in human diseases of sodium dysregulation.
- Conditions
- Lymphedema of Leg, Lymphedema, Secondary, Lymphedema Related Fibrosis
- Trial name
- NCT05242900
- Testing
- Complete decongestive therapy, Standard imaging protocol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Virginia
Breast Cancer, Breast Cancer Treatment Related Lymphedema
Early Intervention
This research study is a Pilot Study examining the use of a compression sleeve with embedded sensor to prevent lymphedema.
- Trial name
- NCT05326165
- Testing
- Juzo Compression Sleeve and Glove, Compression Sleeve Sensor
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Lymphatic Filariases, Onchocerciasis
Prevalence of LF Infection in Districts Not Included in LF Control Activities
Lymphatic filariasis is a neglected tropical disease earmarked for elimination as a public health problem by the year 2020. Since the year 2000, the Global Program for the Elimination of LF has together with endemic countries…
- Trial name
- NCT03131401
- Testing
- Diagnosis of lymphatic filariasis, Diagnosis of lymphatic Filariasis and onchocerciasis, DEC Patch
- Where
- Ghana
- Volunteers
- 3,736 people
- Sponsor
- Noguchi Memorial Institute for Medical Research
Lymphatic Filariasis, Wuchereria Bancrofti Infection
Effect of Albendazole Dose on Clearance of Filarial Worms
This study, conducted in Chennai, India, will determine whether a new treatment regimen of albendazole and diethylcarbamazine for lymphatic filariasis can eliminate the disease more quickly than the standard regimen.
- Trial name
- NCT00375583
- Testing
- DEC/Albendazole
- Where
- India
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Lymphatic Diseases, Lymphatic Abnormalities
A Prospective Natural History Study of Lymphatic Anomalies
Background: The lymphatic system is a network of vessels that carry a clear fluid called lymph through the body. Problems in the lymphatic system can cause pain, fluid buildup, and issues with immunity.
- Trial name
- NCT05731141
- Where
- 2 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Breast Cancer Lymphedema
Lymphedema Treatment Registry
Patients with breast cancer related lymphedema (clinical stage 0-2) will include in this study. Patients will take their demographic and clinical history and will evaluate with measurements of extremity volumes, body mass index…
- Trial name
- NCT04272372
- Testing
- Ketoprofen
- Volunteers
- 60 people
- Sponsor
- Ege University