Clinical trials: Lymphedema of Leg
Lymphedema of Leg
Supermicrosurgical Lymphvenous Bypass Intervention for Treatment
Background: In addition to antegrade anastomosis, retrograde anastomosis has been thought to offer further improvements after lymphaticovenous anastomosis (LVA) by bypassing the retrograde lymphatic flow.
- Trial name
- NCT05270629
- Testing
- Antegrade and retrograde anastomoses, Antegrade-only anastomoses
- Where
- Taiwan
- Volunteers
- 87 people
- Sponsor
- Chang Gung Memorial Hospital
Lymphatic Edema, Cellulitis of Leg
Efficacy of Complex Decongestive Therapy (CDT) in Patients With Venous Insufficiency: a Experimental Study
The study investigates the effectiveness of Complex Decongestive Therapy (CDT) in improving venous flow and reducing symptoms in venous insufficiency patients.
- Conditions
- Lymphatic Edema, Cellulitis of Leg, Vein Disease
- Trial name
- CDT (NCT06231940)
- Testing
- Complex Decongestive Therapy (CDT) in venous insufficiency,
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- University of Salamanca
Lymphedema
Quality of Life Changes on Lower Extremity Lymphedema Patients Using an Advanced Pneumatic Compression Device (PCD)
Assessment of quality of life and symptoms changes in primary or secondary, unilateral or bilateral lower extremity lymphedema patients using an advanced pneumatic compression system.
- Trial name
- NCT02661646
- Testing
- Advanced Pneumatic Compression Device
- Where
- 6 sites in United States
- Volunteers
- 249 people
- Sponsor
- Tactile Medical
Gynecologic Cancer
Randomized Trial of Exercise on Lower Extremity Edema After Lymphadenectomy in Gynecologic Cancer
The primary outcome is the change in lower extremity edema-related symptoms. Secondary outcomes include the compliance rate of management guidelines for lower extremity edema, the performance rate for pelvic and lower extremity…
- Trial name
- NCT01849224
- Testing
- Pelvic and lower extremity exercise
- Where
- South Korea
- Volunteers
- 148 people
- Sponsor
- National Cancer Center, Korea
Quality of Life, Gynaecological Cancer
Side Effects Screening and Early Intervention to Impact in Quality of Life of Gynaecological Cancer Patients
The goal of this randomized study is to assess the impact on self-perceived quality of life (QoL) of systematic screening and early treatment of aftereffects in patients with gynaecological cancers.
- Conditions
- Quality of Life, Gynaecological Cancer, Lymphedema, Lower Limb, Sexual Dysfunction
- Trial name
- HALIS (NCT05918770)
- Testing
- systematic screening and early treatment
- Volunteers
- 168 people
- Sponsor
- Hospital Universitario 12 de Octubre
Lymphedema
Efficacy of GLP-1 Receptor Agonists in Treating Upper and Lower Extremity Lymphedema
Lymphedema affects millions and currently lacks effective drug treatments, relying mainly on compression therapy. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown potential in managing obesity and diabetes, which…
- Trial name
- NCT07012642
- Testing
- GLP-1 Receptor Agonists
- Where
- 2 sites in United States
- Volunteers
- 110 people
- Sponsor
- Advanced Reconstructive Surgery Alliance
Lymphedema
Ubenimex in Adult Patients With Lymphedema of The Lower Limb (ULTRA)
This proof-of-concept study is designed as a randomized, double-blind, placebo-controlled study comparing ubenimex at 150 mg, 3 times daily (total daily dose of 450 mg) with placebo for 6 months treatment period in patients with…
- Trial name
- NCT02700529
- Testing
- ubenimex
- Where
- 4 sites in United States, Australia
- Volunteers
- 54 people
- Sponsor
- Eiger BioPharmaceuticals
Lower Extremity Lymphedema
Effectiveness of Digital Physiotherapy in the Short and Long-Term Management of Lower Extremity Lymphedema
This study investigated the short- and long-term effects of digital physiotherapy in patients with unilateral and bilateral lower extremity lymphedema.
- Trial name
- NCT07014566
- Testing
- Digital Combined Decongestive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Bezmialem Vakif University
Lymphedema Lower Extremity
Assessment of the Efficacy of the Dynamic Decongestive System in the Maintenance Phase of Lower Limb Lymphedema
The trial aims to determine whether the dynamic compression device, used in combination with elastic compression garments, is non-inferior to currently available compression devices (CACD) during the maintenance phase of…
- Trial name
- EDYDES-maint (NCT07603531)
- Testing
- Control group: Currently available compression devices, DDS group: Dynamic compression device (DDS)
- Where
- 3 sites in France, Germany
- Volunteers
- 98 people
- Sponsor
- Jean-Paul Belgrado
Endometrial Cancer, Lymphedema
Prevalence of Self Reported Lymphedema in Patients With Endometrial Cancer
The investigators are interested in understanding how the patient has been doing since their surgery for endometrial cancer and if they are experiencing any symptoms related to lymphedema (swelling) in the your lower body.
- Trial name
- NCT02912767
- Testing
- questionnaire
- Where
- United States
- Volunteers
- 625 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Chronic Leg Ulcer, Kaposi Sarcoma
Compression Therapy for Leg Ulcers and Kaposi Sarcoma in Western Kenya
The efficacy of locally sourced compression therapy in the management of chronic leg ulcers and Kaposi Sarcoma in western Kenya will be studied in a rural setting
- Conditions
- Chronic Leg Ulcer, Kaposi Sarcoma, HIV/AIDS and Infections
- Trial name
- NCT03404297
- Testing
- Locally sourced compression therapy
- Where
- 2 sites in Kenya
- Volunteers
- 30 people
- Sponsor
- Indiana University
Primary Lymphedema
Primary Lymphedema and Mutation CELSR1 (Cadherin EGF LAG Seven-pass G-type Receptor 1)
The investigators will describe the expression of mutation CELSR1 with codon stop and amino acids substitution mechanism in primary lymphedema, in both clinical examination and imaging exploration
- Trial name
- CELSR1 (NCT04919655)
- Where
- France
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 3
The current best practice is a three-stage classification consensus guideline as published by the International Society of Lymphology (ISL).
- Trial name
- EvaLymph-Leg3 (NCT05757284)
- Testing
- Lower Limb Lymhedema assessment
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 140 people
- Sponsor
- KU Leuven
Lymphedema
Assessment of Unilateral Lymphoedema of the Leg
To demonstrate that ImpediMed L-Dex U400 can be used to assess unilateral Lymphoedema of the leg using the same principles for arms.
- Trial name
- NCT00757406
- Where
- Australia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- ImpediMed Limited
Lymphedema of Leg
Establishing Guidelines for Manual Lymphatic Drainage
The purpose of this study is to establish optimal guidelines for Manual Lymphatic Drainage in participants with lower extremity lymphedema.
- Trial name
- MLD (NCT05509062)
- Testing
- Pressure
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Colorado, Denver
Gynecological Cancer, Lower Limb Lymphedema
The Effectiveness of Anti-resistance Exercise on Lower Limb Lymphoedema Among Gynecological Cancer
Background: The incidence of lower limb lymphedema (LLL) after gynecological cancer surgery with lymphadenectomy is about 10-46%. Lower limb lymphedema results in limited physical mobility and reduced patients' quality of life.
- Trial name
- NCT05003973
- Testing
- home-based anti-resistance exercise, usually care
- Volunteers
- 100 people
- Sponsor
- National Cheng Kung University
Lymphedema
Sahid Method for Secondary Unilateral Lower Limb Lymphedema
Manual lymphatic drainage (MLD) is a non-invasive technique frequently used in the management of lymphedema. The Paloma Sahid Method is a patented approach to lymphatic drainage that combines specific manual and mechanical…
- Trial name
- NCT07198698
- Testing
- Paloma Sahid Method, a patented technique (PCT/CL2023/050061)
- Where
- Chile
- Volunteers
- 32 people
- Sponsor
- University Diego Portales
Lower Extremity Lymphedema
Daphnetin Capsules for Lower Limb Lymphoedema Following Gynaecological Surgery
This clinical trial is designed to learn more about treating patients with lower limb lymphoedema following gynaecological surgery.
- Trial name
- NCT06329167
- Testing
- Daphnetin, Aescuven
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The First Hospital of Jilin University
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group
Lymphedema, Lipedema
Multimodal Ultrasound for Differentiating Lymphedema and Lipedema
The aim of this observational study is to evaluate the diagnostic value of multimodal ultrasonography in differentiating between lymphedema and lipedema.
- Trial name
- NCT07489248
- Testing
- Multimodal Ultrasound Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital