Clinical trials: Lymphedema of Leg
Gynecological Cancer, Lower Limb Lymphedema
The Effectiveness of Anti-resistance Exercise on Lower Limb Lymphoedema Among Gynecological Cancer
Background: The incidence of lower limb lymphedema (LLL) after gynecological cancer surgery with lymphadenectomy is about 10-46%. Lower limb lymphedema results in limited physical mobility and reduced patients' quality of life.
- Trial name
- NCT05003973
- Testing
- home-based anti-resistance exercise, usually care
- Volunteers
- 100 people
- Sponsor
- National Cheng Kung University
Lymphedema
Lymphedema Study for Arm or Leg Lymphedema
This study compares the effectiveness of a study drug versus placebo in the treatment of lymphedema.
- Trial name
- NCT02257970
- Testing
- Ketoprofen
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Stanford University
Lymphedema, Lymphedema Lower Extremity
Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema
A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of Koya Dayspring Active Wearable Compression Technology for Treating Lower Extremity Lymphedema
- Conditions
- Lymphedema, Lymphedema Lower Extremity, Chronic Venous Insufficiency, Secondary Lymphedema
- Trial name
- TIBER (NCT04897035)
- Testing
- Dayspring Active Wearable Compression System
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- Koya Medical, Inc.
Lymphoedema of Leg
Intermittent Pneumatic Compression for Treating Lower Limb Lymphoedema
The treatment of lymphoedema and its associated complications represent a considerable drain on increasingly limited NHS resources.
- Trial name
- IMPRESS II (NCT03856281)
- Testing
- Intermittent Pneumatic Compression
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Cwm Taf University Health Board (NHS)
Lower Extremity Lymphedema
Effectiveness of Digital Physiotherapy in the Short and Long-Term Management of Lower Extremity Lymphedema
This study investigated the short- and long-term effects of digital physiotherapy in patients with unilateral and bilateral lower extremity lymphedema.
- Trial name
- NCT07014566
- Testing
- Digital Combined Decongestive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people
- Sponsor
- Bezmialem Vakif University
Lymphedema, Lipedema
Multimodal Ultrasound for Differentiating Lymphedema and Lipedema
The aim of this observational study is to evaluate the diagnostic value of multimodal ultrasonography in differentiating between lymphedema and lipedema.
- Trial name
- NCT07489248
- Testing
- Multimodal Ultrasound Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Lymphedema, Gait Dysfunction
Impact of Virtual Reality (VR) Based Exercises on Lower Limb Lymphedema Outcomes (LELO)
This randomized controlled study aims to investigate the effects of virtual reality (VR)-assisted gait training, in addition to Complex Decongestive Therapy (CDT), on gait parameters, physical function, quality of life, and edema…
- Conditions
- Lymphedema, Gait Dysfunction, Physical Rehabilitation, Chronic Edema
- Trial name
- VR-LELO (NCT07472543)
- Testing
- Complex Decongestive Therapy (CDT) plus virtual reality (VR)-assisted gait training group, Complex Decongestive Therapy alone group
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Lymphedema, Secondary Lymphedema
Efficacy of Complete Decongestive Therapy for Limb Lymphedema: Response Profile and Predictive Modeling
Background: Complete decongestive therapy (CDT) is the standard treatment for lymphedema, but response varies by localization and laterality.
- Conditions
- Lymphedema, Secondary Lymphedema, Breast Cancer-Related Lymphedema, Upper Extremity Lymphedema
- Trial name
- LYMPH-PROG (NCT07878598)
- Testing
- Intensive phase of Complete Decongestive Therapy
- Where
- Russia
- Volunteers
- 150 people
- Sponsor
- Ryazan State Medical University
Compression; Vein, Venous Insufficiency
Digital Supported Compression Bandaging in Patients With Chronic Edema in the Lower Limbs
Patients with chronic edema of the lower limb referred to compression bandaging in a hospital setting will be invited to participate in the validation study of a novel sensor (CIMON), which have been developed for assessing the…
- Conditions
- Compression; Vein, Venous Insufficiency, Lymphedema of Leg, Digital Technology
- Trial name
- CIMON (NCT06438133)
- Testing
- CIMON, Sens Motion
- Where
- 5 sites in Denmark
- Volunteers
- 52 people
- Sponsor
- Carsten Bogh Juhl
Venous Stasis Ulcer, Quality of Patient Care
Venous Leg Ulcer and Lymphedema Registry
This is an observational, longitudinal real world registry of venous leg ulcers created from electronic health record data obtained in the course of clinical care.
- Trial name
- VLULR (NCT02813187)
- Testing
- cellular and tissue based therapy, debridement, advanced wound therapy
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- U.S. Wound Registry
Lymphedema
Causes of Kinesiophobia in Lymphedema
In this study, the reason for the fear of movement in patients with lymphedema will be investigated and recommendations will be given to the patients to eliminate it.
- Trial name
- NCT05105594
- Testing
- survey application
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Lower Extremity Lymphedema, Endometrial Cancer
Lymphedema in Endometrial Cancer
Objectives: (1) To determine the incidence of lower-extremity lymphedema after staging surgery for endometrial cancer; (2) to describe lymphedema-related morbidity after staging surgery for endometrial cancer and (3) to evaluate…
- Trial name
- NCT01914276
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Lymphedema, Stage 0 Cervical Cancer
Flexitouch® Home Maintenance Therapy or Standard Home Maintenance Therapy in Treating Patients With Lower-Extremity Lymphedema Caused by Treatment for Cervical Cancer, Vulvar Cancer, or Endometrial Cancer
This randomized phase III trial is studying Flexitouch® home maintenance therapy to see how well it works compared with standard home maintenance therapy in treating patients with lower-extremity lymphedema caused by treatment…
- Conditions
- Lymphedema, Stage 0 Cervical Cancer, Stage 0 Uterine Corpus Cancer, Stage 0 Vulvar Cancer
- Trial name
- NCT00577317
- Testing
- Management of Therapy Complications, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Gynecologic Oncology Group
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 1
Of all of the different measurement methods that are currently available for use in clinical practice for assessing the same lymphedema characteristic (for example water displacement versus perimetry, both assessing swelling) or…
- Trial name
- EvaLymph-Leg1 (NCT05269264)
- Testing
- Assessor A (first measurement): measurement methods and questionnaires for the assessment of LLL, Assessor B: measurement methods and questionnaires for the assessment of LLL, Assessor A (second measurement: measurement methods and questionnaires for the assessment of LLL
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Lower Limb Lymphedema
Development of a Clinical Screening, Diagnostic and Evaluation Tool for Patients With Lower Limb Lymphedema: Aim 3
The current best practice is a three-stage classification consensus guideline as published by the International Society of Lymphology (ISL).
- Trial name
- EvaLymph-Leg3 (NCT05757284)
- Testing
- Lower Limb Lymhedema assessment
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 140 people
- Sponsor
- KU Leuven
Lower Extremity Lymphedema
Aerobic Exercise Effects in Lower Extremity Lymphedema
Lower extremity lymphedema negatively affects patients' functional status, quality of life, and activities of daily living. Complete decongestive therapy (CDT) is considered the gold-standard conservative treatment for patients…
- Trial name
- NCT07726277
- Testing
- aerobic exercise program, complet decongestive therapy
- Volunteers
- 50 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Lower Extremity Lymphedema
Platelet Rich Plasma, Complex Decongestive Physiotherapy and Low Level Laser in Treatment of Lower Extremity Lymphoedema
At the end of the study, comparative information about the effects of PRP, complex decongestive physiotherapy and low level laser on edema volume, range of motion, muscle strength, functional capacity and quality of life will be…
- Trial name
- NCT03080207
- Testing
- PRP method, Low Level Laser, Complex Decongestive Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul University
Lymphedema, Perioperative/Postoperative Complications
Bioimpedance Spectroscopy in Detecting Lower-Extremity Lymphedema in Patients With Stage I, Stage II, Stage III, or Stage IV Vulvar Cancer Undergoing Surgery and Lymphadenectomy
This phase II trial studies bioimpedance spectroscopy in detecting lower-extremity lymphedema in patients with stage I, stage II, stage III, or stage IV vulvar cancer undergoing surgery and lymphadenectomy.
- Conditions
- Lymphedema, Perioperative/Postoperative Complications, Stage IA Vulvar Cancer AJCC v7, Stage IB Vulvar Cancer AJCC v7
- Trial name
- NCT01406769
- Testing
- Bioelectric Impedance Analysis, Lymphadenectomy, Therapeutic Conventional Surgery
- Where
- 11 sites in United States
- Volunteers
- 120 people
- Sponsor
- Gynecologic Oncology Group
Lower Limb Lymphedema, Fibrosis
Effect of Modified Complete Decongestive Therapy on Lower Limbs Fibrosis Post Cellulitis
this study will be designed to investigate the therapeutic benefits of kinesio tape in combination to complete decongestive therapy on limb volume , skin fibrosis, functional capacity ,ankle range of motion, lymphedema associated…
- Conditions
- Lower Limb Lymphedema, Fibrosis, Cellulitis of Leg
- Trial name
- NCT05661123
- Testing
- Complete decongestive therapy
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mastectomy Related Lymphedema, Lymphedema of Upper Limb
Testing an Intervention to Foster Hope for Cancer Survivors With Lymphedema
The specific objectives and research questions of the proposed study are: 1. a. Administer a group rehabilitation intervention to address loss and foster hope in 30 participants with upper and lower limb SLC --15 in an…
- Conditions
- Mastectomy Related Lymphedema, Lymphedema of Upper Limb, Lymphedema of Lower Extremity
- Trial name
- NCT02453295
- Testing
- Intervention Group
- Volunteers
- 60 people
- Sponsor
- University of Ottawa