Clinical trials: Lymphocytes
Breast Neoplasms
Study of Autologous Tumor-Draining Lymph Node-Derived Lymphocytes for Advanced HER2-Negative Breast Cancer
RATIONALE: Patients with HER2-negative advanced breast cancer have limited choice on targeted therapies, and often show only modest responses to available immunotherapies.
- Trial name
- NCT05981001
- Testing
- Surgery for harvesting tumor-draining lymph nodes, Cyclophosphamide, Fludarabine
- Where
- China
- Volunteers
- 170 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Cancer
Heparin or M-EDTA in Preventing Catheter-Related Infections and Blockages in Patients at High Risk for a Catheter-Related Infection
RATIONALE: Heparin or M-EDTA may prevent catheter-related infections and blockages in patients at high risk for a catheter-related infection.
- Trial name
- NCT00378781
- Testing
- Heparin, Minocycline-EDTA
- Sponsor
- M.D. Anderson Cancer Center
HIV Infections
Role of PLA2G1B During HIV Infection
The main objective of this study is to qualify and quantify, by microscopy techniques, CD4+ lymphocyte abnormalities during HIV infection in 7 patients who are naive to any ARV (antiretroviral ) treatment and secondarily to…
- Trial name
- PREDIACC (NCT04208711)
- Testing
- biological sample
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Diaccurate SAS
Acute Myeloblastic Leukemia
Transplant T CD4+ CCR7+ In Hematopoietic Stem Cells Allograft
This is a preclinical study prior to the establishment of a cell therapy protocol applicable to humans. The main objective is to evaluate the decrease in alloreactivity of TCD4 + population by partial selective depletion of CD4 +…
- Trial name
- CCR7-CD4-DPL (NCT03280290)
- Testing
- blood
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Melanoma; Renal Cell Carcinoma
Spontaneous Regression in Metastatic Melanoma and Renal Cell Carcinoma
The purpose of this study is to collect blood and clinical data from patients with metastatic melanoma and renal cell cancer who have experienced spontaneous regression for studies of immune response and other factors that may…
- Trial name
- NCT03728842
- Testing
- Blood collection for laboratory studies, Data collection from medical record
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Indiana University
HIV Infections
The Effects of Anti-HIV Drugs on the HIV Virus in HIV-Infected Patients
The purpose of this study is to examine the HIV virus in the blood and lymphoid tissues of patients taking anti-HIV medications. HIV infection is closely linked to the growth of the HIV virus in the body.
- Trial name
- NCT00006442
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Intensive Care
Effects of Neutrophil/Lymphocyte, Platelet/Lymphocyte, CRP/Albumin and Lactate on Mortality in Trauma Patients Admitted to Intensive Care
Intensive care units are medical units where patients are closely monitored 24 hours a day due to critical health problems that threaten their lives and where rapid interventions are made when necessary.
- Trial name
- NCT06667310
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Harran University
Metastatic Melanoma, Renal Cell Cancer
Mechanism of Action of High-Dose IL-2 (Aldesleukin) in Metastatic Melanoma and Kidney Cancer
Background: -Although IL-2 can shrink tumors in about 20 percent of patients with metastatic kidney cancer and in 15 percent of patients with metastatic melanoma, it is not fully known how the drug works.
- Trial name
- NCT00304460
- Testing
- aldesleukin
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- National Cancer Institute (NCI)
Healthy Volunteers
Development of a Cell Culture Process for the Production of Human T-lymphocyte Precursors
The purpose of this study is to finalise the development of a process for the production of T-cell progenitor cells.
- Trial name
- SMART101-HV1 (NCT05118113)
- Testing
- Collection of mobilized hematopoietic stem cells (apheresis products) from healthy volunteers
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Smart Immune SAS
Childhood Lymphocyte-Depleted Classical Hodgkin Lymphoma, Childhood Mixed Cellularity Classical Hodgkin Lymphoma
Chemotherapy With or Without Additional Chemotherapy and/or Radiation Therapy in Treating Children With Newly Diagnosed Hodgkin's Disease
This randomized phase III trial is studying different chemotherapy regimens given with or without radiation therapy to compare how well they work in treating children with newly diagnosed Hodgkin's disease.
- Conditions
- Childhood Lymphocyte-Depleted Classical Hodgkin Lymphoma, Childhood Mixed Cellularity Classical Hodgkin Lymphoma, Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma, Childhood Nodular Sclerosis Classical Hodgkin Lymphoma
- Trial name
- NCT00025259
- Testing
- Bleomycin Sulfate, Cisplatin, Cyclophosphamide
- Where
- 175 sites in United States, Australia and 5 more
- Volunteers
- 1,734 people
- Sponsor
- Children's Oncology Group
T-Cell Large Granular Lymphocyte Leukemia
Oral Azacitidine for the Treatment of Relapsed or Refractory T-cell Large Granular Lymphocytic Leukemia
This phase I/II trial studies the best dose, possible benefits and/or side effects of oral azacitidine in treating patients with T-cell large granular lymphocytic leukemia that has come back (relapsed) or has not responded to…
- Trial name
- NCT05141682
- Testing
- Oral Azacitidine
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Jonathan Brammer
Acute on Top of Chronic Liver Cell Failure
Neutrophil to Lymphocyte Ratio and Mean Platelet Volume as a Prognostic Predictor Among Patients With Acute on Top of Chronic Liver Cell Failure
Acute on chronic liver failure (ACLF) is a clinical syndrome of sudden hepatic decompensation observed in patients with pre-existing chronic liver disease and associated with one or more extrahepatic organ failures and increased…
- Trial name
- ACLF (NCT06857682)
- Where
- Egypt
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Assiut University
Relapsing-Remitting Multiple Sclerosis
Retrospective Study to Determine Effect of Rebif and Tecfidera on Infections and Lymphocytes
This study will be a single center, retrospective, pilot study to determine the effect of Rebif (interferon beta-1a) and Tecfidera (dimethyl fumarate) on infections on total lymphocyte counts, grade of lymphopenia, Cluster of…
- Trial name
- NCT03284970
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Relapsing Remitting Multiple Sclerosis
Impact of Vitamin A Supplementation on Immune System in Multiple Sclerosis Patients
The aim of this study is to study the comparison between the effects of supplementation with 25000 IU preformed vitamin A (retinyl palmitate) or placebo for 6 months on immune system and Th1/Th2 balance in patients with Multiple…
- Trial name
- NCT01225289
- Testing
- Vitamin A
- Where
- 2 sites in Iran
- Volunteers
- 36 people
- Sponsor
- Tehran University of Medical Sciences
HIV Infections
A Study of Two Anti-HIV Drug Combinations
The purpose of this study is to compare the safety and effectiveness of taking lamivudine (3TC) plus zidovudine (ZDV) plus a protease inhibitor (PI) with taking the 3TC/ZDV combination tablet (Combivir) plus a PI.
- Trial name
- NCT00002203
- Testing
- Lamivudine/Zidovudine, Lamivudine, Zidovudine
- Where
- 7 sites in United States, Puerto Rico
- Sponsor
- Glaxo Wellcome
Metastatic Uveal Melanoma, Metastatic Cutaneous Melanoma
Hepatic Arterial Infusion of Autologous Tumor Infiltrating Lymphocytes in Patients With Melanoma and Liver Metastases
The purpose of this study is to evaluate the feasibility, safety and tolerability of treatment with autologous tumor infiltrating lymphocytes (TIL) administered via hepatic arterial infusion in patients with liver metastases…
- Trial name
- HAITILS (NCT04812470)
- Testing
- Autologous Tumor Infiltrating Lymphocytes, Melphalan, Interleukin-2
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Vastra Gotaland Region
HIV Infections, Pregnancy
Active Immunization of HIV-1 Infected, Pregnant Women With CD4 Lymphocyte Counts >= 400/mm3: A Phase I Study of Safety and Immunogenicity of MN rgp120/HIV-1 Vaccine (NOTE: Some Patients Receive Placebo)
To evaluate the safety of rgp120/HIV-1MN vaccine in HIV-1 infected pregnant women with CD4 counts >= 400 cells/mm3. To evaluate the immunogenicity of this vaccine in pregnant women and the passive acquisition of vaccine-specific…
- Trial name
- NCT00001041
- Testing
- rgp120/HIV-1MN
- Where
- 6 sites in United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Breast Cancer
Study on the Safety and Efficacy of Autogenous Tumor Infiltrates Lymphocytes for the Treatment of Advanced Breast Cancer
Prospective, single-center, single-arm, open-label,interventional study evaluating adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocyte (TIL) infusion (HS-IT101) after lymphodepletion preparative with…
- Trial name
- NCT05505812
- Testing
- HS-IT101
- Where
- China
- Volunteers
- 10 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Arthritis, Juvenile Rheumatoid
Safety and Efficacy of Measles, Mumps, Rubella Vaccination in Juvenile Idiopathic Arthritis
Background: The safety of vaccination in patients with autoimmune diseases using immune suppressive therapy is often discussed. Previous studies in Juvenile Idiopathic Arthritis (JIA) patients showed no increase in disease…
- Trial name
- VAART (NCT00731965)
- Testing
- Measles, Mumps, Rubella vaccination
- Where
- 5 sites in Netherlands
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- N.M. Wulffraat
Healthy
Collection and Generation of Antigen-specific T-lymphocyte Cell Lines From Primary, Third-party, Related, and Unrelated Donors
The purpose of this study is to obtain lymphocyte collections from normal healthy volunteer donors in order to create Good Manufacturing Practice grade banks of virus-specific and tumor-reactive T-cells of defined HLA type and…
- Trial name
- NCT03114566
- Testing
- Leukapheresis
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center