Clinical trials: M-protein
Protein Metabolism
Prandial Metabolic Phenotype in Adults
Previous studies suggest that changes in metabolism due to the effects of aging might serve as a potential for therapeutic agents.
- Trial name
- NCT05400733
- Testing
- Total Amino Acids, Essential Amino Acids, Essential Amino Acids + Hydroxy-methylbutyric acid (HMB)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Protein Absorption and Amino Acid Availability
MA of Tryptophan in Cornmeal in Healthy Adults>60y
The world's population will reach 12 billion by this century's end. As the human population increases, the world faces the continuous challenge of optimizing a limited food supply.
- Trial name
- NCT07272668
- Testing
- Tryptophan
- Where
- Canada
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Cow's Milk Protein Allergy (CMPA)
TeriFort 1+ Study: Efficacy and Safety of an Extensively Hydrolyzed Formula in the Management of Cow's Milk Protein Allergy in Young Children: A Prospective, Single-Arm Interventional Study (TeriFort 1+)
This study aims to evaluate the clinical effect, as reported by physicians, of an extensively hydrolyzed formula in young children aged 1~3 years with diagnosed with or highly suspected CMPA in a real-world clinical practice…
- Trial name
- NCT07855796
- Testing
- Diagnosed with or highly suspected CMPA: Extensively Hydrolyzed Formula intervention
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Teyi Yinuo Health Technology Co., Ltd.
Protein Metabolism
Peanut Sip Feeding Protocol
Peanuts are considered a functional food and regular consumption is associated with positive health effects. Protein is the second most common nutrient in peanuts after fat.
- Trial name
- NCT06693544
- Testing
- Peanut protein
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
CKD, Low Protein Dietary Intake
Suitability of a High-energy, Low-protein Formula (Renalive® LP)
Inclusion criteria (1) Diagnosed with chronic kidney disease stage 3b-5 (with history of eGFR<45 mL/min/1.73 m2) Exclusion criteria (1) Has received dialysis or are expected to start dialysis within the next 3 months.
- Conditions
- CKD, Low Protein Dietary Intake, Malnutrition (Calorie)
- Trial name
- NCT06892249
- Testing
- Renalive® LP,
- Where
- 2 sites in Taiwan
- Volunteers
- 80 people
- Sponsor
- Fresenius Kabi Taiwan Ltd.
HER2-positive Breast Cancer, Metastatic Cancer
PRE-ISPY Phase I/II Oncology Platform Program
PRE-ISPY Phase I/II (I-SPY-P1) is an open-label, multisite platform study with multiple ongoing drug regimen arms added by protocol amendment which is designed to evaluate single agents or combinations in locally advanced…
- Conditions
- HER2-positive Breast Cancer, Metastatic Cancer, Metastatic Breast Cancer, Metastatic
- Trial name
- PRE-ISPY (NCT05868226)
- Testing
- ALX148, Fam-Trastuzumab Deruxtecan-Nxki, Zanidatamab
- Where
- 10 sites in United States
- Volunteers
- 280 people
- Sponsor
- QuantumLeap Healthcare Collaborative
Hemophilia A
Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa
The rationale for this study is to further understand and describe the long-term prophylactic effectiveness of efanesoctocog alfa in preventing joint bleeds in a real-life setting.
- Trial name
- NCT06940830
- Testing
- Efanesoctocog alfa
- Where
- 31 sites in Croatia, Czechia and 6 more
- Volunteers
- 252 people
- Sponsor
- Swedish Orphan Biovitrum
Elranatamab, Myeloma
A Study of Elranatamab (PF-06863135) in Chinese Participants With Refractory Multiple Myeloma.
The purpose of this study is to understand the study medicine (called Elranatamab, or PF-06863135) as potential treatment for refractory multiple myeloma.
- Conditions
- Elranatamab, Myeloma, Multiple Myeloma, Relapsed Multiple Myeloma
- Trial name
- NCT05228470
- Testing
- Elranatamab
- Where
- 15 sites in China
- Volunteers
- 39 people
- Sponsor
- Pfizer
Healthy Ageing, Protein Supplementation
The Effects of PeptiStrong and Whey on Muscle Function In Older Adults
Examining the effects of PeptiStrong and protein on muscle function in older adults
- Conditions
- Healthy Ageing, Protein Supplementation, Muscle Health, Muscle Function
- Trial name
- NCT07528469
- Testing
- PeptiStrong + whey protein, Whey protein
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Nuritas Ltd
Diabetes Mellitus, Type 2, Insulin
Assessing the Value of Avocados on Glycemic Control in Type 2 Diabetes
The objective of this study is to assess the effects of Hass Avocados on glycemic control. The investigators hypothesize that Hass Avocado consumption will reduce fasting blood sugar compared to an isocaloric amount of other…
- Conditions
- Diabetes Mellitus, Type 2, Insulin, Fructosamine, C-Reactive Protein
- Trial name
- AVOCADO-T2D (NCT05958368)
- Testing
- Avocado, Other Fruit(s)
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Sarcopenia, Cirrhosis, Liver
LIver FRAilty Management IN Cirrhosis (LIFRAMIN)
The goal of this clinical trial is to compare food for special medical purposes (Aminolife Plus, by Piemme Pharmatech) vs. placebo in improving muscle mass and function in a cohort of cirrhotic patients.
- Conditions
- Sarcopenia, Cirrhosis, Liver, Malnutrition; Protein
- Trial name
- LIFRAMIN (NCT06573229)
- Testing
- Aminolife Plus by Piemme Pharmatech, Italy
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hemophilia A
A Study to Evaluate Impact of Efanesoctocog Alfa on Long-term Joint Health in Participants With Hemophilia A in Taiwan
This is a national, multicenter, retrospective/prospective, observational study in Taiwan designed to assess effectiveness, safety, and usage of efanesoctocog alfa prophylaxis treatment in hemophilia A participants.
- Trial name
- PROTECT-ALT (NCT06684314)
- Testing
- Efanesoctocog alfa
- Where
- 10 sites in Taiwan
- Volunteers
- 79 people
- Sponsor
- Sanofi
Protein Metabolism
Effects of Protein Type and Mineral Form on Amino Acid Availability
To compare postprandial plasma amino acid availability, expressed as incremental area under the curve (iAUC), over a 6 hour period following ingestion of 25 g of different protein isolates in healthy, young adults.
- Trial name
- ProMin (NCT07677098)
- Testing
- Protein beverage
- Where
- Netherlands
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Establish the Amount of CENPV Protein in Human Oocytes as a Diagnostic Tool Against Damage Caused by Ageing or by the Procedure of Vitrification of Oocytes, Advance Maternal Age
CENP-V as a Potential Diagnostic Marker of Damage in Human Oocytes
Proper chromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner.
- Conditions
- Establish the Amount of CENPV Protein in Human Oocytes as a Diagnostic Tool Against Damage Caused by Ageing or by the Procedure of Vitrification of Oocytes, Advance Maternal Age, Vitrification and Thawing
- Trial name
- CENP-PILOT (NCT06788379)
- Where
- Spain
- Volunteers
- 160 people
- Sponsor
- Vida Recoletas Sevilla
Fibroblast Activation Protein (FAP)-Positive Advanced Solid Tumours
Clinical Evaluation of 177Lu-FAP-VG11 Injection in Patients With Fibroblast Activation Protein -Positive Advanced Solid Tumours
This is an exploratory clinical study evaluating the safety, tolerability and biodistribution characteristics of 177Lu-FAP-VG11 injection in patients with FAP-positive advanced solid tumours.
- Trial name
- NCT07808177
- Testing
- 177Lu-FAP-VG11
- Where
- China
- Volunteers
- 7 people
- Sponsor
- Shandong Cancer Hospital and Institute
Obesity & Overweight, Collagen Protein
Collagen Supplements and Post-MBS Muscle Mass/Body Image
This prospective, observational cohort study aims to evaluate whether the use of collagen-containing supplements is associated with differences in muscle mass, body composition, and body image among patients who have undergone…
- Conditions
- Obesity & Overweight, Collagen Protein, Bariatric Surgery, Metabolic and Bariatric Surgery
- Trial name
- NCT07809152
- Testing
- Collagen-containing supplement
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mudanya University
Overweight and Obesity, Bariatric Surgery Candidate
Protein Digestion After Bariatric Surgery in Older Adults
The goal of this clinical trial is to investigate protein digestibility after bariatric surgery. Does protein digestibility decrease after Roux-en-Y-Gastric Bypass? Does protein digestibility decrease after Sleeve Gastrectomy…
- Conditions
- Overweight and Obesity, Bariatric Surgery Candidate, Aging, Protein Malabsorption
- Trial name
- ProDigBO (NCT06076187)
- Testing
- Dual isotope protein digestibility method
- Where
- 2 sites in Belgium
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy
Non-Immunoglobulin E-mediated Food Allergies in Children
Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFA) are an evolving web of clinical conditions characterized by subacute and/or chronic symptoms and include food protein-induced enterocolitis syndrome (FPIES), food…
- Conditions
- Non IgE Mediated Food Allergy, Food Protein-Induced Enteropathy, Food Protein-Induced Proctocolitis, Food Protein-Induced Enterocolitis Syndrome
- Trial name
- NIGEFA (NCT04462978)
- Testing
- Non IgE-mediated food allergy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federico II University
BCR-JAK2 Fusion Protein Expression, Blasts 20 Percent or Less of Peripheral Blood White Cells
Ruxolitinib in Treating Patients With Hypereosinophilic Syndrome or Primary Eosinophilic Disorders
This phase II trial studies how well ruxolitinib works in treating patients with hypereosinophilic syndrome or primary eosinophilic disorders.
- Conditions
- BCR-JAK2 Fusion Protein Expression, Blasts 20 Percent or Less of Peripheral Blood White Cells, Blasts More Than 5 Percent of Bone Marrow Nucleated Cells, Blasts More Than 5 Percent of Peripheral Blood White Cells
- Trial name
- NCT03801434
- Testing
- Ruxolitinib
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Stanford University
Obesity, Elevated High-sensitivity C-reactive Protein (hsCRP)
A Study to See How Safe a New Medicine (NNC6022-0004) is in Healthy People and People Living With Obesity
This study is being done to look at the efficacy single and multiple ascending dose study investigating safety, tolerability, pharmacokinetics, food effect and target engagement in healthy adults including a single cohort in…
- Trial name
- NCT07693868
- Testing
- NNC6022-0004
- Where
- Netherlands
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S