Clinical trials: MBL
Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss
Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction
A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including…
- Conditions
- Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss, Recurrent Implantation Failure, Infertility
- Trial name
- NCT05169541
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aalborg University Hospital
Multiple Myeloma, Leukemia
Specimen Collection for Agricultural Health Study Cohort Pesticide Exposure Study
Background: Multiple myeloma (MM), a type of cancer that affects the white blood cells, is often preceded by a precancerous disorder known as monoclonal gammopathy of undetermined significance (MGUS).
- Conditions
- Multiple Myeloma, Leukemia, MGUS, Monoclonal B-Cell Lymphocytosis
- Trial name
- NCT01139476
- Where
- United States
- Volunteers
- 1,892 people
- Sponsor
- National Cancer Institute (NCI)
Marginal Bone Loss
Evaluation of Marginal Bone Loss (MBL) 12 Months Post-loading of Implants Supporting Individual Crowns, Based on the Height of the Intermediate Abutment and Its Placement Time. Immediate Abutments of 2 or 3 Mm Show the Lowest MBL, Whereas 1.5 Mm or Delayed Abutments Are Associated with Higher MBL.
Objectives:To determine which combination of abutment height and timing of placement is most effective in reducing marginal bone loss (MBL).
- Trial name
- NCT06667531
- Testing
- Implant
- Where
- Spain
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Quintas Hijós Clínica Dental
Enterobacteriaceae Infections, Carbapenem-Resistant Enterobacteriaceae Infection
Aztreonam-Avibactam in Immunocompromised Hosts
The goal of this observational study is to learn about the effectiveness and safety of aztreonam-avibactam (ATM-AVI), an antibiotic used to treat infections caused by highly resistant bacteria, in adults with weakened immune…
- Conditions
- Enterobacteriaceae Infections, Carbapenem-Resistant Enterobacteriaceae Infection, Immunocompromised Host, Drug Resistance, Multiple, Bacterial
- Trial name
- IMMUNO-AVI (NCT07890480)
- Testing
- Aztreonam-Avibactam, Ceftazidime-Avibactam Plus Aztreonam
- Where
- Argentina
- Volunteers
- 814 people
- Sponsor
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
Monoclonal B-Cell Lymphocytosis, Stage 0 Chronic Lymphocytic Leukemia
Lenalidomide in Improving Immune Response to Vaccine Therapy in Patients With Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Monoclonal B Cell Lymphocytosis
This randomized phase II trial studies how well lenalidomide improves immune response to pneumococcal 13-valent conjugate vaccine in patients with chronic lymphocytic leukemia, small lymphocytic lymphoma, or monoclonal B cell…
- Conditions
- Monoclonal B-Cell Lymphocytosis, Stage 0 Chronic Lymphocytic Leukemia, Stage I Chronic Lymphocytic Leukemia, Stage I Small Lymphocytic Lymphoma
- Trial name
- NCT02309515
- Testing
- Laboratory Biomarker Analysis, Lenalidomide, Pneumococcal 13-valent Conjugate Vaccine
- Where
- 3 sites in United States
- Volunteers
- 12 people
- Sponsor
- Mayo Clinic
Lymphoproliferative Disorders, Premalignant
Familial B-cell Lymphoproliferative Disorders
This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of…
- Conditions
- Lymphoproliferative Disorders, Premalignant, Monoclonal B-Cell Lymphocytosis, Chronic Lymphocytic Leukemia
- Trial name
- Familial_LPD (NCT05718986)
- Testing
- No intervention
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of Haifa
HCV Infection, Liver Transplantation
Study in Hepatitis C Virus (HCV) Infected Patients Undergoing Liver Transplantation to Evaluate a Human Monoclonal Antibody Against Hepatitis C
The purpose of this study is to determine whether a human monoclonal antibody against Hepatitis C (MBL-HCV1) is effective in preventing detectable levels of Hepatitis C virus in patients undergoing liver transplantation due to…
- Trial name
- MBL-HCV1 (NCT01121185)
- Testing
- MBL-HCV1
- Where
- 8 sites in United States
- Volunteers
- 13 people
- Sponsor
- MassBiologics
Endometriosis
Genetic Polymorphisms of Mannan-binding Lectin (MBL)and Serum Levels of MBL in Patients With Endometriosis
The purpose of the study is to investigate the possible association between low levels of MBL and the development of endometriosis
- Trial name
- NCT01738932
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- University of Aarhus
Carotid Artery Plaque, Mannose-Binding Lectin Complement Pathway
Lectine Pathway in Unstable Carotid Plaque
The study is aimed to investigate the possible role of lectin pathway - an alternative pathway of complement activation - in affecting stability of carotid atherosclerotic plaques and the possible correlations with clinical…
- Trial name
- NCT03822195
- Testing
- Carotid endoarterectomy
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes
Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome
Blood cancers occur when the molecules that control normal cell growth are damaged. Many of these changes can be detected by directly examining parts of the cancer or cells in blood.
- Conditions
- Monoclonal Gammopathy of Undetermined Significance (MGUS), Myelodysplastic Syndromes, Hematological Malignancies, B-cell Malignancy, Low-grade
- Trial name
- NCT02269592
- Where
- 7 sites in United States
- Volunteers
- 10,000 people
- Sponsor
- Dana-Farber Cancer Institute
Hypothyroidism; Irradiation
TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients
To offer the possibility of a treatment that could achieve a meaningful reduction in the incidence of post-radiation therapy hypothyroidism.
- Trial name
- WIN-HYPO2021 (NCT05316922)
- Testing
- Levothyroxine
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Septic Shock
Use of Fc-MBL to Detect and Monitor the Presence of PAMPs During Septic Shock
Use Mannose Binding Lectin (MBL) as a biomarker to measure levels of Pathogen- Associated Molecular Patterns (PAMP) during septic shock. This will allow evaluating interest of this biomarker to monitor and manage a septic shock.
- Trial name
- Fc-MBL/PAMPs (NCT03457038)
- Testing
- Blood Test
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Autoimmune Hemolytic Anemia, Chronic Lymphocytic Leukemia
Ibrutinib for the Treatment of AIHA in Patients With CLL/SLL or CLL-like MBL
This is a multicenter, single arm, phase II study aimed at evaluating ibrutinib therapy for the treatment of AIHA in patients with CLL/SLL or CLL-like MBL.
- Conditions
- Autoimmune Hemolytic Anemia, Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis CLL-Type
- Trial name
- NCT05694312
- Testing
- Ibrutinib 420 mg
- Where
- 3 sites in Italy
- Volunteers
- 45 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Diabetes Mellitus, Type 2
Immune Profile and Complication Risk in Type 2 Diabetes
The aim of this study is to investigate the relation between individual differences in pattern recognition molecules (PRM's) in the innate immune system and the prevalence and development of vascular complications in patients…
- Trial name
- IMPACT (NCT00674271)
- Where
- Denmark
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Periodontal Diseases
Influence of Periodontal Disease Treatment on Serum Levels of Sirtuin 1 and Mannose-binding Lectin
The premise of the relationship between the atherosclerotic process of coronary artery disease and periodontal disease is the immunoinflammatory process, which causes a significant increase in serum concentration of…
- Trial name
- NCT03753451
- Testing
- treatment of periodontal disease
- Where
- 2 sites in Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Chronic Lymphocytic Leukemia, Monoclonal B-Cell Lymphocytosis
Hematopoiesis in MBL and CLL Versus Healthy Age-Matched Control Subjects
This study evaluates hematopoiesis to determine how MBL/CLL affected bone marrow responds to fight off infections in the body.
- Trial name
- NCT06536452
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Jaw, Edentulous, Partial Edentulism
Evaluation of MBL Around Implants Placed in Crestal or Subcrestal Positions: a RCT
The objective of this randomized controlled trial is to evaluate changes in marginal bone levels and soft tissue dimensions around implants placed with the IAI at different positions in relation to the alveolar crest
- Trial name
- NCT03806608
- Testing
- Crestal, Subcrestal
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Chronic Viral Hepatitis C, Monoclonal B-Cell Lymphocytosis
Study to Assess Monoclonal B-Cell Lymphocytosis in Individuals With Chronic Hepatitis C
This study evaluates the incidence of monoclonal B-cell lymphocytosis MBL) in patients with chronic hepatitis C and to determine if monoclonal b-cell lymphocytosis is affected by treatment for hepatitis C.
- Trial name
- NCT06564051
- Testing
- Non-Interventional Study
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Mayo Clinic
Serious Bacterial Infection
Efficacy, Safety, and Tolerability of ATM-AVI in the Treatment of Serious Infection Due to MBL-producing Gram-negative Bacteria
Phase 3 study to determine the efficacy, safety, and tolerability of aztreonam- avibactam (ATM- AVI) versus best available therapy (BAT) in the treatment of hospitalized adults with complicated intra-abdominal infections (cIAI)…
- Trial name
- NCT03580044
- Testing
- ATM-AVI, BAT
- Where
- 42 sites in United States, Argentina and 10 more
- Volunteers
- 15 people
- Sponsor
- Pfizer
Acute Leukemia, Invasive Fungal Infection
Study of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute Leukemia
The aim of this study is to investigate levels of a protein, mannose binding lectin, in patients with acute leukemia who develop or not an invasive fungal infection.
- Trial name
- MBL INFFONG (NCT02823132)
- Testing
- blood sample
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Centre Hospitalier Universitaire Dijon