Clinical trials: MGD
Meibomian Gland Dysfunction
Vectored Thermal Pulsation, Intense Pulsed Light, and Eyelid Warm Compress Therapies for MGD
Meibomian gland dysfunction (MGD), closely associated with Dry Eye Disease (DED), is a chronic condition where terminal ducts are obstructed and/or glandular secretion changes. The efficacy of traditional treatment options, e.g.
- Trial name
- NCT05577910
- Testing
- Vectored thermal pulsation (VTP) therapy, Intense pulsed light with meibomian gland expression (IPL+MGX) therapy, Eyelid Warm Compress Therapy (EW)
- Where
- 4 sites in Hong Kong
- Volunteers
- 374 people
- Sponsor
- Chinese University of Hong Kong
Meibomian Gland Dysfunction
Methods to Enhance AZR-MD-001 for Meibomian Gland Dysfunction (MGD)
Single-center, single-masked (the individual(s) performing efficacy and safety measures will be masked to treatment assignment for the patient(s) they are assessing), vehicle-controlled, randomized study.
- Trial name
- NCT04314362
- Testing
- AZR-MD-001 ointment/semi-solid drug
- Where
- Australia
- Volunteers
- 32 people
- Sponsor
- Azura Ophthalmics
Adenocarcinoma, Non-Small-Cell Lung Carcinoma
Study of Motexafin Gadolinium (MGd) for Second Line Treatment of Non-Small-Cell Lung Cancer
The purpose of this study is to determine the effect of MGd in non-small-cell lung cancer (NSCLC) when given alone, and to evaluate the difference between two dosing regimens.
- Conditions
- Adenocarcinoma, Non-Small-Cell Lung Carcinoma, Lung Neoplasms
- Trial name
- NCT00129844
- Testing
- Motexafin Gadolinium
- Where
- 16 sites in United States, Canada
- Volunteers
- 108 people
- Sponsor
- Pharmacyclics LLC.
Meibomian Gland Dysfunction (MGD)
Treatment of Meibomian Gland Dysfunction
The current study aims to test the efficacy of treatment for a device that utilises a thermal pulsation system, which applies heat from the inner surface of the eyelids (Lipiflow) in patients suffering from meibomian gland…
- Trial name
- NCT01683318
- Testing
- Thermal Pulsation therapy
- Where
- Singapore
- Volunteers
- 25 people
- Sponsor
- Singapore National Eye Centre
Meibomian Gland Dysfunction (MGD)
The Effect of an Eyelid Warming Device for the Management of Meibomian Gland Dysfunction
Along the edge of the eyelids, there are glands (meibomian glands) that produce and deliver oils (meibum) onto the tear film. These oils serve to slow down the evaporation of tears.
- Trial name
- Hummingbird (NCT02284997)
- Testing
- MGDRx® EyeBag
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- University of Waterloo
Dry Eye
I-DROP MGD Symptomatic Relief and Tear Film Stability
The objective of the study is to compare the difference in tear film stability and symptomatic relief between I-DROP MGD and another commercially available drop in the Canadian market.
- Trial name
- NCT05011708
- Testing
- I-DROP MGD, Thealoz Duo
- Where
- 2 sites in Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- I-MED Pharma
Evaporative Dry Eye Disease
Comparative Efficacy Study to Demonstrate the Non-inferiority of I-DROP® MGD Versus 2 Competitor Eye Drops in Managing Evaporative Dry Eye
A Pilot Comparative study between I-DROP MGD vs two commercially available lubricant eye drops for the management of evaporative dry eye
- Trial name
- NCT06686368
- Testing
- I-DROP MGD, Theloze Duo, Systane Complete PF
- Volunteers
- 60 people
- Sponsor
- I-MED Pharma
Meibomian Gland Dysfunction, Evaporative Dry Eye Disease
Comparison Between iLux and LipiFlow in the Treatment of Meibomian Gland Dysfunction (MGD): A 12-month, Multicenter Study
The purpose of this post-approval study is to demonstrate that iLux treatment offers comparable treatment effectiveness to LipiFlow for MGD treatment at 12 months post single treatment.
- Trial name
- NCT03956225
- Testing
- Systane iLux® Dry Eye System, LipiFlow® Thermal Pulsation System
- Where
- 15 sites in United States
- Volunteers
- 299 people
- Sponsor
- Alcon Research
Dry Eye
Effect of Intense Pulse Light (IPL) Treatment on Tear Film Osmolarity
Evaluate changes in tear film osmolarity and other DED signs/symptoms following treatment with IPL.
- Trial name
- NCT02992535
- Testing
- Intense Pulse Light Energy delivery (IPL)
- Volunteers
- 60 people
- Sponsor
- Carones Ophthalmology Center
Meibomian Gland Dysfunction
Evaluation of AZR-MD-001 in Patients With Meibomian Gland Dysfunction (MGD)
AZ202001 is a multicenter study of AZR-MD-001 ointment and AZR-MD-001 vehicle in patients with Meibomian Gland Dysfunction (MGD)
- Trial name
- NCT04391959
- Testing
- AZR-MD-001 Active, AZR-MD-001 Vehicle
- Where
- 5 sites in Australia, New Zealand
- Volunteers
- 31 people
- Sponsor
- Azura Ophthalmics
Aqueous Deficient Dry Eye, Meibomium Gland Dysfunction
Non-invasive Tear Film Dynamic Measurements in Normal, MGD and ADDE Subjects After Saline Instillation
Compare the objective tear film dynamic measurements in three different populations (MGD [Meibomium Gland Dysfunction], ADDE [Aqueous Deficient Dry Eye] and normal/control [non-dry eye]) and the subjective experience before and…
- Trial name
- NCT01128049
- Testing
- Subjective Questionnaire, Measurement with wavefront sensor (right eye, then left eye), Instill Saline Drop
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma
Study of Motexafin Gadolinium (MGd) in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
The primary purpose of this study is to determine if motexafin gadolinium may be an effective treatment for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL).
- Trial name
- NCT00100711
- Testing
- Motexafin Gadolinium
- Where
- 3 sites in United States
- Volunteers
- 27 people
- Sponsor
- Pharmacyclics LLC.
Meibomian Gland Dysfunction
Efficacy and Safety of Thermic Devices in the Treatment of Meibomian Gland Dysfunction
Dry eye syndrome is a common eye disease that affects 1 to 2 out of 10 persons around the planet. One common cause of this disease is the meibomian gland dysfunction.
- Trial name
- NCT03767530
- Testing
- Mibo Thermoflo, Warm compresses and eyelid massage
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Universidad Autonoma de Nuevo Leon
Meibomian Gland Dysfunction, Evaporative Dry Eye
Dextenza With ILUX for Treatment of MGD
To evaluate the benefit of treatment with a physician administered intracanalicular dexamethasone insert in evaporative dry eye disease (DED) patients with meibomian gland disfunction (MGD) and underlying inflammation undergoing…
- Trial name
- NCT04658927
- Testing
- Dexamethasone, 0.4mg, Prednisone acetate, Control
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Warrenville Eyecare
Meibomian Gland Dysfunction, Dry Eye Disease
Fingerprick Autologous Blood (FAB) in Mebomian Gland Dysfunction (MGD)
Dry eye disease remains one of the most common complaints seen in ophthalmic clinics. Causes of dry eye are multifactorial, with the most common cause of evaporative dry eye disease being meibomian gland dysfunction (MGD).
- Trial name
- NCT02943382
- Testing
- Fingerprick autologous blood (FAB)
- Volunteers
- 20 people
- Sponsor
- Bedford Hospital NHS Trust
Blepharitis, Dry Eye Syndrome
Treatment of Meibomian Gland Dysfunction Prior to Cataract Surgery
The purpose of this pilot feasibility study is to assess whether treating meibomian gland dysfunction (MGD) prior to cataract surgery helps promote meibomian gland function, visual quality and ocular comfort after cataract…
- Trial name
- NCT01808560
- Testing
- LipiFlow Pre-Treatment, LipiFlow Post-treatment
- Where
- 7 sites in United States
- Volunteers
- 34 people
- Sponsor
- TearScience, Inc.
Dry Eye, MGD-Meibomian Gland Dysfunction
Comparative Effects of USB-Powered Warm Compress and Self-Heating Eye Mask in the Management of Meibomian Gland Dysfunction
Why was this study done? People with Meibomian Gland Dysfunction (MGD) often have dry, irritated eyes because the tiny oil glands in their eyelids do not work properly.
- Trial name
- NCT07618169
- Testing
- USB-Powered Warm Compress, Self-Heating Eye Mask
- Where
- Saudi Arabia
- Volunteers
- 15 people
- Sponsor
- King Saud University
Dry Eye Syndrome
Efficacy Comparison of Two Kinds of Treatment in Treating Dry Eye Caused by Meibomian Gland Dysfunction
This study aims to evaluate the efficacy of intense pulsed light in treating dry eye caused by meibomian gland dysfunction and make a comparison between the traditional treatment.
- Trial name
- NCT02958514
- Testing
- intense pulsed light, Tobramycin and Dexamethasone Ophthalmic Ointment
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Meibomian Gland Dysfunction
The Influence of Meibomian Gland Expression on Corneal Aberrations in MGD Patients
To evaluate the influence of corneal-aberrations before and after the meibomian gland thermal massage treatment.
- Trial name
- NCT05028491
- Where
- China
- Volunteers
- 62 people
- Sponsor
- Wenzhou Medical University
Meibomian Gland Dysfunction (MGD), Contact Lens Discomfort (CLD)
An Evaluation of AZR-MD-001 as Treatment for Meibomian Gland Dysfunction (MGD) or Contact Lens Discomfort (CLD)
SOVS2019-070 is a single-center study of AZR-MD-001 ointment and AZR-MD-001 vehicle in patients with Meibomian Gland Dysfunction (MGD) or Contact Lens Discomfort (CLD).
- Trial name
- NCT03972501
- Testing
- AZR-MD-001 Vehicle, AZR-MD-001 Active Dose
- Where
- Australia
- Volunteers
- 26 people
- Sponsor
- Azura Ophthalmics