Clinical trials: MODS
Organ Failure, Multiple, Indigestion
The Impact and Effect of Traditional Chinese Medicine Treatment on Organ Failure in Critically Ill Patients
Critically ill patients are at risk of or suffering from one or more key organs or organ system failure. This study will measure the effect of traditional Chinese medicine(TCM) interventions on critically ill patients admitted to…
- Conditions
- Organ Failure, Multiple, Indigestion, Delayed Gastric Emptying, Respiratory Failure
- Trial name
- NCT06452966
- Testing
- traditional Chinese medicine, Routine ICU care, historical Routine ICU care
- Where
- Taiwan
- Volunteers
- 350 people
- Sponsor
- China Medical University Hospital
Pediatric Sepsis-induced Multiple Organ Dysfunction Syndrome, Septic Shock
Early Continuous Renal Replacement Therapy for Pediatric Septic Shock
Septic shock is a major cause of morbidity and mortality in critically ill children. Continuous renal replacement therapy (CRRT) is increasingly used as adjunctive support in pediatric septic shock to improve hemodynamic…
- Trial name
- NCT07370753
- Where
- Vietnam
- Volunteers
- 50 people
- Sponsor
- National Children's Hospital, Vietnam
Cardiac Disease, Multiple Organ Dysfunction Syndrome
Efferon LPS Hemoadsorption in Cardiac Surgery Patients
This randomized controlled study aims to evaluate the efficacy and safety of intraoperative and early postoperative hemoadsorption using the Efferon® LPS device in patients undergoing cardiac surgery with cardiopulmonary bypass…
- Trial name
- NCT07532174
- Testing
- Efferon LPS
- Where
- 3 sites in Russia
- Volunteers
- 60 people
- Sponsor
- Efferon JSC
Sepsis, Septic Shock
Can Gdf-15 Level Predict Progression to Multiple Organ Failure in Patients With Septic Shock
The aim of this observational study is to investigate whether GDF-15 levels can predict clinical outcome in patients admitted to the intensive care unit with a diagnosis of septic shock.
- Conditions
- Sepsis, Septic Shock, Multi Organ Failure
- Trial name
- NCT06808100
- Where
- Turkey (Türkiye)
- Volunteers
- 250 people
- Sponsor
- Ankara City Hospital Bilkent
Multivisceral Failure Syndrome, Monovisceral Failure
Measurement of Intestinal Permeability in Intensive Care Patients With Single or Multiple Organ Failure
Multivisceral failure syndrome (MVFS) in humans is associated with a very high risk of mortality, ranging between 30 and 50%. This syndrome is associated with significant systemic inflammation and a high risk of bacteremia, the…
- Conditions
- Multivisceral Failure Syndrome, Monovisceral Failure, Infection in ICU
- Trial name
- BLUE-REA (NCT06845865)
- Testing
- enteric dyed solution
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Direction Centrale du Service de Santé des Armées
Trauma, Inflammation
Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Trauma and major operation are associated with an excessive inflammation reaction due to tissue injury. This overwhelming immune response is considered to be a major risk factor in the pathogenesis of late inflammatory…
- Conditions
- Trauma, Inflammation, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- CAESAR (NCT01275976)
- Testing
- C1-esterase inhibitor, Saline 0.9%
- Where
- Netherlands
- Volunteers
- 11 people
- Sponsor
- UMC Utrecht
Multiple Organ Failure
Feasibility Study of MicroKine Dx System in Critically-ill Pediatric Patients.
This study will enroll approximately 25 pediatric patients to assess the performance and real-world feasibility of multi-biomarker based prognostic and predictive algorithms to aid in the clinical management of pediatric…
- Trial name
- NCT04295278
- Testing
- MicroKine Dx system
- Volunteers
- 25 people
- Sponsor
- PreDxion Bio, Inc.
Tuberculosis, Pulmonary, Mycobacterium Tuberculous
Utility of MODS for Diagnosis of MDR-TB and Second-Line Antituberculous Drug Susceptibility Testing in Mali
Background: -Tuberculosis (TB) is an infection of the lungs caused by bacteria. In Mali, TB is diagnosed with a test that is fast and inexpensive but not always accurate.
- Conditions
- Tuberculosis, Pulmonary, Mycobacterium Tuberculous, Antitubercular Agents, Tuberculosis, Mulutidrug-Resistant
- Trial name
- NCT01381757
- Where
- 2 sites in United States, Mali
- Volunteers
- 34 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cytomegalovirus Infections, HIV Infections
A Study of HIV and Cytomegalovirus (CMV) in HIV-Infected Patients
To define relationships between 1) HIV load and risk of CMV disease, 2) CMV load and the risk of developing CMV disease, and 3) CMV load and HIV load.
- Trial name
- NCT00001089
- Where
- 36 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Organ Dysfunction Syndrome
The Prognostic Assessment of Extubation in Aged Patients With Multiple Organ Dysfunction Syndrome
The multiple organ dysfunction syndrome (MODS) has remained the major factor contributing to prolongation of intensive and mortality.
- Trial name
- NCT01802983
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Chinese PLA General Hospital
Multiple Organ Failure, Critical Illness
Supplemental Parenteral Nutrition in Critically Ill Adults: A Pilot Randomised Controlled Trial
One of the essential treatments for assisting patients in their recovery from illness is the provision of nutrition in a liquid form which is delivered into the stomach or as a fluid into the vein.
- Trial name
- NCT01847534
- Testing
- Supplemental PN, Standard Care
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 100 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Surgery, Multiorgan Failure
The Influence of Nursing Technique Applied at the Central Venous Catheter Insertion Site Upon the Incidence of Infection
Assessing the impact of the nursing technique applied at the insertion site of the central venous catheter using hydrophilic methacrylate gel (HMG) and 2% Chlorhexidine (CHG) upon the incidence of inflammatory complications when…
- Conditions
- Surgery, Multiorgan Failure, Haematologic Disease
- Trial name
- NCT03875352
- Testing
- CHG technique, HMG technique
- Where
- Czechia
- Volunteers
- 221 people
- Sponsor
- University Hospital Ostrava
Hematopoietic Cell Transplantation
A Prospective Registry of Pediatric Cellular Therapy Patients at Risk for Endothelial Dysfunction, Sinusoidal Obstruction Syndrome and/or Multi-Organ Dysfunction Syndrome (MODS).
This is a prospective international multi-center registry and biorepository trial of children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT) to assess the impact of endotheliopathies in the…
- Trial name
- NCT05090345
- Testing
- Biorepository Trial
- Where
- 3 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Shock, Death
Polish Nationwide Register of Hospitalized Patients in Cardiac Intensive Care Units
Cardiac Intensive Care Units (CICUs) provide care for a diverse patient population. Understanding the clinical characteristics, analysis of treatment modalities, and prognosis of patients hospitalized in the CICU are important to…
- Conditions
- Shock, Death, Cardiac Intensive Care Unit, Treatment Complication
- Trial name
- POL-CICU (NCT06371677)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Warsaw
ICU Mortality (Survival Rate)
FOUR-Based Modification of ICU Severity Scores
The goal of this observational study is to evaluate whether the Full Outline of UnResponsiveness (FOUR) score can replace the Glasgow Coma Scale (GCS) as the neurologic component of established intensive care unit (ICU) severity…
- Trial name
- FOUR-ICU (NCT07832773)
- Where
- Iraq
- Volunteers
- 2,000 people
- Sponsor
- Al-Nahrain University
Acute Lung Injury, Acute Respiratory Distress Syndrome (ARDS)
Using Human Menstrual Blood Cells to Treat Acute Lung Injury Caused by H7N9 Bird Flu Virus Infection
The purpose of this study is to determine whether human menstrual blood-derived stem cells are effective in the treatment of infection of H7N9 virus caused acute lung injury.
- Conditions
- Acute Lung Injury, Acute Respiratory Distress Syndrome (ARDS), Multiple Organ Failure
- Trial name
- NCT02095444
- Testing
- Menstrual blood stem cells
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- S-Evans Biosciences Co., Ltd.
Congenital Disease
Kids Intestinal Dysfunction in Congenital Heart Disease: the Kind Heart Study
Approximately 40,000 infants are born each year in the United States with congenital heart defects (CHD), and heart defects are the leading cause of birth defect-related deaths in the United States.
- Trial name
- NCT02824705
- Testing
- Congenital Heart Disease Surgery
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Arizona
Acute Kidney Injury, Multi Organ Failure
Long Term Renal Function After CRRT in the Paediatric Intensive Care Unit, a Follow-up Study.
In this study the investigators will evaluate the long-term renal function in children treated with continuous renal replacement therapy (CRRT) due to acute kidney injury (AKI) and multiple organ failure (MOF) in the pediatric…
- Conditions
- Acute Kidney Injury, Multi Organ Failure, Children, Only
- Trial name
- NCT05629273
- Where
- Sweden
- Volunteers
- 156 people
- Sponsor
- Region Stockholm
Respiratory Failure, Renal Failure, Acute
Plasma Exchange (PLEX) and Convalescent Plasma (CCP) in COVID-19 Patients With Multiorgan Failure
This Randomized Control Trial (RCT) proposes combination of extracorporeal cytokine removal by plasma exchange (PLEX) and additional infusion of convalescent plasma (CCP) collected from COVID-19 recovered individuals at the end…
- Trial name
- COVID-PLEX (NCT04634422)
- Testing
- Plasma exchange and convalescent plasma
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- Wladimir Szpirt
Septic Shock, Multiorgan Failure
Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
- Conditions
- Septic Shock, Multiorgan Failure, Sepsis
- Trial name
- NCT07539883
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Seoul National University Bundang Hospital