Clinical trials: MODS
Sepsis, Acute Respiratory Distress Syndrome
European Registry for Hemadsorption in Sepsis With the Seraph Filter
Although new techniques like extracorporeal blood purification have lately emerged, septic patients still have very high hospital mortality rates. Sepsis can be induced by either viremia, bacteriemia or in some cases both.
- Conditions
- Sepsis, Acute Respiratory Distress Syndrome, Infections - Pathogen Unspecified, Disease
- Trial name
- NCT05608096
- Testing
- Hemoperfusion
- Where
- Croatia
- Volunteers
- 300 people
- Sponsor
- Croatian Society for Organ Support
Cardiovascular Risk Factor, Nicotine Dependence
Short-Term Cardiovascular Effects of E-Cigarettes: Influence of E-Liquid pH
This study will examine the short-term cardiovascular (CV) effects of e-liquid pH in a randomized, crossover clinical and behavioral pharmacology study of experienced adult e-cigarette users (N=21).
- Trial name
- TCORS-2 (NCT04449510)
- Testing
- Electronic Cigarette
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Multiple Organ Failure, End Stage Cardiac Failure
Timing of Acute Palliative Care Consultation in Critically Ill Patients
A prospective randomized controlled trial studying the ordering of palliative care consultations in the emergency department (Ig) versus later palliative care consultations in the hospital--ICU or hospital ward(Cg).
- Conditions
- Multiple Organ Failure, End Stage Cardiac Failure, End Stage Chronic Obstructive Airways Disease, Chronic Kidney Disease Stage 5
- Trial name
- NCT02858778
- Testing
- Early order of palliative care consultation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Pancreatitis, Multiple Organ Failure
Albumindialysis in Acute Pancreatitis
The incidence of acute pancreatitis has been doubled during last three decades in Finland. Alcohol is the main cause of acute pancreatitis in Finland accounting for 70 % of cases.
- Trial name
- pancreatitis (NCT00483912)
- Testing
- Molecular adsorbent recirculating system
- Where
- Finland
- Sponsor
- Tampere University
Sepsis Syndrome, MODS
Nafamostat Mesilate for Anticoagulation During CRRT in Critically Ill Patients
Continuous renal replacement therapy is widely used in intensive care medicine, which is known as an alternative therapy to save injured kidney . Anticoagulation is an important part of this therapy.
- Conditions
- Sepsis Syndrome, MODS, AKI, Hemorrhage
- Trial name
- NMFADCICIP (NCT05382078)
- Where
- China
- Volunteers
- 188 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Hemoperfusion, Multiorgan Failure
Hemoperfusion in Critical Patients With Septic Multiorgan Dysfunction Syndrome.
Low-level interventional clinical trial to evaluate the effectiveness and safety of extracorporeal support with hemoperfusion in critical patients with septic multiorgan dysfunction syndrome.
- Conditions
- Hemoperfusion, Multiorgan Failure, Sepsis
- Trial name
- NCT05044403
- Testing
- Extracorporeal support with haemoperfusion, Conventional treatment
- Where
- Spain
- Volunteers
- 48 people
- Sponsor
- Hospital Clinic of Barcelona
Organ Failure, Multiple
Evaluation of Corrected Carotid Flow Time Variations During Passive Leg Lift to Predict Response to Filling.
Patients hospitalized in intensive care often require intravenous administration of fluid in order to optimize the functioning of the heart and thus ensure perfusion of vital organs such as the kidneys, the brain or the digestive…
- Trial name
- CAROT (NCT04732481)
- Testing
- passive leg lift test
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Centre Hospitalier de Cornouaille
Acute Pancreatitis, Organ Failure, Multiple
Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity of Severe Acute Pancreatitis
In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1（SCD-1） and the disease severity as well as the presence of adverse clinical events, such as local…
- Trial name
- NCT03282253
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Nanjing University School of Medicine
Acute Respiratory Distress Syndrome Caused by COVID-19
Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19
Background: There are no proven therapies specific for Covid-19. The full spectrum of Covid-19 ranges from asymptomatic disease to mild respiratory tract illness to severe pneumonia, acute respiratory distress syndrome (ARDS)…
- Trial name
- DEXA-COVID19 (NCT04325061)
- Testing
- Dexamethasone
- Where
- 24 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Hospital Universitario de Gran Canaria Doctor Negrín
Critical Illness, Enteral Nutrition
Trial of Enteral Glutamine on Clinical Outcomes in Critically Ill Patients
Glutamine supplementation has beneficial effects on morbidity and mortality in critically ill patients, possibly in part through an attenuation of the proinflammatory cytokine response and a Immune function.
- Conditions
- Critical Illness, Enteral Nutrition, Multiple Organ Failure, Infection Complication
- Trial name
- NCT02998931
- Testing
- Glutamin, Maltodextrin
- Where
- 2 sites in Iran
- Volunteers
- 200 people
- Sponsor
- Shahid Beheshti University
Multiple Organ Dysfunction With Severe Endotoxemia
Efficacy and Safety of Hemoperfusion With Polymyxin B in Septic Shock Associated With Severe Endotoxemia in Cardiac Surgery Patients (РМХ vs SS)
Sepsis is a state of multiple organ dysfunction caused by a generalized immune-inflammatory response of the body to an infectious agent, with pronounced heterogeneity and interchangeability of clinical and laboratory…
- Trial name
- РМХ vs SS (NCT04920565)
- Testing
- hemoperfusion with polymyxin B
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Septic Shock
Extracorporeal Cytokine Removal in Patients With Septic Shock in an Adult Intensive Care Unit
Goals Primary: compare changes in norepinephrine requirements before and after hemoperfusion (HP) treatment. Secondary: demonstrate the decrease in levels of IL-6 , assess the total and individual change of SEQUENTIAL ORGAN…
- Trial name
- NCT04231695
- Where
- Argentina
- Volunteers
- 20 people
- Sponsor
- Hospital Jose Maria Cullen
Heat Stroke, Early Waking
Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs.
- Conditions
- Heat Stroke, Early Waking, MODS, Proteinosis
- Trial name
- NCT05155358
- Testing
- Peripheral blood test
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
SARS-CoV 2 Pneumonia
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome…
- Trial name
- COVIDIOL (NCT06279910)
- Testing
- Calcifediol
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Cardiac Valve Disease, Coronary Artery Disease
The PRE-OP ENERGY Trial
The PRE-OP ENERGY Trial proposes to test the overarching hypothesis that a pre-surgery high energy diet will protect patients against organ damage during cardiac surgery with cardiopulmonary bypass.
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Organ Failure, Multiple
- Trial name
- NCT04015973
- Testing
- High energy diet
- Where
- United Kingdom
- Volunteers
- 116 people
- Sponsor
- University of Leicester
Multi Organ Failure, Left Ventricular Dysfunction
Acute Cardiac Dysfunction in Critical Illnes
The overall aim of the study is to establish the clinical importance of cardiac dysfunction, by estimating its incidence and impact on short- and long-term outcomes, in a mixed population of critically ill patients with…
- Conditions
- Multi Organ Failure, Left Ventricular Dysfunction, Right Ventricular Dysfunction, Tako Tsubo Cardiomyopathy
- Trial name
- NCT05860504
- Testing
- Echocardiography, Cardiac magnetic resonance imaging, Coronary CT
- Where
- Sweden
- Volunteers
- 592 people
- Sponsor
- Sahlgrenska University Hospital
Covid19, Organ Failure, Multiple
DNA Damage in Critically Ill COVID-19 Patients
Critically ill patients with COVID-19 are exposed to high oxidative stress which is potential harm to the DNA. Peripheral lymphocytes' DNA will be investigated using the comet assay on changes in oxidative damage to the purine…
- Conditions
- Covid19, Organ Failure, Multiple, DNA Damage
- Trial name
- NCT04772703
- Testing
- COMET ASSAY
- Where
- Czechia
- Volunteers
- 10 people
- Sponsor
- University Hospital Hradec Kralove
ASA Class III/IV Patients, COPD III/IV
Remimazolam Versus Propofol for Procedural Sedation in Gastrointestinal Endoscopy: A Single-Centre Prospective Observational Comparative Study in a High-Risk Population
Remimazolam is a new, ultra-short-acting benzodiazepine approved in Romania for procedural sedation. It shows significant clinical benefits compared to other sedatives like Propofol or Midazolam, especially in elderly or…
- Conditions
- ASA Class III/IV Patients, COPD III/IV, Age 65 and Older, Multiple Organ Failure
- Trial name
- NCT07362173
- Testing
- Administering remimazolam, Administering propofol
- Where
- Romania
- Volunteers
- 203 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
SARS-CoV-2, Coronavirus
Personalized Health Education Against the Health Damage of Novel Coronavirus (COVID-19) Outbreak in Hungary
The additional effect of personalized health education compared to general education following the internationally accepted principles will be evaluated in the prevention of the serious course of the novel coronavirus infection.
- Conditions
- SARS-CoV-2, Coronavirus, COVID-19, 2019-nCoV
- Trial name
- PROACTIVE-19 (NCT04321928)
- Testing
- Personalized health education, General health education
- Where
- Hungary
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Traumatic Complication of Injury
Inflammatory Cytokine Variations in Traumatic Injury Responses
The purpose of this study is to determine if the type of surgery (orthopaedic, general surgery, thoracic, etc.) affects the level of cytokines and thus potentially the risk of multisystem organ failure.
- Trial name
- Cytokine (NCT00593892)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham