Clinical trials: MRI, Functional
Smoking
Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms
A single center, double blind, randomized, placebo controlled, two-treatments, two-period crossover study conducted in adult smokers.
- Trial name
- NCT00657020
- Testing
- Nicotine
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Schizophrenia
The Effects of Aripiprazole on the Processing of Rewards in Schizophrenia
The objective of this study is to determine whether subjects with negative symptoms of schizophrenia have abnormal functioning of brain circuits relevant to reward processing, and to determine whether any such abnormalities are…
- Trial name
- NCT00209027
- Testing
- fMRI, Aripiprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
PTSD
Efficacy and Neural Mediators of Response to Trauma Management Therapy for PTSD
Social difficulties are serious and frequent complicating factors in the treatment of post-traumatic stress disorder (PTSD). To better understand how treatment of post-traumatic stress disorder impacts neural mechanisms of social…
- Trial name
- NCT03449576
- Testing
- Trauma Management Therapy, Exposure Therapy with Psychotherapy group
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
Cognitive Rehabilitation in Parkinson's Disease
We are testing a computer game-style rehabilitation program for people with Parkinson's disease (PD). People with PD often have difficulty with motor planning, such as initiating or starting movements.
- Trial name
- NCT01085968
- Testing
- PC based training
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Bipolar Disorder, Alcohol Drinking
Acute Alcohol Response In Bipolar Disorder: a fMRI Study
Alcohol use disorders (AUDs) affect up to 60% of individuals with bipolar disorder during their lifetime-a rate 3 to 5 times higher than what occurs in the general population.
- Conditions
- Bipolar Disorder, Alcohol Drinking, Alcohol Use Disorder
- Trial name
- BACS (NCT04063384)
- Testing
- alcohol beverage
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Schizophrenia, Schizophreniform Disorder
DECIFER: Depression and Citalopram In First Episode Recovery
This study seeks to examine the effectiveness of citalopram added to treatment with any oral or injectable second-generation antipsychotic plus standardized psychoeducation in first episode schizophrenia patients.
- Trial name
- DECIFER (NCT01041274)
- Testing
- Citalopram, Psychoeducation, Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- NYU Langone Health
Fibromyalgia
Effectiveness of Acupuncture in Relieving Pain Due to Fibromyalgia
This study will determine the effectiveness of acupuncture versus a placebo in altering brain activity and relieving pain due to fibromyalgia.
- Trial name
- NCT00142597
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Michigan
Low Back Pain
Imaging Study of Chronic Low Back Pain in Patients Taking Pain Medication
Duloxetine has recently been shown to be effective in reducing the pain in chronic pain patients. Duloxetine is known to exert a central mechanism, however the precise human brain structures responsible for mediating its…
- Trial name
- NCT00388414
- Testing
- duloxetine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Stanford University
Pulmonary Hypertension
Targeting Right Ventricle in Pulmonary Hypertension Gilead
This study is looking to see if giving ranolazine to subjects on stable pulmonary hypertension therapies but with right ventricular dysfunction (RVEF <45%) will improve their health by improving right ventricular (RV) function.
- Trial name
- NCT02829034
- Testing
- Ranolazine
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of Pennsylvania
Post Traumatic Stress Disorder
Neural Mechanisms of Mindfulness-based Cognitive Therapy (MBCT) for Posttraumatic Stress Disorder (PTSD)
This study will examine the effects of psychotherapy as treatment for PTSD, and specifically how brain activity and brain connectivity is affected by Mindfulness Based Cognitive Therapy (MBCT) and an active mind-body comparison…
- Trial name
- NCT03874793
- Testing
- Mindfulness-Based Cognitive Therapy, Muscle Relaxation Therapy
- Where
- 2 sites in United States
- Volunteers
- 61 people
- Sponsor
- Ohio State University
Stress Disorders, Post Traumatic, Trust
Neuroimaging the Impact of Treatment on Neural Substrates of Trust in Post-Traumatic Stress Disorder (PTSD)
Traumatic experiences can have a profound negative effect on the lives and well-being of both the people who experience them and their loved ones.
- Trial name
- NCT01244477
- Testing
- Group CPT-C
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- VA Office of Research and Development
Subcortical Aphasia, Ischemic Stroke
The Effect of Venlafaxine on Language Function in Patients With Subcortical Aphasia: A fMRI Study
Previous studies have demonstrated that venlafaxine significantly improves the language function of healthy subjects and increase of fMRI activation in cortical language area.
- Trial name
- NCT03588572
- Testing
- Venlafaxine hydrochloride capsules
- Where
- 2 sites in China
- Volunteers
- 43 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Alcohol Use Disorder, Early Trauma Complications
Neurobiological Responses in Alcoholism and Early Trauma
Alcohol use disorder (AUD) accompanied by early trauma presents clinical challenges, including elevated rates of comorbid emotional symptoms and relapse.
- Trial name
- NCT04128228
- Testing
- 8-week outpatient treatment
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Yale University
Major Depression
Study of Brain Response to Emotional Pictures Using a fMRI While on Duloxetine
The purpose of this study is to find out what parts of the brain have increased or decreased activity when people are depressed and how antidepressant medicine changes this activity in depressed patients.
- Trial name
- NCT00532480
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Indiana University
Parkinson Disease, Physical Activity
Neuroplasticity in Parkinson´s Disease After Training
This project aims to determine the effects of the HiBalance program on neuroplastic changes in people with mild to moderate Parkinson´s disease.
- Conditions
- Parkinson Disease, Physical Activity, Gait Disorders, Neurologic, Neural Degeneration
- Trial name
- BETA-PD (NCT03213873)
- Testing
- HiBalance, Speech and communication therapy
- Where
- Sweden
- Volunteers
- 95 people
- Sponsor
- Karolinska Institutet
Osteoarthritis, Knee
Mechanistic Studies on Video-guided Acupuncture Imagery Treatment of Knee Pain
The aim of this study is to investigate brain response and connectivity changes evoked by video-guided acupuncture imagery treatment (VGAIT) and verum and sham acupuncture in knee osteoarthritis patients to elucidate the…
- Trial name
- NCT03261505
- Testing
- Acupuncture
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Massachusetts General Hospital
Post-Traumatic Stress Disorder
Cannabinoid Control of Fear Extinction Neural Circuits in Post-traumatic Stress Disorder
The goal of this study is to look at how a type of drug called cannabinoids are related to the processing of fear signals, the experience of emotions and fear, and the pattern of activity in the brain that is involved in these…
- Trial name
- NCT02069366
- Testing
- Dronabinol
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Chronic Pain, Back Pain
Hippocampal Stimulation in Chronic Low Back Pain
In this study the investigators aim to examine the effects of Transcranial Magnetic Stimulation (TMS) on hippocampal network connectivity and pain levels in individuals with chronic low back pain.
- Conditions
- Chronic Pain, Back Pain, Pain
- Trial name
- NCT04888494
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Northwestern University
Brain Diseases, Metabolic, Inborn, Urea Cycle Disorder
Neurologic Injuries in Adults With Urea Cycle Disorders
Urea cycle disorders (UCDs) are a group of rare inherited metabolism disorders. The purpose of this study is to evaluate how UCD-related neurologic injuries affect adults with one of the most common types of UCD.
- Conditions
- Brain Diseases, Metabolic, Inborn, Urea Cycle Disorder, Ornithine Transcarbamylase Deficiency
- Trial name
- NCT00472732
- Where
- 2 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Andrea Gropman
Stress Disorder, Post Traumatic
Dopamine Enhancement of Fear Extinction Learning in PTSD (1R21MH108753)
The purpose of this study is to investigate a new use for a medication called levodopa (L-DOPA). L-DOPA has been approved for use in Parkinson 's disease, but not for Posttraumatic Stress Disorder (PTSD).
- Trial name
- NCT02560389
- Testing
- Levodopa
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- University of Wisconsin, Madison