Clinical trials: MS
Multiple Sclerosis
Exercise and Brain Health in MS
Physical activity is now recognized as a therapy for Multiple Sclerosis (MS) that not only improves physical fitness and functional mobility, but there is some evidence that it may also positively influence the more invisible…
- Trial name
- NCT03638739
- Testing
- Twice-weekly exercise
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- McMaster University
Relapsing Remitting Multiple Sclerosis
Impact of Vitamin A on Multiple Sclerosis (MS)
The aim of this study is the comparison between the effects of supplementation with 25000 IU preformed vitamin A (retinyl palmitate) or placebo for first 6 months and 10000 IU/day for next 6 months on disease activity and…
- Trial name
- MS (NCT01417273)
- Testing
- vitamin A
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Tehran University of Medical Sciences
Multiple Sclerosis
Use of a Smartphone Application to Predict the Prognosis in Patients With Newly Diagnosed Multiple Sclerosis.
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system for which the investigators now have many treatment alternatives.
- Trial name
- MSST (NCT04595799)
- Where
- 10 sites in France
- Volunteers
- 240 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Adjustment Disorder
RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
The purpose of this study is to determine if treatment with a single dose of RE104 for Injection reduces depressive symptoms or depressive symptoms mixed with anxiety symptoms in participants with Adjustment Disorder due to…
- Trial name
- NCT07002034
- Testing
- RE104 for Injection
- Where
- 32 sites in United States
- Volunteers
- 100 people
- Sponsor
- Reunion Neuroscience Inc
Multiple Sclerosis
French Adaptation of the California Card Sorting Task (CCST) in Multiple Sclerosis
Cognitive impairment affects up to 65% of multiple sclerosis (MS) subjects, especially executive functions. The California Card Sorting Task (CCST) assesses specific components of problem-solving ability.
- Trial name
- E3C-DIFSEP (NCT02887352)
- Testing
- assessment of problem-solving ability
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Multiple Sclerosis
Study of Exercise on Impact of Cognitive Functioning in Multiple Sclerosis Patients
Cognitive impairment affects roughly 50% of people with multiple sclerosis (MS). There are currently no satisfactory medical treatments for cognitive impairments related to MS and alternative forms of treatment are needed.
- Trial name
- NCT02106052
- Testing
- Aerobic exercise, Stretching and toning exercise
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Washington
Multiple Sclerosis
A Study Comparing Shared Solutions® Plus MS Center Support Versus Shared Solutions® Alone
To compare the effectiveness of a 90-day Copaxone® adherence enhancement program for a sample of MS patients who are at high risk of nonadherence and receive support from Shared Solutions® and their MS Center versus those who…
- Trial name
- NCT00240006
- Testing
- Shared Solutions® plus MS Center v. Shared Solutions®
- Volunteers
- 307 people
- Sponsor
- Teva Neuroscience, Inc.
MS (Multiple Sclerosis)
Understanding Evaluation of Patient Information Sheets by User Testing Method
The purpose of this randomized, open label, crossover, single site study is to compare the PISs of two Multiple Sclerosis clinical trials to elucidate potential aspects of the given written information that could impact on the…
- Trial name
- NCT03155334
- Testing
- PIS User Testing
- Where
- 2 sites in Italy, Romania
- Volunteers
- 100 people
- Sponsor
- Fondazione Italiana Sclerosi Multipla
Spasticity in People With Multiple Sclerosis
Study of VSN16R for the Treatment of Spasticity in Multiple Sclerosis
Phase II a Proof of concept study in Multiple Sclerosis (MS) patients with spasticity.
- Trial name
- NCT02542787
- Testing
- VSN16R
- Where
- 4 sites in United Kingdom
- Volunteers
- 160 people
- Sponsor
- Canbex Therapeutics Ltd
Radiologically Isolated Syndromes; Multiple Sclerosis
Comparison of Digital Biomarkers in Subjects With Radiologically Isolated Syndrome (RIS) and Multiple Sclerosis (MS) Patients With Clinically Normal Neurological Examination
Radiologically Isolated Syndrome (RIS) is the preclinical stage of Multiple Sclerosis (MS). It is the incidental discovery of white matter abnormalities on brain or spinal cord magnetic resonance imaging (MRI), whose shape…
- Trial name
- SPAM 3 (NCT07135752)
- Testing
- Precision assessment
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Demyelinating Disorders, MCI
Exploring the Utility of [18F]3F4AP for Demyelination Imaging
The overall objective is to obtain an assessment of the pharmacokinetics of [18F]3F4AP in healthy volunteers and subjects with demyelinating diseases such as mild cognitive impairment (MCI), Alzheimer's Disease (AD), Multiple…
- Conditions
- Demyelinating Disorders, MCI, Alzheimer's Disease (AD), MS (Multiple Sclerosis)
- Trial name
- NCT06999434
- Testing
- [ 18F]3F4AP, [18F]MK6240, [11C]PIB
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Yale University
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive
Imaging of Intracerebral Inflammation in MS
In this study we plan to image the compartmentalized inflammation in MS using molecular imaging by positron emission tomography (PET) with a very highly resolutive camera.
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis, Primary Progressive
- Trial name
- INFLASEP (NCT02305264)
- Testing
- 18F-DPA-714 and 18F-FDG
- Where
- 2 sites in France
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis
Study of Betaferon Adherence in Patients With Multiple Sclerosis Treated With Interferon Beta-1b
The primary objective of the study is to evaluate the adherence to the treatment with interferon beta-1b, in patients diagnosed with isolated syndrome (CIS), relapsing-remitting multiple sclerosis (RRMS), or secondary progressive…
- Trial name
- ADHERENCE (NCT03408093)
- Testing
- Interferon beta-1b (Betaseron, BAY86-5046)
- Volunteers
- 120 people
- Sponsor
- Bayer
Multiple Sclerosis
Assessing the Effects of Ongoing Ocrelizumab (OCR) Therapy on Fatigue and Cognition in Veterans With Multiple Sclerosis
This study seeks to assess the effects of long-term ocrelizumab therapy on fatigue (extreme tiredness) as well as cognition (thinking and reasoning skills, such as memory, learning and attention), in veterans with multiple…
- Trial name
- ML45855 (NCT07181811)
- Testing
- Multiple Sclerosis patients who have been on Ocrelizumab will undergo cognitive and fatigue assessments
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Anza Memon
Multiple Sclerosis, MS
A Closed Loop, Doctor to Patient, Mobile Application for Depression in People With Multiple Sclerosis
The researchers want to find out if an electronic application called MS CATCH can enhance patients' and doctors' experiences during and in between clinical visits.
- Conditions
- Multiple Sclerosis, MS, Depression
- Trial name
- MS-CATCH (NCT05865405)
- Testing
- MS CATCH
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Multiple Sclerosis
Oct-A and Perimetry in Multiple Sclerosis
This study aims to assess retinal vascular density using OCT-A and correlate these parameters with visual field changes in MS patients with and without a history of ON
- Trial name
- MS (NCT07175324)
- Testing
- optical coherence tomography angiography, Visual Field Perimetry
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
Efficacy and Safety of BIIB033 (Opicinumab) as an Add-on Therapy to Disease-Modifying Therapies (DMTs) in Relapsing Multiple Sclerosis (MS)
The primary objective of Part 1 of this study is to evaluate the effects of BIIB033 versus placebo on disability improvement over 72 weeks.
- Trial name
- AFFINITY (NCT03222973)
- Testing
- BIIB033 (opicinumab)
- Where
- 159 sites in United States, Australia and 13 more
- Volunteers
- 263 people
- Sponsor
- Biogen
Multiple Sclerosis
TRPMS to Improve Mobility and Depression in Multiple Sclerosis
This study is aimed to test the efficacy of 10 sessions of Transcranial Rotating Permanent Magnetic Stimulation (TRPMS) paired with aerobic exercise or computerized cognitive training (CT) on mobility and depression symptoms in…
- Trial name
- NCT04578041
- Testing
- TRPMS (Transcranial Rotating Permanent Magnet Stimulation), Aerobic Exercise Program, Computerized CT (Cognitive Training)
- Sponsor
- NYU Langone Health
Multiple Sclerosis
Ocrevus Zunovo for MS: Mixed Methods
Ocrevus Zunovo implementation, feasibility, acceptability, patient satisfaction, treatment persistence, and impact on MS disease outcomes will be analyzed in this mixed methods study.
- Trial name
- NCT07710105
- Testing
- Clinical Questionnaires, Semi-Structured Interviews, Ocrevus Zunovo
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Northwestern University
Heart Failure
MODULA-Study: Modul 10: Benefit of CRT-Therapy in CRT-Patients With QRS-Complex of 120 - 150 Ms
The purpose of this study is to compare the benefit of cardiac resynchronization therapy (CRT)-therapy in patients with a QRS-complex of 120-150 ms to patients with a QRS-complex of > 150 ms.
- Trial name
- NCT00180401
- Testing
- CRT-P and CRT-D devices
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Boston Scientific Corporation