Clinical trials: MS (Multiple Sclerosis)
Multiple Sclerosis
The Effect of Hybrid Telerehabilitation-Based Structured Exercise Programs in Patients With Multiple Sclerosis
The aim of our study is to compare the effects of hybrid telerehabilitation (TR)-based exercise program applied in patients with MS, only TR-based exercise program and only clinical-based exercise program on walking speed…
- Trial name
- NCT06293079
- Testing
- Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Biruni University
Multiple Sclerosis
Cognitive and Emotion Regulation Training in MS
The investigators propose to conduct a randomized feasibility study of mindfulness meditation training (MMT) relative to an active cognitive training control group and waitlist control group in improving emotional regulation in…
- Trial name
- CERT-MS (NCT02717429)
- Testing
- Mindfulness Meditation, Computerized Cognitive Training
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Ohio State University
Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting
Assessing Changes in Multi-parametric MRI in MS Patients Taking Clemastine Fumarate as a Myelin Repair Therapy
The clinical trial is intended to assess for clinical evidence of Clemastine Fumarate as a myelin repair therapy in patients with chronic inflammatory injury-causing demyelination as measured by multi-parametric MRI assessments.
- Conditions
- Multiple Sclerosis (MS), Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Chronic Progressive
- Trial name
- ReVIVE (NCT05359653)
- Testing
- Clemastine Fumarate
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of California, San Francisco
Multiple Sclerosis
Ocrevus Zunovo for MS: Mixed Methods
Ocrevus Zunovo implementation, feasibility, acceptability, patient satisfaction, treatment persistence, and impact on MS disease outcomes will be analyzed in this mixed methods study.
- Trial name
- NCT07710105
- Testing
- Clinical Questionnaires, Semi-Structured Interviews, Ocrevus Zunovo
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Northwestern University
Multiple Sclerosis
Targeting Residual Activity By Precision, Biomarker-Guided Combination Therapies of Multiple Sclerosis (TRAP-MS)
Background: In people with multiple sclerosis (MS), brain and cerebrospinal fluid (CSF) biomarkers indicate inflammation or disease. Researchers want to see if 4 drugs given alone or combined affect MS biomarkers.
- Trial name
- NCT03109288
- Testing
- Cilostazol, Leucovorin, Pirfenidone
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Multiple Sclerosis
Study of Empathy in MS
Multiple sclerosis is a chronic inflammatory disease of the central nervous system whose exact etiology remains unclear, underpinned by multiple pathophysiological mechanisms, and is a cause of significant motor and cognitive…
- Trial name
- SEmPathy (NCT05332951)
- Testing
- Interpersonal Reactivity Index
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Multiple Sclerosis, Clinically Isolated Syndrome
A Study Evaluating B Cell Levels In Infants Of Lactating Women With CIS Or MS Receiving Ocrelizumab
This study will evaluate the pharmacokinetics of ocrelizumab in the breastmilk of lactating women with clinically isolated syndrome (CIS) or multiple sclerosis (MS) [in line with the locally approved indications] treated with…
- Trial name
- SOPRANINO (NCT04998851)
- Testing
- Ocrelizumab
- Where
- 8 sites in United States, Spain and 1 more
- Volunteers
- 26 people
- Sponsor
- Hoffmann-La Roche
Multiple Sclerosis, Healthy
COVID-19 Vaccine Response in Treated MS Patients
The primary goal of this study is to assess the impact of the two major disease modifying therapy (DMT) classes (B cell therapies and S1P modulators) on humoral and cell-mediated immunity to SARS- CoV-2 vaccination compared to…
- Trial name
- NCT05060354
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Multiple Sclerosis
Interventional Clinical Trial for CCSVI in Multiple Sclerosis Patients
To investigate the safety and tolerability of balloon venoplasty compared to sham in Multiple Sclerosis patients with Chronic Cerebrospinal Venous Insufficiency (CCSVI) as measured by adverse events occurring within 48 weeks of…
- Trial name
- NCT01864941
- Testing
- Catheter venography with balloon venoplasty, Catheter venography with balloon venoplasty and balloon
- Where
- 4 sites in Canada
- Volunteers
- 104 people
- Sponsor
- University of British Columbia
Multiple Sclerosis
Psychometric Properties Mobility Measures MS
Current study will investigate the quality (psychometric properties) and clinical utility of several mobility measures, according to disability level.
- Trial name
- MCS-III-MOB (NCT02339688)
- Testing
- conventional MS rehabilitation
- Where
- Belgium
- Volunteers
- 254 people
- Sponsor
- Hasselt University
Multiple Sclerosis
Home-based Spinal Cord Stimulation for Hand & Arm Function in MS
This is a pilot study designed to test the feasibility of in-home, non-invasive (transcutaneous, applied by surface electrodes over the skin) electrical spinal cord stimulation combined with exercises for restoring upper…
- Trial name
- eSTIM-MS Home (NCT07673354)
- Testing
- Spinal Cord Stimulation + Hand/arm Exercises
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Washington
Neuropathic Pain, Allodynia
Botulinum Toxin Type A for Treating Allodynic Pain in SCI and MS
This study will examine the efficacy of Botulinum Toxin Type A ("Botox") in treating Allodynic-type neuropathic pain in people with spinal cord injury or multiple sclerosis.
- Trial name
- NCT01911377
- Testing
- Botulinum Toxin Type A, Normal Saline for Injection
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Manitoba
Sclerosis, Multiple, MS (Multiple Sclerosis)
EXOPULSE Mollii Suit, Motor Function & Multiple Sclerosis (EXOSEP 2)
The goal of this clinical trial is to demonstrate the improvement of motor functions related symptoms in patients with MS and spasticity using Exopulse Mollii suit stimulation in Multiple Sclerosis patients with spasticity.
- Conditions
- Sclerosis, Multiple, MS (Multiple Sclerosis), Spasticity, Muscle, Spastic
- Trial name
- NCT05857280
- Testing
- EXOPULSE Mollii Suit Stimulation
- Where
- United Arab Emirates
- Volunteers
- 36 people
- Sponsor
- Sheikh Shakhbout Medical City
Multiple Sclerosis
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cell Intravenous Infusion for MS
This trial will study the safety and efficacy of intravenous infusion of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of multiple sclerosis
- Trial name
- NCT05003388
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 15 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Multiple Sclerosis
Drug Risk Aversion Calculator Use to Facilitate MS Patient Self-efficacy
The investigators seek to determine if the use of a Side Effect Aversion Calculator helps patients with multiple sclerosis (MS) more comfortably and rapidly identify the disease modifying drug (DMD) that is best suited for the…
- Trial name
- DRAC (NCT03375541)
- Testing
- Risk Aversion Calculator
- Sponsor
- Duke University
Relapsing Remitting Multiple Sclerosis
Study Evaluating Rebif, Copaxone, and Tysabri for Active Multiple Sclerosis
This was a multicenter, randomized, open-label, parallel-group, active-controlled study. Prior to randomization, participants were to have been treated with glatiramer acetate or interferon β-1a (44 μg).
- Trial name
- SURPASS (NCT01058005)
- Testing
- BG00002 (natalizumab), interferon beta-1a, glatiramer acetate
- Where
- 42 sites in United States, Australia and 11 more
- Volunteers
- 84 people
- Sponsor
- Biogen
Relapsing-Remitting Multiple Sclerosis
Autologous T Cell Vaccine (TCV) for Multiple Sclerosis
This is a 1 year study to evaluate the efficacy, safety, and tolerability of Tovaxin T cell therapy in subjects with a clinically isolated syndrome (CIS) and relapse-remitting multiple sclerosis (RR-MS).
- Trial name
- TERMS (NCT00245622)
- Testing
- Tovaxin Autologous T cell vaccine
- Where
- 33 sites in United States
- Volunteers
- 150 people
- Sponsor
- Opexa Therapeutics, Inc.
Neurogenic Bladder, Multiple Sclerosis
Neuromodulating Cortical Regions Involved in Neurogenic Bladder in MS
Neurogenic overactive bladder (NOAB), characterized by urinary frequency, urgency or urgency incontinence symptoms occurring during the storage phase of the bladder, is the most common urinary complaint in multiple sclerosis…
- Conditions
- Neurogenic Bladder, Multiple Sclerosis, Overactive Bladder
- Trial name
- MSBLADDER (NCT06072703)
- Testing
- Magstim Rapid2 System
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- The Methodist Hospital Research Institute
Multiple Sclerosis
Armergometry to Improve Mobility in MS
Chronic progressive multiple sclerosis patients will be randomised to home-based arm ergometry training for 12 weeks or a waitlist control group which will have access to the treatment after 12 weeks when primary endpoint…
- Trial name
- AMBOS (NCT03147105)
- Testing
- arm ergometry
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Multiple Sclerosis
Multi-center Database Registry to Study Thalamus Changes Using AI in MS
In this study the Investigator's propose to validate a newly developed approach, DeepGRAI (Deep Gray Rating via Artificial Intelligence), to simplify the calculation of thalamic atrophy in a clinical routine and allow academic…
- Trial name
- NCT03920995
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- University at Buffalo